Gene E02H4.3 (Nematode worm)

E02H4.3

Species: Nematode worm
Alias: E02H4.3, aSWK174, E02H4.3a, CE31462
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 14294910-14288596, WormBase Genetic Map location: No interpolated position.,

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
E02H4.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 329 Kinase domain by global Sugen HMM Fasta, JSON
E02H4.3.AA Protein Genbank 903 None Fasta, JSON

Protein domain

Protein domains of E02H4.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase E02H4.3.AA CLK 551-879 54 2.4e-245 744.81 In-house 1-350 (350) Show / Hide 
Range on Protein: 551-879
Range on HMM: 1-350/350
Sequence Identity: 54% (194 aa)

FTIYDTLGEGTFGKVVRVNDSLS-DTFMALKIIKNVSKYREAAKLEVK-VLQKLAEK-DPEKKNW--VIHMGSYFDY-NGHICLLFDLMGSSIFDFLKAN
..|..|||||||||||...|. . ....|||||.||.||||||..|.. ...|..|| ||..|.|  ...| ..||| .||||..|.|.| ||.||.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

H------YKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDS-----RYTTKLVDKKVGKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSAT
.      |.|||.... |...|||.|||||||.||||||||||||.||||     ..|.|. .|| ..    ... ..|.........||...|||||||
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN----KKS-NNCVCHYWHVKNTHICVIDFGSAT

---FDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLG-DIPLRMAKRT-----KTKFFINGRLDWVNT
   ||||||| ||||||||||||||.||||||||||||||||.|||||.||||||.||||||||||..| .|| .|..||     |.|.|...||||...
KIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWH

SADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF
..|..||..|||||...|.|.||||..||.||..||...| .|.....||||..|
NSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase E02H4.3.AA CMGC 551-879 17 2.3e-95 313.82 In-house 1-513 (513) Show / Hide 
Range on Protein: 551-879
Range on HMM: 1-513/513
Sequence Identity: 17% (96 aa)

FTIYDTLGEGTFGKVVRVNDSLSD--------------TFMALKIIKNVSKYREAAK-------------LEVKVLQKLAEK---------DPEKKNW--
..| . .||||.|.|..  | ...               . |.|.|||.  | | ||              |.| |..| ..         ||..|.   
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIHMGSYFDYNG-----------------HICLLFDLMGSSIFDFLKANH--YKP------------------------YPMEQTLHITWQLCNAVK--F
....  .| ...                 |..| |..|. . ....| |.  |..                        ... .   ...|.....|  .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHDNK--LTHTDLKPENILFVD-----------SRYTTKLVDKKVGKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSATFDHEH----------------
.| ..    |.||||||||. .           |    .              . . . .    ... .....|||.|.. |.|                
CHSHWGNIIHRDLKPENILINHNCELITRMMWKS----E--------------D-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVN

--------HSIIVSTRHYRAPEVILELG----------WSQPCDVWSIGCILYELYTG--------VTLFQTHEN-----------REHLAMMERVLGDI
        ..  |.||.|||||..|  .          ...|.|.||.|||..|.|||         .||..| .            ..|... .||| .
KDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTP

PLRMAKRT---------KTKFFINGRLDWVNT-------------SADAA---------YVRDNCKPLRRSMSCTDP-----------------------
. .|....         . ...    |.| |.               . |         . . ..||... . . ..                       
T-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHK

---------EHVELFELIENMLMFEPLARMKLPEALQHRYF
         .. ....|...|| ..|  |..  .|||| ||
FNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase E02H4.3.AA S_TKc 551-879 20 7.9e-71 242.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 551-879
Range on HMM: 1-231/231
Sequence Identity: 20% (72 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGS---SIFDFLKANHY-
..| ...|.|.|||| .. .  ..  .|.||||      | .. |...|.|       .  .....  .|.  .|... .....    . ||..| . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

---KPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKVGKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSATFDHEHHSIIV
   .|.|  .. ....|.|.|....|...  | ||||||||. .                                   |. ..|||.|..     . ..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------------------------HIKICDFGLARQL----TTFC

STRHYRAPEVILELGWSQ-PCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAKRTKTKFFINGRLDWVNTSADAAYVRDNCKPLRRSM
 |..|.||||.   |..  .||.||.||||||...| ..|.     .. .|.....                                            
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------------------------

SCTDPEHVELFELIENMLMFEPLARMKLPEALQ-------HRYF
        |. ..|...| ..|  |.   ||||       | .|
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase E02H4.3.AA Pkinase 551-879 19 6.7e-57 200.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 551-879
Range on HMM: 1-293/293
Sequence Identity: 19% (70 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKL-----EVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLM-GS----SIFDF
..|  ..|.|.||.| .  .  .    |.|||| ...  .  .      |......|       .| .. .  .| ...||.. .... |     . ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N----HPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LKANHYKPY--PMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKVGKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSA----TF
...  ....  ....  .. .|.. .....|...  | ||||||||.. ......                             .|...|||.|    . 
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA----------------------------CVKICDFGLAKQFDY-

DHEHHSIIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCILYELYTGVTLFQTH----ENREHLAMMERVLG-----DIPLRMAKRTKTKFFINGRLDWVNT
  .  . .. |..|.|||||.   ......|.||.||||||...| ..|. |    . .....|..|..|     |.|    ... . |..         
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----

SADAAYVRDNCKPLRRSMSCTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF
              .  .   .  . |. ..|...| . |  |   ...||| .|
--------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase E02H4.3.AA DYRK 551-696 34 2e-43 150.57 In-house 1-150 (320) Show / Hide 
Range on Protein: 551-696
Range on HMM: 1-150/320
Sequence Identity: 34% (51 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLKANHYKPY-
..|.. .| |.||.||.. |   .  .|.|||.|  ..   |. |.| |..| ..||. |  ..||  || . .| |. |.|.  . ..||| || ... 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PMEQTLHITWQLCNAVKFLHDN-KLTHTDLKPENILFVD--SRYTTKLVD
... .  .. |.... |||| | .. | |||||||. ..  ...| |..|
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVID
Kinase E02H4.3.AA DYRK2 551-684 29 3.2e-37 118.34 In-house 1-134 (318) Show / Hide 
Range on Protein: 551-684
Range on HMM: 1-134/318
Sequence Identity: 29% (40 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLKANHYKPYP
..|   .| | || ||.. |   ... |.|.| | ... . |  |...|... ..|.     ..||  || . .|.|. |.|.. .. ...| ||.. . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

MEQTLHITWQLCNAVKFLHDNKLTHTDLKPENIL
..     . .. .. .||| |.. | ||||||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase E02H4.3.AA Ciliate-E2 551-879 14 2.4e-36 122.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 551-879
Range on HMM: 1-365/365
Sequence Identity: 14% (66 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREA--------AKLEVKVL--QKLAEKDPEKKNW-----------------------VIHMG
. .   .|.|.||.| .... . .   |.|||.   . .           . ..|..  ... ..  |.. .                       .| | 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

SYFD--YNGHICLLFDLMGS-SIFDFLKAN----------HYKPYPMEQTLHITWQLCN---------------AVKFLHDNK-LTHTDLKPENILFVDS
 .|    . .| | ...    . ||..| |            |.. ... ..|..|...               |...|| ..   | |.|||||||   
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

RYTTKLVDKKVGKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSAT-------------------FDHEHHSIIVS----------------TRHYRAPEV
                                   . .|||| ..                   | .   |.  .                | .| |||.
-----------------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

ILELG---------WSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAKRTKTKFFINGRLDWVNTSADAAYVRDNCK-PLRRSMS
.   .         ..  ||.||.|.||||. .| . |                                                 . ... ... .  
LNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------------------------------QQQIKQCKIDFPCP

CT------------DPEHVELF--ELIEN----MLMFEPLARMK-LPEALQHRYF
.             .......    || .    ||  .|  |.    ..|.| .|
EWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase E02H4.3.AA CAMK 556-778 17 2e-32 101.23 In-house 267-596 (425) Show / Hide 
Range on Protein: 556-778
Range on HMM: 267-596/425
Sequence Identity: 17% (59 aa)

TLGEGTFGKVVRVNDSLSD------------TFMALKIIKNV-----------------------------SKYREAAKLEVKVLQKLAEKDP-EKKNWV
|||.|.|||| .. . ..             .  | |||.                                | |.  . |.....|| ...   .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IHMGSYFDYNGH-------------------ICLLF---DLMGS-----SIFDFLKANHY-------------KPYPMEQTLHITWQLCNAVKFLHDNKL
|..  ... . .                   ... .   ...        .||..... .             . .. ... .. .|.| ||...|... 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THTDLKPENILFVDSRYTT-KLVDKKVGKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSAT-FDHEH-------------------------HSIIVSTR
 | ||||||||..|.   . . | .  .          . | .   ...  . .|||| |. ||. .                          .  . | 
VHRDLKPENILLDDNNDDSDP-V-E-HD----------EIF-D---WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP

HYRA-PEVIL--------------ELGWSQPCDVWSIGCILYELYTG
.| | |||..              . . ...||.||.|.||| . .|
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCG
Kinase E02H4.3.AA HIPK 551-687 32 2.4e-32 98.81 In-house 1-136 (329) Show / Hide 
Range on Protein: 551-687
Range on HMM: 1-136/329
Sequence Identity: 32% (44 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLKANHYKPYP
. . . || ||||.||.      .   |.||.||   |    . ||..|..| .....  . .. .  .|.   |.|| |...   ..||.| |.. | |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYH-FVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

MEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVD
.     |. |   | . | .  | | |||||||. ||
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVD
Kinase E02H4.3.AA Ciliate-E2-Unclassified 551-783 17 2.3e-29 99.04 In-house 1-271 (352) Show / Hide 
Range on Protein: 551-783
Range on HMM: 1-271/352
Sequence Identity: 17% (53 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKN---------------------WVIHMGSYFDYNGHICLL
..|  ..|.| |||| .. ..  . . |.|..| . .|    .....   .. .|  ..|.                      ...|  .|    .|.. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

FDLM-GSSIFDFLKANHY---------------KPYPMEQTL-----HITWQLCNAVKFLHDNK-LTHTDLKPENILFVDSRYTTKLVDKKVGKFVLRRF
 ... | . ....| ..                |  . .|..     ....|.... ..|| ..   | |.||||||| .. .                 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----------------

KIDDCFQPLRVLHSTHVRLIDFGSATF------------------DHEHHSIIVSTRHYR----APEVILELGWSQP----CDVWSIGCILYELYTGVTL
               ....||||.. .                  .... . .. |  |     ||||. . . ...    ||.|| |.||||. .|   
-------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP

FQ
|.
FY
Kinase E02H4.3.AA DYRK1 551-696 32 4.9e-28 95.21 In-house 1-149 (321) Show / Hide 
Range on Protein: 551-696
Range on HMM: 1-149/321
Sequence Identity: 32% (48 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLKANHYKPYP
. |   .| | ||.||.  |..   ..|.|||||   . . |..|...|  . ..|.|.|  ..|.   | .  |.|| |.|.   ..| |.  |..   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

MEQTLHITWQLCNAVKFLHDNKLT--HTDLKPENILFVDS-RYTTKLVD
.  |  .  |.| |. |.    |   | |||||||| . . |   |..|
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIID
Kinase E02H4.3.AA DYRK 724-879 30 8e-27 95.44 In-house 146-320 (320) Show / Hide 
Range on Protein: 724-879
Range on HMM: 146-320/320
Sequence Identity: 30% (54 aa)

VRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRM---A-KRTKTKFFINGRL
. .|||||..| |.. .  .  |.|||||||| .  . . |.|| ||||.||.||  ||.   . . ||..  ||| .|  |   . .| |.||| . . 
IKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMY

DWVNTSADAAY------V--------RDNCKPLRRSMSCTDPEHVELF-ELIENMLMFEPLARMKLPEALQHRYF
. . .. .  .      .          .  | ||.   ..  ....|  .|. .|...|  |..  .||||  |
CECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase E02H4.3.AA DyrkP 723-819 43 3.1e-22 69.43 In-house 146-244 (323) Show / Hide 
Range on Protein: 723-819
Range on HMM: 146-244/323
Sequence Identity: 43% (43 aa)

HVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAK--RTKTKFFINGRL
.|..|||||. | |.| |  |  | |||||||.   .    |.||.|||| ||.||  |||  .    || .  ..| .|  | .  |    || . ||
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRKRL
Kinase E02H4.3.AA DYRK2 724-879 26 3.9e-22 68.5 In-house 143-318 (318) Show / Hide 
Range on Protein: 724-879
Range on HMM: 143-318/318
Sequence Identity: 26% (48 aa)

VRLIDFGSATFDHE-HHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRMAKR------TKTKFFIN
. .||||| .|.|. .    . .| |||||||| .  . . | || |||. |||||. ||      . .|.|  |||  |  . .       ...| |.|
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFN

---------------GRLDWVNTSADAAYVRDNCKPLRRSMS-CTDPEHVELFELIENMLMFEPLARMKLPEALQHRYF
                 .  . ...       . |..  ..  |.|.    . . |   .  .|  ||.  .||.| ..
SHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDE---NFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase E02H4.3.AA DYRK1 724-805 35 1.4e-13 43.57 In-house 145-226 (321) Show / Hide 
Range on Protein: 724-805
Range on HMM: 145-226/321
Sequence Identity: 35% (29 aa)

VRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENREHLAMMERVLGDIPLRM
...|||||.    .     .  | ||.|||.|.. ..   |.||.|||| |. ||  ||   .  . .  .  |||  | .|
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHM
Kinase E02H4.3.AA DyrkP 551-684 30 2.4e-12 36.26 In-house 1-138 (323) Show / Hide 
Range on Protein: 551-684
Range on HMM: 1-138/323
Sequence Identity: 30% (42 aa)

FTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKLA-EKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLK---ANHY
. | . ||   | | .   |   .  | .||| |   | . .  |.|.|. .    | . || |...  ||    |. .. .|.   ...| |    |  
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKN-VLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

KPY-PMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENIL
..|  .     || |.  |. ..|  .| | ||||||||
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENIL
Kinase E02H4.3.AA HIPK 724-778 42 1.3e-09 25.9 In-house 144-199 (329) Show / Hide 
Range on Protein: 724-778
Range on HMM: 144-199/329
Sequence Identity: 42% (24 aa)

VRLIDFGSATFDHEH-HSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTG
|. ||||||    .   .  .  |.|||||.|| |   .  |.|| ||.. ||. |
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG
Kinase E02H4.3.AA TyrKc 551-819 16 1.8e-08 -85.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 551-819
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)

FTIYDTLGEGTFGKVVR-VNDSLSDTFMALKIIKNVSKYREAAKLEVKVLQKL-------------AEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGS-
 |  ..|||| ||.|.. . .    .  | | .|. .  ||.   | ... ||             . .. ..          | | . ..... .|   
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----------FMYIEPLMIVMEYMPHG

SIFDFLKANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDKKVGKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSATFD
.  |.|.... |  .|.. |.. || ..   .||.... | ||   |.|  . .                                 .|.  ||| . . 
DLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------------------------TVKISDFGLSRDI

HEH------HSIIVSTR--HYR--------APEVILELGWSQPCDVWSIGCILYELYT-------G-----VTLFQTHENREHLAMMERVLGD-------
...      .. ....   . .        |||.| .   .   |||| |  ..|..|       |     .. .. .|. ..  .|..   |       
YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVC

IPLRMAKRTKT--KF---------FINGRL
 |  | .  |.  ..          |  ..
CPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase E02H4.3.AA DYRK1 854-879 42 1.6e-05 14.84 In-house 296-321 (321) Show / Hide 
Range on Protein: 854-879
Range on HMM: 296-321/321
Sequence Identity: 42% (11 aa)

ELIENMLMFEPLARMKLPEALQHRYF
.||. || ..| .|..  .|||| .|
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase E02H4.3.AA CAMK 855-879 36 1.6e-05 12.96 In-house 401-425 (425) Show / Hide 
Range on Protein: 855-879
Range on HMM: 401-425/425
Sequence Identity: 36% (9 aa)

LIENMLMFEPLARMKLPEALQHRYF
|| .||  .|  ||.. ..|.|  .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase E02H4.3.AA Ciliate-E2-Unclassified 854-879 26 0.000536 9.78 In-house 323-352 (352) Show / Hide 
Range on Protein: 854-879
Range on HMM: 323-352/352
Sequence Identity: 26% (8 aa)

ELIE----NMLMFEPLARMKLPEALQHRYF
..|.     ||   |  |. ....|.| .|
DFINDLLQKMLKKNPNKRITFEQILNHPWF