Gene F39F10.2 (Nematode worm)
F39F10.2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| F39F10.2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 265 | Kinase domain by global Sugen HMM | Fasta, JSON |
| F39F10.2.AA | Protein | Genbank | 298 | None | Fasta, JSON |
Protein domains of F39F10.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | F39F10.2.AA | Worm8 | 10-270 | 77 | 1.9e-267 | 783.06 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 10-270 Range on HMM: 1-261/261 Sequence Identity: 77% (201 aa) YTLGKVLGRGSFGSVQLAQDKRSNEMRVMKLIRKERDGHRDETWRRETFTLTALSDVSGVTKMFEYGSTETHNWIVMEQLSDDLITIVRRNETKMFSKPT |||.||||||..|.|.|.||.|.||.||||||.||..||||||||.|||.||||.||.||..||.||||..||||||||||||||.|..|||.||||||| YTLEKVLGRGMYGDVHLCQDDRNNEWRVMKLIHKEHNGHRDETWRHETFALTALADVNGVPRMFDYGSTDYHNWIVMEQLSDDLINIICRNENKMFSKPT SYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSYKNRVRKLVLVDYGLSCWFKDHNQNRTPPAPFDNRCMHLIHTPAKTATGHPHMEAEDLVQVAYLSCS .|||||||||||||||..||||.||||||||||..||...|||||.|.||||||||.||||||||...|||||||||.||.||||||||||.|||||||. GYQIMWQLVKILQDIHSFGIVHGDIKADNLMVSHSNRMFMLVLVDFGCSCWFKDHNGNRTPPAPFPSNCMHLIHTPAHTANGHPHMEAEDLMQVAYLSCI LHQFMPWKDVEAPKMTKMKKKFAKNPKKYLGNHQDLKPIIKMLVKQKHGVEPDYEGILDLL ..|.|||||....||||||.||||||||.||.|||||||||||.||||..||||..|.||| CRQYMPWKDIDEHKMTKMKMKFAKNPKKFLGEHQDLKPIIKMLAKQKHYKEPDYKEIMDLL |
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| Kinase | F39F10.2.AA | CK1 | 10-266 | 17 | 3.7e-57 | 196.19 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 10-266 Range on HMM: 1-339/339 Sequence Identity: 17% (59 aa) YTLGKVLGRGSFG-SVQLA-----QDKRSN-----EMRVMKLIRK-ERDGH----RDETWRRETFTLT---------------ALSDVSGVTKMFEYGST ....| .| |.|| . .. |. .| | .||. .| ....| ... . ... .. .. ... .. . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED ETHNWIVMEQLSDDLITIVR--RNETKMFSKPTSYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSYK-------------NRVRKLVLVDYGLSCWFKD . .|..||. | .| . . |. .. ||..|...|..|... |...| .|..| |||.||...... |. |.....|.|.... | DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARR-KY HNQNRTP-----------PAPFDN--------RCMHLIHTPAKTATGHPHMEAEDLVQVAYLSCSLHQF---MPWKDVEAPKMT------KMKKKFAKNP . . .. . |. . | . ... . |.... ||. ..|. . .. .||......... |||..| ... RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGC-TARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEK KKYLGN-----------HQDLKPIIKMLVKQKHGVEPDYEGI |... .|.. .|.|.. ..|.. .|||| | KMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | F39F10.2.AA | TTBKL | 10-158 | 23 | 5.7e-24 | 77.87 | In-house | 1-156 (288) | Show / Hide |
Range on Protein: 10-158 Range on HMM: 1-156/288 Sequence Identity: 23% (37 aa) YTLGKVLGRGSFGSVQLAQDKRSNEMRVMKLIRKERDGHRDETWRRETFTLTALS--DVSGVTKMFEYGSTETHNWIVMEQLSDDLITIVRRNETKM-FS .. |..|.| ||.| .. |. . . . .. . | | .. | . | |..|. . . . |. ..| .. |..||. ....| . ... .| || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS KPTSYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSYKNR----VRKLVLVDYGLS . |.. |. |... |...| .|..| |.| | .. |. . | . |.|.|.. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMA |
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| Kinase | F39F10.2.AA | Worm7 | 10-170 | 33 | 7.1e-21 | 66.67 | In-house | 1-164 (263) | Show / Hide |
Range on Protein: 10-170
Range on HMM: 1-164/263
Sequence Identity: 33% (55 aa)
YTLGKVLGRGSFGSVQLAQDKRS-NEMRVMKLIRKERD--GHRDETWRRETFTLTALSDVSGVTKMFEYGSTETHNWIVMEQLSDDLITIVRRNETKMFS
|.| . | |.|| | . || | .. | | | . || . || .|... |.| . | ||| | .|.|| | ||
YKLIHKIGNGQFGEVWQVIDKQDGNVPMIVKIINKYKNGSMKRDISYDREIEFFKYCHHVPNIPKLFHHFTHVGWNCIVMSEEGQNLRDVVKRNNNKPFS
KPTSYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSYKNRVRKLVLVDYGLSCWFKDHNQNRTP
| ||. | || . .| |....| .|. ||.| |.||.|.| ||| | | |
TNNVIRIAWQIGSTLCFIHNKSFIHRDVHSQNVLVTLKNKVCKMVLIDFGNAVRFKDVNGNELP
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| Kinase | F39F10.2.AA | AGC | 10-169 | 13 | 4.7e-20 | 47.11 | In-house | 1-262 (395) | Show / Hide |
Range on Protein: 10-169 Range on HMM: 1-262/395 Sequence Identity: 13% (37 aa) YTLGKVLGRGSFGSVQLAQDK------RSNEMRVMKLIRKER-DGHRD--ETWRRETFT-----------LTALSDVS------------GVTK-MFEYG . . ||.|.|||| | |...| .... || ..|.. .. . . | |. .. ..| .. FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF STETH--NWIVMEQLS----------D-DLITIVRRN-ETKMFSKPTSYQIMWQ-------LVKILQDIHA-IGIVHTD-IKADNLMVSYKNRVRKLVLV ...| .||| .. . .| .. . . |. ... .. . .| |. .| ||.| | .| .|.. . . |. QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT DYGLSCWFKDHN-------------------------------------------------QNRT | ||...... . ..|| DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRT |
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| Kinase | F39F10.2.AA | CAMK | 15-168 | 16 | 5.1e-17 | 50.7 | In-house | 1-253 (425) | Show / Hide |
Range on Protein: 15-168 Range on HMM: 1-253/425 Sequence Identity: 16% (41 aa) VLGRGSFGSVQLAQDKRSN------------EMRVMKLIRKER---------------------------DGHRDETWRRETFTLTALS------DVSGV .||||||| | |...|... . .| | |.. ... . ||| . |. | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI TKMFE--------------------YGSTETHNWIVM---EQLSDD------LITIVRRNE------------TKMFSKPTSYQIMWQLVKILQDIHAIG |..| . ....| ..|| | | . ||.. .. |. ....|.. .. .| . IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHTDIKADNLMVSYKN--------------RVRKLVLVDYGLSCWFKDHNQNR ||| |.| .|......| . .. ..| |... |.. ..|. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNF |
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| Kinase | F39F10.2.AA | CMGC | 10-164 | 15 | 1e-16 | 50.6 | In-house | 1-257 (513) | Show / Hide |
Range on Protein: 10-164 Range on HMM: 1-257/513 Sequence Identity: 15% (39 aa) YTLGKVLGRGSFGSVQLAQDKRSN--------------EMRVMKLIRKERDGHRDET--------WR---RETFTLTALS----------------DVSG |. |..|.|..| | ..|||.| |. .| |... .... .. || | |. . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VTKMFEYGSTET-----------------HNWIVMEQLSDDLITIVRRNETK----MFSKPTSYQ---------------IM------WQLVKILQ--DI . |.... .. | .|.| . || . ..| .. . . . .| .|. . | . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HAIG--IVHTDIKADNLMVSYKNRV-----------------RKLVLVDYGLSCWFKDH | . |.|.|.| |.... .... .| . | ||..|. .| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH |
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| Kinase | F39F10.2.AA | S_TKc | 10-249 | 16 | 1e-14 | 38.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-249
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)
YTLGKVLGRGSFGSVQLAQDKRSNEMRVMKLIRKERDGHRDETWRRETFTLTALSDVSGVTKMFEYGSTETHNWIVMEQLSD---DLITIVRRNET----
|......|.|.||.| ....|.... .| |. |. ||| | . . |.... . .| ..||| .. || .. ... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
KMFSKPTSYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSYKNRVRKLVLVDYGLSCWFKDHNQNRTPPAPFDNRCMHLIHTPA---------KT-----
. |. . .|.|... |. .| ||.| |.| .|.... . . | ||.. . .... || .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------TTFCGTPWYMAPEVLGYGKCKCDW
----------ATGHPHMEAEDLVQVAYLSCSLHQFMPWKDVEAPKMTKMKKKFAKNPKKYLGNHQDLK--------PII
..| | . .. .. . . . | ..| . |.|.| .. . |. | .
WSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | F39F10.2.AA | Pkinase | 10-169 | 22 | 2e-14 | 52.12 | Pfam | 1-169 (293) | Show / Hide |
Range on Protein: 10-169 Range on HMM: 1-169/293 Sequence Identity: 22% (39 aa) YTLGKVLGRGSFGSVQLAQDKRSNEMRVMKLIRKERDGH--RDETWR-RETFTLTALSDVSGVTKMFEYGSTETHNWIVMEQLSD-----DLITIVR-RN |..|...|.||||.| ....| .... ..| |.|... . . . .| .| . | . . ..... ...| ..||| . || .... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR ETKM-FSKPTSYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSYKNRV-RKLVLVDYGLSCWF-KDHNQNRT .... || . .|.|... |. .|. ||.| |.| .|.... .. . .. . | ||.. | .|. | HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT |
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| Kinase | F39F10.2.AA | Worm6 | 10-170 | 22 | 6.2e-13 | 43.03 | In-house | 1-174 (279) | Show / Hide |
Range on Protein: 10-170 Range on HMM: 1-174/279 Sequence Identity: 22% (39 aa) YTLGKVLGRGSFGSVQLAQDKRSNE--MRVMKLIRKER--DGHRDETWRRETFTLTALSDVS--GVTKMFEYGSTET--HNWIVMEQLSDDLITIVRRNE ....| .| |.||.| ...|| .. . .||. |. . ..| ..|.|. ...|....| .. |.|||. . .| . . . WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKC---EKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP TKMFSKPTSYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSY-----KNRVRKLVLVDYGLSC--WFKDHNQ-NRTP .. || .|...| | . ..| | .| .| |.|. | . | ... ..|.|.. ...... ||| DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTP |
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| Kinase | F39F10.2.AA | CAMKL | 10-45 | 43 | 1.5e-11 | 32.94 | In-house | 1-37 (297) | Show / Hide |
Range on Protein: 10-45 Range on HMM: 1-37/297 Sequence Identity: 43% (16 aa) YTLGKVLGRGSFGSVQLAQD-KRSNEMRVMKLIRKER |..||.||.|||| |.||.. . .|. .| | |.. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKK |
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| Kinase | F39F10.2.AA | CAMK-Unique | 10-47 | 26 | 5.8e-09 | 25.52 | In-house | 1-38 (363) | Show / Hide |
Range on Protein: 10-47 Range on HMM: 1-38/363 Sequence Identity: 26% (10 aa) YTLGKVLGRGSFGSVQLAQDKRSNEMRVMKLIRKERDG |......| |.|| | ..|. ...|...|...| YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHG |
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| Kinase | F39F10.2.AA | CAMK-Unique | 112-159 | 29 | 1e-07 | 21.3 | In-house | 161-221 (363) | Show / Hide |
Range on Protein: 112-159 Range on HMM: 161-221/363 Sequence Identity: 29% (18 aa) QIMWQLVKILQDIHAIGIVHTDIKADNLMVSYKNR-------------VRKLVLVDYGLSC .|| .|. . | ..||| |.|..|.||.| ...| |.||.| FIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCC |
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| Kinase | F39F10.2.AA | CAMKL | 124-166 | 27 | 4.5e-07 | 18.47 | In-house | 143-188 (297) | Show / Hide |
Range on Protein: 124-166 Range on HMM: 143-188/297 Sequence Identity: 27% (13 aa) IHAIGIVHTDIKADNLMVSYKN-RVRKLVLVDYGLSCWFKDH----NQ .| |||| |||..|....... . .. ..| |.| ..... .| CHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQ |
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| Kinase | F39F10.2.AA | TyrKc | 10-231 | 15 | 0.000112 | -147.0 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-231 Range on HMM: 1-280/280 Sequence Identity: 15% (44 aa) YTLGKVLGRGSFGSVQLAQDKRSNEMRVMKLIRKERDGHRDETWRRETFTLTAL-SDVSGVTKMFEYGSTE-------THNWIVMEQLSD-DLITIVRRN ||||.||.| || | ... | .. | .... | .|| .. | . . ... . ... .|||| . || |.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH ETKMFSKPTSYQIMWQLVKILQDIHAIGIVHTDIKADNLMVSYKNRVRKLVLVDYGLSCWFKDH-------NQNRT-----PP-----------APFDNR . | .. .. ...|| . . .| ...| |. | | .|. ...|. | ||| .|. |. . .... RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKIS---DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK C----------------MHLIHTPAKTATG--HPHMEAEDLVQVA-YLSCSLH--------QFMPWKDV-----EA-----PKMTKMKKKF . . . .| . . |. .|. .. . . .. .. | .. ...| FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | F39F10.2.AA | TTBKL | 215-270 | 20 | 0.002727 | 7.05 | In-house | 227-288 (288) | Show / Hide |
Range on Protein: 215-270 Range on HMM: 227-288/288 Sequence Identity: 20% (13 aa) PWKDVEAPK-MTKMKKKFAKNPKKYLGNH-------QDLKPIIKMLVKQKHGVEPDYEGILDLL ||...| .. . .|||. .. .. ... . . .. |.| . .|||| |. .. PWTNMEDKMEIEHMKKN--MKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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