Gene F33E2.2 (Nematode worm)

F33E2.2

Species: Nematode worm
Alias: CE23702, aSWK418, F33E2.2
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 12580846-12573782, WormBase Genetic Map location: No interpolated position.,

Classification

Group: TKL
Family: MLK
Subfamily: LZK

Sequence

Name Sequence Type Origin Length Description Download
F33E2.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 242 Kinase domain by global Sugen HMM Fasta, JSON
F33E2.2.AA Protein Genbank 928 None Fasta, JSON

Protein domain

Protein domains of F33E2.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F33E2.2.AA LZK 135-375 69 1e-206 693.05 In-house 1-241 (241) Show / Hide 
Range on Protein: 135-375
Range on HMM: 1-241/241
Sequence Identity: 69% (168 aa)

ISELEWLGSGSQGAVFRGQLENRTVAVKKVNQLKETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRNTITRELFAQWVKEIADGM
||||.|||||.|||||||...|.|||||||..||||.|||||.|.|.|||||.|||..||||||.||||..|||..||..|.|||..|...|.|.||.||
ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGM

HYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVG
|||||.|.|||||||||||||..|..||||||||||...||||.|||||||.|||||.|...||.||||..|||||||||||.|.||.....||||.|||
HYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVG

TNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHW
.|.|.||||...|.|..||.|||.|||.||||||..|..||
SNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase F33E2.2.AA MLK 135-375 41 2.3e-135 456.01 In-house 1-291 (291) Show / Hide 
Range on Protein: 135-375
Range on HMM: 1-291/291
Sequence Identity: 41% (121 aa)

ISELEWLGSGSQGAVFRGQLENRT-----VAVKKVN-------------QLKETEIKHLRHLRHQN----IIEFLGVCSKSPC-YCIVMEYCSKGQLCTV
| ..||.||||.|.|..|.  |..     ||||.|.             . .|.|..|||.|.|.|    ||.|.|||...|| .|||||||..|.|..|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKSRNT--------------ITRELFAQWVKEIADGMHYLHQNK---VIHRDLKSPNILISA------EDSIKICDFGTSHMQKKMDSTMMSFCGTVSWM
|.....              .. .....| . .| ||||||...   .|||||||.||||..      ..  ||||||||.. ..|...|||..||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEMI---KKQPCNEKVDVYSFGVVLWEMLTRETPYA-NIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHW
|||.|   . ....||.||.|.|||||||||||.||.  . .|||...|. | | .|.| ..|...  |.||| .|. ..||||..| ||.
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase F33E2.2.AA TKL 141-375 27 9.7e-97 327.7 In-house 1-364 (364) Show / Hide 
Range on Protein: 141-375
Range on HMM: 1-364/364
Sequence Identity: 27% (100 aa)

LGSGSQGAVFRGQLEN----------RTVAVKKVN----------------------------------QLKETEIKHLRHLRHQNIIEFLGVCSKSPC-
.|||. | |..|.. .          ..||||| .                                  . .| ||.... |||.||. |.|.|  .|| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YCIVMEYCSKGQLCTVLKSRNTITRELFAQWVKEIADGMHYLHQNK--------VIHRDLKSPNILISAEDS--------------IK
            .|||||||..| |. .|        ... .|...|| ||.|||...        .|||||||.|||.                   .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ICDFGTSHMQKKMDS-------------------TMMSFCGTVSWMAPEMIKKQ----------------PCNEKVDVYSFGVVLWEMLTRETPYANIAQ
|||||.| . ... .                   | |. |||  |||||....|                . .||.||||||.||||.|||..||...  
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

M---------AIIFGVGTNILSLPMP------------EEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHW
|         ... .|. . | .|.|            . .|...  |...| ... ..||||. | .. 
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase F33E2.2.AA Dicty4 135-377 37 2.5e-68 227.01 In-house 1-277 (277) Show / Hide 
Range on Protein: 135-377
Range on HMM: 1-277/277
Sequence Identity: 37% (103 aa)

ISELEWLGSGSQGAVFRGQLENRTVAVKKV---NQ-LKETEIKHLRH-------LRHQNIIEFLGVCS----KSPCYCIVMEYCSKGQLCTVLKS-----
|   . .|.|| | |..|      |||||    || . | ... .|.       .|| ||. |.| |     ...  |||.||..|| | ..| .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

RNTITRE--LFAQ---WVKEIADGMHYLHQ-N-KVIHRDLKSPNILISAEDSIKICDFGTSH-MQKKMDSTM--MSFCGTVSWMAPEMIKKQPCNEKVDV
   |. .  |. .     . .| || .||  |  .||||||| |.|...   .|.|||| |  |.|  | .   |. |||. |||||.  .|| |||.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGVVLWEMLTRETPYA--NIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQH--WEI
|||| ||||.|||. ||.   .  | ....|.   | .|.|   |. .  ||. |..    .||||. | |    | 
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase F33E2.2.AA Pkinase 135-375 27 6.8e-65 226.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 135-375
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

ISELEWLGSGSQGAVFRGQLENRT--VAVKKVNQLKET-----------EIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKG----QLCTVLK--SR
.  .. .|||| | |....  .    ||||...  .|            ||. ...|.| ||.......  .. ...||||| .|     |.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NTI--TRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSI----KICDFGTSHMQ-KKMDSTMMSFCGTVSWMAPEMIK-KQPCNEKVDVYSF
...  . .    ....|. |. |.|....||||||. ||||. .. |    |||||| .       .| |..||||  .|||| |.  |.   |||..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLWEMLTRETPYANI------AQMAIIFGVGTNILSLPMPEEAP-------------------KGLVLLIKQCLSQKGRNRPSFSHIRQH--W
|..|.|||....|. .        ||..|. ..  .|. . |.. .                   . .  .|| || ..   ||.. .| ||  .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase F33E2.2.AA S_TKc 135-377 27 8.8e-65 222.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 135-377
Range on HMM: 1-231/231
Sequence Identity: 27% (71 aa)

ISELEWLGSGSQGAVFRGQLEN--RTVAVKKVNQLKETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSK--GQLCTVLKSRNT------ITRELFA
   |. .|.|. | |....  .  | ||.|....  . ||. |.. .| ||. ...|.    ....|||||.   | | ...|.|..      ..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

QWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNE-KVDVYSFGVVLWEMLTRETPYAN
 ....|.... |.|....||||||  |||..    ||||||| .          ..||||  .||||..   . .  |.|..|.|..|.|||....|.  
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-

IAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQ-------HWEI
  ||. .| .             .. .  .|..||    ..||.   . |       |  .
--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F33E2.2.AA TKL-Unique 138-375 30 1.3e-62 214.32 In-house 2-290 (290) Show / Hide 
Range on Protein: 138-375
Range on HMM: 2-290/290
Sequence Identity: 30% (89 aa)

LEWLGSGSQGAVFRGQLENRTVAVKKVNQ-----LKETE--IKHL---RHLR-HQNIIEFLGVCS----KSPCYCIVMEYCSKGQLCTVLK---------
.. .|.|..|.|..|      ||.|. .      .....  ....     |. | ||  . |.|     . | .|||||||. | |  ||          
WNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

-SRNTITRELFAQWVKEIADGMHYLHQNK--VIHRDLKSPNILISAE-----DSIKICDFGTSHMQKKMDSTMMS---------FCGTVSWMAPEMIKK-
 . .... ... . .. ||.||.||| ..  .|||||||.|.|.. .      .|||||||.|  ..|.. .  .         .||.  |||||...  
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-QPCNEKVDVYSFGVVLWEMLTRET------PYANIAQMAIIFGVGT--NILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHW
    .||.||||||.||||..||.       || ...| ...  | .    . .| |.. || .  ||.||  .   .||||. |.   
FCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase F33E2.2.AA ZAK 135-374 39 1.6e-62 214.05 In-house 1-257 (257) Show / Hide 
Range on Protein: 135-374
Range on HMM: 1-257/257
Sequence Identity: 39% (102 aa)

ISELEWLGSGSQGAVFRGQ--LEN---RTVAVKKVNQL-KETEIKHLRHLRHQNIIEFLGVCSKSPC-YCIVMEYCSKGQLCTVLKSRNTITRE------
|   .  | |. |.|.|..  .     |..|||||  . || ||  |  .||.||| | |.|   |  | || || .|| |     |      .      
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEI--LSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGN

---LFAQWVKEIADGMHYLHQN---KVIHRDLKSPNILISAEDSIKICDFGTSH-MQKKMDSTMMSFCGTVSWMAPEMI-KKQPCNEKVDVYSFGVVLWE
      .|  .|| |||||| .   |.||||||| |. | ..  .||||||||  .      | ||. ||  |||||||    |  |  ||.|.||||||
SMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHC--THMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWE

MLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQH
||||| ||     . |   .      |  |   |. .  |. ||     . ||..  |   
MLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase F33E2.2.AA MLK 135-375 35 1.6e-57 188.55 In-house 1-280 (280) Show / Hide 
Range on Protein: 135-375
Range on HMM: 1-280/280
Sequence Identity: 35% (100 aa)

ISELEWLGSGSQGAVFRGQLENRTVAVKKVNQLKETEIKHL--------------RHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRNTITR
.   | .|.|  | |.|.| .   ||||   |  |  .                   |.|.|||. .||| . |  |.|||||  | |  |.. .  |  
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK-RIPP

ELFAQWVKEIADGMHYLHQNK---VIHRDLKSPNILISAEDS-------------------------IKICDFGTSHMQKKMDSTM-MSFCGTVSWMAPE
.    |   || ||.|||..    .||||||| ||||  .                            || |||   .  ..  |  ||  ||  |||||
HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFG---LAREWHKTTRMSAAGTYAWMAPE

MIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHW
 ||.    .  || |.||.|||.||.|.||  |  .|. .||  | | || |.  |     |.. |  |    ||.||.| |  
VIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase F33E2.2.AA TyrKc 135-375 28 3.1e-57 197.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 135-375
Range on HMM: 1-280/280
Sequence Identity: 28% (80 aa)

ISELEWLGSGSQGAVFRGQLENRTVAVKKVN----QLKETEIKHLRHL--RHQNIIEFLGVCSKS-------PCYCIVMEYCSKGQLCTVL-KSRNTITR
|. .. ||.|  | |..|..  ..||||...    .    |.. ...|  .|.||. ..|||...       . ..|||||...| |   | |.|.... 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

ELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKM-------DSTMMSF--CGT----VSWMAPEMIKKQPCNEKVDVYSF
. . ..   ||.|| |||....|||||   |.|....  .||.||| |   .         |  ...   .|     . ||||| |..  ...| ||.||
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GVVLWEMLTR-ETPYANI----AQMAIIFGVGTNILSLPMPEE--------APKGLVLLIKQCLSQKGRNRPSFSHIRQHW
||..||..|. ..|| ..       . ..    .   .| |..        .|. .  ..|||   .  .||.|| |.. .
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase F33E2.2.AA STE 135-374 19 1.5e-55 190.88 In-house 1-356 (359) Show / Hide 
Range on Protein: 135-374
Range on HMM: 1-356/359
Sequence Identity: 19% (72 aa)

ISELEWLGSGSQGAVFRGQLENRT-----------------VAVKKVN---------------------QLKE---TEIKHLRHLR--HQNIIEFLGVCS
   .| .|.|. | |...   . .                 .|.|..|                     . ..    ||| .....  |.||....| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KS-------PCYCIVMEYCSKGQLCTVLK---SRNT-----------ITRELFAQWVKEIADG-MHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSH
|           .|.|||.. | |  ..|   ...            .  .. |  ...|  | ..|||....||||.|. |||.     .|.||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

