Gene gcy-11 (Nematode worm)
gcy-11
Sequence
Protein domains of gcy-11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | gcy-11.AA | RGC | 505-775 | 31 | 9.3e-114 | 384.22 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 505-775 Range on HMM: 1-300/300 Sequence Identity: 31% (95 aa) ENTLVTVRKINKT----QLKLTREMKQEIDLLMNETHENLNRFFGLINESD------LIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQF |...| ..|.|.. ....||.|..|. .... |.|||.|.|.. ... .. .. | .| ||.|.|.|||. .|.||| ||. |.|||.|. EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY LHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPDVFYDLVIFSNKYNSKTKNPIKKFSTDLLWFAPEIIRRYAVKHDLS-----KLEL || | |.|||||||.|| ||..| .|....|......... .... .. .. |...... .. ... ..||.|||..|... .|. . ... LHH-SPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP--CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGT AKADIYSLAIVLYEIYGRQG-----PFGDD----LLDSDEIIEQLKFP--DGG-ALTRPDIHLITK-----APYPLASVVEKCWVEDPASRPS-IQKVRE |.|.||..|..|||..|.| ||... |. .|||| .| | .|| ...||.|| ... .. | .....|| |||. ||. ....|. QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK LLEP .|. QLKT |
|||||||||
| Kinase | gcy-11.AA | RGC | 505-775 | 31 | 9.3e-114 | 384.22 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 505-775 Range on HMM: 1-300/300 Sequence Identity: 31% (95 aa) ENTLVTVRKINKT----QLKLTREMKQEIDLLMNETHENLNRFFGLINESD------LIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQF |...| ..|.|.. ....||.|..|. .... |.|||.|.|.. ... .. .. | .| ||.|.|.|||. .|.||| ||. |.|||.|. EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY LHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPDVFYDLVIFSNKYNSKTKNPIKKFSTDLLWFAPEIIRRYAVKHDLS-----KLEL || | |.|||||||.|| ||..| .|....|......... .... .. .. |...... .. ... ..||.|||..|... .|. . ... LHH-SPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP--CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGT AKADIYSLAIVLYEIYGRQG-----PFGDD----LLDSDEIIEQLKFP--DGG-ALTRPDIHLITK-----APYPLASVVEKCWVEDPASRPS-IQKVRE |.|.||..|..|||..|.| ||... |. .|||| .| | .|| ...||.|| ... .. | .....|| |||. ||. ....|. QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK LLEP .|. QLKT |
|||||||||
| Kinase | gcy-11.AA | TKL | 691-773 | 26 | 4.4e-14 | 47.13 | In-house | 269-364 (364) | Show / Hide |
Range on Protein: 691-773 Range on HMM: 269-364/364 Sequence Identity: 26% (25 aa) KADIYSLAIVLYEIYGRQGPFGDDLLDSDE------IIEQLKFPDGGALTRPDI-------HLITKAPYPLASVVEKCWVEDPASRPSIQKVRELL |.|.|| .|||.||. |. |. |. .. . .. . .| ...|.| . .| .... ..|| .|| .||| |.. . | KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
|||||||||
| Kinase | gcy-11.AA | S_TKc | 500-777 | 14 | 4.6e-12 | 0.0 | SMART | 16-231 (231) | Show / Hide |
Range on Protein: 500-777 Range on HMM: 16-231/231 Sequence Identity: 14% (41 aa) HLAKYEN--TLVTVRKINKTQLKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPR--KSLMDLLRNDDLR-----LDRMFKVSFVEDVVK .... . .| . .|. . ...||..|.. |.|. .... . . | .. . | . .|.|.... . .. ... ... YKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC GLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPDVFYDLVIFSNKYNSKTKNPIKKFSTDLLWFAPEIIRRYAVKHDLSKLELA .|...|. .| | || .| .| .