Gene efk-1 (Nematode worm)

efk-1

Species: Nematode worm
Alias: efk-1, EEF-2 kinase, F42A10.4, F42A10.4b, CE30787, aSWK435
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: III: 6164032-6160397,

Classification

Group: Atypical
Family: Alpha
Subfamily: eEF2K

Sequence

Name Sequence Type Origin Length Description Download
efk-1.AA Protein Genbank 760 None Fasta, JSON

Protein domain

Protein domains of efk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Alpha_kinase efk-1.AA Alpha_kinase 107-301 35 1.9e-109 370.79 SMART 1-255 (255) Show / Hide 
Range on Protein: 107-301
Range on HMM: 1-255/255
Sequence Identity: 35% (91 aa)

RKQWTEDIVDVRL-HPDSFARGAMRECYRLKKCSKH----GTSQDWSSNYVAKRYICQVDRRVLFD--------DVRLQMDAKLWAEEYNR---YNP-PK
...||.... |.. .| .||.||||.||.....|.|    .. . . ..|..|.|....|....|.        ||..|| .|.||.|.|.   .|| ||
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQHNPCPK

KIDIVQMCVIEMI-------DVKGSPL----------------YHLEHFIEGKYIKYNSNSGFVSNAARLT------------PQAFSHFTFERSGHQMM
|||.....|....       | .....                .|.|.|.||...|||.|.|.|.. .| |            .|||||.|.|.|.|||.
KIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQML

VVDIQGV----GD--LYTDPQIHTVV--GTDYGDGNLGTRGMALFFHSHRCNDIC
|.|||||    ||  .||||||||    |. .|.|||| .|.. ||..|.||.||
VCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase efk-1.AA Alpha 113-301 32 2.2e-90 257.38 In-house 1-215 (215) Show / Hide 
Range on Protein: 113-301
Range on HMM: 1-215/215
Sequence Identity: 32% (69 aa)

DIVDVRLHPDSFARGAMR------ECYRLKKCSKHGTSQDWSS-NYVAKRYICQVDRRVLFDDVRLQMDAKLWAEEYNRYN------PPKKIDIVQMCVI
. . ...    |..||||      .|.. .| .| .  . | | .||....|  |.| ... ...... ..||..||.. .      |.|  .. ... .
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSFKYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYEL

EMIDVKGSPLYHLEHFIEGKYIKYNSNSGFVS-----NAARLTPQAFSHFTFERSGHQMMVVDIQ-GVG-DLYTDPQIHT----VVGTDYGDGNLGTRGM
.  . .....|..|...||.|.|||.|.|.|.     | .....|||||.|...|..| ||||.| ||| ...||||||.     .|...||||.| .||
IHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGM

ALFFHSH--RCNDIC
. ||..|   ||..|
FRFFYTHHVQCNHYC
Kinase efk-1.AA Alpha_kinase 124-301 35 1.2e-79 275.68 Pfam 1-225 (225) Show / Hide 
Range on Protein: 124-301
Range on HMM: 1-225/225
Sequence Identity: 35% (82 aa)

FARGAMRECYRLKKCSKHGTSQDW--SSNYVAKRYIC----QVD------RRVLFDDVRLQMDAKLWAEEYNRY-----NPPKKIDIVQMC-VIEMIDVK
||.||||.|.|... .     ..|   .|.|||.|.     ...      .   |.|.. || .. |.|..|.      |||..|.....| |.|..|  
FAQGAMRWCFRMFDTW----DPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

G---------------SPLYHLEHFIEG-KYIKYNSNSGFV-SNAARLTP-----QAFSHFTFERSGHQMMVVDIQGVG--D---LYTDPQIHTVVGTD-
.                .....|..||| ...|||.|.|.| .| .| .|     |||||||..||..||||.||||||  .   ..|||||||. |   
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYE

--Y--GDGNLGTRGMALFFH-SHRCNDIC
  .  |.|||| .|.  ||. .|.||.||
MDFDEGMGNLGQEGIEKFFQNQHKCNHIC
Kinase efk-1.AA VWL 210-306 42 5.6e-40 116.91 In-house 105-206 (206) Show / Hide 
Range on Protein: 210-306
Range on HMM: 105-206/206
Sequence Identity: 42% (44 aa)

YHLEHFIEGKYIKYNSNSGFVSNAARLTP----QAFSHFTFERSGHQMMVVDIQGVG-DLYTDPQIHTVVG-TDYGDGNLGTRGMALFFHSHRCNDICET
|  | .||| | ||| |.|...      .    |||||||.  |  . |.||.||..  . ||||||.      .|.||||  ||  ||..| ||..|  
YFVENYIEGDYQKYNNNAGWCNQTDM-EYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQK

MDL
. |
LQL
Kinase efk-1.AA Alpha-Unclassified 212-301 29 7.1e-28 87.87 In-house 110-215 (215) Show / Hide 
Range on Protein: 212-301
Range on HMM: 110-215/215
Sequence Identity: 29% (32 aa)

LEHFIEGKYIKYNSNSG----FVSNAARLTP--QAFSHFTFERSGHQMMVVDIQG-VG------DLYTDPQIHTVVGTDYG--DGNLGTRGMALFFHSH-
.|  ..| . ||..|.|    ||      ..  ....|.|.. ..|.  |.| || |.         |||||||.    |.  ..| | |..  .| .| 
VEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIR-QRYQGFKTNCGMRFIDYWFNNHH

-RCNDIC
  || .|
VQCNHYC
Kinase efk-1.AA ChaK 212-301 32 5.7e-09 31.72 In-house 122-219 (219) Show / Hide 
Range on Protein: 212-301
Range on HMM: 122-219/219
Sequence Identity: 32% (32 aa)

LEHFIEGKYIKYNSNSG---FVSNAARLTPQAFSHFTFERSGHQMMVVDIQGVGDLYTDPQI-----HTVVGTDYGDGNLGTRGMALFFHSHRCNDIC
.|... | . ||| | |      |       ||||.|.|     ..|.|.||||.  ||| .         .  .|  |||   .  |   | ||  |
IEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC
Sel1 efk-1.AA Sel1 643-676 28 0.007587 12.59 Pfam 1-37 (43) Show / Hide 
Range on Protein: 643-676
Range on HMM: 1-37/43
Sequence Identity: 28% (11 aa)

KGAMLYMA--HAYETGQHLG-PNR-RTDYKK-SIDWYQR
  |.....  ..|..||. |   .   ||.| .. |||.
P-AQYNLGMYYMYYHGQFGGCVPQDD-DYEKEAFYWYQK
Sel1 efk-1.AA Sel1 707-740 33 0.009472 12.27 Pfam 6-43 (43) Show / Hide 
Range on Protein: 707-740
Range on HMM: 6-43/43
Sequence Identity: 33% (13 aa)

LAKMAEMYKEGG-YG-LNQ-D-FER-AYGLFNEAAEAAM
|. | .|| .|  .|   | | .|. |. ..  |||.  
LG-MYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH