Gene F59E12.3 (Nematode worm)

F59E12.3

Species: Nematode worm
Alias: aSWK148, CE17143, F59E12.3
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 5638352-5639751, WormBase Genetic Map location: II:-1.2,

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
F59E12.3.AA Protein Genbank 338 None Fasta, JSON
F59E12.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 247 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of F59E12.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F59E12.3.AA Worm6 22-269 31 1e-112 380.76 In-house 1-273 (279) Show / Hide 
Range on Protein: 22-269
Range on HMM: 1-273/279
Sequence Identity: 31% (87 aa)

YTINEKIAEGSFGAIFKVTEKSTGT--RLVLKAEL--PGSPSNDLRIELVTMLRVFRS---YVPEVTDKG-VFN-GTKFLIMPLFGKSLEDIIGALP---
.....||.||.|||..||..||...  . ..|.|   .......|..|......|...   ......|.| |.| |.....|.|.||.|.|.. ..|   
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

-----GNKCSLSTAIGHRVVHWSHYLHRDLKPGNFCVGS-----GKDIRRIFLVDFGMSR--RYCGQDNVIYQPR-TRCQFRGTPVYAPRASHNRAEHNR
     |.|... . ......|. ...|||.||||||.|       .....|...||||.|  .||...|....|| |.|.||||. |||.|.|.. |..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KSDLESWGYMMIEMTTGKLPWYIDGLSFFEEPNYRYIYDALRRVMKRCRLKEFPFDWEPASKKRFTLKSLWPR
| |.||| |||.||..|.|||.    ....|........ .|..|.|......|... .. ..... .| |.|
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDR
Kinase F59E12.3.AA CK1 22-217 23 3.4e-72 246.16 In-house 1-273 (339) Show / Hide 
Range on Protein: 22-217
Range on HMM: 1-273/339
Sequence Identity: 23% (64 aa)

YTINEKIAEGSFG-AIFKV-----TEKSTG-----TRLVLKAELPGSPSN-DLRIELVTMLRVFRS----------------------YVPEVTDKG-VF
... .||.||.|| .|.||     . ....     .. ..|.|   |     ...|.. |.. ..                       ... . ..| . 
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NGTKFLIMPLFGKSLEDIIG--ALPGNKCSLSTAIG--------HRVVHWSHYLHRDLKPGNFCVGS-------------GKDIRRIFLVDFGMSR-RYC
.. ....|.|.|..|||.    .....|.|..|..          ...|. ...|||.||.|||.|              ... |.....||||.| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

GQDN------------VIYQPRT---RCQFRG-TPVYAPRASHNRAEHNRKSDLESWGYMMIEMTTGK--LPW
  |.            .. .||.   ...||| |. |.....|.. |. |. ||.||.||.||.. |.  |||
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPW
Kinase F59E12.3.AA TTBKL 22-217 28 2.2e-34 113.52 In-house 1-228 (288) Show / Hide 
Range on Protein: 22-217
Range on HMM: 1-228/288
Sequence Identity: 28% (66 aa)

YTINEKIAEGSFGAIFKVTEKST-GTRLVLKAELPG-SPSNDLRIELVTMLRVFR----SYVPEVTDKGVFNGTKFLIMPLFGKSLEDIIGALPGNK-CS
..| ..|.|| ||....|  ... ... ..|.|.   .  .   .. | .|        ...|.. . |   .  |..| | |..| |.   .| .| .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTA--IGHRV------VHWSHYLHRDLKPGNFCVGSGKD----IRRIFLVDFGMSRRYCGQDN-----------VIYQPRT---RCQFRGTPVYAPRAS
 .|.  ||...      .|   ..|||.||.|.|.|  ..     |...|.||||.|.|   |.            .  ||.   ...||||. |.  . 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HNRAEHNRKSDLESWGYMMIEMTTGKLPW
|.|.|  |. || || ||.||.  | |||
HDRKEQGRHDDLWSWMYMIIELHCG-LPW
Kinase F59E12.3.AA CK1-Unique 77-238 25 6.6e-28 93.83 In-house 72-268 (337) Show / Hide 
Range on Protein: 77-238
Range on HMM: 72-268/337
Sequence Identity: 25% (51 aa)

VPEVTDKGVFNGTKFLIMPLFGKSLEDIIGALPG-----N---------KCSLSTAIGHRVVHWSHYLHRDLKPGNFCVGSGK--DIRRIFLVDFGMSRR
..|| | ..   .....| . |.|.| .  .. .     |         .|.. .  . .. ||  ..||..||.|.| .. .  . . ..  |.| .||
FCEVHDFHQHRDWWWIVMTMHGPSMEECCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRR

--YCGQDNVIYQPRTRCQFRGTPVYAPRASHNRAEHNRKSDLESWGYMMIEMTTGK--LPW---------------YIDGLSFFEEPNYRYIYDALR
       ..| ||| .  |||.. |.|...|   || |..|.||| ||..    .   | |               |. || | .   || | . ||
VFFVSNNHQIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKLDKIIPSGIDNIIVYLRGLKFEDPVDYRQIENELR
Kinase F59E12.3.AA TTBK 22-217 30 3e-22 75.45 In-house 1-207 (257) Show / Hide 
Range on Protein: 22-217
Range on HMM: 1-207/257
Sequence Identity: 30% (63 aa)

YTINEKIAEGSFGAIFKVTEKSTG-TRLVLKAELPGSPSNDLRIELVTMLRVF--RSYVPEVTDKGVFNGTKFLIMPLFGKSLEDIIGALPGNKCSLSTA
 ..  ||  | || |.  ..  .   .  .| |    |   |..| |  |.    . .|      |  .   ...| | ||.| |   . |  . ||||.
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKME-VAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT

I--------GHRVVHWSHYLHRDLKPGNFCVG-SGKDIRRIFLVDFGMSRRYCGQDNVIYQPRTRCQFRGTPVYAPRASHNRAEHNRKSDLESWGYMMIE
.        . . .|   .|||| || || .|   . .|.....|||. |.|      .  ||    ||||  ||   .|   |  |. || |  ||..|
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

MTTGKLPW
   | |||
FVQGQLPW
Kinase F59E12.3.AA CK1-D 22-217 31 3.5e-21 71.38 In-house 1-205 (261) Show / Hide 
Range on Protein: 22-217
Range on HMM: 1-205/261
Sequence Identity: 31% (66 aa)

YTINEKIAEGSFGAIFKVTEKSTGTRLVLKAELPGSPSNDLRIELVTMLRVFRSYV--PEVTDKGVFNGTKFLIMPLFGKSLEDIIGALPGNKCSLSTAI
| |  ||  |||| |.  |. .|.    .| |   .    | ||   . ....  .  ||.   |       ..| | | ||||.     . | || | .
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIE-SKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLF-NYCHRKFSLKTVL

------GHRV--VHWSHYLHRDLKPGNFCVGSGKDIRRIFLVDFGMSRRYCGQDNVIYQP-RTRCQFRGTPVYAPRASHNRAEHNRKSDLESWGYMMIEM
        |.  .|   ..|||.|| || .| ||    ....|||...||         | |   .  ||  ||    |   |  |. |||| ||...  
MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

TTGKLPW
  | |||
NRGSLPW
Kinase F59E12.3.AA CK1-A 22-217 29 5.1e-18 60.11 In-house 1-205 (261) Show / Hide 
Range on Protein: 22-217
Range on HMM: 1-205/261
Sequence Identity: 29% (61 aa)

YTINEKIAEGSFGAIFKVTEKSTGTRLVLKAELPGSPSNDLRIELVTMLRVFRSY-VPEVTDKGVFNGTKFLIMPLFGKSLEDIIGALPGNKCSLSTAIG
| .  ||  |||| |.   .   |  . .| |        |  |      . .   .|..   |       ..| | | ||||.   .   . .. | . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCKRRFTMKTVLM

------HRV--VHWSHYLHRDLKPGNFCVGSGKDIRRIFLVDFGMSRRYCGQDNVIYQP-RTRCQFRGTPVYAPRASHNRAEHNRKSDLESWGYMMIEMT
       |.  ||   ..|||.|| || .| |.   ..||.|||....|  .   .  | |.  .  ||  ||    |   |  |. |.|| ||.|.   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

TGKLPW
 |||||
RGKLPW
Kinase F59E12.3.AA CK1-Unclassified 123-161 42 3.7e-17 47.19 In-house 119-158 (244) Show / Hide 
Range on Protein: 123-161
Range on HMM: 119-158/244
Sequence Identity: 42% (17 aa)

VVHWSHYLHRDLKPGNFCVG-SGKDIRRIFLVDFGMSRRY
..|  ...|||.|| ||..| .||   .....||| | ||
YLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRY
Kinase F59E12.3.AA Dual 129-206 36 5.1e-15 46.83 In-house 134-212 (282) Show / Hide 
Range on Protein: 129-206
Range on HMM: 134-212/282
Sequence Identity: 36% (29 aa)

YLHRDLKPGNFCVGSGKDIRRIFLVDFGMSRRYCG-QDNVIYQPRTRCQFRGTPVYAPRASHNRAEHNRKSDLESWGYM
||||. || || .| | |   ... ||.. | |   .  .   .|.   . |.  || ||  .  .  || |||.| ||
YLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYM
Kinase F59E12.3.AA CK1 123-161 42 3.6e-14 45.36 In-house 120-159 (271) Show / Hide 
Range on Protein: 123-161
Range on HMM: 120-159/271
Sequence Identity: 42% (17 aa)

VVHWSHYLHRDLKPGNFCVGS-GKDIRRIFLVDFGMSRRY
.||  ...|||.|| ||..|  ||.  .....|||.. ||
YVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRY
Kinase F59E12.3.AA S_TKc 22-262 19 1.9e-11 -9.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-262
Range on HMM: 1-231/231
Sequence Identity: 19% (51 aa)

YTINEKIAEGSFGAIFKVTEKSTGTRLVLKAELPGSPSNDLRIELVTMLRVFRSYVPEVTDKGVFNGTKFLIMPLFGK---SLEDIIGALPGN-------
|.| .|| .|.||  .|...|.|| .  .|        ...| |.  . .    ..    |  .  .  ...| . .    .| |.|   ...       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

----KCSLSTAIGHRVVHWSHYLHRDLKPGNFCVGSGKDIRRIFLVDFGMSRRYCGQDNVIYQPRTRCQFRGTPVY-APRASHNRAEHNR-KSDLESWGY
    .    .. .    |  . .|||||| |  . .     .| . |||..|..               | ||| | ||        ... |.|  | | 
EHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

MMIEMTTGKLPWYIDGLSFFEEPNYRYIYDALRRVMKRCRLKEFP--FDWEPASK-------KRFT
...|| .|. |.. .    |.        . ..  ...|  |.         | .         . 
ILYEMLCGYPPFP-QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F59E12.3.AA Pkinase 130-218 28 6e-06 22.24 Pfam 130-213 (293) Show / Hide 
Range on Protein: 130-218
Range on HMM: 130-213/293
Sequence Identity: 28% (26 aa)

LHRDLKPGNFCVGSGKDI-RRIFLVDFGMSRRYCGQDNVIYQPRTRCQFRGTPVY-APRASHN-RAEHNRKSDLESWGYMMIEMTTGKLPWY
.|||||| |. . .  .|  .. . ||| .. .      .   .    | ||| | ||   .. . .. .|.|  | | ...|| .|..|..
IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase F59E12.3.AA CK1-Unclassified 22-49 42 9e-06 12.98 In-house 1-27 (244) Show / Hide 
Range on Protein: 22-49
Range on HMM: 1-27/244
Sequence Identity: 42% (12 aa)

YTINEKIAEGSFGAIFKVTEKSTGTRLV
| . |||  |||| |.|.. . |. ..|
YRVIEKIGQGSFGEIYKCINMQTN-EEV
Kinase F59E12.3.AA CK1 22-44 39 0.000117 12.18 In-house 1-22 (271) Show / Hide 
Range on Protein: 22-44
Range on HMM: 1-22/271
Sequence Identity: 39% (9 aa)

YTINEKIAEGSFGAIFKVTEKST
| . .|| .|||| |....   |
YRVGRKIGQGSFGDIYLGINM-T
Kinase F59E12.3.AA CK1 218-233 37 0.00021 11.37 In-house 324-339 (339) Show / Hide 
Range on Protein: 218-233
Range on HMM: 324-339/339
Sequence Identity: 37% (6 aa)

YIDGLSFFEEPNYRYI
||..|.....|.| .|
YIRSLKYYDRPDYEMI
Kinase F59E12.3.AA TyrKc 22-272 17 0.000357 -155.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-272
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

YTINEKIAEGSFGAIFKVTEKSTGTRLVL-KAELPGSPSNDLRIELVTMLRVFRSY----VPEVTDKGVFN---------GTKFLIMPLFGK-SLEDIIG
 | ..|. || || ..| | |    . |  |   ...     | ..   .|. ...       |   ||           .  ...| .  . .| | . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ALPGNKCSLSTAIGHRVVHW--------------SHYLHRDLKPGNFCVGSGKDIRRIFLVDFGMSRRYCGQD-----NVIYQPRTRCQFRG-TPV--YA
.  ..       . ..  .                .. ||||   |  ||...   ..   |||.||     |        | .... . ..  |.  .|
KHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PRASHNRAEHNRKSDLESWGYMMIEMTT-GKLPWY------IDGLSFFEEPNYR-------Y--------IYDALRRVMKRCRLKEFPFDWEPASKKRFT
| .  |  . . |||  |.| .| |. | |. |..      ..    .|    .       .          |.. ..||.|        |.   ..| |
PECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC--------WHEDPEDRPT

LKSLWPRCKL
 . .  . ..
FSEI--HECF
Kinase F59E12.3.AA Pkinase 22-51 43 0.000445 15.5 Pfam 1-30 (293) Show / Hide 
Range on Protein: 22-51
Range on HMM: 1-30/293
Sequence Identity: 43% (13 aa)

YTINEKIAEGSFGAIFKVTEKSTGTRLVLK
|.| .|| .||||  .| ..|.|| . ..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK
Kinase F59E12.3.AA CK1 218-231 42 0.007521 5.88 In-house 258-271 (271) Show / Hide 
Range on Protein: 218-231
Range on HMM: 258-271/271
Sequence Identity: 42% (6 aa)

YIDGLSFFEEPNYR
|. .|.|.|.|.|.
YCRQLHFEEKPDYM
Kinase F59E12.3.AA TTBKL 218-237 25 0.017796 4.26 In-house 269-288 (288) Show / Hide 
Range on Protein: 218-237
Range on HMM: 269-288/288
Sequence Identity: 25% (5 aa)

YIDGLSFFEEPNYRYIYDAL
..  |.. ..|.| .||  .
HLRSLRYYDRPDYEMIYECF
Kinase F59E12.3.AA CK1 199-217 47 0.06471 2.62 In-house 198-216 (271) Show / Hide 
Range on Protein: 199-217
Range on HMM: 198-216/271
Sequence Identity: 47% (9 aa)

DLESWGYMMIEMTTGKLPW
|.|| ||...    |.|||
DMESLGYVLMYFLRGSLPW
Kinase F59E12.3.AA CK1-A 218-233 43 0.074342 2.13 In-house 246-261 (261) Show / Hide 
Range on Protein: 218-233
Range on HMM: 246-261/261
Sequence Identity: 43% (7 aa)

YIDGLSFFEEPNYRYI
|. .| | |.|.| |.
YCRNLRFEEQPDYMYL
Kinase F59E12.3.AA CK1-Unclassified 199-217 57 0.097201 0.93 In-house 198-216 (244) Show / Hide 
Range on Protein: 199-217
Range on HMM: 198-216/244
Sequence Identity: 57% (11 aa)

DLESWGYMMIEMTTGKLPW
|||| || .|    |.|||
DLESLGYVLIYFLKGSLPW
Kinase F59E12.3.AA Dual 90-104 40 0.106757 1.33 In-house 87-101 (282) Show / Hide 
Range on Protein: 90-104
Range on HMM: 87-101/282
Sequence Identity: 40% (6 aa)

KFLIMPLFGKSLEDI
|...| ..| ||..|
KYWVMSPYGPSLQEI
Kinase F59E12.3.AA Dual 218-237 30 0.208094 0.34 In-house 263-282 (282) Show / Hide 
Range on Protein: 218-237
Range on HMM: 263-282/282
Sequence Identity: 30% (6 aa)

YIDGLSFFEEPNYRYIYDAL
|..|...   | | |.   |
YVNGYQYDSTPDYDYFRNCL
Kinase F59E12.3.AA CK1-Unique 22-46 24 0.260505 0.34 In-house 1-25 (337) Show / Hide 
Range on Protein: 22-46
Range on HMM: 1-25/337
Sequence Identity: 24% (6 aa)

YTINEKIAEGSFGAIFKVTEKSTGT
. . ..|  |..|   .| .  .||
WCVIKHIGYGGYGCVHRVIFVNNGT