Gene F33D11.7 (Nematode worm)
F33D11.7
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| F33D11.7.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 254 | Kinase domain by global Sugen HMM | Fasta, JSON |
| F33D11.7.AA | Protein | Genbank | 347 | None | Fasta, JSON |
Protein domains of F33D11.7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | F33D11.7.AA | Worm6 | 42-310 | 39 | 1.3e-142 | 480.05 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 42-310 Range on HMM: 1-279/279 Sequence Identity: 39% (111 aa) WKVVKAIQSDKGFNTIYVAEHVQKKK--LAAVKVER--KTEAIKMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKE--YNWIAITLCGKSLRALRKNQPK |||.| |... ||...|..|. ..|| |.|.|. ......||..|..||..|.... |..|||....|. .. .|.| .||.||.|. ||||.|. WKVTKKIGEG-GFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHK-CRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPD GKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAH--QYMNKDGTLKPPSAHPWKYVGSLRHMPRAAFSKVEF .|.....||..|.|||...|.||..|||||.| |. |.||||..... ....||.||||... .|.||...|..| .......| .|..|.|.... |. RKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQ SRMEDLEMWFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQ---MREMLGGLPP-EFFDIMQMVDKLSFTDTPNYKEI .|..|.|.|||| ||...|||||.|.|....|....| ||. .. ||...|. |. || |||...|..|. |.|.|| | CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | F33D11.7.AA | CK1 | 42-310 | 26 | 5.1e-92 | 312.02 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 42-310 Range on HMM: 1-339/339 Sequence Identity: 26% (91 aa) WKVVKAIQSDKGFN-TIYVA-----EHVQKK-----KLAAVKVERKTEAIK-MLQFELFVLLTVEKKN--------QCKQFCK----------LFEKGNE ||||| | . || .|| . . .. . . .|.|||.|... . .. |..... ... ..|.||| . .|.| WKVVKKIG-EGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEE KE-YNWIAITLCGKSLRALRK-NQP-KGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTG-------DN-QSDMRNIYILDFGFAH-QY .. ||.. .||.|..| ||| |.. ..|... ..| .|.|.|..||..|..|||||.. |. |..||... .. ....|..|..|||.|. .| DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY MNKDGTL------------KPPSAH--PWKYVG-SLRHMPRAAFSKVEFSRMEDLEMWFYMSVELVKGC--LPWAHLKKPKE-----VHDYQKLCRNGLQ ..|||. .|| | ...| .|...... .| .| ||..|||| .|..||. ||| ..|.... |.. . ... RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK MREML--------GGLPPEFFDIMQMVDKLSFTDTPNYKEI | .. ..|.|| .||.....|.. |.|.|..| MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | F33D11.7.AA | TTBK | 42-310 | 34 | 1.4e-43 | 151.08 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 42-310 Range on HMM: 1-257/257 Sequence Identity: 34% (94 aa) WKVVKAIQSDKGFNTIYVAEHVQKK-KLAAVKVERKTEAIKMLQFELFVLLTVEKKNQCKQF-CKLFEKGNEKEYNWIAITLCGKSLRALRKNQPKGKLT ||||| | || || |. .. . |.||| |. | || || | ... |. . | . ..|.. .| ||.| || .||.|. . WKVVKKI-GGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVL----KKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFS VACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYMNKDGTLKPPSAHPWKYVGSLRHMPRAAFSKVEFSRMEDL . | . | |...|. | .|| || . || ||.|| | | .|..|.|||| | ||.| | || . . | | | | | || LSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR----NPSTCRKCYMLDFGLARQYTNACGEVRPPREVAG-FRGTVRYASINAHRNREMGRHDDL EMWFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMREMLGGLPPEFFDIMQMVDKLSFTDTPNYKEI ||| || |.| ||| .| .| .. .| .| .|.|| |. . | . |.|.|. | WSLFYMLVEFVQGQLPWRKIKDKDQVG----EMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | F33D11.7.AA | TTBKL | 42-209 | 32 | 4.9e-32 | 105.5 | In-house | 1-180 (288) | Show / Hide |
Range on Protein: 42-209 Range on HMM: 1-180/288 Sequence Identity: 32% (60 aa) WKVVKAIQSDKG-FNTIYVAEHVQ-KKKLAAVKVERKT-EAI-KMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKEYNWIAITLCGKSLRALRKNQPKGK |..|| | ..| | ..| .. .. ||. ||.|.| .. | . . ...|. ||. .| .. |.|. . |..| ||... ||||..|..||| | .| WMIVKMI--GEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKL-QPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKK -LTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYMNKDG-----------TLKPP ... . .. |||..| ..|..||||| | |. ...| |.... .. |..|..|||.| ||..||| ....| RFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWG-YHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRP |
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| Kinase | F33D11.7.AA | CK1-A | 42-310 | 25 | 2.2e-22 | 75.8 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 42-310 Range on HMM: 1-261/261 Sequence Identity: 25% (70 aa) WKVVKAIQSDKGFNTIYVAEHVQKKKLAAVKVERKTEAIKMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKEYNWIAITLCGKSLRALRKNQPKGKLTVA ...|. | | | ||.. ... . |.|.|.. | .| | ... | . .. |.||.|| . . | | || | | | . |. YRLVRKIGSG-SFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQG---CVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCKRRFTMK CGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYMNKDGTLKPPSAHPWKYVGSLRHMPRAAFSKVEFSRMEDLEM | .| | . .| .| .|||| . | | .| | ....||| | .| . | . . .| | | .| || .|.| TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCN-----KLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMES WFYMSVELVKGCLPWAHLKKPKEVHDYQKLC--RNGLQMREMLGGLPPEFFDIMQMVDKLSFTDTPNYKEI |. . .| ||| .| | |. . . .. | | || .|. . .| | ..|.| . MGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | F33D11.7.AA | TTBKL | 242-314 | 29 | 4.6e-19 | 61.08 | In-house | 215-288 (288) | Show / Hide |
Range on Protein: 242-314 Range on HMM: 215-288/288 Sequence Identity: 29% (22 aa) WFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMREML--GGLPPEFFDIMQMVDKLSFTDTPNYKEIYGLL |.|| .||..| ||| ......|.. | . . . .| ..|.|| ..|... |.. |.|.| || .. WMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | F33D11.7.AA | CK1-D | 109-310 | 28 | 1.1e-16 | 55.31 | In-house | 64-261 (261) | Show / Hide |
Range on Protein: 109-310 Range on HMM: 64-261/261 Sequence Identity: 28% (59 aa) GNEKEYNWIAITLCGKSLRALRKNQPKGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYMNKDGTLKP |.| .|| . . | | || | | . | . | .|.| .. .| .| |||| . | | .| | .||.||| | .| GQEGDYNVMVMDLLGPSLEDLF-NYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM-----VYIIDFGLAKRYRDARTHQHI PSAHPWKYVGSLRHMPRAAFSKVEFSRMEDLEMWFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMR--EMLGGLPPEFFDIMQMVDKLSFTDTPN | | | .| || .||| |. . .| ||| || |...| .. . .. |.| || . | . .| | | |. PYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPD YKEI | . YCYL |
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| Kinase | F33D11.7.AA | CK1-Unclassified | 57-205 | 28 | 2.3e-15 | 41.84 | In-house | 15-166 (244) | Show / Hide |
Range on Protein: 57-205 Range on HMM: 15-166/244 Sequence Identity: 28% (44 aa) IYVAEHVQKKKLAAVKVERKTEAIKMLQFELFVLLTVEKKNQC----KQFCKLFEKGNE--KEYNWIAITLCGKSLRALRKNQPKGKLTVACGLSVAQQC || . ..| ....|.|.|.|. ...|..| .. . . | | . |... | | .|| . .| |.|| | .| ..|... | | | IYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCNRKFSLKTVLMIADQM LKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYM--NKDGT .. .| ||. .|||| | | .|. . ..|| |||.. | |.|. IQRIEYLHNKNFIHRDIKPDNFLMGK----LGKNHHQVYIIDFGLSKRYIDMDKTGK |
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| Kinase | F33D11.7.AA | CK1-Unique | 42-256 | 19 | 4.5e-15 | 48.71 | In-house | 1-232 (337) | Show / Hide |
Range on Protein: 42-256 Range on HMM: 1-232/337 Sequence Identity: 19% (47 aa) WKVVKAIQSDKGFNTIYVAEHVQKK-----------KLAAVKVERKTEAIKMLQFELFVLLTVEKKNQ-CKQFCKLFEKGNEKEYNWIAITLCGKSLRAL |.| | | .. |. . . | | . . . . .. .. . ..| . . . ||.. . . . || |. |.|. . WCVIKHIGYG-GYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEEC RKNQPKG-KLTVA------CGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQ-SDMRNIYILDFGFAHQ--YMNKDGTLKPPSAHPWKYVGS . .|. . | | . . ||| ..| | ||.||. | . .... . . .|.||.| . . ...| . .. | CM-MMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYC----YMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQP-RPITPFRGC LRHMPRAAFSKVEFSRMEDLEMWFYMSVELVKGC--LPW .. |.. .| .| |.| |||| . || . | | KDYCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW |
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| Kinase | F33D11.7.AA | Dual | 42-245 | 26 | 1.4e-14 | 45.35 | In-house | 1-212 (282) | Show / Hide |
Range on Protein: 42-245 Range on HMM: 1-212/282 Sequence Identity: 26% (59 aa) WKVVKAIQSDKGFNTIY-VAEHVQ---KKKLAAVKVERKTEAIKMLQFELFVLLTVEKKNQC----------KQFCKLFEKGN--EKEYNWIAITLCGKS ||||. . | || .| | . | |.| ..|.| | . . . | |. .|..| | | . . |. . ... . . | | WKVVNLLGSG-GFRDVYHVHRFSQVNPKNKCYILKTE--SEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPS LRALRKNQPKGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYMN-KDGTLKPPSAHPWKYVGSLRHMP | |. | |.. | || | |. . || .|..|||. |. |..| | .| .||. . | . . ... |. | .| LQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGL-----GMDETTVYMQDFRIVRKYIDPENKKHRTARKK-VKMYGCGRYAC RAAFSKVEFSRMEDLEMWFYM || ... | ||| | || RACMMQKDQGRKDDLECWIYM |
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| Kinase | F33D11.7.AA | CK1 | 42-205 | 26 | 5.8e-14 | 44.63 | In-house | 1-166 (271) | Show / Hide |
Range on Protein: 42-205 Range on HMM: 1-166/271 Sequence Identity: 26% (45 aa) WKVVKAIQSDKGFNTIYVAEHVQKKKLA---AVKVERKTEAIKMLQFELFVLLTVEK---KNQCKQFCKLFEKGNE--KEYNWIAITLCGKSLRALRKNQ .|.. | . | || .... ... . |.|.|... .|..| .. . |||. . .. | | ..|| . ..| |.|| | .| YRVGRKIGQ-GSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNF PKGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYM-NKDGT ..|... | .| | .. .| .| .|||| . | | .|| . . ..|| |||.| .| |... CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR----YGKHCHQVYIIDFGLAKRYRDDKTHQ |
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| Kinase | F33D11.7.AA | S_TKc | 53-319 | 13 | 2.3e-08 | -54.18 | SMART | 11-231 (231) | Show / Hide |
Range on Protein: 53-319
Range on HMM: 11-231/231
Sequence Identity: 13% (40 aa)
GFNTIYVAEHVQKKKLAAVKVERKTEAIKMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKEYNWIAITLCGK---SLRALRKNQPKGK----LTVACGLS
.| . | . |. ... |.|. . .... |. .| ... .||.. . .. .. .|. .|. . |...... .. .
AFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF
VAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDMRNIYILDFGFAHQYMNKDGTLKPPSAHPWKYVGSLRHMPRAAFSKVEFSRMEDLEMWFYM
...| ...|| .|..|.||| . |. . . .| | |||.| |. ..|.. |. . |
YMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------------GYG
S------------VELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMREMLGGLPPEFFDIMQMVDKLSFTDTPNYKEIYG----LLTNAIL
|.. |. |. ..|.. .. . .||. |... . .. | |. .
KCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | F33D11.7.AA | CK1 | 280-308 | 26 | 1.5e-05 | 15.3 | In-house | 242-271 (271) | Show / Hide |
Range on Protein: 280-308 Range on HMM: 242-271/271 Sequence Identity: 26% (8 aa) EMLGG-LPPEFFDIMQMVDKLSFTDTPNYK .. | .| ||.. .. . .|.| ..|.|. QLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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| Kinase | F33D11.7.AA | Dual | 286-314 | 20 | 0.012258 | 4.54 | In-house | 254-282 (282) | Show / Hide |
Range on Protein: 286-314 Range on HMM: 254-282/282 Sequence Identity: 20% (6 aa) PPEFFDIMQMVDKLSFTDTPNYKEIYGLL | .. .. .|. .... || | . | PRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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