Gene F59A6.4 (Nematode worm)

F59A6.4

Species: Nematode worm
Alias: F59A6.4Nlength=48exon_count=1, aSWK076, CE01982, F59A6.4
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 5005119-5008037, WormBase Genetic Map location: II:-2.24, Secondary Group: CK1, Secondary Family: Dual

Classification

Group: CK1
Family: Dual

Sequence

Name Sequence Type Origin Length Description Download
F59A6.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
F59A6.4.AA Protein Genbank 752 None Fasta, JSON
F59A6.4.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 294 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of F59A6.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F59A6.4.AA Dual 104-371 50 2.2e-182 612.18 In-house 12-282 (282) Show / Hide 
Range on Protein: 104-371
Range on HMM: 12-282/282
Sequence Identity: 50% (136 aa)

FKVLSQIRKSSRLLDHDVYVVKDVEADEEYRMKVARKDLQILKIEAALLRRLEKIPGDKCFVSLVEYGNVSKDKLEFLVVSSYGSTLQEILKKTINGPLS
|.........|.............|..|...|....|.........|..|..|||||||||...|.||....||....|.|.||..||||..|.|.|.||
FRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLS

MDCSFVVGLQMLRAIQNLHSLGYVHRNINPSAFNCGLGMDETSLYLQDFRQVRKFEE--NKKHVTARSTVKMFGCGRFANRACQNSKDQGRKDDLESWIY
|.|||.|..|||||||.|||.||.||||.|..|.||||||||..|.||||.|||...  ||||.|||..|||.||||.|.|||...||||||||||.|||
MHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIY

TLFYLIDHGS-LSWKNEADSQIVVQQKDLFMTGDGKEQFSRAPRGLAPLLSKVNGYEFTSAPEYDSFKNLI
..|.|.|... .||..|.|......|||.||....|.|.|..||.|.||.|.||||...|.|.||.| | .
MVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase F59A6.4.AA CK1 120-367 20 2.5e-67 230.02 In-house 15-339 (339) Show / Hide 
Range on Protein: 120-367
Range on HMM: 15-339/339
Sequence Identity: 20% (66 aa)

DVYVV-----KDVEAD-----EEYRMKVARKD----LQILKIEAALLRRLEKI----------------PGDKCFVSLVEYGNVSKDKLEFLVVSSYGST
..| |     ||.. .     ||| ||| .|.    .  |..|. ... |...                .  .... ...|.   .|.  ..| . .| .
QIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPN

LQEILK--KTINGPLSMDCSFVVGLQMLRAIQNLHSLGYVHRNINPSAFNCGL-------------GMDETSLYLQDFRQVR-KFE-------------E
|....|  .  |. .|| ... ...||| |.. .|. |..||.| |. | .|.             ....  .|. ||  .| |.              .
LEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDK

NKKHVTARS---TVKMFG-CGRFANRACQNSKDQGRKDDLESWIYTLFYLIDHGS-LSWKNEADSQI-----VVQQKDLFMTGDGKEQFSR---------
...| ..|.   .... | . |.. ..|.. |.|||.|||.||.|.|..... .. | |.|  |        |...|  |.. . . . .          
TWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFFLCCPKKDHD

APRGLAPLLSKVNGYEFTSAPEYDSF
 |. . ...  ...... ..|.|. .
CPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F59A6.4.AA Worm6 120-367 23 5.5e-29 101.23 In-house 14-279 (279) Show / Hide 
Range on Protein: 120-367
Range on HMM: 14-279/279
Sequence Identity: 23% (64 aa)

DVYVVKDVEADE--EYRMKVAR----KDLQILKIEAALLRRLEKIPGDKCFVSLVEYGNVSKDKLEFLVVSSYGSTLQEILKKTINGPLSMDCSFVVGLQ
.||.|.| .  .  .. ||. .       | ||.|.. | ......  . |......|.| ..   ..|   .|  |... | . .. .|| ..  ...|
AVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHK-CRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQ

MLRAIQNLHSLGYVHRNINPSAFNCGL-----GMDETSLYLQDF---RQVRKFEENKKHVTAR-STVKMFGCGRFANRACQNSKDQGRKDDLESWIYTLF
.|.||. ||. |..||.. |. | .|        ..  .|. ||   |. .. .....  | |  ...  |  |.| .|| . ..|.||||.||| | . 
CLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMV

YLIDHGSLSWKNEADSQIVVQQKDLFMTGDG---KEQFSR-APR-GLAPLLSKVNGYEFTSAPEYDSF
 .| .| | |..  |.. | ..|   .       ...| .  |. ..   .  . .| . ..|.|.  
EMI-VGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase F59A6.4.AA CK1-Unique 211-315 27 3.7e-19 63.09 In-house 123-233 (337) Show / Hide 
Range on Protein: 211-315
Range on HMM: 123-233/337
Sequence Identity: 27% (31 aa)

GLQMLRAIQNLHSLGYVHRNINPSAFNCGLGM--DETSLYLQDFRQ-VR--KFEENKKHVTARSTVKMFGCGRFANRACQNSKDQGRKDDLESWIYTLFY
|.| | .|   |  |. ||.. |  .  .     ..  .|  |.   .|  . . |      | .....|| ... ..|   ...||.||.||| |.|  
GYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYH

LIDHG-SLSWK
|..    ||||
LVHNTRGLSWK
Kinase F59A6.4.AA CK1-D 203-315 30 4.9e-16 52.93 In-house 93-206 (261) Show / Hide 
Range on Protein: 203-315
Range on HMM: 93-206/261
Sequence Identity: 30% (35 aa)

SMDCSFVVGLQMLRAIQNLHSLGYVHRNINPSAFNCGLGMDETSLYLQDFRQVRKFEENK--KHVTARSTVKMFGCGRFANRACQNSKDQGRKDDLESWI
|.    ....||.. |. .|.  ..|| | |  |  |||      |. ||   ... . .  .|.  |    . |  |.|        .| |.|||||  
SLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLG

YTLFYLIDHGSLSWK
| | |   .||| |.
YVLMYFN-RGSLPWQ
Kinase F59A6.4.AA TTBK 121-303 29 9.2e-14 45.04 In-house 15-197 (257) Show / Hide 
Range on Protein: 121-303
Range on HMM: 15-197/257
Sequence Identity: 29% (55 aa)

VYVVKDVEAD-EEYRMKV--ARKDLQILKIEAALLRRLEKIPGDKCFVSLVEYGNVSKDKLEFLVVSSYGSTLQEILKKTINGPLSMDCSFVVGLQMLRA
.|  ||.  . |.  .||  |..  |.||.| | |..|      . .|    .|    ||  ..| .  |  | .   |   |  |.     .|.|.| .
IYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQG----CDHVCRF-IGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQS

IQNLHSLGYVHRNINPSAFNCGLGMDET-SLYLQDFRQVRKFEENKKHV-TARSTVKMFGCGRFANRACQNSKDQGRKDDLESWIYTL
|.  ||.|. || | || |  |.   ..   |. ||   |..   .  | ..|.     |  |.|      ... ||.||| |  | |
IESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML
Kinase F59A6.4.AA CK1-A 213-315 30 5.1e-13 42.2 In-house 103-206 (261) Show / Hide 
Range on Protein: 213-315
Range on HMM: 103-206/261
Sequence Identity: 30% (32 aa)

QMLRAIQNLHSLGYVHRNINPSAFNCGLGMDETSLYLQDFRQVRKF--EENKKHVTARSTVKMFGCGRFANRACQNSKDQGRKDDLESWIYTLFYLIDHG
||.  |  .|  ...|| | |  |  |.|     |.| ||   .|.  .. ..|.  |   .. |  |.|    .   .| |.||.||  | . |    |
QMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF-NRG

SLSWK
.| |.
KLPWQ
Kinase F59A6.4.AA TTBKL 121-252 25 2.6e-09 27.67 In-house 15-153 (288) Show / Hide 
Range on Protein: 121-252
Range on HMM: 15-153/288
Sequence Identity: 25% (36 aa)

VYVVKDVEADEEYRMKVARKDL-----QILKIEAALLRRLEKIPGDKCFVSLVEYGNVSKDKLEFLVVSSYGSTLQEILKKTINGP-LSMDCSFVVGLQM
|| |.|..  ... .... |.      ...|.|. .| .| . .| . |  ....|.  ...  |.| .  |  || . |.  |.  .|   . ..| | 
VYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQP-NGSPHFPKCHCSGK--RKDYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQC

LRAIQNLHSLGYVHRNINPSAFNCGLGMD------ETSLYLQDF
| |.. .|. |..|| . |.  || .|        .  .|| ||
LYALKQMHDCGFIHRDVKPC--NCCWGYHDHSCERCRHVYLIDF
Kinase F59A6.4.AA CK1 210-314 29 1.1e-08 26.26 In-house 110-216 (271) Show / Hide 
Range on Protein: 210-314
Range on HMM: 110-216/271
Sequence Identity: 29% (32 aa)

VGLQMLRAIQNLHSLGYVHRNINPSAFNCGL-GMDETSLYLQDFRQVRKF--EENKKHVTARSTVKMFGCGRFANRACQNSKDQGRKDDLESWIYTLFYL
.. ||.. |. .|. ...|| | |  |  |. | ... .|. ||    ..   ....|.  |   .. |  |.|       . |.|.||.||  | |.|.
IADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYF

IDHGSLSW
.  ||| |
L-RGSLPW
Kinase F59A6.4.AA CK1-Unclassified 211-252 37 1.5e-08 21.34 In-house 110-152 (244) Show / Hide 
Range on Protein: 211-252
Range on HMM: 110-152/244
Sequence Identity: 37% (16 aa)

GLQMLRAIQNLHSLGYVHRNINPSAFNCG-LGMDETSLYLQDF
. ||.  |..||. ...|| | |  |  | ||   . .|. ||
ADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDF
Kinase F59A6.4.AA TTBKL 288-327 40 5.4e-07 19.73 In-house 204-241 (288) Show / Hide 
Range on Protein: 288-327
Range on HMM: 204-241/288
Sequence Identity: 40% (16 aa)

KDQGRKDDLESWIYTLFYLIDHGSLSWKNEADSQIVVQQK
|.|||.||| ||.|.. .| .   | |.|. |  .... |
KEQGRHDDLWSWMYMIIELHCG--LPWTNMEDKMEIEHMK
Kinase F59A6.4.AA CK1-Unclassified 290-316 55 0.000519 7.75 In-house 193-218 (244) Show / Hide 
Range on Protein: 290-316
Range on HMM: 193-218/244
Sequence Identity: 55% (15 aa)

QGRKDDLESWIYTLFYLIDHGSLSWKN
|.|.|||||  |.| |..  ||| | |
QSRRDDLESLGYVLIYFL-KGSLPWQN
Kinase F59A6.4.AA Dual 434-709 63 1.2e-202 679.49 In-house 1-282 (282) Show / Hide 
Range on Protein: 434-709
Range on HMM: 1-282/282
Sequence Identity: 63% (179 aa)

WKVINLLGSGGFGDVYKVHRESQ--PITKCYALKTESEEGEKRYLRLKIEVTVMMKTAEKKKENK---FKNFIEFVDRGKCEQLKCKYVVMGLVGPSLED
|||.||||||||.|||.|||.||  |..|||.||||||||||..||||.|..||||.|||.|..|   .|.||||||.|||||.||||.||...||||..
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

IRRKYLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLEDREDTVYMLDFGIAKLYVD-ENGEHKVKRKKVKFLGTLRYACRACMMQQEQ
|||||..|..|.|.|||||||...|.|||||||||||.|||||...||...|.||||.||.|...|.| ||..|...|||||..|..||||||||||..|
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQ

GRKDDLETWIYLVFDLMDESHGMPWRSLCSPKEILKSKNEFFTNFDSSSVSATLKRLKGLVSYVDNMQYETTPDYDYIINFL
|||||||.|||.||||||..|||.||..|......|.|..|...||....|....|||.|||||...||..||||||..|.|
GRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase F59A6.4.AA CK1 434-705 26 7.79999999999e-101 341.29 In-house 1-339 (339) Show / Hide 
Range on Protein: 434-705
Range on HMM: 1-339/339
Sequence Identity: 26% (90 aa)

WKVINLLGSGGFG-DVYKV-----HRESQP---ITKCYALKTESEEGEKRYLRLKIEVTVMMK------------TAEKKKE-NKFKNFIEFVDRGKCEQ
|||. ..|.|||| ..|||      ... .    ...||.|.|... .... .|..|. ...|            ..... . .... ..  .. ...|.
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

LKCKYVVMGLVGPSLEDIRR--KYLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGL-------------EDREDTVYMLDFGIAK-LYV
 ...|.|| |.||.|||.|.  .   . ||. |....|||.. ||...|..|..||||||.|...|.             ......|||.|||.|.  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DENG------------EHKVKRK---KVKFLG-TLRYACRACMMQQEQGRKDDLETWIYLVFDLMDESHGMPWRSLCSPKE-----ILKSKNEFFTNFDS
| .|            .|. .|.   |..| | |.||. ..|. ..||||.|||..|.|....... ..|.||. . ....     . | | ||....  
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SSVSATLK----------RLKGLVSYVDNMQYETTPDYDYI
|  .  |.           .  .. |.....|...|||..|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F59A6.4.AA Worm6 434-653 38 4.2e-76 259.15 In-house 1-222 (279) Show / Hide 
Range on Protein: 434-653
Range on HMM: 1-222/279
Sequence Identity: 38% (88 aa)

WKVINLLGSGGFGDVYKVHRESQPITKCYALKTESE-EGEKRYLRLKIEVTVMMKTAEKKKENKFKNFIEFVDRGKCEQLKCKYVVMGLVGPSLEDIRRK
|||  ..|.||||.|||| ..|    | .|.| |.. |..||   ||.|. |..... .|     ..| ...|||| ..   .|.|| |||..|.|.|. 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQM-LKMECMVLKAVKHHK----CRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKN

YLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGL-----EDREDTVYMLDFGIAK--LYVDENGEHKVKR-KKVKFLGTLRYACRACMMQ
   . ||  |.  .|||.  |..|||..|..|||.||.|...|       . . |.||||||...   | ....| .  | ....| ||.||| .||. .
RPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKG

QEQGRKDDLETWIYLVFDLMDESHGMPWR
|||.||||.|.| |.. ..     . |||
QEQCRKDDCESWFYMMVEMIVG--CLPWR
Kinase F59A6.4.AA TTBKL 434-709 28 1.6e-57 192.77 In-house 1-288 (288) Show / Hide 
Range on Protein: 434-709
Range on HMM: 1-288/288
Sequence Identity: 28% (85 aa)

WKVINLLGSGGFGDVYKVHRESQPITKCYALKTESEEGEKRYLRLKIEVTVMMKTAEKKKENKFKNFIEFVDRGKCEQLKCKYVVMGLVGPSLEDIRRKY
|... ..|.|||| ||.|   . . ..|.|.| |. . |.   |.|.|| |.|| .....    . |..... || ..  . ..|| |.||.| |.|.. 
WMIVKMIGEGGFGQVYHVWDMKDK-KDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGS----PHFPKCHCSGKRKD--YNFMVMTLCGPNLQDLRKMM

LLGS-FSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLEDR----EDTVYMLDFGIAKLYVDENGEH-----------KVKRK---KVKFLGTL
  .  ||. |.  ..||.. ||...|..|..|||.||.|...|..|.    . .|| .|||.|. |....||            . .|.   |. | ||.
PNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTT

RYACRACMMQQEQGRKDDLETWIYLVFDLMDESHGMPWRSLCSPKEILKSKNEFFTNFDSSSV---SATLKRLKGLVSYVDNMQYETTPDYDYIINFL
||.  .  . .||||.|||  |.| .  |...    ||... ...|| . |..  ..  ..         . .   . .. ...|  .|||..|....
RYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG---LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase F59A6.4.AA CK1-Unique 434-653 27 2.9e-42 144.31 In-house 1-233 (337) Show / Hide 
Range on Protein: 434-653
Range on HMM: 1-233/337
Sequence Identity: 27% (64 aa)

WKVINLLGSGGFGDVYKVHRESQP----ITKCYALKTESEEGEKRYLRLKIEVTVMMKTAEKKKENK-FKNFIEFVDRGKCEQLKCKYVVMGLVGPSLED
|.|| ..|.||.|.|..|  .  .      . |. |||     |.  ||.||  ||        . |  . | |  | .   .   .. || ..|||.| 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDW--WWIVMTMHGPSMEE

IRRKYLLGSFSKH------TSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLED--REDTVYMLDFGIAKL--YVDENGEHKVKRKKVKFLGTLRYAC
.....   .| .       .  . . |.  ..   |  |..||..||.||  .      . . ||||.|| .    |. |.. . .|....| |...|. 
CCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCP

RACMMQQEQGRKDDLETWIYLVFDLMDESHGMPWR
..|   .|.||.||.|.| |.  .| .   |. |.
CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase F59A6.4.AA TTBK 516-705 32 1.6e-33 115.83 In-house 72-257 (257) Show / Hide 
Range on Protein: 516-705
Range on HMM: 72-257/257
Sequence Identity: 32% (62 aa)

YVVMGLVGPSLEDIRRKYLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLE-DREDTVYMLDFGIAKLYVDENGEHKVKRKKVKFLGTL
|.|| | | .| | ||| . | ||  |   . .| . ...  ||.|.||||||| |.|.|.   .   .|||||| |  |.   ||    |.   | || 
YMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTV

RYACRACMMQQEQGRKDDLETWIYLVFDLMDESHGMPWRSLCSPKEILKSKNEFFTNFDSSSVSATLKRLKGLVSYVDNMQYETTPDYDYI
|||       .| ||.|||    |.    .     .||| .    .. . |... .      .    . ..  .  .  ..||..|||  |
RYASINAHRNREMGRHDDLWSLFYMLVEFVQGQ--LPWRKIKDKDQVGEMKEKYDHRM---LLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase F59A6.4.AA CK1-Unclassified 434-634 32 2.1e-33 95.96 In-house 1-200 (244) Show / Hide 
Range on Protein: 434-634
Range on HMM: 1-200/244
Sequence Identity: 32% (67 aa)

WKVINLLGSGGFGDVYKVHRESQPITKCYALKTESEEGEKRYLRLKIEVTVMMKTAEKK-KEN--KFKNFIEFVDRGKCEQLKCKYVVMGLVGPSLEDIR
 .||  .|.| ||..||.   .|   . .|.| |..  .  .  |..|. .|.     . . .    |..      |. ||  . ..|| | ||||||. 
YRVIEKIGQGSFGEIYKC-INMQTN-EEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNC-DNFI-KGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-

RKYLLG-SFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVG-LEDREDTVYMLDFGIAKLYV--DENGEHKVKRKKVKFLGTLRYACRACMMQQE
 . . .  ||  |  . | | .. .. ||. ...|||||| |. .| |. . ..||. |||..| |.  |..|.|   | . .. || |||        |
-FNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIE

QGRKDDLE
|.|.||||
QSRRDDLE
Kinase F59A6.4.AA CK1 434-634 29 1e-30 103.06 In-house 1-200 (271) Show / Hide 
Range on Protein: 434-634
Range on HMM: 1-200/271
Sequence Identity: 29% (61 aa)

WKVINLLGSGGFGDVYKVHRESQPITK-CYALKTESEEGEKRYLRLKIEVTVMMKTAE-KKKENKFKNFIEFVDRGKCEQLKCKYVVMGLVGPSLEDIRR
 .|.  .|.| |||.|.. .  .   .  .| | |..  .  .  |..|. ...     .. .|. ...      |..|| .. ..|| | ||||||   
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HP-QLHYEAKIYKILQGHNC-DNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-F

KYLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGL-EDREDTVYMLDFGIAKLYVD-ENGEHKVKRKKVKFLGTLRYACRACMMQQEQGR
..  . ||  |  ..| | .. .. .|. ...|||||| |. .|. . ....||. |||.|| |.| ....|   | . .. || |||     .  ||.|
NFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSR

KDDLE
.||.|
RDDME
Kinase F59A6.4.AA CK1-D 517-705 33 4.5e-24 81.73 In-house 72-261 (261) Show / Hide 
Range on Protein: 517-705
Range on HMM: 72-261/261
Sequence Identity: 33% (65 aa)

VVMGLVGPSLEDIRRKYLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLEDREDTVYMLDFGIAKLYVDEN-GEHKVKRKKVKFLGTLR
.|| |.||||||.   |    ||  |   .| | .. .. .|.  ..|||||| |. .||  | ..||..|||.|| | | .  .|   | .    || |
MVMDLLGPSLEDL-FNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTAR

YACRACMMQQEQGRKDDLETWIYLVFDLMDESHGMPWRSLCSPKEILKSKNEFFTNFDSSSVSATL-----KRLKGLVSYVDNMQYETTPDYDYI
||     .  || |.||||   |..      |  .||  |       . | |  ..   |    ||     .  .  . |. |....  ||| |.
YASINTHQGIEQSRRDDLESLGYVLMYFNRGS--LPWQGLKA--ATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase F59A6.4.AA CK1-A 517-640 34 7.5e-21 70.28 In-house 72-195 (261) Show / Hide 
Range on Protein: 517-640
Range on HMM: 72-195/261
Sequence Identity: 34% (43 aa)

VVMGLVGPSLEDIRRKYLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLEDREDTVYMLDFGIAKLYVDENGEHKVKRKKVKFL-GTLR
.|| |.||||||.   .    |.  |   .| | .. .  .|  ...|||||| |. .|..     ....|||.|| | |.. .. .. .. | | || |
MVMDLLGPSLEDL-FNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTAR

YACRACMMQQEQGRKDDLETWIYLV
||     .  || |.||.|   | .
YASINAHLGIEQSRRDDMESMGYVM
Kinase F59A6.4.AA S_TKc 434-727 16 4.9e-11 -15.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 434-727
Range on HMM: 1-231/231
Sequence Identity: 16% (52 aa)

WKVINLLGSGGFGDVYKVHRESQPITKCYALKTESEEGEKRYLRLKIEVTVMMKTAEKKKENKFKNFIEFVDRGKCEQLKCKYVVMGLVGP---SLEDIR
.......|.|.|| |||..  .    . .|.|  .        ... |. ...|        . .| . . |       .. |.|| ...    .| |. 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-------EHIRREIQILKK--------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYI

RKYLLGS----FSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLEDREDTVYMLDFGIAKLYVDENGEHKVKRKKVKFLGTLRY-ACRACMMQQ
.|.  .     |.  .   .. |.. ||. .|| | .|||.||.|  .       ..   |||.|...               | ||. | |   .    
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----

EQGRKDDLETWIY----------LVFDLMDESHGMPWRSLCSPKEILKSKNEFFTNFDSSSVSATLKRLKGLVSYVDNMQYETTPDYDYIINFLKT----
          . .          ... ..      |..    .....|                                  . .  | | . |.     
---------GYGKCKCDWWSCGCILYEMLC--GYPPFP---QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEK

--TATEAGA--KISKKLDWI
  || || .     |.  |.
RPTA-EALQDEWDIKCHPWF
Kinase F59A6.4.AA TTBK 434-487 35 1.1e-05 16.11 In-house 1-51 (257) Show / Hide 
Range on Protein: 434-487
Range on HMM: 1-51/257
Sequence Identity: 35% (20 aa)

WKVINLLGSGGFGDVYKVHRESQPITK--CYALKTESEEGEKRYLRLKIEVTVMMK
|||.   | |||| .|        |..  . |.| || .  |  |..  || |. |
WKVVKKIGGGGFGEIYEAK---DMINHHEQVAIKVESAQQPKQVLKM--EVAVLKK
Kinase F59A6.4.AA Worm6 690-705 43 0.000235 11.92 In-house 264-279 (279) Show / Hide 
Range on Protein: 690-705
Range on HMM: 264-279/279
Sequence Identity: 43% (7 aa)

YVDNMQYETTPDYDYI
|.|...|...|||..|
YIDQYSYWDRPDYKFI
Kinase F59A6.4.AA CK1-A 434-449 43 0.00094 8.94 In-house 1-16 (261) Show / Hide 
Range on Protein: 434-449
Range on HMM: 1-16/261
Sequence Identity: 43% (7 aa)

WKVINLLGSGGFGDVY
....  .||| |||.|
YRLVRKIGSGSFGDIY
Kinase F59A6.4.AA Pkinase 434-473 32 0.003224 12.46 Pfam 1-38 (293) Show / Hide 
Range on Protein: 434-473
Range on HMM: 1-38/293
Sequence Identity: 32% (13 aa)

WKVINLLGSGGFGDVYKVHRESQPITKCYALKTESEEGEK
....  .|||.|| ||| |. . ..   .|.|. . ..||
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEK
Kinase F59A6.4.AA Pkinase 536-571 36 0.009504 10.8 Pfam 101-138 (293) Show / Hide 
Range on Protein: 536-571
Range on HMM: 101-138/293
Sequence Identity: 36% (14 aa)

GSF--SKHTSFNVAIQTVTALQDLHSIGYLHRDIKPAN
|.|  | ..  ... |.. .|. .|| | .|||.||.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN
Kinase F59A6.4.AA CK1-A 687-705 36 0.014849 4.64 In-house 243-261 (261) Show / Hide 
Range on Protein: 687-705
Range on HMM: 243-261/261
Sequence Identity: 36% (7 aa)

LVSYVDNMQYETTPDYDYI
...|. |...| .||| |.
YMNYCRNLRFEEQPDYMYL
Kinase F59A6.4.AA CK1 690-703 35 0.0517 2.96 In-house 258-271 (271) Show / Hide 
Range on Protein: 690-703
Range on HMM: 258-271/271
Sequence Identity: 35% (5 aa)

YVDNMQYETTPDYD
|. ....| .|||.
YCRQLHFEEKPDYM
Kinase F59A6.4.AA CK1-D 434-449 43 0.122916 1.35 In-house 1-16 (261) Show / Hide 
Range on Protein: 434-449
Range on HMM: 1-16/261
Sequence Identity: 43% (7 aa)

WKVINLLGSGGFGDVY
...   .||| |||.|
YRIGRKIGSGSFGDIY