||.. |. . . | . . |||.. . . ALEYCHSH-GI-IHRDLKPENILLDE--HIKICDFGLARQL-----------------------------TTFCGTPWYMAPEVL----------GYGKC KADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAPYPLASVVEKCWVEDPASRPSIQKVRE-----LLEPLS |.|..|. ..||| . .. || . ........ . .. . ..||.. ||. ||.. .. . . | KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | gcy-11.AA | Pkinase | 669-773 | 15 | 1e-09 | 35.44 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 669-773 Range on HMM: 177-293/293 Sequence Identity: 15% (20 aa) WFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAP-------------------YPLA . |||.|| .. |.|..|. ..||| . .. || .. ..|. ..|.. . .... . .. . .. YMAPEVIR-------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK SVVEKCWVEDPASRPSIQKVREL--L .....|. ||..||... . . . DFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | gcy-11.AA | LRRK | 691-775 | 25 | 1.2e-09 | 30.34 | In-house | 262-351 (351) | Show / Hide |
Range on Protein: 691-775 Range on HMM: 262-351/351 Sequence Identity: 25% (25 aa) KADIYSLAIVLYEIYGRQ-GPFGD---------DLLDSDEIIEQLKFPDGGALTRPDIH----LITKAPYPLASVVEKCWVEDPASRPSIQKVRELLEP |.|.|| ...|.|.. || ||.. ...|.|||.| || | . . . . . ..|| .|| .||. ... . |. KVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGL---------RPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
|||||||||
| Kinase | gcy-11.AA | MLK | 691-773 | 21 | 2.1e-09 | 28.91 | In-house | 216-291 (291) | Show / Hide |
Range on Protein: 691-773 Range on HMM: 216-291/291 Sequence Identity: 21% (18 aa) KADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAPYPLASVVEKCWVEDPASRPSIQKVRELL |.|..| ..||.|. |. |. ...... . |... ... .| .... ..|| .||..||| . . . | KCDVWSWGVVLWEMLTREVPYK-------QHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | gcy-11.AA | TKL-ciliate1 | 691-773 | 24 | 4.1e-09 | 27.34 | In-house | 199-279 (279) | Show / Hide |
Range on Protein: 691-773 Range on HMM: 199-279/279 Sequence Identity: 24% (21 aa) KADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDI---HLITKAPYPLASVVEKCWVEDPASRPSIQKVRELL |.|||...||.|. | || . ... || || . . | . . .|| ..|. ||. . . . | KIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFP-----GRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL |
|||||||||
| Kinase | gcy-11.AA | TyrKc | 500-773 | 20 | 7.5e-09 | -79.56 | SMART | 16-280 (280) | Show / Hide |
Range on Protein: 500-773
Range on HMM: 16-280/280
Sequence Identity: 20% (64 aa)
HLAKYENTLVTVRKINKTQLKLTREMKQEIDLLMNE--THENLNRFFGLINES-------DLIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVK
..... . | | .... ... .|. .... |.|. |..| . .. . .. . | | .| | ||. .| ..|| .. .
YKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIAC
GLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGM-EQIRVE---EPESKPDVFYDLVIFSNKYNSK-----TK--NPIKKFSTDLLWFAPEIIRRYA
| ..||. | | | || |.. ..| | |. | . | .| .| .| ||. | ||| |
GMEYLHSKNCI--HRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------------ESKDYYRKKEHKGGKTMLPIR-------WMAPECI----
VKHDLSKLEL---AKADIYSLAIVLYEI--YGRQGPFGDDL--LDSDEIIEQLKFPDGGALTRPDIHLITK-----APYPLASVVEKCWVEDPASRPSIQ
. | |..| ....|| || | . |. . .. .|.||..| .|. . .|. .. .| . .. ..|| |||..||. .
-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--QGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFS
KVRELL
..|..
EIHECF
|
|||||||||
| Kinase | gcy-11.AA | TKL | 500-626 | 15 | 1.1e-08 | 27.45 | In-house | 10-199 (364) | Show / Hide |
Range on Protein: 500-626 Range on HMM: 10-199/364 Sequence Identity: 15% (30 aa) HLAKYEN----------TLVTVRKINKTQLKL--------------------------TREMKQEIDLLMNET-HENLNRFFGLINESDL---------- . .|. . . | | |..... .. |. . | ..|. . |.|. .| | .... YKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGP ---IFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGS------KIGYHGNLKSSNCIVDAYWR--------------IKLSNYG .. . | |. || ..| ..... |. .|...|| . | .|||.|. || |. .|.. .| WGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFG |
|||||||||
| Kinase | gcy-11.AA | TKL-Unique | 502-626 | 21 | 1.2e-08 | 26.86 | In-house | 16-162 (290) | Show / Hide |
Range on Protein: 502-626 Range on HMM: 16-162/290 Sequence Identity: 21% (32 aa) AKYENTLVTVRKINK---TQLKLTREMKQEIDLLMNET-HENLNRFFG-LI----NESDLIFTIHSYGPRKSLMDLLR---------NDDLRLDRMFKVS .|. . |.. .... .....| . |. .. . |.|. ...| . ...... . .| |. ||.|.| |. . |. .|. GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCI-VMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVK FVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAY-----WRIKLSNYG ...|...|. .|| .. .|..||||| || |.||.. | MAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFG |
|||||||||
| Kinase | gcy-11.AA | DRK | 519-626 | 30 | 1.9e-08 | 24.76 | In-house | 38-145 (258) | Show / Hide |
Range on Protein: 519-626 Range on HMM: 38-145/258 Sequence Identity: 30% (33 aa) LKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAYW ... |...||.|. . | | | | |.. | . | || || | .. . .| . |. ||. .|| | | ||| | || | ENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHW RIKLSNYG ..| . .| QVKVADFG |
|||||||||
| Kinase | gcy-11.AA | TKL-Unique | 645-713 | 27 | 2e-06 | 18.88 | In-house | 163-236 (290) | Show / Hide |
Range on Protein: 645-713 Range on HMM: 163-236/290 Sequence Identity: 27% (22 aa) LVIFSNKYNSKTKNPI-----KKFSTDLLWFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQG------PFGD |..|..| | .|.| . . . ..| |||..|. .. |.|.|| .|||.||. |. |. . LSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQG |
|||||||||
| Kinase | gcy-11.AA | TAK1 | 740-772 | 25 | 8e-06 | 15.6 | In-house | 249-284 (284) | Show / Hide |
Range on Protein: 740-772 Range on HMM: 249-284/284 Sequence Identity: 25% (9 aa) LITK---APYPLASVVEKCWVEDPASRPSIQKVREL ..| .| .. . ..|| ..|..||| | . . METNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY |
|||||||||
| Kinase | gcy-11.AA | DRK | 755-775 | 57 | 5e-05 | 13.02 | In-house | 238-258 (258) | Show / Hide |
Range on Protein: 755-775 Range on HMM: 238-258/258 Sequence Identity: 57% (12 aa) CWVEDPASRPSIQKVRELLEP || ||| ||| | . | || CWNEDPQHRPSMQECLERLEA |
|||||||||
| Kinase | gcy-11.AA | DRK | 691-711 | 61 | 7.6e-05 | 12.38 | In-house | 182-202 (258) | Show / Hide |
Range on Protein: 691-711 Range on HMM: 182-202/258 Sequence Identity: 61% (13 aa) KADIYSLAIVLYEIYGRQGPF |||.|| |||| |. || |. KADVYSFAIVLWECVTRQDPY |
|||||||||
| Kinase | gcy-11.AA | TAK1 | 690-711 | 40 | 9.3e-05 | 11.88 | In-house | 204-225 (284) | Show / Hide |
Range on Protein: 690-711 Range on HMM: 204-225/284 Sequence Identity: 40% (9 aa) AKADIYSLAIVLYEIYGRQGPF .|.|||| .|.. |. |. |. MKCDIYSWGIIMWEVISRKHPY |
|||||||||
| Kinase | gcy-11.AA | TKL-Unique | 753-773 | 38 | 0.000194 | 11.77 | In-house | 270-290 (290) | Show / Hide |
Range on Protein: 753-773 Range on HMM: 270-290/290 Sequence Identity: 38% (8 aa) EKCWVEDPASRPSIQKVRELL ..|| || ||| . ... | QQCWHHDPSQRPSFDEIIHRL |
|||||||||
| Kinase | gcy-11.AA | Dicty4 | 691-711 | 61 | 0.000218 | 10.74 | In-house | 197-217 (277) | Show / Hide |
Range on Protein: 691-711 Range on HMM: 197-217/277 Sequence Identity: 61% (13 aa) KADIYSLAIVLYEIYGRQGPF ||| || .|||.|| || |. KADVYSFGIVLWEILTRQEPY |
|||||||||
| Kinase | gcy-11.AA | Dicty4 | 745-775 | 30 | 0.000492 | 9.54 | In-house | 245-277 (277) | Show / Hide |
Range on Protein: 745-775 Range on HMM: 245-277/277 Sequence Identity: 30% (10 aa) PYPLASVVEKCWVEDPASRPSIQKVREL--LEP | .... ...|| .|| .||| . . . || PPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
|||||||||
| Kinase | gcy-11.AA | Dicty4 | 561-621 | 29 | 0.011125 | 4.96 | In-house | 85-154 (277) | Show / Hide |
Range on Protein: 561-621 Range on HMM: 85-154/277 Sequence Identity: 29% (21 aa) PRKSLMDLLRN------DDLRLD--RMFK-VSFVEDVVKGLQFLHE-GSKIGYHGNLKSSNCIVDAYWRIK |. .| ||.. . || .. . |...|.. ||. . | | |||.| ||. ||.| PKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVI-IHRDLKSHNLLVDKNWRVK |
|||||||||
| CYCc | gcy-11.AA | CYCc | 812-1006 | 47 | 3.7e-112 | 379.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 812-1006 Range on HMM: 1-231/231 Sequence Identity: 47% (110 aa) DERKRNESLLLQLLPKSVANSLKNGQ-PVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFD-----CYKVETIGDAYMFVSGL .|...|..|| |.||..|||.||.|. ||... ||.|.|.|.||||||.|.|..||.|||||||..||.||.|||... |||||||||||| |||. MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC PEVNS-------------------YLHAGEVASASLELLDSIKTFTVSHC----PDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGE |..| . || ..|. .|. ....||| | |. |...||.||| |||||| |||||||||||.||||| .|. |||.|. PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD PMRIQISSDAYELI-------LKCGGYVTEQ |..|..|...|... .||....|. PGQIHVSEETYWCLCLDQFERRRCGQFEFEP |
|||||||||
| Guanylate_cyc | gcy-11.AA | Guanylate_cyc | 839-1025 | 40 | 1.1e-74 | 259.23 | Pfam | 1-214 (214) | Show / Hide |
Range on Protein: 839-1025 Range on HMM: 1-214/214 Sequence Identity: 40% (88 aa) VDAEFYDSVSIYFSDIVGFTALSSKST----PLQVVNMLNNLYTNFDTIIDKF--DCYKVETIGDAYMFVSGLPEV-----NSYLHAGEVASASLELLDS | |. ||.|.|.|.|||||||..|... |.|.|.||| .||.||...|.. .||||.||||.|| |||||. ... || .| .|..... VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY IKTFTVSHCPDEK-----LRLRIGNHTGPVVTGVVG--IRMPRYCLFGDTVIIANMMESSGEPM--RIQISSDAYELILKCGGYVTEQ-----REKIVLK .... | | . | ...||| |||||| ||.| .||||||..|||| |. ||| |.| .|..| .|. .|||..... . | | .| CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYR-CLKCHENFQFECHLQHRGEIPVK NKLE---VMTYWMND | . . ||. . GKGKMGEMETYFLHG |
|||||||||
| HNOBA | gcy-11.AA | HNOBA | 799-833 | 42 | 1e-06 | 25.29 | Pfam | 200-234 (234) | Show / Hide |
Range on Protein: 799-833 Range on HMM: 200-234/234 Sequence Identity: 42% (15 aa) LEDVIKERTEQLEDERKRNESLLLQLLPKSVANSL | | ... .. || |.|....|| . .|||||| | LKDKLEQMHRELEEEKKKTDDLLYSMFPKSVANRL |
|||||||||