Gene D2024.1 (Nematode worm)
D2024.1
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| D2024.1.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 277 | Kinase domain by global Sugen HMM | Fasta, JSON |
| D2024.1.AA | Protein | Genbank | 359 | None | Fasta, JSON |
Protein domains of D2024.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | D2024.1.AA | TTBKL | 25-296 | 40 | 8.10000000001e-136 | 457.51 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 25-296 Range on HMM: 1-288/288 Sequence Identity: 40% (116 aa) YQVVESIGDGAYGQVF--KVSKNAKK-YAMKVEPNRLDGGPASITKEIEVMMELNNRGAKFFPIFETGGREPKFHMVVMTLLGENLQVLRMKGCNPKACT ...|..|| |..|||. ...|..|. .|||.|.|||.||.. . .|..|.|.|...|...||.. .|........||||.|.|||.||.. .|.|... WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS PGTWSRIGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSDE-VLTSRVFYLIDFGISSKFIRHIK---GTPINQQNGFEFRTENK--KVHSLVGTPKYTSP .|||||||||||...||||||||.|.|.||.|..|| .|. ...|..||||||.. ..... . | || ..|....|.. . . ... ||..|.|| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNG-PI-HENKWMMRRPRNFRHKAPFRGTTRYCSP KAHAMADLGRGDDFWSLMYMIAELVKPLPWEILEAKM-LEKTKLKSKLKDLYGI--------DAFGKIETMLQACTFHSFPNYEMIYHAF .|.....|| ||.||.||||.||...|||. .| || .|..|...|..|| . . |.|....| .......|.|||||. | NMHDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | D2024.1.AA | CK1 | 25-292 | 26 | 2.8e-93 | 316.2 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 25-292 Range on HMM: 1-339/339 Sequence Identity: 26% (91 aa) YQVVESIGDGAYG-QVFKV------SKNA------KKYAMKVEPNRLDGGPASITKEIEVMMELN------------------NRGAKFFPIFETGGREP ..||. ||.|..| |..|| ... ..|||||||. |.. . .|......|. . | ....... .|.|. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED KFH-MVVMTLLGENLQVLRMKGCNPK-ACTPGTWSRIGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSDE----------VLTSRVFYLIDFGISS-KFI ... ..||||||.||. ||....... .. .|| .|.||.|.....||||||.| |.||.||. | .. ..|..|.||||.. |.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR RHIK-----GTPINQQNGFEFRTENK--KVHSLVG-TPKYTSPKAHAMADLGRGDDFWSLMYMIAELVKP---LPWEILEAKM--------LEKTKLKSK . . | | ... .. |. . | ....| |..|.|. .| ..|| || ||..||..|..|. ||| ....| .| . ... DKDGHNRWNG-P--RDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDE LKDLYGID------------AFGKIETMLQACTFHSFPNYEMI | .. .. | || ... .......|.|||| KKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | D2024.1.AA | Worm6 | 25-292 | 25 | 3.3e-42 | 146.55 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 25-292 Range on HMM: 1-279/279 Sequence Identity: 25% (74 aa) YQVVESIGDGAYGQVFKVSKNAKK----YAMKVEPNRLDGGPASITKEIEVMMELNNRGAKFFPIFETGGREPK--FHMVVMTLLGENLQVLRMKGCNPK ..|.. ||.|..| |.||.. .| .|||.| |. |...........|. .| |. .. |. .||||.|.||. ||. . WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP-DR ACTPGTWSRIGIQCLFVVKQMHDCGFLHHDLKPANFVWGQS--DEVLTSRVFYLIDFGISSKFIRHIKGTPINQQNGFEFRTENK-KVHSLVGTPKYTSP . . || .|.|||| . ..| |||.| |.||.|| |. .| .. |..|||.. .. . ||. . .. . ... .||..| . KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTP---------RWTACGFRGTVRYAPL KAHAMADLGRGDDFWSLMYMIAELVKP-LPWEILEAKMLEK-TKLKS--KL-----KDLYG-ID--AFGKIETMLQACTFHSFPNYEMI .| ...| || | .||..|.... ||| .... .. | . .. ....| . | .| ... ... |.|. | ACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | D2024.1.AA | CK1-Unique | 25-240 | 22 | 4.8e-19 | 62.7 | In-house | 1-224 (337) | Show / Hide |
