Gene egl-15 (Nematode worm)

egl-15

Species: Nematode worm
Alias: F58A3.2a, CE28238, F58A3.2, egl-15, F58A3.2A, aSWK378
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 11020162-11027138, WormBase Genetic Map location: X:2.74573,

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
egl-15.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 289 Kinase domain by global Sugen HMM Fasta, JSON
egl-15.AA Protein Genbank 1040 None Fasta, JSON

Protein domain

Protein domains of egl-15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG egl-15.AA IG 40-127 15 3.4e-10 41.12 SMART 1-58 (58) Show / Hide 
Range on Protein: 40-127
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

NERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKDKIRKDNNRMMLHLKNIDVSDQ---GLWSCRVHNAYGQISR--NFTVEVI
 . ..| .|. ... |  .       . ||                        |.. |. ..|.   |   |...  .||..   ..|..| 
PP-VTVKEGETVTLTC-VS------QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set egl-15.AA I-set 66-126 20 3.1e-08 30.46 Pfam 32-92 (92) Show / Hide 
Range on Protein: 66-126
Range on HMM: 32-92/92
Sequence Identity: 20% (13 aa)

VEWYRNDKLLKNDQID--KDKIRKDN-NRMMLHLKNIDVSDQGLWSCRVHNAYGQISRNFTVEV
|.|..... |..   |  . ... |. ..  |  .|.. .| |  .|.. | .|. .  ....|
VSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 egl-15.AA IGc2 46-116 19 5.5e-05 22.7 SMART 1-56 (56) Show / Hide 
Range on Protein: 46-116
Range on HMM: 1-56/56
Sequence Identity: 19% (14 aa)

FLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKDKIRKDNNRMMLHLKNIDVSDQGLWSCRVHNAYG
  |. . . |  |. .  . . ||. .. |              ..  |..||. ..| |. .|.. |. |
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set egl-15.AA V-set 94-127 26 3.075118 2.65 Pfam 95-128 (128) Show / Hide 
Range on Protein: 94-127
Range on HMM: 95-128/128
Sequence Identity: 26% (9 aa)

LHLKNIDVSDQGLWSCRVHNAYGQISRNFTVEVI
|...|. .|| |   | | | . ..  . |  ..
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGc2 egl-15.AA IGc2 305-374 31 7.8e-19 69.81 SMART 1-56 (56) Show / Hide 
Range on Protein: 305-374
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

PAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVG
  |... |.|.| |.|.|.| ||| |..|              ..|.|..... ..|||. .|.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set egl-15.AA I-set 307-384 24 3.5e-16 57.44 Pfam 15-92 (92) Show / Hide 
Range on Protein: 307-384
Range on HMM: 15-92/92
Sequence Identity: 24% (20 aa)

GRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNR---WSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVII
| |....|...|.|.||. |.|.|..|.    .|  . ....     .|.....  .|.|.  | | |..|.|.. .....
GETARFECQVTGDPPPQVSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG egl-15.AA IG 299-385 16 1.5e-09 38.95 SMART 1-58 (58) Show / Hide 
Range on Protein: 299-385
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

NETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADS---GEFHCEALNKVGSAKK--YFHVIIV
 . .   .| |..|.| ..     || ||                        |.. .. ..||   |.. |.|    |....   ..... 
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set egl-15.AA V-set 307-384 15 1.183733 4.08 Pfam 21-128 (128) Show / Hide 
Range on Protein: 307-384
Range on HMM: 21-128/128
Sequence Identity: 15% (17 aa)

GRTLKLNCRAK-GY----PEPQIIWYK-NGK------ML-----KKSSARSGGYEFKFN------------RWSLEVEDAVVADSGEFHCEALNK-VGSA
| ...|.|  . .|    .. .| ||.          .      .... ..|.|.  |.            ..||   .. ..|||  .| . |   .. 
GQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYF

KKYFHVII
 .  ....
GHGTRLTV
IG egl-15.AA IG 399-503 19 9.5e-12 46.27 SMART 1-58 (58) Show / Hide 
Range on Protein: 399-503
Range on HMM: 1-58/58
Sequence Identity: 19% (21 aa)

LANQSVNINDTATFHCKVVSDLLPHIIWVRINKINGSYSYYNNSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQ---GIYACLSGNSLGMSM
   ..|.  .|.|..| |      .| |                                           ||| ||...|.   |.| |      |.  
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYW

A--NATLTVN
.  ..|||| 
SIQGTTLTVQ
I-set egl-15.AA I-set 460-502 43 4.5e-08 29.9 Pfam 49-92 (92) Show / Hide 
Range on Protein: 460-502
Range on HMM: 49-92/92
Sequence Identity: 43% (19 aa)

HVHHVG-DESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTV
... .| ...|||| ||  || |.| |   ||.| . . |.|||
QMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 egl-15.AA IGc2 405-492 19 4.6e-08 34.03 SMART 1-56 (56) Show / Hide 
Range on Protein: 405-492
Range on HMM: 1-56/56
Sequence Identity: 19% (17 aa)

NINDTATFHCKVVSDLLPHIIWVRINKINGSYSYYNNSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLG
.. ...|. |..  .  | | |.. ..                                  ...|||| ||...| |.|.|.  |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set egl-15.AA V-set 397-502 16 0.000313 16.42 Pfam 1-128 (128) Show / Hide 
Range on Protein: 397-502
Range on HMM: 1-128/128
Sequence Identity: 16% (22 aa)

NILANQ----------SVNINDTATFHCKVVSDL----LP-HIIWVR-INKINGSYSYYNNSAEEYMF-----NYTE------MDTF-DKAHVHHVGD--
 .   |          .|.  ...|..|.. .|      . .| |.|  .          ... ....     .|..      .. | .. .. . ..  
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPP---------GQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKN

ESTLTIFNVSLDDQGIYACLSGNS-LGMSMANATLTV
  .||| |....| |.| | . |.  .   .  .|||
DFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
Kinase egl-15.AA FGFR 640-928 64 2.1e-229 768.37 In-house 1-293 (293) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-293/293
Sequence Identity: 64% (190 aa)

LSLVHMLGEGAFGEVWKATYKETENN----EIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHR
|.|..|||||.||.||.|..|.....    ||.||||.|||....|.|.|||||||..|.||.|.|...|.||||..|||||.||.|.||||||||||.|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGR
|.....||.|||.|||. |||....|||||||||||..||..|.|||.||..|||.|.||||||||||||.|..|.||.||||.||.||.|||||..|||
PPGMDYKKDSQEYTDYK-PRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGR

LPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIA-MPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL
|||||||.|||...|||..|||||||||||||||.||.|||.|. ..|||..||||.|||.||.|.||.||.||.||..|...||.||..|.||
LPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase egl-15.AA Pkinase_Tyr 640-928 43 6.00000000001e-152 515.23 Pfam 1-270 (270) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-270/270
Sequence Identity: 43% (131 aa)

LSLVHMLGEGAFGEVWKATYK-ETENNEIAVAVKKLKMSAHEKE--LIDLVSEMETFKVIGEHENVLRLIGCCT-GAGP--LYVVVELCKHGNLRDFLRA
... ..|||||||||.|.|.| . .|..| ||||.|| .|....  . |. .|... | .| |.|..||.|.||   .|  .|.|.|...||.|.|.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

HRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYY-RKRG
||                            |  ..||  .|.|..||.|.||..|.||..|||||||||.||....| ||.||||.||..  ||| ||||
HR----------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRG

NGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTP-YPTIAMPELYANL-KEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL
.|.|||||||.|..  ...|..|||||.|||.|||.|.|..| || .   |.|. . ..||||..|..||.|.|.||..||... |.||.|. |.  |
GGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase egl-15.AA TyrKc 640-928 39 4.1e-148 499.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-280/280
Sequence Identity: 39% (128 aa)

LSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIG-EHENVLRLIGCCTGA-------GPLYVVVELCKHGNLRDFL
..| ..|||||||||.|.|.|      | ||||.|| .|    . |. .|..  . .| .|.|..||.|.||         .||..|.|...||.|.|.|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCN------
|.||||                               |. ..|..|.||.|.||..|.||..|||||||||.|||..|. ||||||||||..        
RKHRPK-------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGES

-DYYRKRG--NGR--LPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPT-----IAMPELYANLKEGYRMEPPHL--------CPQEVYHLM
 |||||..  .|.  |||.|||.|... ...| .|||||.||..|||.|.|..|||      .   |.....|.||||..|.         ||.|.| .|
KDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM

CSCWREKLEERPSFKTIVDYL
 .||.|. |.||.|..|....
KQCWHEDPEDRPTFSEIHECF
Kinase egl-15.AA TK 640-928 25 1.2e-127 430.34 In-house 1-486 (486) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

LSLVHMLGEGAFG---EVWKATYKE----------------------TENNEIAVAVKKLK--MSAHEKELID--------------LVSEMETFKV-IG
. |.. ||||.||   ||.|.....                      .|.... |||| ||   .....| .|              ...||. ..  .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

EHENVLRLIGCCTGA------------GPLYVVVELCKHGN----LRDFLRAHRPKEEKAKKSSQELTDYLEP--------------------RKASDKD
.|.|..||.|.||              .|...|.|...||.    |||.||..|||. .   ..... .  .|                    . ....|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

DIEL-----IPNLTQRHLVQ-------------------FAWQVAQGMNFLASK------KIIHRDLAARNVLVGDGHV-----------LKISDFG---
...       | ||...|.|                   ..||.|.|| .|.||      ...||||||||.|||...|            ||.|||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRDVHCNDYYRKRG------------------------NGRLPIKWMALEALDSNV---------YTVESDVWSYGVLLWEIMTLG-GTPYPTI
     |.||.. .|.|....                        .|.|||.||| |.|...|         .| .|||||.|||.|||.|.| ...|. .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

AM---------PELYANLKEG--------------YRMEPPHLCP--------------QEVYHLMCSCWREKLEERPSFKTIVDYL
            |.. .|..|              .||..| .||              .|.| ||..||... |.||.|......|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase egl-15.AA VEGFR 640-928 41 1.8e-115 389.88 In-house 1-332 (332) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-332/332
Sequence Identity: 41% (138 aa)

LSLVHMLGEGAFGEVWKAT---YKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCT---GAGPLYVVVELCKHGNLRDFLRA
| |  |||.|||| | .|.    . .|.. . ||||.||  |   |   |.||..  . || | ||  . ||||     ||| | || |..||| ..||.
LKLGKMLGRGAFGQVHEASAFGIRKMETCTT-VAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRT

HRPK--EEKAK--------------------------KSSQELTDYLEPRKASDK--------DDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRD
 |    ... |                           |.| ..    . |.|          .|... | ||  .|. .. ||| || ||||.|.||||
KRMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDP-LTMEDLICYSFQVARGMEFLASRKCIHRD

LAARNVLVGDGHVLKISDFGLSRD-VHCNDYYRKRGN-GRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIA-MPELYANLKEGYRME
|||||.|.    |.||.||||.|.    .. | ..|. |||||||||.|..  .|||  ||||||||.|||| .||| |||..    |..  ||.||||.
LAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMR

PPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL
 | .|..|.|| | .||..  ||||.|   |  |
APDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase egl-15.AA TK-Unique 640-928 37 1.7e-107 363.46 In-house 1-294 (294) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-294/294
Sequence Identity: 37% (119 aa)

LSLVHMLGEGAFGEVWKATYKETE---NNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAG-PLYVVVELCKHGNLRDFLRAHR
| .   .||||||.||.......    .  . ||||.|| .|.. .  |. .| . .| .| |.|.....||||  . | . . | |  |||...||  |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PK---------------EEKAKKSSQELT--DYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLAS--KKIIHRDLAARNVLVGDGHVLKISDF
|.                ...|..  ...  | .                        ||||.|.||..|||  |||.||||.|||||.....|.||.||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH-----------------------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDF

GLSRDVHC-NDYYRKRGNGRLPIKWMALEALD--SNVY-TVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLC-PQEVYHLMCSCW
|..|||.  ..| .... ||.||.|||.|.|    ..| | .|||||.|||.|||.|||..||| .  ...  ....||||. |  | ..|.| || |||
GMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCW

REKLEERPSFKTIVDYL
... |||||| .|.. |
QWEPEERPSFRQIKHRL
Kinase egl-15.AA UTK 640-928 35 5.9e-104 351.67 In-house 1-296 (296) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-296/296
Sequence Identity: 35% (114 aa)

LSLVHMLGEGAFGEVWKATYKETE--NNEIAVAVKKLKMSAH-EKELI---DLVSEME------TFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNL
. |   ||.|||||| ||....      | .||||... .|  ..|     |.  |         |.   .|.|||||.| ||  .|...|.|... |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMENGDL

RDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGH-------VLKISDFG---
|..|| |||. .                        .    || ......||..| ||..|.|....||||||||.||.. .       | ||.|||   
RSYLRRHRPTPP------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGG

LSRDVH---------CNDYYRKRGNGRLPIKWMALEALDSN-VYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEG--YRMEPPHLCPQEVYH
.||.|.           .||......|.||.||| |||...  .|  |||||.||..|||.| | .||| .. ... ... .|  |||..|. || .|| 
MSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYR

LMCSCWREKLEERPSFKTIVDYL
|| .||.   .|||.|...|. .
LMHRCWHYDPQERPDFEDLVQQM
Kinase egl-15.AA Tie 648-928 45 3.6e-103 314.9 In-house 1-267 (267) Show / Hide 
Range on Protein: 648-928
Range on HMM: 1-267/267
Sequence Identity: 45% (127 aa)

EGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQE
|| || | ||. |  .  .. ||.|..|  | |..  | . |.| .  .| | |.. |.| |   | ||| .|  ..||| ||||  |  |         
EGNFGQVMKAMIKK-DGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIE---------

LTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALD
 ||   .|. . .  ...   |. . ...||  ||.||..|. |..|||||||||.||..  | ||.||||||    .. | |.  ||||..|||.|.| 
-TDPAFAREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLN

SNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL
  ||| .|||||||||||||..||||||  ..  |||  | .||||| |  |  |||.||  |||..  |||.|  |.  |
YSVYTTKSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase egl-15.AA Src 640-928 36 1e-95 324.26 In-house 1-255 (255) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-255/255
Sequence Identity: 36% (106 aa)

LSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEE
. |.  ||.| |||||....    |... |||| ||      .  ..  | .. |    ||....|   |.   | | | |. .||.| |.|..      
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK------

KAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHC--NDYYRKRGNGRLP
                        .   .|  ..|. .|.|||.||..| |...|||||||||||||.. | |. |||| | .     | |  |   ..|
-----------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFP

IKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYH-LMCSCWREKLEERPSFKTIVDYL
|||.| ||.. ...|. |||||.|.||.||.| | .|||    .|   ... ||||  || ||.|.|. .|. ||... |.|| |... ..|
IKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase egl-15.AA PDGFR 769-928 52 2e-83 267.62 In-house 198-358 (358) Show / Hide 
Range on Protein: 769-928
Range on HMM: 198-358/358
Sequence Identity: 52% (85 aa)

LTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIM
|| . |. |. |||.|| |||||  .||||||||||.  |.| || |||| ||.     |  .|| |||.|||| | . ..|||..|||||||.||||| 
LTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIF

TLGGTPYPTIAMPE-LYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL
.|||.||| . . .  |   ||||||. |   |.|.|  | .|| .. | ||.|. ..  |
SLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase egl-15.AA Ret 774-930 51 5.5e-80 272.03 In-house 137-293 (293) Show / Hide 
Range on Protein: 774-930
Range on HMM: 137-293/293
Sequence Identity: 51% (81 aa)

LVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGT
.. ||||. .|| .|.. |..||||||||||| .| ..|||||||.|||   | | ||  .|.|.|||| |.|  .|||. |||||.|||.||| |.|. 
IISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGAN

PYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDW
||| |.   |.  || ||||. |  |  |.| .|  ||..  . ||.|| |   .  
PYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase egl-15.AA RTKB 769-928 44 1.1e-63 213.54 In-house 106-264 (264) Show / Hide 
Range on Protein: 769-928
Range on HMM: 106-264/264
Sequence Identity: 44% (71 aa)

LTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVES-DVWSYGVLLWEI
| |. || |. |.|.|| || ....|||||.||||||. .   ||.|||..| .   .|  . .  |||||||| | . .  ||  | ||||.||  |||
LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY--ETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEI

MTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL
 .||||||.. .  ..   |  |.|.. | . ||...|.|  || .  ..||.|. .|| .
FSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase egl-15.AA S_TKc 640-931 21 4.9e-39 136.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 640-931
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

LSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKH--GNLRDFLRAHRPK
  ..  .|.||||.|.|.. |.       ||.|..|        ... .|..  |    |.|. .|....   . ||.| |.| .  |.|.|... ....
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

EEKAKKSSQELTDYLEPRKASDKDDIELIPN--LTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGR
                             ..  ..  |   ...|........ |..||||||   |.|. .  ..||.||||.| .             
G----------------------------LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFC

LPIKWMALEALDSNVYTV-ESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVD-Y-----L
    .|| | |    |.  ..|.|| |..|.| .. | .|.|   | ... ...           ..|. .... |..   |.||.   .          
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

DWM
 |.
PWF
Kinase egl-15.AA Pkinase 640-928 20 2.9e-38 136.36 Pfam 1-293 (293) Show / Hide 
Range on Protein: 640-928
Range on HMM: 1-293/293
Sequence Identity: 20% (69 aa)

LSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELID--LVS--EMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHG----NLRDFL
. ..  .|.|.||.|.|.. | |.     ||||..| . |||.  |  ..   | .  | .  |.|..||.....  . .|.| |.| .|     | |..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVG-DGHV---LKISDFGLSRDVHCNDY
..                          ...  ..  .. ...  ...|...|.... |..||||||   |.|.  .||.   .||.||||.. .  .  
ST--------------------------WRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-N

YRKRGNGRLPIKWMALEALD-SNVYTVESDVWSYGVLLWEIMTLGGTPYPTI------AMPELYANLKEGYRMEP-PHLCP-------------------
..        . .|| | .  .. |. ..|.||.|..|.| .. | .|.|         . ..... ...  ... | .|.                   
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWS

QEVYHLMCSCWREKLEERPSFKTIVDY--L
.|  .....|.. . ..||... |.    .
EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase egl-15.AA RTKB 640-751 39 3.2e-29 95.67 In-house 1-114 (264) Show / Hide 
Range on Protein: 640-751
Range on HMM: 1-114/264
Sequence Identity: 39% (45 aa)

LSLVHMLGEGAFGEVWKATYKETENN-EIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKE
..| . ||.||||||..| ...   | | ..|.| || .| . |  |  |||   | .|.| ||. .|| | .. |. . |||| .|||||.||. |  .
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

EKAK-KSSQELTDY
...   ... |.|.
HNPQSLKQAQLVDF
Kinase egl-15.AA PDGFR 640-735 38 4.1e-19 57.66 In-house 1-98 (358) Show / Hide 
Range on Protein: 640-735
Range on HMM: 1-98/358
Sequence Identity: 38% (38 aa)

LSLVHMLGEGAFGEVWKATYK--ETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHR
|..   || |||| |  ||      .   . |||| || .||  |   | ||       |.|.|.  | | ||  || |.. | |  | | ..|.  |
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR
Kinase egl-15.AA Ret 640-735 40 1.4e-18 60.02 In-house 1-100 (293) Show / Hide 
Range on Protein: 640-735
Range on HMM: 1-100/293
Sequence Identity: 40% (41 aa)

LSLVHMLGEGAFGEVWKATYKETENNE--IAVAVKKLKMS-AHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAG--PLYVVVELCKHGNLRDFLRAH
| |   |||| || | ||.  .         |||| ||   |   |. || ||..  | .  | .| .| | |.  .  |. ..|| || | || |||  
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
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