MQKK----------------MDSTMMSFCGTVSWMAPEMIKK------QPCNEKVDVYSFGVVLWEMLTRETPYANIAQM----AII--FGVGT------
   .                |..   .|.||  |||||.|..      .....|.|..|.| ...||.| . |...   |    .|.  ....       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----NILSLPM-----------------PEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQ--H
    .. .||                  |..  . .   |..||    ..||. |   .  |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEH
Kinase F33E2.2.AA TK 135-375 16 4.9e-55 182.56 In-house 1-486 (486) Show / Hide 
Range on Protein: 135-375
Range on HMM: 1-486/486
Sequence Identity: 16% (78 aa)

ISELEWLGSGSQG---AVFRGQLENR---------------------------TVAVKKVN----QLKET--------------------EIKHLRH--L
|  .. ||.|  |    |..|....|                           .|||| .     . .|                     |.| ..|  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHQNIIEFLGVCSKSPC------------YCIVMEYCSKGQ----LCTVLKSR-----------------------------------------------
.|.||. ..|||... .            ..|||||...|     | . |...                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------NTITRELFAQ-------------------WVKEIADGMHYLHQN------KVIHRDLKSPNILISAEDS-----------IKICDFGTS--
         ...|   . |                   .   ||.|| |||..      ...||||   |.|.. ..            .||.||| |  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----HMQKKMDSTMMSFCGTVS----------------------------WMAPEMIKKQP---------CNEKVDVYSFGVVLWEMLTRE-TPYANIAQ
    .  .  ...     .. .                            ||||| ....          . .| ||.||||..||..|.  .||.    
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

M---------AIIFGVGTNI--------------LSLPMPEEAP--------------KGLVLLIKQCLSQKGRNRPSFSHIRQHW
          . ..   ..               . .| |. .|              . . .|..|| . . . ||.|| ...  
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase F33E2.2.AA DRK 142-377 36 3e-52 175.25 In-house 8-258 (258) Show / Hide 
Range on Protein: 142-377
Range on HMM: 8-258/258
Sequence Identity: 36% (91 aa)

GSGSQGAVFRGQLENRTVAVKKVNQLKET----------EIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRN-TITRELFAQWVKEI
| |. | ||||      ||||.   . .           ||  .  ||| ||. |.| |  .|  ||.||| ..| |  .|      .   |  |    .
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDC

ADGMHYLHQNK--VIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDS--TMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQ
| || |||     .||||||| | |.     .|. ||| |   ||. .  . |  |||  | |||    |.  || |||||..||||..||. ||. .  
AKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPT

MAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHWEI
. ..| ||   . .|||.  |   . |.. |..     |||.  . .  | 
FQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase F33E2.2.AA Pkinase_Tyr 135-266 31 7.6e-34 115.26 Pfam 1-156 (270) Show / Hide 
Range on Protein: 135-266
Range on HMM: 1-156/270
Sequence Identity: 31% (49 aa)

ISELEWLGSGSQGAVFRGQLE------NRTVAVKKVNQ-----------LKETEIKHLRHL-RHQNIIEFLGVCS-KSPC--YCIVMEYCSKGQLCTVLK
|. .. ||.|. | |..| .       . .||||....           . . |.| ...| .|.||. ..|||. ..    ..|||||. .| | . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----RNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFG
.    .. .| .   |.  .||.|| ||.... |||||   |.|.. .  .||||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase F33E2.2.AA Pkinase_Tyr 287-377 34 3.4e-18 62.23 Pfam 180-270 (270) Show / Hide 
Range on Protein: 287-377
Range on HMM: 180-270/270
Sequence Identity: 34% (32 aa)

WMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRE-TP-YANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHWEI
||||| |.   ...| ||.||||..||..|.  .| |...    ..  .. .   .|.|| .|. .  |.|||  ..  .||.|| |  |...
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL