Gene flr-4 (Nematode worm)
flr-4
Group:
Other
Family:
Other-Unique
Sequence
Protein domains of flr-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
S_TKc | flr-4.AA | S_TKc | 40-331 | 21 | 3.7e-39 | 137.34 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 40-331 Range on HMM: 1-231/231 Sequence Identity: 21% (67 aa) YKYIQDLGKGRFGTVCKFSNGN--TFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPR--GSVKD |. .. .||| ||.|.| . . .|... .... | . |.| . ||...... | . .|. ||.. |...| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD LLVKET-------LGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSS ...| . | .| .|. ....||.|.|.. .||||.| .|.|... ||.. ||| | | | |. |.||||| YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-- ALGPGNRNAYEL-PADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYAKSEDGKVLPYTSEVLVPSSSNCVQKIVDLVFIKSPEHRPNTHKLRI-- | ..|.|..||...||| .|| ..... |... |. . . ... . | ||.|| .. --------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDE ---QIKKIL . . WDIKCHPWF |
|||||||||
Pkinase | flr-4.AA | Pkinase | 40-260 | 25 | 2.2e-38 | 136.82 | Pfam | 1-211 (293) | Show / Hide |
Range on Protein: 40-260 Range on HMM: 1-211/293 Sequence Identity: 25% (61 aa) YKYIQDLGKGRFGTVCKFSNGNTFE--TVKKVDLTIFNHWTQ------SETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRG |. .. .|.| ||.|.| . .| . ||.... ..| . || .. .||. |. || ..... |.. .|. ||.. | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---------HPN------IVRLYDWFEDKDHIYMVMEYCEGG ----SVKDLLV---KETL--GEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSI----KLANFGLVRDLAVDGFGIAIASEITLDFRATL . .|.. . .. |.....|. .....|.|.|. .||||.| .|.|| .|. | |.. ||| . . .. . .| |. LYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTP LYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP |.||||. .. | ..|.|..||...|||..||| WYMAPEVIR------GGQYYGPKVDMWSCGCILYEMLCGRPP |
|||||||||
Kinase | flr-4.AA | STE | 40-323 | 20 | 1e-37 | 130.76 | In-house | 1-351 (359) | Show / Hide |
Range on Protein: 40-323 Range on HMM: 1-351/359 Sequence Identity: 20% (76 aa) YKYIQDLGKGRFGTVCKF---------SNGNT--------FETVKKVDLTIFN-----HWTQSETKVSNRLDTFLYEFRHLHKVTNDNN----RIVNFLG .. |. .||| ||||.| ..|.. . .|...| | . . ..|. .. . .. . |. .. | ||...| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQ-EN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG IYADS-------NQMYIMSEYLPRGSVKDLLV-K-ETLG-------------EDTAIKYLMETVEA-LDYLHNLSPPVIHRDIKAANLLITSNDSIKLAN | . .. .| ||.. ||. |.. | .... |. .... ..... |.|||.. .||||||.|| |. .||.. CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCD FGLVRDLAVDGFGI--AIASEI----TLDFRA-----TLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYA ||. |. .. .| .. . | | . . | . ||||.. .. ... | .||| |||| |||. .||.... . .. ... FGVCGQLTDSMANIQSNN-I-IDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM KS---------EDGKVLPY---------------TSEVLVPSSSNCVQKIVDLVFIKSPEHRPNTHKL . .. || | . . | . . ... ..| |..||....| QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTT---YPHKWSPEFKDFINKCLQKDPNKRPTASQL |
|||||||||
Kinase | flr-4.AA | Ciliate-E2 | 40-260 | 19 | 1e-25 | 85.22 | In-house | 1-295 (365) | Show / Hide |
Range on Protein: 40-260 Range on HMM: 1-295/365 Sequence Identity: 19% (59 aa) YKYIQDLGKGRFGTVCKF---SNGNTF-----------------ETVKKVDLTIFNHW----TQSETKVSNRLDTFLYEFRHLHKV-----TNDNNRIVN || |. .|.| ||.|.| .... | ..|.. . |... . .| .. .... | . . . ..... |.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY--KKI-NEKNILEQLNHPNIIK FLGIYA--DSNQMYIMSEYLPRGSVKDLLVKE-TLG-----------EDTAIKYLMETVE---------------ALDYLHNLSPPVIHRDIKAANLLIT . . | | .|. ||. |. .|.. . . | .... . .. || |||. . .|||||| |.|. MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF- SNDSIKLANFGLVRDLAVD---GFGIAIASEITLDFRA-----------------------TLLYVAPEVLSS-----ALGPGNRNAYELPADIWALGCT ||.. ||| ... | ... ... .. . |. |.|||.|.. ... | .|||.||.. ----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVI FIEMLLKRPP . ||| ..|| LYEMLFGKPP |
|||||||||
Kinase | flr-4.AA | TKL | 108-260 | 20 | 4.7e-25 | 87.17 | In-house | 87-288 (364) | Show / Hide |
Range on Protein: 108-260 Range on HMM: 87-288/364 Sequence Identity: 20% (43 aa) IVNFLGIYADSNQ-------------MYIMSEYLPRGS-VKDLLVKETLGEDTAIKYLMETVEALDYLHNLS------PPVIHRDIKAANLLITSNDS-- || |.|. .... ..| || |.|| .|. . .. ... ...|||. ||.||||.| .|.|. .| IVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV ------------IKLANFGLVRDLAVDGFGIAIASE------------ITLDFRATLLYVAPEVLSSALGPGNRN---------AYELPADIWALGCTFI .|.. ||| |.. .| .... | . |. . ||||| .. . . | .|... | . SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW EMLLKRPP |.| ..| EILTRCRP |
|||||||||
Kinase | flr-4.AA | STE-Unique | 119-260 | 22 | 3.2e-24 | 82.52 | In-house | 367-552 (616) | Show / Hide |
Range on Protein: 119-260 Range on HMM: 367-552/616 Sequence Identity: 22% (43 aa) NQMYIMSEYLPRGSVKDLLVKETLG----------EDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSND-----SIKLANFGLVRDLAVDGFG |. .| ||.. |...... . |. .|.|. . .|.|.||| |.||||.|..| .... . ..|...||. .. |.|. NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE I-------------------------------AIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP | . . . | | .|||.. . . .| | | . .||| |||....|. || KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQ-IN-NPYDTKVDIWSLGCMCFHMCCGCPP |
|||||||||
Kinase | flr-4.AA | ASK | 92-263 | 36 | 1.2e-22 | 71.96 | In-house | 38-199 (254) | Show / Hide |
Range on Protein: 92-263 Range on HMM: 38-199/254 Sequence Identity: 36% (65 aa) LYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLVKE--TLG--EDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLI-TSNDSI |.| ||| | || .|| .. . . | | | ||. .|| . |.| | .| | |||. ..||||| | |. | . LHEEIALHKQLRHRN-IVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTKQILEGLKYLHENQ--IVHRDIKGDNVLVNTYSGVV KLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFE |.. || . || || ..| |. || |.||||. | | | |||||..||| .|| .|| .| KISDFGTCKRLA----GINPCTET---FTGTLQYMAPEVIDQ----GQR-GYGKPADIWSFGCTMVEMATGKPPFHE |
|||||||||
Kinase | flr-4.AA | ULK | 108-260 | 28 | 7.4e-22 | 73.14 | In-house | 80-255 (329) | Show / Hide |
Range on Protein: 108-260 Range on HMM: 80-255/329 Sequence Identity: 28% (51 aa) IVNFLGIYADS--NQMYIMSEYLPRGSVKDLLVKE-TLGEDT----------AIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSND---------- || .. .. .| | ||. || . | .... | .|.||| ||.... .... .|| .|||||| .| ||. .. IVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHP --SIKLANFGLVRDLAVDGFGIAIASEIT---LDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP .|.| ||. . . |.. .... . . .. | || ||..|.. . .. . |. .||| ||| | ||| .|| NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKR-LCGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIFYEMLYGKPP |
|||||||||
Kinase | flr-4.AA | MEKK15 | 40-260 | 30 | 8.5e-21 | 72.13 | In-house | 1-206 (264) | Show / Hide |
Range on Protein: 40-260 Range on HMM: 1-206/264 Sequence Identity: 30% (67 aa) YKYIQDLGKGRFGTV-CKFSNGNTFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLV .| . |||| .||| | | ||.|.| ... . ... | | | | | || .||. . | . | ...| ||. .. WKKGNILGKGAYGTVYCGLTNTGQLIAVKQVEL------DEIDKEKAKQQYRKLQEEVDLLKTLKHKN-IVAYLGVCLEDNVVNIFMQFVPGGSISSIIN K-ETLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNA . | | || .. |||. |.||||| .|... . ||| || . |.. | . |.. | | ..||||. . RFGPLDEMVFCKYTKQILQGVQYLHENC--VVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRT-HSDMLKSMRGTPYWMAPEVI-------METG YELPADIWALGCTFIEMLLKRPP | .|||..||| || ..|| YGRKSDIWSIGCTVFEMATRKPP |
|||||||||
Kinase | flr-4.AA | ULK | 105-260 | 26 | 1.6e-20 | 69.58 | In-house | 75-251 (324) | Show / Hide |
Range on Protein: 105-260 Range on HMM: 75-251/324 Sequence Identity: 26% (49 aa) NNRIVNFLGIYADS--NQMYIMSEYLPRGSVKDLLVKE-TLGEDT----------AIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSND------- . || .. .. .| | ||. || . | .... | .|.| | ||.... .... .||. .|||||| .|.||. .. H-HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKK -----SIKLANFGLVRDLAVDGFGIAIA----SEITLDFR---ATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP .|.| ||. . . ... . | | || ||..|.. . .. . |. .||| ||| | ||| ..| VHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNE-----KRIKGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIFYEMLYGKYP |
|||||||||
Kinase | flr-4.AA | STE20 | 108-264 | 31 | 9.6e-20 | 69.06 | In-house | 66-230 (288) | Show / Hide |
Range on Protein: 108-264 Range on HMM: 66-230/288 Sequence Identity: 31% (55 aa) IVNFLGIYADS----NQMYIMSEYLPRGSVKDLLV-----KE-----TLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGL ||...| | . .. .| ||. ||. |.. . .. |. . |....|||||. .|||||||.| |.|.. ..||| ||. IVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNH--IIHRDIKADNILLTEDGEVKLADFGV VRDLAVDGFGIAIASE-ITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEY .| | . . | | . ||||.. || .. | .|||.|| | |||. .||.|.. CAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQCMEGP--DKGYDYKCDIWSLGITAIEMAEGEPPYFDM |
|||||||||
Kinase | flr-4.AA | STE11 | 106-260 | 31 | 1.1e-19 | 68.0 | In-house | 70-237 (303) | Show / Hide |
Range on Protein: 106-260 Range on HMM: 70-237/303 Sequence Identity: 31% (55 aa) NRIVNFLGIYA---DSNQMYIMSEYLPRGSVKDLLV-K-ET--LGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITS-NDSIKLANFGLVRDL ..|| ..|. . . ..| || | ||....| | . . | . || |.| ||| .||||||.||.|. | . ..||| || . | KNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRL AVDGFGIAIASEITLD---FRATLL--------YVAPEVLSSAL-GPGNRNAYELPADIWALGCTFIEMLLKRPP | .. . ... .. .. |. . ||||.. . | .||||.|||| |||. .|| AWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRD-----GYGRKADIWSLGCTVIEMATGKPP |
|||||||||
Kinase | flr-4.AA | TyrKc | 40-327 | 19 | 8.7e-12 | -32.13 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-280/280 Sequence Identity: 19% (63 aa) YKYIQDLGKGRFGTVCKFSNGNTFETV--KKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKV--TNDNNRIVNFLGIYADS-------NQMYIMSEYL . .. || | ||.|.| ..| |.. . |. | | ..|. ..| ||...|. .. ...| || ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPN--IVRLYGVCTQQGRNFMYIEPLMIVMEYM PRGSVKDLLVKET--LGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVD---GFGIAIASEITL----DFR--AT | |. || | | | .. ... . .||| ..||||. | | |...| .| . ||| ||. | | . . .. . . PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLP LLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDE----IPKVLLGYAKSEDGKVLPYTSEVLVP-----SSSNCVQKIVDL . |||.. | . . |.|. | . |.. . . .. .. . ... ..|. .| ... | .. | | IRWMAPECI-------NYGKFTTKSDVWSFGVCMWEIF-----TYGQQPYPGMIQQMMSNQEV-IEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQ-IMKQ VFIKSPEHRPNTHKLRIQI || ||. .. .. CWHEDPEDRPTFSEIHECF |
|||||||||
Kinase | flr-4.AA | Pkinase_Tyr | 104-197 | 29 | 1.3e-08 | 29.83 | Pfam | 62-161 (270) | Show / Hide |
Range on Protein: 104-197 Range on HMM: 62-161/270 Sequence Identity: 29% (30 aa) DNNRIVNFLGIYA-DSNQ--MYIMSEYLPRGSVKDLLVKE-----TLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVR .. ||...|. .. . .|| || | |. .| | | | . ... .. ....||.. ||||. | | |.|.| .| . ||| | HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR DL |. DI |
|||||||||
Kinase | flr-4.AA | TKL | 46-56 | 54 | 0.005418 | 6.63 | In-house | 1-11 (364) | Show / Hide |
Range on Protein: 46-56 Range on HMM: 1-11/364 Sequence Identity: 54% (6 aa) LGKGRFGTVCK .|.|.||.|.| IGSGGFGEVYK |
|||||||||
Kinase | flr-4.AA | STE20 | 40-56 | 35 | 0.013942 | 5.61 | In-house | 1-17 (288) | Show / Hide |
Range on Protein: 40-56 Range on HMM: 1-17/288 Sequence Identity: 35% (6 aa) YKYIQDLGKGRFGTVCK |. .. .|.| .|.|.| YELLEKIGQGSYGKVYK |
|||||||||
Kinase | flr-4.AA | ULK | 40-56 | 50 | 0.07728 | 2.38 | In-house | 1-18 (324) | Show / Hide |
Range on Protein: 40-56 Range on HMM: 1-18/324 Sequence Identity: 50% (9 aa) YKYIQDLGKGRFG-TVCK | .. |||| || .|.| YCLNHCLGKGSFGVKVYK |
|||||||||
Kinase | flr-4.AA | ULK | 40-56 | 52 | 0.083266 | 2.19 | In-house | 1-17 (329) | Show / Hide |
Range on Protein: 40-56 Range on HMM: 1-17/329 Sequence Identity: 52% (9 aa) YKYIQDLGKGRFGTVCK | .. |||| ||.|.| YCLNHCLGKGSFGKVYK |
|||||||||
Kinase | flr-4.AA | Pkinase_Tyr | 40-56 | 41 | 0.137705 | 6.0 | Pfam | 1-17 (270) | Show / Hide |
Range on Protein: 40-56 Range on HMM: 1-17/270 Sequence Identity: 41% (7 aa) YKYIQDLGKGRFGTVCK . .. ||.| ||.|.| ITFGKKLGEGAFGEVYK |