Gene daf-2 (Nematode worm)

daf-2

Species: Nematode worm
Alias: Y55D5A.5, aSWK379, Y55D5A_392.a, daf-2, CE27499
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 3024336-2991292, WormBase Genetic Map location: III:-9.61094,

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
daf-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 275 Kinase domain by global Sugen HMM Fasta, JSON
daf-2.AA Protein Genbank 1843 None Fasta, JSON

Protein domain

Protein domains of daf-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain daf-2.AA Recep_L_domain 177-302 37 1.8e-42 144.53 Pfam 1-121 (121) Show / Hide 
Range on Protein: 177-302
Range on HMM: 1-121/121
Sequence Identity: 37% (51 aa)

NCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQ--HYALIIYRNPD--L-EIGL
||||..|.|.|. . .|                .....  ||..||||| ||.. | ..  . . |||||.| ||.|..  .|||.|| ||.  | |...
NCTVIYGNLEITWRDEHNE--------------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWM

DKLSVIRN--GGVRIIDNR--KLCYTKT-IDWKHLI
 .|..|..  |||.| .|   ||||| | |.|....
WNLKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like daf-2.AA Furin-like 358-492 28 6.3e-24 79.07 Pfam 31-182 (182) Show / Hide 
Range on Protein: 358-492
Range on HMM: 31-182/182
Sequence Identity: 28% (46 aa)

CWSNT--TCQ----KSCAYDRLLPTKEIGP-GCD--ANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDA----------------HLYLLLQ
||. .   ||    | |.       .. .  .|   ..|. ||.|| |||   |..|.|.||...|| | | ..|                  . |    
CWGPNPQHCQTLTKKVCP-------EQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPPMMIYNPTTFQMEPNPDGTYQFEG

RRCVTREQCLQLNPVLSNKTVPIKATAGLCSDKCPDGYQINP-DDHRECRKCVGKCEIVCE
.||||...| .|..  ..  . |    | |   || ||..|  .. ..| .| |.|  ||.
WRCVTFKECPKLSHNPDCNYYVI--HNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU daf-2.AA FU 380-429 24 0.000631 20.29 SMART 1-48 (48) Show / Hide 
Range on Protein: 380-429
Range on HMM: 1-48/48
Sequence Identity: 24% (13 aa)

GPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHK---GKCIEKCDAHLYL
.  |     .||..| .||   . ...| .|.. |..   |.|...| .  | 
DGVC----KPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain daf-2.AA Recep_L_domain 508-624 31 5.7e-36 122.65 Pfam 1-121 (121) Show / Hide 
Range on Protein: 508-624
Range on HMM: 1-121/121
Sequence Identity: 31% (40 aa)

LCNIIDGNLTIEIRGKQDSGMASELKD---IFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFRN-LYAITVFENPN--LKKLFDST-TDLTLDR
 |..|.|||.|..|....      |..    |.||..||||||....... .|..|.||| |. ..|| .  ||. ...|||  |..|..   ...| ..
NCTVIYGNLEITWRDEHNE-----LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKN

GTVSIANNK--MLCFKYIKQLMSKLN
|.| | ||.  .||. ..........
GGVYIHNNPHPKLCYTHTEIMWWMIY
FN3 daf-2.AA FN3 773-1049 5 1.3e-05 25.92 SMART 1-69 (69) Show / Hide 
Range on Protein: 773-1049
Range on HMM: 1-69/69
Sequence Identity: 5% (17 aa)

PDPPT----LALAQVDSD------AIHITWEAPLQPNGDLTHYTIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLL
|.||.    | .  |.|.       ....|..|       ..|.                                                        
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------------------

TMMGHEDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHI
                                                                                                    
----------------------------------------------------------------------------------------------------

SKKKPSSSSTTSTPAPTIASMYALTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHY----TLYAISLSACQ-NMTVPG
                                                             |....|| .    | | ....|   |.  .|
-------------------------------------------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 daf-2.AA FN3 1070-1160 14 0.005415 16.95 SMART 1-69 (69) Show / Hide 
Range on Protein: 1070-1160
Range on HMM: 1-69/69
Sequence Identity: 14% (15 aa)

IDKVLN-ETIEWRFMNNSQ-----QVNVTWDPPTEVNGGIFGYVVKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADG-----RYFVSVTATSV--
 . . | ......  ...      .|...|.||      | ||.                             . . .|  |     .| ..|.| .   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-----------------------------YTVTGLKPGQYPWTEYEFRVRAVNGND

HGAG
.| |
AGEG
Kinase daf-2.AA InsR 1243-1519 55 2.1e-213 715.24 In-house 1-278 (278) Show / Hide 
Range on Protein: 1243-1519
Range on HMM: 1-278/278
Sequence Identity: 55% (155 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKRE
.||...||.||||.||.|.....|.....|||.||||.........|....|.||..||.|.....|.|.||.|..||..||||||..|.|..||||.|.
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

DEVFNETDCN-FFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDS
.|.||...|| .......|..|..||.||||||||...||.|||||.||||.|.|.|||||||||.||...||||...||.|.|||||.|||||||.|..
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

KSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAA
.||||||||||.||||||.|||.||||..||.||||...|...||.|..||...|.|||.|.|..|||||...|.|  
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase daf-2.AA TyrKc 1243-1517 36 3.2e-124 419.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-280/280
Sequence Identity: 36% (112 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNF--KTNFIVKLYGVISTV-------QPAMVVMEMMDLGNL
..||.. ||| ||.||.|| .           ..|.|   .|         . ||.||...  .   ||.||||...        .| |.||| |..|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

RDYLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYH-------DYYKP----SGKR
.||||..|..             .. ....... ||..||.||.| .. |||||||||..... ||||.|||..||.  .       |||..    .|| 
KDYLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

MMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIG-----LSNDEVLNYIGMARKVIKKPE-------CCENYWYKVMKMCWRYSPRDRPTF
|.|.|||.||....||| .|||||||||...|. |.|.||| |     .||.||..|.   .   . |.       ||    |..||.||.. | |||||
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

LQLVHLL
 ......
SEIHECF
Kinase daf-2.AA Pkinase_Tyr 1243-1517 39 3.9e-113 383.8 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-270/270
Sequence Identity: 39% (112 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTE--NLNYLMEANIMKNF-KTNFIVKLYGVIS-TVQP--AMVVMEMMDLGNLRDY
...|.. |||.||.||.|| .    ....   |.|.|.  ..  . .      . ||.|||.. .   ||.||||..   .|   ..||| | .|.|.||
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYY-KPSGKRMMPVRWMSPESLK
||..|          .  . ..     ....||..||.|||| .. |||||||||..... .|||.|||.|||..  ||| . .|. ..|..||.||...
LRKHR----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

DGKFDSKSDVWSFGVVLYEMVTLGAQP-YIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLL
.||| .|||||||||...|..|.|.|| | |.|| ||..||.  .   ..|| |    |..||.||.| | ||||| .... |
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase daf-2.AA TK 1243-1517 23 6.1e-106 356.23 In-house 1-486 (486) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-486/486
Sequence Identity: 23% (117 aa)

VVLGQQCGEGSFG---KVYLGTGNNVVSLMGDRF------------------GPCAIKINVDDPASTENL-------------NYLMEANIMKNFK----
..||.. ||| ||   .||.|. ..   . |.||                   |.|.|.  .. |....              ..|.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-TNFIVKLYGVISTV------------QPAMVVMEMMDLGN----LRDYLRSKREDEVF--------NETDCNFFDI-----------------------
    ||.||||.. .            .| |.|||.|..|.    ||||||..|...          ...... . .                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHCMKGDITYSHESNSPCPEEQD

--------------------------------IPRDKFHEWAAQICDGMAYLESL------KFCHRDLAARNCMINRDET-----------VKIGDFG--
                                ..    . ...||..||.||.|.      .| |||||||||..... .           .||.|||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------MARDLFY------------------------HDYYKPSGKRMMPVRWMSPESLK---------DGKFDSKSDVWSFGVVLYEMVTLGAQPYIG-
      .|||. .                        .|||. . ....|.|||.||.|.         .||| .|||||||||...|..|.|..|| | 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

LSN---------DEVLNYIGMA-------------RKVIKKPECCE--------------NYWYKVMKMCWRYSPRDRPTFLQLVHLL
.||         .||..|. .              |   ..|. |                 .| .|..||.| |.||||| ||.. |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase daf-2.AA UTK 1243-1517 32 1e-77 264.5 In-house 1-296 (296) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-296/296
Sequence Identity: 32% (100 aa)

VVLGQQCGEGSFGKVYLGTGNNVV---SLMGDRFGPCAIKINVDDPASTENL---NYLMEAN---IMKNFK-TNFIVKLYGVISTVQPAMVVMEMMDLGN
| ||.| |.| || |.... ...     .|. .   |     ....| .|       ..||.   .||.|.    ...|.|| .  .| |.|.|.|  |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ----HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGD

LRDYLRSKREDEVFNETDCNFFDIIPRDKFH-----EWAAQICDGMAYLESLKFCHRDLAARNCMINRD-------ETVKIGDFG---MARDLF------
||.|||. |..             .... .      ..|..| .||.||.| .| ||||||||| ....       ...||.|||   |.|..       
LRSYLRRHRPTPP-----------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN

---YHDYYKPSGKRMMPVRWMSPESLKDG-KFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMA-RKVIKKPECCENYWYKVMKMCWRYSPRD
   . .||.... ...|.|||.||.| .. .| .||||||||||..|..| |..|| |.||..|.  ..   |   ..|. |    |..|. ||.|.|..
RYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQE

RPTFLQLVHLL
||.| .||  .
RPDFEDLVQQM
Kinase daf-2.AA TK-Unique 1243-1517 33 3.3e-75 256.17 In-house 1-294 (294) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-294/294
Sequence Identity: 33% (103 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGP--CAIKINVDDPASTENLNYLMEANIMKNFK-TNFIVKLYGV-ISTVQPAMVVMEMMDLGNLRDYLR
...|.. |||.|| |. |.   |........ .   |.| . |.   |.  ..| |...||. .    ||...|. ... .| | .|| .  |||..|||
LEVGDVIGEGAFGQVWRGE---VWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

SKRED-----------------EVFNETD-CNFFDIIPRDKFHEWAAQICDGMAYLES--LKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKP
..| .                 . ...|.  . .| .       .| ||. ||.||.|   |. ||||.|||.....| ..||.|||||||.  .  |  
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSM

SGK-RMMPVRWMSPESLK--DGKF-DSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECC-ENYWYKVMKMCWRYSPRDRPTFLQL
...  ..|.|||.|||||  .| .  .|||||||||...|..||||.|| |........ |  . .  ..|| |  .  |..|| ||...| .||.| |.
MCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI

VHLL
.| |
KHRL
Kinase daf-2.AA Trk 1243-1517 36 3.6e-72 243.96 In-house 1-275 (275) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-275/275
Sequence Identity: 36% (101 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKRE
.|| .  ||| ||||.|.   | .   .  .   |.|    |..      .  || .. | . . |||.|||    .| . | | |  | |. |||..  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMM--VAVKT-LKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGP

D-EVFNETDC-NFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFY-HDYYKPSGKRMMPVRWMSPESLKDGKF
| ... . .          |.    | ||  || |. |. | |||.|.|||..  .  |||||||| ||..   |||.  .. |.|.||| |||    ||
DAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKF

DSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLL
   |||||||||. |  | | ||. .||| || ..|   |   ..|. |    |..|  ||.  |  | .  .. ...
TYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase daf-2.AA Src 1243-1517 35 4.9e-70 237.12 In-house 1-255 (255) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-255/255
Sequence Identity: 35% (98 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKRE
. | .. |.| || |. |. |. .        . |.|    .  |.| .  | ||.|||... . .|.|| | |.  |   | | |  |.| |||.    
IKLCRKLGQGQFGEVWMGYWNGNT--------KVAVKTLKPGTMSPEAF--LQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---

DEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFY--HDYYKPSGKRMMPVRWMSPESLKDGKFD
     ....    .    .  . |||. .||||||| .. ||||||||  .. .  .|..||| || |.    | | ..   ..|..|. || .  |.| 
-----DGEGRHLHLP---QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFT

SKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYK-VMKMCWRYSPRDRPTFLQLVHLL
 ||||||||. |.|.|| |  || | .| |||  . ..     .|. |  . |. .|..||. .|..||||  | . |
IKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQV-ERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase daf-2.AA Fer 1243-1518 30 2.5e-66 224.87 In-house 1-283 (283) Show / Hide 
Range on Protein: 1243-1518
Range on HMM: 1-283/283
Sequence Identity: 30% (91 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGD-RFGP--CAIKINVDDPA-STEN--LNYLMEANIMKN-FKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRD
|.|| . ||| ||.||.|.   .. .. . .. .  .|.| .  . . .|.      . ||.||.| ..   .||.|||..  || |.|||... |.|..
VTLGKKLGEGAFGEVYKGR-R-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDS

YLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVK---IGDFGMARD--LFYHDYYKPSGKRMMPVRWMS
||. . ..             .. .. .. ..|...||.||.| .  |||.||||| .  |...|   | ||||.|.     .||...   ...|.||..
YLKKNKNK------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLA

PESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIG----LSNDEV----LNYIGMARKVIKKPECCENYWYKVMK-MCWRYSPRDRPTFLQLVHLLA
||....| . .|.|||||||...|  | ||.|| |    . . .|       |  ...  . |. .    ...|. .|| . | ||||. .... | 
PETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase daf-2.AA ALK 1243-1519 34 1e-59 204.71 In-house 1-273 (273) Show / Hide 
Range on Protein: 1243-1519
Range on HMM: 1-273/273
Sequence Identity: 34% (98 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFG-PCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKR
. |.   | | || || |    .  . ||    . |.|    |.   . . ..||| || .|.   .|.. |.    || |.| | |  | .. .||  |
ITLVRALGHGAFGEVYMG---QYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECR

EDEV-FNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDET---VKIGDFGMARDL-FYHDYYKPSGKRMMPVRWMSPESLKD
  .. .. .     | .        .  .  |  |||. .| ||| |||||     .    .||.|||||||  .  |||   |. |||| || || . |
PHPESLQPSQLTMKDLL------QCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMD

GKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAA
| | ||.||||||| . |   ||  || | .| ||.  .      .  |  |    |..|  ||.  | |||.| ...  . .
GIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGR-MDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase daf-2.AA Ack 1363-1517 39 4e-57 191.22 In-house 108-266 (266) Show / Hide 
Range on Protein: 1363-1517
Range on HMM: 108-266/266
Sequence Identity: 39% (63 aa)

HEWAAQICDGMAYLESLKFCHRDLAARNCMINRDE-TVKIGDFGMARDLFY-HDYYKPSGKR--MMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTL
.... ||..||.|||.  . ||||||||    .|. .|||.|||  | |    |||. ...|    |  |. ||.|. ..| ..||||.||| | || . 
CDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSY

GAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLL
| .|..|..  ..|  |. ..    .|.||    |..|. ||   | ||||| ... .|
GEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase daf-2.AA CTKB 1366-1519 41 9.5e-55 188.2 In-house 115-269 (269) Show / Hide 
Range on Protein: 1366-1519
Range on HMM: 115-269/269
Sequence Identity: 41% (64 aa)

AAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIG
|| . |||||. |..  |||||||||..  .  | |||||. || .   ||| ..   .|.|||||||. || . . |||||.|.|..|..| .  || .
AADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWSYGIVIWEIMTFAKMPYPE

-LSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAA
 ..| ||   |        .|. |    |  |  ||   | ||. |  |   .  
YETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISFKELHEKTLL
Kinase daf-2.AA S_TKc 1243-1525 25 1.7e-41 145.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 1243-1525
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDL--GNLRDYLRSK
  .... |.|.|||||... ..           .||||           . . | .|.|. .  .|||||.|. . .   .|||..|   |.|.||....
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

RE---DEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDG
.    . .|.| .. |.           ..|||....|. |....||||   | ....  ..||.|||.|| |                 .|.|| |   
GRHGLRFPFPE-HARFY-----------MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

KFDS-KSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVH-LLAAEASPEF
...  |.|.||.|..||||.. |  |.         ..  | .|.       .  .   .. |... |..|||  .. .  ... . | |
GYGKCKCDWWSCGCILYEMLC-GYPPFP--------QMQMMFKKIG-----SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase daf-2.AA Pkinase 1243-1517 22 1.4e-32 116.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1243-1517
Range on HMM: 1-293/293
Sequence Identity: 22% (70 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYL---MEANIMKNFKTNFIVKLYGVISTVQPAMV-VMEMMDLG----NLR
 ..|.. |.||||.||...  .            |.||   . .. . . ..   .|. |||...  .||.||..  .  . .  ||| .. |     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF

DYLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETV----KIGDFGMARDLFYHDYYKPSGKRMMPV---R
||..         . ...|    . .    .. ||. |..|. | ...||||   |..|... ..    ||.||| |. .     | ...  . ..   .
DYIST--------WRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPW

WMSPESLK-DGKFDSKSDVWSFGVVLYEMVTLGAQPYIGL------SNDEVLNYIGMARKVIKKPECCE-------------------NYWYKVMKMCWR
.|.|| .. . . ..|.|.||.|..||||.. |  |. |       . ..... |....     |. |.                       ...| |..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

YSPRDRPTFLQLVHL--L
. | .|||. |...   .
KDPKKRPTAEQILQHPWF
Kinase daf-2.AA CTKB 1243-1341 37 1.7e-08 26.37 In-house 1-97 (269) Show / Hide 
Range on Protein: 1243-1341
Range on HMM: 1-97/269
Sequence Identity: 37% (38 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDR-FGPCAIKINVDDPASTENLNYLM-EANIMKNFKTNF-IVKLYGVISTVQPAMVVMEMMDLGNLRDYLRS
.|| |. ||| || || |    .   | |    | |||.  |  .| |  |  | |  ||.       ||.| |.     | ..|.|.|  | |.  || 
IVLKQKLGEGHFGVVYAGEAKKI---MPDQAVTPVAIKMLQD--SSSEATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRN

KR
 |
SR
Kinase daf-2.AA Ack 1243-1338 31 1.9e-05 14.36 In-house 1-94 (266) Show / Hide 
Range on Protein: 1243-1338
Range on HMM: 1-94/266
Sequence Identity: 31% (31 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDD--PASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPA-MVVMEMMDLGNLRDYLR
. |. . |.|.|| |  |.  |  .  |..  . |.|.  .|  .. ..    | |..|| .     .|.||||  . ||. | |.|.  .| | | ||
ITLCEKLGDGCFGVVWRGEWTN-PG--GKHI-QVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLD-QPMLMMVTELAPCGSLLDCLR