Gene F46F6.2 (Nematode worm)

F46F6.2

Species: Nematode worm
Alias: aSWK020, CE31703, F46F6.2
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 10400995-10406300, WormBase Genetic Map location: No interpolated position.,

Classification

Group: AGC
Family: PKN

Sequence

Name Sequence Type Origin Length Description Download
F46F6.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
F46F6.2.AA Protein Genbank 1018 None Fasta, JSON

Protein domain

Protein domains of F46F6.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HR1 F46F6.2.AA HR1 74-141 18 0.102681 9.28 Pfam 1-74 (74) Show / Hide 
Range on Protein: 74-141
Range on HMM: 1-74/74
Sequence Identity: 18% (14 aa)

ELRSVIRKDLTKKLKIKSGYSRIKLI---TSDRRQ----SEFLRYELSDLNEQIADLQEDLQALEMYNSGAFDED
. .. .|| . . .||| |   ..     |.|...     . .  .|.. |  |. |.. |. |.  ...  ...
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 F46F6.2.AA HR1 159-227 32 3.1e-09 36.26 Pfam 1-74 (74) Show / Hide 
Range on Protein: 159-227
Range on HMM: 1-74/74
Sequence Identity: 32% (24 aa)

SKLVILQLELEKELKVKRGLEQFLRG---APDKSK---VHGDSQSLLDDSRAKIAMLRMQIERLSQEAPAVEGEP
..|  |. ..|.|.|.| | |  .|    . |..|   |. . |. | .|. ||. ||||.|.| |. .  ... 
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 F46F6.2.AA HR1 233-305 17 2.7e-09 36.47 Pfam 1-74 (74) Show / Hide 
Range on Protein: 233-305
Range on HMM: 1-74/74
Sequence Identity: 17% (13 aa)

LAIDDLIIRFHKEKLIMDGSRNMIRIL---RSKRKPDSKAVDEAMNSYVIASEKADLIKLALLKYASSLPLEHDHR
.....|  ....|. |..|..||.| .     ..|.  |.  .. .    .. | .... .| |. ....  |. .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKH-RKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
C2_PKD F46F6.2.AA C2_PKD 385-530 22 8.9e-67 228.16 In-house 1-183 (183) Show / Hide 
Range on Protein: 385-530
Range on HMM: 1-183/183
Sequence Identity: 22% (42 aa)

PGFISVYGMDASGKKKKSA----------RGPNSSEEVFCVLRIDNRF----IGATEL-RKIVDRNWDQKFDVDLDRSRELQIELFYHDD---RSMCGFA
.||..|....|.|.|.|..          ..........||...|...    ||.|.. .|.....|...||......|..||.......   ..|....
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

AVKLSNLIET----SSKVGIIVPVEPQGNIFVQFKYMNPVVSRKPKL---------------ERQRRLFRVKESNDGARQKLG
..||...||.    |....|....||||...||.|..|.....|...               .|||..|.....|.....|..
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
Kinase F46F6.2.AA PKN 690-949 78 4.90000000001e-199 667.53 In-house 1-260 (260) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-260/260
Sequence Identity: 78% (204 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDDVFDE
||.|.||||||||||.|||...|..|||.|.|||.||..||||||||.|||||||..|.||||||||..||||.|||.|.|||.||||||.|||.|||.|
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDVFSE

VRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPP
.|.|||||||||||..||.|.|||||.||||||||.||||||||||||||.||..|.||||||||||||||||.|.|||||.|||||||||.||||||.|
PRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECP

FSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFF
|.||||||.||.|...||||||.||||.||||||||||.||.|||.|||||||||.|.||
FPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase F46F6.2.AA AGC 690-949 31 5e-172 449.16 In-house 1-395 (395) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-395/395
Sequence Identity: 31% (127 aa)

FRLISVLGRGHFGKVILSQHN------PTSNYYALKVLKKGD-ILGRD--EVESLMVE------------KRIFEVSSRAR-------HPFLVN-LNGCF
|... |.|.|.||||.| ...       |  |||.||||| . |. ..  .||  |.|            ..|.|  .  .       |||.|. |  .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTNEH--VFFCMEYSM---------GG-DLMRHIHDD----VFDEVRGCFYAAC-------VVLGLDFLHK-HNIIYRD-IKLDNLLLDREGYVKIADFG
|...|  ..|.|||           || .|. |....    .||| | .||||.       .||.|..||. ..||.|| .|..|.|||..|..|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKENMGPF--------------------------------------------------DKTSTFCG--TPEFLAPEVLSDSSYTRAIDWWG--LGVLIF
||||.|.                                                    |.|.||||  |||..|||.|    |..| |||.  ||.|..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGEPPFSGD----------DEEEIFDSII------SEDVRYP----------RYLSVESIAIMRRLLRKVPEKRLGYGERD-----AEDIKIQRFF
|||.| |||.||          ...|.|..|.      ...|..|          |..|.|   ....|| | ||||||.|..|     ||.||   .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase F46F6.2.AA PKC 690-949 50 3.9e-141 460.33 In-house 1-262 (262) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-262/262
Sequence Identity: 50% (133 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDD-VFD
|... |||.| ||||.|. .  |  ||| |||||  |.  | ||. |.|||... ...  ||||..|  ||||... || |||  ||||| || .   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK--HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFK

EVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEP
| .  |||| ....| |||...||||| |||| |||.|| .||||||.||||| . |.||||||||...|||.|.   |. ..||| .||| .||..| .
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERD---AEDIKIQRFF
||.|.||.|.|.||  ....|||.||.|. .|.  .. | |||||| ....   ..||.   ||
PFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase F46F6.2.AA Akt 690-949 43 4.3e-114 366.14 In-house 1-264 (264) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-264/264
Sequence Identity: 43% (117 aa)

FRLISVLGRGHFGKVILSQHNPTSNYY-ALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHI-HDDVF
|... |||.| ||||.| . . | ..| |.|||||  |. ...||  . |..| .      |||.|||.  |||... .|.|.|  ||.|  |. .. .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

DEVRGCFYAACVVLGLDFLHKHNIIYRD-IKLDNLLLDREGYVKIADFGLCKEN-MGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWG-LGVLIFEML
.| |  ||.| ..|....||..||||||  |. |.|.|..|.....|||||||| .  .||| ||||||| ||||.|..  .|.| |||| ||....||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

VGEPPFSGDDEEEIFDSIISEDVRYP--RYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFF
 | |||  .| .. |. | ...|..|  ...| |   . ..|| | |.||||.|. ||..||   .|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase F46F6.2.AA Alpha 690-949 48 2.1e-112 379.72 In-house 1-259 (259) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-259/259
Sequence Identity: 48% (127 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHD-DVFD
|  ..|||.| ||||.|.    |   || |.|||  |   | ||  |||||.   ...   |||| .  ||||    .| |||  ||||| ||     | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGK--PPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFK

EVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEP
|    |||| .  || |||.  ||||| |||| .||.|| .||||||.||||| . . | ||||||...|||. .   | ...|||  ||| .||..| |
EPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQP

PFSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFF
|| |.||.|.| .|    | ||. .|.|...| . .| | | |||| |  . .||.   ||
PFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase F46F6.2.AA Delta 690-949 49 1.5e-111 376.91 In-house 1-259 (259) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-259/259
Sequence Identity: 49% (130 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDDV-FD
| .  |||.| ||||.|.    . .|||.| |||  .|  |.||. |||.|.  ..  ..||||  |   |||.||.|| |||  ||||| || .   ||
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALA--WEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFD

EVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEP
| |  |||. ...|| ||||..|||||.||||.|||..| .||||||.|||||    |.|||||||...|||..    |....|||  |||..|||.|  
EKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFF
||.|.||.|.|.||. .   |||... |.  ....|. . ||||||  .  . ||..  ||
PFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase F46F6.2.AA Eta 690-949 48 8.10000000001e-106 357.86 In-house 1-261 (261) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-261/261
Sequence Identity: 48% (128 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHI-HDDVFD
|  | |||.| ||||.| ..  | . ||.|||||  |.  |.||  | ||||  .   ..|||| .|  ||||.. .|| |||  ||||| .| .   ||
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLA--RKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFD

EVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEP
| |  |||| |.. | |||.|..||||.||||.|||.||  |.||||.||| .     |.||||||...|||.| .  |  ..||| .|||..||. |.|
EPRARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQP

PFSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGE--RDAEDIKIQRFF
||  | |...|.||. .|| || .|. | ..|..  . | |.||||  .   . ..|.   ||
PFEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase F46F6.2.AA SGK 690-949 38 9.90000000001e-102 314.97 In-house 1-283 (283) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

FRLISVLGRGHFGKVILSQHNPT------------------SNYYALKVLKKGDIL-------GRDEVESLMVEK-RIFEVSSRARHPFLVNLNGCFQTN
|....|.| | |||| . .|  .                     ||.|||.|  |.        . |.   | |.  |    .  .|||.|||   ||| 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVIL---KNMKHPFIVNLHYAFQTK

EHVFFCMEYSMGGDLMRHIH-DDVFDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVL
.  .| |.|  ||..  |.     | | |  |||| .|. |. ||. .||||| | .|.||| .|.... |||||||.. . |.|.||||||| ||||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

SDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFF
    . |. ||| || . .||..| |||   . .. .| ||... . |.. |..   ..  || | |.||||   ||...||   ||
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase F46F6.2.AA AktR 690-949 40 1.2e-97 330.71 In-house 1-268 (268) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-268/268
Sequence Identity: 40% (110 aa)

FRLISVLGRGHFGKVILSQHN-PTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIH-DDVF
|... .||.| ||||.| |..  .  .||.|..|| .|  |   . .  |. | |  . ..|||.|.|  ||||.|. ||.|||. ||.| .|.  .  |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIME--MCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

DEVRGCFYAACVVLGLDFLHKH-NIIYRDIKLDNLLLDREGYVKIADFGLCK-ENMG-PFDKTSTFCGTPEFLAPEVLSD-SSYTRAIDWWGLGVLIFEM
.| .  ||.| ..|.|..||.| ||||||.| .|.||| .|.|||.|||| | ..|    .|. .|||||| .|||..     .....||| .|..|.||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LVGEPPFSGDDEEEIFDSIISED---VRYPRYLSVESIAIMR-RLLRKVPEKRLGYGERDAEDIKIQRFF
..| |||  .. ...|..|....   . || |.| .   .   .|| | |.|||||.  ..|.||   .|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase F46F6.2.AA S_TKc 690-949 33 1.2e-93 318.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMG--GDLMRHIHDDV-
.... ..|.| |||| . .|. |  ..|.|..|          |... | .| .     .||..|.| ..||. .|....|||  |  |||...|..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTR-AIDWWGLGVL
      |.| . .||.. ....|...|.|.||.||.| .|.|||.   .||.||||...        .||||||...|||||   .|.. ..||| .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IFEMLVGEPPFSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERDA--EDIKIQRFF
..|||.|.|||.  .....|. |           | | . ..|..|.| ||||..  |  .  .|||.  .|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F46F6.2.AA RSK 693-949 39 3e-89 302.8 In-house 1-278 (278) Show / Hide 
Range on Protein: 693-949
Range on HMM: 1-278/278
Sequence Identity: 39% (110 aa)

ISVLGRGHFGKVILSQHN---PTSNYYALKVLKKGDILGRDE-VESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDDVF-
..|||.| .||| | .      |  .|| |||||  |  |.  ..  | | .| | .   .|||.|.|.  |||..... .||| .||.| .|.   .. 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ--QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

---DEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDR---EGYVKIADFGLCKE-NMGPFDKTSTFCGTPEFLAPEVLS----DSSYTRAIDWWGL
   .| . |||.| .|| ...||.. ||.||.|..| |.|    || .|. |||.||. .     .| |||.| |..|||.|     .. ...| ||| |
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLIFEMLVGEPPFSG---DDEEEIFDSIISED--VRYP--RYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFF
|||..|||.| ||| |   .. .||.. | . .  .. |   ||| |   . |..| . |.||||.| .|||.||   .|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase F46F6.2.AA Pkinase 690-949 27 1.5e-75 262.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 690-949
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLM-VEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGG----DLMRHIH-
.......|.| ||.| . .|  |.  .|.|..|| ..    ... .   | .|    .   ||. | | ..|... |. ..||| .||    ||...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--DDVF--DEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYV----KIADFGLCKEN-MGPFDKTSTFCGTPEFLAPEVLS-DSSYTRAIDW
  . .|  .|   .||.  .. ||...|...||.||.|..|.|.|..|..    ||.||||.|     .   ..||||||...||||.  .. |....|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WGLGVLIFEMLVGEPPFSGD------DEEEIFDSIISEDVRYPRYLS---------------------VESIAIMRRLLRKVPEKRLGYGERDAEDIKIQ
|..|....||| |.|||.|.      |. .... | . ....... .                      | . .....|.| |.||..     ||.|.  
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

RFF
 .|
PWF
Kinase F46F6.2.AA TyrKc 690-948 22 2.1e-13 -5.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 690-948
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRA--RHPFLVNLNGCFQTN-------EHVFFCMEYSMGGDLMR
 .|. .||.|.||.| . . .      | |.||..       .| .| | ||    ..   .|| .|.| |.  .        | ..  |||  .|||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIM---CKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HIHDDV--FDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGP-------FDKTSTF--CGTPEF----LAPEVLSDS
....    .     . ..  .  | ..||..|.| ||.   | |..... |||.||||...             ....   .|   .    .|||.. ..
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

SYTRAIDWWGLGVLIFEML-VGEPPFSG-----DDEEEIFDSIISEDVRYPRYL---------SVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRF
 .| . | |  ||...|..  |..| .|      . .|..  . . . . .            . |   ||..  .  ||.|    |       ...|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase F46F6.2.AA Pkinase_Tyr 749-838 27 0.000823 13.53 Pfam 62-159 (270) Show / Hide 
Range on Protein: 749-838
Range on HMM: 62-159/270
Sequence Identity: 27% (27 aa)

RHPFLVNLNGCFQ-TNEH--VFFCMEYSMGGDLMRHIHDD-----VFDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCK
.|| .|.| |.     |.  ..  |||  .|||  . ..       ..  . . ... .  |...|. .|.| ||.   | |..... |||.||||..
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase F46F6.2.AA Pkinase_Tyr 690-704 40 0.012493 9.53 Pfam 1-15 (270) Show / Hide 
Range on Protein: 690-704
Range on HMM: 1-15/270
Sequence Identity: 40% (6 aa)

FRLISVLGRGHFGKV
 ... .||.|.||.|
ITFGKKLGEGAFGEV
Kinase F46F6.2.AA Pkinase_Tyr 857-892 36 0.238843 5.19 Pfam 181-218 (270) Show / Hide 
Range on Protein: 857-892
Range on HMM: 181-218/270
Sequence Identity: 36% (14 aa)

LAPEVLSDSSYTRAIDWWGLGVLIFEMLV-GEPP-FSG
.|||..... .| . | |  |||..|..  || | . |
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG
S_TK_X F46F6.2.AA S_TK_X 952-1016 31 3e-13 51.28 SMART 1-79 (79) Show / Hide 
Range on Protein: 952-1016
Range on HMM: 1-79/79
Sequence Identity: 31% (25 aa)

ISWEWDKLLN--REIRPPFQPQIR----NPEDVSNFDLEFTQEKARFSAASSTRPITEADQRL---------FNNFDFSI
 .. ||||.|  .|| |||.|.|.    .|.|.|||| ||| |...     .. ..  ..|.          | .|... 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Pkinase_C F46F6.2.AA Pkinase_C 971-1018 33 1.1e-10 40.88 Pfam 1-46 (46) Show / Hide 
Range on Protein: 971-1018
Range on HMM: 1-46/46
Sequence Identity: 33% (16 aa)

QIRNPEDVSNFDLEFTQEKARFSAASSTRPITEADQRLFNNFDFSIVP
|...|.|.|||| |||.|... .  ...| ....||..| .| ..   
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD