Gene F40A3.5 (Nematode worm)
F40A3.5
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| F40A3.5.AA | Protein | Genbank | 410 | None | Fasta, JSON |
| F40A3.5.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 241 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of F40A3.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | F40A3.5.AA | TK-Unique | 94-375 | 26 | 4.2e-77 | 262.47 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 94-375 Range on HMM: 1-294/294 Sequence Identity: 26% (84 aa) IEVDDFQIGQTADGFIFRGGVFP--KTRNRFNAKVTTAVKISFPIVSKSISLLEDALRLSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPGGTLADYFQ .||.| .||..| |...||.|.. |...... .....|... ..|. | | .. .. ||||....| ... |. ...||..|..|.|.| .|.. LEVGD-VIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLR FKVRE-----------------KDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTEPDLRKCEVKLGDFGDAP-------- .. .. .|. ...||..||......|. ....|..||.... .|.....||||.|| ....|..||| |. TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVY -MGLEYSTPIIAYMPPEILCCAERIPPHRPENDVWMFGVFIWECLTLGAQPHFRKS-----VEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLS-EPHM | .... .|..|.||.|.|. . . |....|||.|||..||..|||| ..... .|.|.. .|.|.. .|..... | . |.. ||.. SMMCSQGRIPIRWMAPESLKCY-HGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMY----NLMKSCWQWEPEE RPRFASTTNASITSRL || | ..|..|| RPSF-----RQIKHRL |
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| Kinase | F40A3.5.AA | TK | 95-370 | 15 | 2.2e-38 | 125.77 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 95-370
Range on HMM: 1-486/486
Sequence Identity: 15% (74 aa)
EVDDFQIGQTADG---FIFRGGVFPKTRNR------------------FNAKVTTAVKISFPIVSKSISLLED---------------ALRLSKLD----
. ..|. . | ...| .... ... ..|...|||. . . | .| |. .....
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HPNLIRLLAVSQLSFTV---------FRPMIALEWLPGGT----LADYFQFKVREKDDSERSP------------------------------------
|||..||..|. . .. .|| .|. |.| | || . . ... ... .|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------IQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTEPDLRK-------CEVKLGDFGDAP
. ....| . .|..... |.||. || | . |. . .||.||.| . .| . .|..||| ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
MGL-----------EYST-----------------------------PIIAYMPPEILCCAERIPP-----HRPENDVWMFGVFIWECLTLGAQPHFR--
.| .| . | .|.|| | . . . .. |||.|||..||..|.|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
-----------KSVEEIKKSFRLP--------DRGLSCP--PTCP--------------LDVWTLVSDCLSE-PHMRPRFASTTNAS
. | | .. . . ... .| | || .. | .| .. | ||.|. ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | F40A3.5.AA | UTK | 143-363 | 23 | 2.1e-20 | 66.5 | In-house | 53-289 (296) | Show / Hide |
Range on Protein: 143-363 Range on HMM: 53-289/296 Sequence Identity: 23% (58 aa) LLEDAL---RLSKLD-HPNLIRLLAVSQLSFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHG ..| | ..... |||..||..| . .||..| ..| |..| . . |.. . .. | ..|. .... .. |.|| . . |. FMEEARELQMMKQFHWHPNVLRLVGVCTQEEP---WMIVTEYMENGDLRSYLR-RHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHS------CGFVHR RIFTRNVLVTEP----DLRKCEVKLGDFG---DAPMGL-----------EYSTPI------IAYMPPEILCCAERIPPHRPENDVWMFGVFIWECLTLGA . ||.||.. . .|..||| . . .|... |. | ||.|.... . .||| |||. ||..| |. DLAARNCLVHMHRMMWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHT---RFTTKSDVWSFGVVCWEIWTWGR QPHFRKSVEEIKKSFRLPD-RGLSCPPTCPLDVWTLVSDCLSE-PHMRPRF .| | ... .... . . . ||. ||..|..|. .| | .||.| LPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDF |
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| Kinase | F40A3.5.AA | TyrKc | 95-375 | 23 | 6.5e-16 | 34.62 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 95-375 Range on HMM: 1-280/280 Sequence Identity: 23% (74 aa) EVDDFQIGQTADGFIFRGGVFPKTRNRFNAKVTTAVKISFPIVSKSISLLEDALRLSKL--DHPNLIRLLAVSQLS----FTVFRPMIALEWLPGGTLAD . . ..| | | ...| .. ||| . ... | ..|| .|||..||..| . . .|| .| |.| | | ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTEPDLRKCEVKLGDFG---DAPMG-------LEYS------ | . . .. ...||.||. .|... |.||. . | . .||.||.|. || .||| | . |. YLRKHRPK--------LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG TP---IIAYMPPEILCCAERIPPHRPENDVWMFGVFIWECLTLGAQPHFR-----KSVEEIKKSFRLPDRGLSCPPT--------CPLDVWTLVSDCLSE . | |.|| . ... .. |||.||| .|| .|.|.||. .| .|. . . .| . .|| || .. .. ..| | GKTMLPIRWMAPECI--NYGK--FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR-MPQPPNDYPMSFVCCPDEMYQIMKQCWHE -PHMRPRFASTTNASITSRL |..||.|. ... DPEDRPTFSEI-----HECF |
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| Kinase | F40A3.5.AA | TKL | 143-363 | 16 | 6.3e-15 | 50.2 | In-house | 72-357 (364) | Show / Hide |
Range on Protein: 143-363
Range on HMM: 72-357/364
Sequence Identity: 16% (49 aa)
LLEDALRLSKLDHPNLIRLLAVSQLSF---TVFRP-------MIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHS------
. | .. .|.|.|||......... . . .| .| |. |||.| .|.. . .... ....... | ||
EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWC
QLDEFGQELTHGRIFTRNVLVTEPDL----------RKCEVKLGDFGDAPMGLEY----------------------STPII---AYMPPEILCCAERIP
. . | . ..|.|| | . .|..||| . . . . ... ..|.||.| .. .
T----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYT
------------PHRPENDVWMFGVFIWECLT---LGAQPHFRKSV---------EEIKKSFRLPDRGL--------SCPPTCPLDVWTLVSDCLSE-PH
. . ||. ||. .||.|| ...... . . . . .. | . ...|.|| .. | || .. |.
EKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPE
MRPRF
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KRPSF
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| Kinase | F40A3.5.AA | Syk | 298-364 | 32 | 1.1e-12 | 39.97 | In-house | 191-257 (257) | Show / Hide |
Range on Protein: 298-364 Range on HMM: 191-257/257 Sequence Identity: 32% (22 aa) DVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDC-LSEPHMRPRFA ||| ||| .|| . .|..| .. |. | .| ..||. || .. | ..| .... || | DVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFIENGHR-MNCPNGCPQEMYQLMNKCWIYKWCDRPTFV |
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| Kinase | F40A3.5.AA | FAK | 298-380 | 30 | 2e-11 | 34.35 | In-house | 208-285 (285) | Show / Hide |
Range on Protein: 298-380 Range on HMM: 208-285/285 Sequence Identity: 30% (26 aa) DVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLS-EPHMRPRFASTTNASITSRLSELHH ||||||| .|| | .| .| . ... .| | || || ..| . | . .| |||| . .|.... DVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGER-LPMPPNCPPTLYSLMTRCWAYDPSKRPRF-----KELKCQLKDIYQ |
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| Kinase | F40A3.5.AA | S_TKc | 124-372 | 21 | 2.6e-11 | -10.93 | SMART | 13-231 (231) | Show / Hide |
Range on Protein: 124-372 Range on HMM: 13-231/231 Sequence Identity: 21% (58 aa) AKVTTAVKIS--FPIVSKSISLLEDALR----LSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPG--GTLADYFQFKVREKDDSERSPIQLKDMLSILY .|| ..... | |. |...| |.| .|||...|. | | . . .| ..| |.| || . . |.. |.|. . ...| GKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHG---LRFPFPE-HARFYMY QVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTEPDLRKCEVKLGDFGDAPMGLEYSTPI--IAYMPPEILCCAERIPPHRP-ENDVWMFGVFIWECLTL |. .||.|.|| . | . |.|..| ..|..||| | .| . ||.||.| .. . . |.| .|. ..|.|. QICCALEYCHS------HGIIHRDLKPENILLDE------HIKICDFGLARQL---TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLC- GAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLS-EPHMRPRFASTTN-------ASIT | | .... | . . ... ... || .| || . GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | F40A3.5.AA | Pkinase_Tyr | 298-364 | 36 | 3.4e-11 | 38.54 | Pfam | 196-264 (270) | Show / Hide |
Range on Protein: 298-364 Range on HMM: 196-264/270 Sequence Identity: 36% (25 aa) DVWMFGVFIWECLTLGAQP-HFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCL-SEPHMRPRFA |||.||| .|| .|.|.|| | ||... . . . ||. || .. .| .| .| .||.|. DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFS |
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| Kinase | F40A3.5.AA | Trk | 296-360 | 38 | 3.6e-11 | 34.04 | In-house | 200-265 (275) | Show / Hide |
Range on Protein: 296-360 Range on HMM: 200-265/275 Sequence Identity: 38% (26 aa) ENDVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRG-LSCPPTCPLDVWTLVSDC-LSEPHMR | ||| ||| .|||.| | || . | |. .. . | | .| .|| .|. . | ||..| ESDVWSFGVVMWECFTYGKQPWYQLSNHEV-IECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQR |
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| Kinase | F40A3.5.AA | EGFR | 298-371 | 32 | 7.1e-11 | 32.17 | In-house | 185-258 (258) | Show / Hide |
Range on Protein: 298-371 Range on HMM: 185-258/258 Sequence Identity: 32% (24 aa) DVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDC-LSEPHMRPRFASTTNASI ||| .|| .|| .| |..|. . .|| .| |. || | .||. . | . . |||.| .. DVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGER-LPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | F40A3.5.AA | Musk | 296-371 | 35 | 8.7e-11 | 31.64 | In-house | 208-282 (282) | Show / Hide |
Range on Protein: 296-371 Range on HMM: 208-282/282 Sequence Identity: 35% (27 aa) ENDVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLS-EPHMRPRFASTTNASI | ||| .|| || . || . . ||. . | . |||| ||..|. | | . .| || |.. . .| ESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNI-LSCPENCPQKVYQLMRRCWQKNPADRPFFCQ-IHHCI |
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| Kinase | F40A3.5.AA | Pkinase_Tyr | 123-227 | 23 | 1.8e-09 | 32.67 | Pfam | 26-130 (270) | Show / Hide |
Range on Protein: 123-227 Range on HMM: 26-130/270 Sequence Identity: 23% (27 aa) NAKVTTAVKISFPIVSKS----ISLLEDALRLSKL-DHPNLIRLLAVSQ-L---SFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSI | |.. |||. . ... .... | ...| .|||..||..| . ...| .| |.| | || . . ... |. .||.|.. NTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLLDYLRKHR-----EDKQPLTMKDLLQM LYQVSQALKYIHSQ .|..... | .|. CWQIAKGMEYLESK |
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| Kinase | F40A3.5.AA | Abl | 298-370 | 29 | 4.5e-08 | 22.48 | In-house | 180-252 (252) | Show / Hide |
Range on Protein: 298-370 Range on HMM: 180-252/252 Sequence Identity: 29% (22 aa) DVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLS-EPHMRPRFASTTNAS ||| ||| .|| | | | .... . | . |. || .|. |. | .. ||.|... .| DVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYR-MERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM |
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| Kinase | F40A3.5.AA | Pkinase | 150-227 | 21 | 2e-06 | 23.56 | Pfam | 54-127 (293) | Show / Hide |
Range on Protein: 150-227 Range on HMM: 54-127/293 Sequence Identity: 21% (18 aa) LSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPGG----TLADYFQFKVREKDDSERSPI--QLKDMLSILYQVSQALKYIHSQ . .|.||| .||. . . . . . .|...|| |.|| . ... .. . .. ...||. ..|.|.||. MKRLNHPNIVRLYDWFEDKDHIY---MVMEYCEGGLYVMDLFDYIST-------WRHGCFYFSEWECKFYMYQILRGLEYCHSM |
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| Kinase | F40A3.5.AA | FAK | 144-263 | 27 | 9.3e-05 | 11.69 | In-house | 72-169 (285) | Show / Hide |
Range on Protein: 144-263 Range on HMM: 72-169/285 Sequence Identity: 27% (33 aa) LEDALRLSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTR ...|. . ..||| ...|. . .. | .| . | | | | . . .. .. ||...|. | | | | | MQEAYIMKQFDHPHIVKLIGI----CEEMPIWIIMELCKYGELRHYLQRNKNS--------LKHATLILYCYQLCMAMAYLES------KKFVHRDIAAR NVLVTEPDLRKCEVKLGDFG |||| || | ||||||| NVLVSSPD---C-VKLGDFG |
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| Kinase | F40A3.5.AA | Abl | 144-267 | 29 | 0.002242 | 6.56 | In-house | 43-146 (252) | Show / Hide |
Range on Protein: 144-267 Range on HMM: 43-146/252 Sequence Identity: 29% (36 aa) LEDALRLSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTR |..| . .. ||||..|| | . | |... | | || .|| | .| ... | | . |.. ...|. . .. | . | LKEAAIMKEMKHPNLVQLLGVCTREPPFY---IITEFMCYGNLLDY----LRECDREELPAVVLLYMAT---QIASGMSYLEK------RHFIHRDLAAR NVLVTEPDLRKCEVKLGDFGDAPM | || | .. ||. ||| | | NCLVGEHHI----VKVADFGLARM |
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| Kinase | F40A3.5.AA | EGFR | 143-164 | 45 | 0.009012 | 4.83 | In-house | 48-69 (258) | Show / Hide |
Range on Protein: 143-164 Range on HMM: 48-69/258 Sequence Identity: 45% (10 aa) LLEDALRLSKLDHPNLIRLLAV .|..|. . .|||.|.|||.| MLDEAYVMASVDHPHLVRLLGV |
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| Kinase | F40A3.5.AA | Pkinase_Tyr | 242-263 | 50 | 0.159921 | 5.78 | Pfam | 139-156 (270) | Show / Hide |
Range on Protein: 242-263 Range on HMM: 139-156/270 Sequence Identity: 50% (11 aa) TRNVLVTEPDLRKCEVKLGDFG .||.|||| . || .||| ARNCLVTE----NNVVKICDFG |
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