Gene F54H5.2 (Nematode worm)
F54H5.2
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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F54H5.2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 265 | Kinase domain by global Sugen HMM | Fasta, JSON |
F54H5.2.AA | Protein | Genbank | 424 | None | Fasta, JSON |
Protein domains of F54H5.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | F54H5.2.AA | TTBKL | 31-297 | 39 | 2e-151 | 509.39 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 31-297 Range on HMM: 1-288/288 Sequence Identity: 39% (115 aa) WQVIRKLGEGGCGSVYLVKNLED-ETEAAMKAESNG-AAGGCVLKLEVAILKKLS--GKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQ--IT |......||||.|.||.|....| ...||||.|.| . |....|.|| .|.||. |.||....... . |.....|||.|..| .. |.. .. .. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS VSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTN-NDECRFFHVLDFGLARQFVVSQSDQP-----SKLMMRRPRE---RSLFRGTTRYCSIRM .....||. .|..|||.||.||||||.||.|...||... ...|| ....|||.|||......... .|.||||||. .. |||||||||..| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HDRAEQGRVDDLWSILYLLAELRGPLPWSSQNDKRVVGEMKRLHSDEVVLQN------SPMEFLEIAKYLRSLTYFHRPDYHKIFMLL |||.||||.||||| .| ..||...|||.. .|| ...||. ..||.. .. .|.||....|.||||.| .||||..|.... HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | F54H5.2.AA | CK1 | 31-293 | 32 | 1.6e-106 | 360.19 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 31-293 Range on HMM: 1-339/339 Sequence Identity: 32% (109 aa) WQVIRKLGEGGCG-SVYLV-----KNLEDE-----TEAAMKAESNGAAGGCVLKLEVAILKKL---------------------SGKPHVCQFLFAARLT |.|..|.||||.| .|.| |.... .|.|||.|.. ..|. ...|.....|. .|.||.|.. .. . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED DFT-YVIMTLLGESLNKIVK--RI-ARQITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTN----------NDECRFFHVLDFGLAR-QFV |. |..|||||..| .. | | | ..... ..|| |. |...||.||||||.||.|...|.... |.|.| ....|||.|| ... DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR VSQSDQ------PSKLMMRRPRE---RSLFRG-TTRYCSIRMHDRAEQGRVDDLWSILYLLAELR-GP--LPWSSQNDKRV-----VGEMKRLHSDEVVL .. .. .. ..|.||| . ||| |.|||||..|.. ||||.||||| .|.|.|. | |||. .|. |..||. . || . DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM QN------------SPMEFLEIAKYLRSLTYFHRPDYHKI .. .| || .|.||.|||.|..||||..| STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | F54H5.2.AA | TTBK | 31-293 | 40 | 2.6e-76 | 259.84 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 31-293 Range on HMM: 1-257/257 Sequence Identity: 40% (108 aa) WQVIRKLGEGGCGSVYLVKNLEDE-TEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQI-TVSSQ |.|..| | || | .| |.. . . |.| || . |||.|||.|||| |..|||.| | .| |..|.|.|..| |. ..|. WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESA-QQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT VRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLW .|. .| ...||..|| ||| || | |.| . || ||||||||.. .. . | ||| |||| || || | | || |||| LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST--CRKCYMLDFGLARQYTNACGE------VRPPREVAGFRGTVRYASINAHRNREMGRHDDLW SILYLLAE-LRGPLPWSSQNDKRVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKI |. |.| | . | ||| || ||||| . |.. | || . ..||.|. |||| | SLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | F54H5.2.AA | Worm6 | 31-293 | 30 | 5e-63 | 215.71 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 31-293 Range on HMM: 1-279/279 Sequence Identity: 30% (88 aa) WQVIRKLGEGGCGSVYLVKNLEDET--EAAMKAESN-GAAGGCVLKLEVAILKKLSGKP--HVCQFLFAARLTD--FTYVIMTLLGESLNKIVKRIA-RQ |.| .|.||||.|.||.|.. .| . . |||.|. . .||.|...||.. .. |.|.. ... | |..|||.|..| . | . | WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK ITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYK--TNNDECRFFHVLDFGLAR-QFVVSQSDQPSKLMMRRPR-ERSLFRGTTRYCSIRMHDR .... .|| | . . | .||||||.||.| . | ...| . ||||..| . . . .| || .. ||||.||... |.. FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNE-----LRTPRWTACGFRGTVRYAPLACHKG AEQGRVDDLWSILYLLAEL-RGPLPWSSQNDKRVVG---EMKRLHSD----EVVLQNSPM-EFLEIAKYLRSLTYFHRPDYHKI ||.| ||. | .|...|. .| ||| .|. |. . .| . . . .... |. || .| .|. .. |. |||| .| QEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | F54H5.2.AA | CK1-A | 31-293 | 29 | 5.1e-31 | 106.78 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 31-293 Range on HMM: 1-261/261 Sequence Identity: 29% (79 aa) WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQITVSSQVR ....||.| | | .|| |... | |.| ||| | | | . . |.| . . . .. . |. ..| ||| || . |. |. . YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESN-KARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLM IAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLWSI .| .. . .| .|||||.|| | .| . | ...|||||... |.. | . | .. || || || | || | ||. |. LADQMIMRIEYVHEKNFIHRDIKPDNFLMGI---GRHCNKLFLIDFGLAKKYRDSRTRQ--HIPYREDKN---LTGTARYASINAHLGIEQSRRDDMESM LYLLAEL-RGPLPW------SSQNDKRVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKI | . || ||| . . | | . |.. . .| || . .| |.| . ||| . GYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | F54H5.2.AA | CK1-D | 31-293 | 29 | 8.6e-27 | 91.46 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 31-293 Range on HMM: 1-261/261 Sequence Identity: 29% (79 aa) WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQITVSSQVR . . ||.| | | .|. .|.. . | |.| |. . |..| . | ..| . . . . |. ..| ||| || . |. . . YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK-HPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLM IAANVLFCLKQIHDIGFIHRDLKPAN--MALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLW .| .. .. || |||||.|| | | || . | ...|||||... ... | . || || || || | || | ||| LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGN-----MVYIIDFGLAKRYRDARTHQ--HIPY---RENKNLTGTARYASINTHQGIEQSRRDDLE SILYLLAEL-RGPLPW-----SSQNDK-RVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKI |. |.| || ||| . .| . | | . ... . | || . | |.| . ..||| . SLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | F54H5.2.AA | CK1-Unique | 31-237 | 25 | 2e-26 | 88.6 | In-house | 1-223 (337) | Show / Hide |
Range on Protein: 31-237 Range on HMM: 1-223/337 Sequence Identity: 25% (58 aa) WQVIRKLGEGGCGSVYLVKNLEDE------TEAAMKAESNGAAGG----CVLKLEVAILKKLS--GK--PHVCQFLFAARLTDFTYVIMTLLGESLNKIV |.|| ..| || | |. | . .. . .|| | ... ..... . . |.. | |.|. | . .||..| |. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KRIAR-QITVS------SQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNN-DECRFFHVLDFGLARQ-FVVSQSDQPSKLMMRRPRERSLFRGT .. |.| . .. . .|. . | ||.||..||.| .. ... . . . .||.| | | || . | .| ||.. |||. MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYM--APSQQHQHCYYMLDYGICRRVFFVSNNHQ-----IRQPRPITPFRGC TRYCSIRMHDRAEQGRVDDLWSILYLLAEL .||.. | |.|| ||. | .|.| | KDYCPCSCHQCREHGRRDDMESWFYMLYHL |
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Kinase | F54H5.2.AA | CK1-G | 31-293 | 29 | 2.3e-22 | 72.52 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 31-293 Range on HMM: 1-266/266 Sequence Identity: 29% (80 aa) WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKP-HVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQITVSSQV ..| .| |.| | ... ||. | | | |..| | |.|.| . | . . .| ||| || |. .| . . YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSR-APQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVC RIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLWS .| . ....|. | || || | | . |.|. . |. |||.|.|.. . | ||. || || || | || | ||. . MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQ-HVIHIIDFGMAKQYIDPETKQHIPY-----REHKSLTGTARYMSINTHLGREQSRRDDMEA ILYL-LAELRGPLPWS---SQNDKRV---VGEMKRLHSDEVVLQN--SPMEFLEIAKYLRSLTYFHRPDYHKI . . . ||| ||| | | .|. || |. .|| | .| .| |.| .| ||| . LGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | F54H5.2.AA | CK1-Unclassified | 31-183 | 25 | 7.4e-18 | 49.3 | In-house | 1-159 (244) | Show / Hide |
Range on Protein: 31-183 Range on HMM: 1-159/244 Sequence Identity: 25% (41 aa) WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKP-------HVCQFLFAARL--TDFTYVIMTLLGESLNKIVKRIAR .||.|.| | | .|...|.....|.|.| |.. . |. |. |.. | . .. .. |. ...|.|||.|| .. . | YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNR QITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALG-YKTNNDECRFFHVLDFGLARQFV . .. || . . ..| .|||||.|| | | . | . . . ||||. .. KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQV---YIIDFGLSKRYI |
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Kinase | F54H5.2.AA | Pkinase | 31-187 | 22 | 7.2e-17 | 60.72 | Pfam | 1-167 (293) | Show / Hide |
Range on Protein: 31-187 Range on HMM: 1-167/293 Sequence Identity: 22% (39 aa) WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKL-----EVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGE-----SLNKIVK-RI ....||.|.|. |.||. .. .. . |.| . . .... |..|.|.| . |...... . . | |..| ... .| ... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR ARQI--TVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQF-VVSQS . . . ... .| |. .|. |.|||||||.| . . ..|. .... |||||.|| ..| HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS |
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Kinase | F54H5.2.AA | CK1 | 31-183 | 28 | 2.9e-16 | 52.64 | In-house | 1-160 (271) | Show / Hide |
Range on Protein: 31-183 Range on HMM: 1-160/271 Sequence Identity: 28% (46 aa) WQVIRKLGEGGCGSVYLVKNLEDETEA---AMKAESNGAAGGCVLKLEVAILKKLSG------KPHVCQFLFAARL--TDFTYVIMTLLGESLNKIVKRI .|.||.|.| | .||..|. ...|. |.| |.| . |. |. |.| | | ... . .. |. ...|.|||.|| . . YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC ARQITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFV |. .. . || . . .| .|||||.|| | | . .| .. ||||| ... NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR--YGKHCHQVYIIDFGLAKRYR |
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Kinase | F54H5.2.AA | S_TKc | 31-301 | 19 | 3.6e-15 | 45.5 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 31-301 Range on HMM: 1-231/231 Sequence Identity: 19% (56 aa) WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGE---SLNKIVKRIARQ----- ....||.|.|. |.||.... .. . |.| . . .. |..|||| . |...... . . |. |..| ... .| .. |. |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP ITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQG .. .... .. |. .|. |.|||||||.| | . |||||||. . | || |.. . | FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL---GYG R-VDDLWS---ILYLLAELRGPLPWSSQNDKRVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKIFM-----LLISIM . | || ||| .. . | | ..... .. . |.... . . .|| ... . . KCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | F54H5.2.AA | CK1-Unclassified | 206-243 | 53 | 2e-07 | 18.01 | In-house | 178-216 (244) | Show / Hide |
Range on Protein: 206-243 Range on HMM: 178-216/244 Sequence Identity: 53% (21 aa) GTTRYCSIRMHDRAEQGRVDDLWSILYLLA-ELRGPLPW ||.|| ||..| ||.| ||| |. |.| |.| ||| GTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW |
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Kinase | F54H5.2.AA | CK1 | 253-291 | 30 | 3e-06 | 17.58 | In-house | 232-271 (271) | Show / Hide |
Range on Protein: 253-291 Range on HMM: 232-271/271 Sequence Identity: 30% (12 aa) GEMKRLHSDEVVLQN-SPMEFLEIAKYLRSLTYFHRPDYH .|.|. . |. .. | || . .| |.| .. .||| MEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | F54H5.2.AA | TyrKc | 31-241 | 13 | 3.5e-05 | -138.75 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 31-241 Range on HMM: 1-280/280 Sequence Identity: 13% (40 aa) WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKL--EVAILKKL-SGKPHVCQFLFAARLT-------DFTYVIMTLL-GESLNKIVKRI . ..||||| | ||. . .. | | ..| . . | |..|| |.. ... ... . ...| . . .|.. .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH ARQITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVS------QSDQPSKL--MMR--RP--------RER ...... . .. . .|. ..||||| | .| . .. . ||||.| .. .| . | RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVK---ISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY SLF------------------RGTTRYCS--------IRMHDRAEQGRVDDLWSI------------LYLL---------------AELRGPL . | .| . | .... . .||. . .| . .|.. . GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | F54H5.2.AA | CK1 | 206-243 | 53 | 9e-05 | 12.58 | In-house | 178-216 (271) | Show / Hide |
Range on Protein: 206-243 Range on HMM: 178-216/271 Sequence Identity: 53% (21 aa) GTTRYCSIRMHDRAEQGRVDDLWSILYLLA-ELRGPLPW ||.|| || .| ||.| ||. |. | | ||| ||| GTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW |