Gene egl-4 (Nematode worm)

egl-4

Species: Nematode worm
Alias: egl-4, aSWK018, F55A8.2a, CE19897, cgk-1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 1847970-1880567, WormBase Genetic Map location: IV:-15.2278,

Classification

Group: AGC
Family: PKG

Sequence

Name Sequence Type Origin Length Description Download
egl-4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
egl-4.AA Protein Genbank 780 None Fasta, JSON

Protein domain

Protein domains of egl-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP egl-4.AA cNMP 201-314 23 1.6e-23 85.38 SMART 1-123 (123) Show / Hide 
Range on Protein: 201-314
Range on HMM: 1-123/123
Sequence Identity: 23% (29 aa)

FLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------GALLGKMRAGTVMGELAILYNCTRTASVQAL-TDVQLWVL
..| | .... ||...|.. . .||......|.||| .... .|...| ..         . ..| ...| . ||||.| . .|||.. |. .....| .
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRSVFQMITQRLGMERHSQLMNFL
|.  |... |. ..     | ...
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding egl-4.AA cNMP_binding 219-304 26 1.1e-21 77.09 Pfam 1-91 (91) Show / Hide 
Range on Protein: 219-304
Range on HMM: 1-91/91
Sequence Identity: 26% (24 aa)

EMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLG-----KMRAGTVMGELAILYNC-TRTASVQALTDVQLWVLDRSVFQMITQRLGM
. . ..|. ....|.|.|....| .|...|.. .          ...| . ||.|...|. .|||.|.||||...|...|..|. . |.   
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP egl-4.AA cNMP 319-442 29 2.2e-27 98.19 SMART 1-123 (123) Show / Hide 
Range on Protein: 319-442
Range on HMM: 1-123/123
Sequence Identity: 29% (38 aa)

IFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQ---IEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTL
.|.||.|. ... .|.|   .|  | ||.|||..|| |..| ||.|.|...     .. .  ....|..|||||| |||    |... .|  . .|  |.
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL----RRPRTAAARACCECCTI

DRESFGKLIGDLESLKKDYGDKERLAQ
.| .| .... |.. . .     .  .
WRIDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding egl-4.AA cNMP_binding 337-429 34 1.4e-22 80.15 Pfam 1-91 (91) Show / Hide 
Range on Protein: 337-429
Range on HMM: 1-91/91
Sequence Identity: 34% (32 aa)

QDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEE-VRTANIIAQAPGVEVLTLDRESFGKLIGDLES
  .|  |..|..||...| |... ||.|||..  |.  |   ...| .||||||.||....  |||...|    .|.. ..||.| .|. .  .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQ-ILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQQHPE
Kinase egl-4.AA PKG 469-729 70 8.10000000001e-215 719.94 In-house 1-260 (260) Show / Hide 
Range on Protein: 469-729
Range on HMM: 1-260/260
Sequence Identity: 70% (185 aa)

VKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDY
.|..||||||||||||||..|..|..|||||..||.|||||||||||..|.|||||...|.||.||.||||||.||||.|.|.||||||.|||||||||.
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

TARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQ
|.|||.|||.|...|||||||.||||||||..|.|.||.||||||||||...||||||||||||||.||||||||||...|||||||..|||..|.|||.
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS

ASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWF
.|||||||..||||.|..|.| |.|...|....||||||||.||||....|.|||.||.||
GSDPMKTYNIILKGIDMWEFP-RKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase egl-4.AA AGC 469-729 28 2e-152 397.31 In-house 1-395 (395) Show / Hide 
Range on Protein: 469-729
Range on HMM: 1-395/395
Sequence Identity: 28% (112 aa)

VKRLATLGVGGFGRVELVCVNG-----DKAKTFALKALKKKH-IVDTR--QQEHIFAE------------RNIMMETS----------TDWIVK-LYKTF
 . | ..| |.||.| ||  ..     |  | .|.| ||||| ||...  ..||. .|            |||... .           ..||| |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RDQKF--VYMLLEVCL---------GG-ELWTTLR---DRGHFDDYTARFYVAC-------VLEGLEYLHR-KNIVYRD-LKPENCLLANTGYLKLVDFG
 |..   .|...| .          || ||.. |.   ..|.||  .|||| |.       .. .|||||. ..|..|| ||||| || . |..||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKKLASGR---------------------------------------------------KTWTFCG--TPEYVSPEIILNKGHDQAADYWA--LGIYIC
..|.. ...                                                   .||||||  ||||..|||.    ...|.|.|.  ||. ..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELMLGRPPFQAS----------DPMKTYTLILKGV----DALEIPN---------RRIGKTATALVKKLCRDNPGERLGSGSG-----GVNDIRKHRWF
|.. |.|||..           .||... .|..|     . ...|.         | . . |  |.|||.  .| .|||.| .     |...|..| ||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase egl-4.AA PKA 469-729 44 9.3e-105 354.33 In-house 1-263 (263) Show / Hide 
Range on Protein: 469-729
Range on HMM: 1-263/263
Sequence Identity: 44% (119 aa)

VKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIV-KLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDD
 ....||| | ||||.|.   ... . .|.| |||  ||...|.||.  |.||.....   || |.| || | .. ||..| . |||. . || .|.|. 
FEIIQTLGTGSFGRVMLCRHKHSG-NYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSN

YTARFYVA-CVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNK-GHDQAADYWALGIYICELMLGRP
..|.||.|  .   ||||| .||.|||||||| |. . |..|. |||||||. .   ||| ||||||  ||||..| ||  . | ||||| | |.. | |
PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFQAS--DPMKTYTLILKGVDALEIPNRRIGKTA---TALVKKLCRDNPGERLGSGSGGVNDIRKHRWF
|| ..  |||..|  |..|   .. | | . . |     |.|||   .. .|.|. ..|||||..|.||
PFYDHNRDPMQIYEKICNGK--IKFP-RHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase egl-4.AA RSK 472-729 36 4.5e-85 288.94 In-house 1-278 (278) Show / Hide 
Range on Protein: 472-729
Range on HMM: 1-278/278
Sequence Identity: 36% (101 aa)

LATLGVGGFGRVELV--CVNGDKAKTFALKALKKKHIVDTRQ-QEHIFAERNIMMETS-TDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGH---
|  || ||.| | |.  |.. |. . .| | |||. || .   ..| ..||||....     ||.|. .|.... .|. .| | |||| | |. ..|   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLAN---TGYLKLVDFGFAKK-LAS-GRKTWTFCGTPEYVSPEIIL----NKGHDQAADYWALGI
|.  .|.|| | .   .|.|| . |..|||||||.|...    | .||.||||.|.  .. . .| |||.| ||. ||..     ..|||.|.|.| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

YICELMLGRPPFQA---SDPMKTYTLILKGVDALEIP-NRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWF
 . |.  |.||||.   ... .. . |.||   |..| .  . ..|  |..|.   .|  |||.| .....|..| ||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase egl-4.AA Akt 472-729 39 1.8e-83 266.66 In-house 4-264 (264) Show / Hide 
Range on Protein: 472-729
Range on HMM: 4-264/264
Sequence Identity: 39% (105 aa)

LATLGVGGFGRVELVCVNGDKAKTF-ALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTA
|  || | ||.| ||  . |  | . |.|.|||..|.. .| ||...||||   .    ||.|.  | .|.  |. .. | |||| . |. .. |.  .|
LKVLGKGSFGKVFLVKKK-DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRA

RFYVACVLEGLEYLHRKNIVYRD-LKPENCLLANTGYLKLVDFGFAKKL-ASG-RKTWTFCGTPEYVSPEIILNKGHDQAADYWA-LGIYICELMLGRPP
|||.| .  ..|.|| |||.||| ||||| |. ..|...| ||| .|.   .   || |||||||| .|||....||..|.| |. ||. . |.| ||||
RFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPP

FQASDPMKTYTLILKGVDALEIPNR-RIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWF
| . |  . . .|. .   ...|.. .| . .  |...|.  .| .|||.|......|. | ||
FYNQDHHQMFKKIKNQ--PVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase egl-4.AA S_TKc 469-729 30 6.1e-80 272.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 469-729
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

VKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLG--GELWTTLRDRGH--
 . | ..| |.||.| ..  ..   . .|.| .|          |||  |..|...   ..||||| .|.| ...|| .| | |  |.| . ...||.  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQ-AADYWALGIYICE
    |.  .||||.. ....|||.|...|..||||||| || .   .|. |||.|..|       ||||||.|..||..   |..  ..| |..|. . |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGV--NDIRKHRWF
.. |.|||.  ...... .|.              . |  ...|... .| .|..         ||..| ||
MLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase egl-4.AA AktR 470-729 39 8.3e-80 271.45 In-house 2-268 (268) Show / Hide 
Range on Protein: 470-729
Range on HMM: 2-268/268
Sequence Identity: 39% (105 aa)

KRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMM-ETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDY
.... || |.||.| ||  . |  | .|.| .|||.|.. .|..|.  |||||  . .   ||||...| ...  . ..| | |||| . |. ...|.  
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

TARFYVACVLEGLEYLHRK-NIVYRDLKPENCLLANTGYLKLVDFGFAK---KLASGRKTWTFCGTPEYVSPEIILN-KGHDQAADYWALGIYICELMLG
.|||| | .| .||||| . ||.|||||||| ||   |..|..||| .|   . .   |. .|||||||..||.|.. |||. ..|.||.|| | |.. |
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTG

RPPFQASDPMKTYTLILKGVDALEIPN-RRIGKTATALVK-KLCRDNPGERLGSGSGGVNDIRKHRWF
 |||....    . .|..    ...|    . ...  |.. ||  .|| .|||... |  .|..| ||
CPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase egl-4.AA Pkinase 469-729 28 4.6e-79 273.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 469-729
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

VKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIF-AERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGG----ELWTTLR--D
 ... ..| |.||.|   |.. .  |..|.| .||.|. .  .|.|.  .|  || . . . ||.|| .|.| . .|| .| | ||    .|.. ..  .
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGHF--DDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYL----KLVDFGFAKK--LASGRKTWTFCGTPEYVSPEIIL-NKGHDQAADYWA
.| |  .. ...||.  .|.||||.|...|..|||||||.|. |.|..    |. |||.||.  . ... ..||||||.|..||.|. ........| |.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGIYICELMLGRPPFQAS------DPMKTYTLILKGVDALEIPNRRIG------------------KTATALVKKLCRDNPGERLGSGSGGVNDIRKHRW
.|. . |...|||||. .      |.|. . .|...    ..|. . .                  ...  ..|.... .| .|..       .| .| |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase egl-4.AA Ciliate-E2b 469-729 33 5.7e-79 239.6 In-house 1-272 (272) Show / Hide 
Range on Protein: 469-729
Range on HMM: 1-272/272
Sequence Identity: 33% (91 aa)

VKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRG--HFD
.     || | || | ||  . .. . .|.|. .|  |. .    |.  | |..       |.|....|.| ...|...| | |.|| . .|. |   . 
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

DYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRK----TWTFCGTPEYVSPEIIL-----NKGHDQAADYWALGIYI
 | ..||.| .. .||||| .||.|||.|||| .. ..||.||.|.| || . .       | | .|||.|  ||||      .||   ..| |..||  
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

CELMLGRPPF--QASDPMKTYTLILKGVDALEIPNRRIGKTA-TALVKKLCRDNPGERLGSGSGGVNDIRKHRWF
 |.| |..|.   . ||   |  |.|. | .. |.    | |   |. ..   .|  |||   |  .    | ||
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG---GSYSWLKSHPWF
Kinase egl-4.AA p70 470-729 35 1.1e-72 247.74 In-house 2-299 (299) Show / Hide 
Range on Protein: 470-729
Range on HMM: 2-299/299
Sequence Identity: 35% (105 aa)

KRLATLGVGGFGRVELVCVNG--DKAKTFALKALKKKHIV----DTRQQE----------------------HIFAERNIMMETSTDWIVKLYKTFRDQK
..|  || ||.| | .|      |. | .| | |.|  ||    ||.                           ||||||  |     |..|   | .  
ELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTNG

FVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKK-LASGRK----------TWTFCGT
  | .||   ||||.. |   | ..  ||.|| . .   ||.|| . |.|||||||||.|   | ..| |||  |. .  | .          |.|||||
KLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGT

PEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWF
.||  |||.. .||..| |.|.||. .   . | ||| .. . ||   ||||   |..|     . .  |.|||   .| .|.|.| . . ||..| .|
IEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPP-YLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase egl-4.AA Ciliate-E2 469-729 23 4.5e-67 229.15 In-house 1-365 (365) Show / Hide 
Range on Protein: 469-729
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

VKRLATLGVGGFGRVELVCVNGD----------------------KAKTFALKALKKKHIVDTRQQEHIF----------AERNIMMETSTDWIVKLYKT
 | .  .| |.|| | ...|  .                      |.| .|.| .||. |  . | .||.           |.||. . . . |.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FR--DQKFVYMLLEVCLGGELWT-------------------TLRDRGHFDDYTAR-------FYVACVLEGLEYLHRKN-IVYRDLKPENCLLANTGYL
|   |.. .|. .| | ||.|.                    |.. ....  . ..       ||.||....||||| || |..||.|||| |.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLVDFGFAKKLA---------SGRK-----------------------TWTFCGTPEYVSPEIILNKG---------HDQAADYWALGIYICELMLGRPP
|..|||..||.          ...|                       ..|.||||.|..|||. .|.         .| ..|.|.||. . |.. |.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQASDPMKTYTLILKGVDALEIPNRR-----------IGKTATALVKKLCRD--------NPGERLGSGSGGVNDIRKHRWF
|        .  |...   .  |. .           . |  .  .| |..         .| .|..    | ..| .| ||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase egl-4.AA RSK 472-729 32 4.8e-65 222.41 In-house 4-271 (271) Show / Hide 
Range on Protein: 472-729
Range on HMM: 4-271/271
Sequence Identity: 32% (88 aa)

LATLGVGGFGRVELV--CVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYT
.  .|.| |. | ..  |.  |  . .| | .||. .. . .     .||.|. .     ||||.  | |.. ||| .. . ||.| . |   . |    
HECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSERE

ARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANT----GYLKLVDFGFAKKLASGRK-TWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGR
..|| | ..  .|||| . ||.||||||| |.. .    | .|..||||||.| .  . . |||.| .|. ||..  .|||||.|.| .|.   |   |.
VKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGC

PPFQASDPMKTYTLILKGVDAL-----EIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWF
.|||. .   . ..|..  ...      ...  | ..|  |. ..   .|  |||.|  ||..|..| ||
TPFQNKPRDTPMNIIQRIKLGMFSMTHGNWD-FISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase egl-4.AA S_TK_X 730-780 25 3.6e-13 51.01 SMART 1-79 (79) Show / Hide 
Range on Protein: 730-780
Range on HMM: 1-79/79
Sequence Identity: 25% (20 aa)

MGFDWEGLRS--RTLKPPILPKVS----NPADVTNFD-NYPP-----DNDVP----------------PDEFSGWDEGF
 |.||..|..  ....||. ||..    .| |. |||  ..      ..| |                ||.| |..  |
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase egl-4.AA TyrKc 469-723 19 4e-10 -59.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 469-723
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

VKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMET--STDWIVKLYKTFRDQ-------KFVYMLLEVCLGGELWTTL
.. . .|| | ||.| .   .     . | | ||. .      .| .  | .||..   . . ||.||   ..|       . .....| . .| |   |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RDRGH-FDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASG-----RKTWTFC----GTPE-----YVSPEIILNKGH
|.... .   .   .   . .| ||||.||.. |||   |||... .  |  ||| .... ..     .|         |.         .|| |  .  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DQAADYWALGIYICELM-LGRPPFQA-----SDPMKTYTLILKGVDALEIPNR--------RIGKTATALVKKLCRDNPGERLGSGSGGVNDI
  . | |. |. . |.. .| .|         ..   . .. .| . ...|             .  . . |. .. .| .|       . ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-HECF