Range on Protein: 25-240 Range on HMM: 1-224/337 Sequence Identity: 22% (54 aa) YQVVESIGDGAYGQVFKVSKNAKK--------YAMKVEPNRLDGGPASITKEIEVMMELNNRG-----AKFFPIFETGGREPKFHMVVMTLLGENLQVLR ..| . || | || | .| . . |.|| | . . . | || ... . |. . . . |||..| .. .. WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC MKGCNPKACTPG------TWSRIGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSD-EVLTSRVFYLIDFGISSK--FIRHIKGTPINQQNGFEFRTENKK |. . . |.. . . | |||.|. || ||.| ..||.|.. . . ...| .|.||. . |. | . | .. MM-MKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQ--HCYYMLDYGICRRVFFV----------SNNHQIRQPRPI VHSLVGTPKYTSPKAHAMADLGRGDDFWSLMYMIAELV . . |...| . | ..||.|| |. ||. || T-PFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYHLV |
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| Kinase | D2024.1.AA | TTBK | 25-180 | 32 | 1.5e-18 | 62.21 | In-house | 1-152 (257) | Show / Hide |
Range on Protein: 25-180 Range on HMM: 1-152/257 Sequence Identity: 32% (52 aa) YQVVESIGDGAYGQVFKVSKNAKK---YAMKVEPNRLDGGPASITK-EIEVMMELNNRGAKFFPIFETGGREPKFHMVVMTLLGENLQVLRMKGCNPKAC .|| || |..| .. . |.||| . | . | |. |. | | .. | . ||. || .||.|.|.|| || | . WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQ---PKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPR-GCF TPGTWSRIGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSDEVLTSRVFYLIDFGISSKFI . .| |.|.| | ... |. |||| | || || |. | | |..||| ... SLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR--NPSTCRKCYMLDFGLARQYT |
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| Kinase | D2024.1.AA | CK1-Unclassified | 25-107 | 27 | 4.8e-14 | 37.86 | In-house | 1-90 (244) | Show / Hide |
Range on Protein: 25-107 Range on HMM: 1-90/244 Sequence Identity: 27% (25 aa) YQVVESIGDGAYGQVFKV--SKNAKKYAMKVEPNRLDGGPASITKEIEVMMELNNRG-----AKFFPIFETGGRE--PKFHMVVMTLLGENL |.|.| || |. |...|. ... ...|.|.| . ...|. .|..|.|. | .| . |.| . .||.|||..| YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL |
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| Kinase | D2024.1.AA | S_TKc | 25-297 | 17 | 2.6e-12 | 3.69 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-297
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)
YQVVESIGDGAYGQVFKVSKNA--KKYAMKVEPNRLDGGPASITKEIEVMMELNNRG-AKFFPIFETGGREPKFHMVVMTLLGE---NLQVLRMKGCNPK
|.... || ||.|.|.|. .. ...|.|. . .| .||..... . |.. .|.. .. .|| ... .| . | ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG
AC---TPGTWSRIGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSDEVLTSRVFYLIDFGISSKFIRHIKGTPINQQNGFEFRTENKKVHSLVGTPKYTSP
. .. . .. | . .. .|. |..| ||||.| . . ..|||.. .. ....||| | .|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL------------------------TTFCGTPWYMAP
KAHAMADLGR-GDDFWSLMYMIAELVK-PLPWEILEAKMLEKTKLKSKLKDLYGIDAFGKIETMLQACTFHSFPNYEMIY-------HAFK
|. | ||. ...|.. |.. ...|..| . .| |. .|| . | | .
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | D2024.1.AA | CK1 | 25-107 | 23 | 4.9e-11 | 34.44 | In-house | 1-91 (271) | Show / Hide |
Range on Protein: 25-107 Range on HMM: 1-91/271 Sequence Identity: 23% (22 aa) YQVVESIGDGAYGQVFKVSKNAK---K--YAMKVEPNRLDGGPASITKEIEVMMELNN---RG-AKFFPIFETGGRE--PKFHMVVMTLLGENL |.|.. || |. |..... . . .|.|.|.|. | . .|. ....|.. . .. .| . |.| .. .||.|||..| YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL |
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| Kinase | D2024.1.AA | CK1-A | 25-250 | 26 | 3.6e-10 | 31.98 | In-house | 1-210 (261) | Show / Hide |
Range on Protein: 25-250 Range on HMM: 1-210/261 Sequence Identity: 26% (61 aa) YQVVESIGDGAYGQVFKV--SKNAKKYAMKVEPNRLDGGPASITKEIEVMMELNNRGAKFFPIFETGGREPKFHMVVMTLLGENLQVLRMKGCNPKACTP |..| || |..| .. .| . |.|.| |. . | | | .|. .| . |.| . ..|| ||| | | |. . | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARH--PQLIYEAKVYRIL--QGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCK-RRFTM GTWSRIGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSDEVLTSRVFYLIDFGISSKFIRHIKGTPINQQNGFEFRTENKKVHSLVGTPKYTSPKAHAMAD | . | . . .| .|.| |.|| ||. | .|||||.. |. .. . ..|.. . |.|| .| | .|| . KTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCN---KLFLIDFGLAKKYRD------SRTRQHIPYREDKN----LTGTARYASINAHLGIE LGRGDDFWSLMYMIAEL-VKPLPWEILEA | ||. |. |.. . ||| ..| QSRRDDMESMGYVMMYFNRGKLPWQGMKA |
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| Kinase | D2024.1.AA | AGC | 25-53 | 35 | 4.3e-10 | 20.77 | In-house | 1-37 (395) | Show / Hide |
Range on Protein: 25-53 Range on HMM: 1-37/395 Sequence Identity: 35% (13 aa) YQVVESIGDGAYGQVFKVSKNA--------KKYAMKV .... || |..|.|. | |. | ||||| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV |
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| Kinase | D2024.1.AA | CK1-Unclassified | 128-234 | 33 | 9.2e-09 | 22.01 | In-house | 109-204 (244) | Show / Hide |
Range on Protein: 128-234 Range on HMM: 109-204/244 Sequence Identity: 33% (36 aa) IGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSDEVLTSRVFYLIDFGISSKFIRH-IKGTPINQQNGFEFRTENKKVHSLVGTPKYTSPKAHAMADLGRG |. | . . ..| ..|.| |.|| ||. |. . . |.||||.| ..|. |. | .. ||| .|.|| |.| || .| IADQMIQRIEYLHNKNFIHRDIKPDNFLMGK--LGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYR-------ENK---NLTGTARYASINAHLGIEQSRR DDFWSLMY || ||.| DDLESLGY |
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| Kinase | D2024.1.AA | TTBK | 208-245 | 51 | 3.9e-08 | 24.87 | In-house | 169-207 (257) | Show / Hide |
Range on Protein: 208-245 Range on HMM: 169-207/257 Sequence Identity: 51% (20 aa) GTPKYTSPKAHAMADLGRGDDFWSLMYMIAELVK-PLPW || | | || ..|| || ||| || | |. ||| GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW |
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| Kinase | D2024.1.AA | CK1 | 128-236 | 29 | 9e-07 | 19.55 | In-house | 110-206 (271) | Show / Hide |
Range on Protein: 128-236 Range on HMM: 110-206/271 Sequence Identity: 29% (32 aa) IGIQCLFVVKQMHDCGFLHHDLKPANFVWGQSDEVLTSRVFYLIDFGISSKFIRHIKGTPINQQNGFEFRTENKKVHSLVGTPKYTSPKAHAMADLGRGD |. | . . .| ..|.| |.|| ||. | . . |.||||.. ... .. | .. ||| .|.|| |.| .| .| | IADQMIQRIEYVHNKNFIHRDIKPDNFLMGR--YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYR-------ENK---NLTGTARYASINTHLGIEQSRRD DFWSLMYMI | ||.|.. DMESLGYVL |
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| Kinase | D2024.1.AA | Pkinase | 25-76 | 27 | 8e-06 | 21.65 | Pfam | 1-58 (293) | Show / Hide |
Range on Protein: 25-76 Range on HMM: 1-58/293 Sequence Identity: 27% (16 aa) YQVVESIGDGAYGQVFKVSKNAKK--YAMKVEPNRLDGGPASITK----EIEVMMELN |.... || |..|.|.| . .|.|. . | . .|. ||..| .|| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN |
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| Kinase | D2024.1.AA | NDR | 25-53 | 38 | 1.4e-05 | 12.43 | In-house | 1-31 (350) | Show / Hide |
Range on Protein: 25-53 Range on HMM: 1-31/350 Sequence Identity: 38% (12 aa) YQVVESIGDGAYGQVFKVSKN--AKKYAMKV ..... || ||.|.|. | |. . ||||. FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKI |
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| Kinase | D2024.1.AA | NDR | 136-155 | 40 | 0.000135 | 9.38 | In-house | 117-136 (350) | Show / Hide |
Range on Protein: 136-155 Range on HMM: 117-136/350 Sequence Identity: 40% (8 aa) VKQMHDCGFLHHDLKPANFV . ..| |. |.|.|| ||. IESVHKMGYIHRDIKPDNFL |
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| Kinase | D2024.1.AA | Pkinase | 139-215 | 23 | 0.000203 | 16.71 | Pfam | 124-180 (293) | Show / Hide |
Range on Protein: 139-215 Range on HMM: 124-180/293 Sequence Identity: 23% (18 aa) MHDCGFLHHDLKPANFVWGQSDEVLTSRVFYLIDFGISSKFIRHIKGTPINQQNGFEFRTENKKVHSLVGTPKYTSP .|..|..| ||||.|. .. .. . . ..|||.. .| | ....||| | .| CHSMGIIHRDLKPENILID-NNGHIDA-CVKICDFGLAKQFD----------------Y-NNS-MTTFCGTPWYMAP |
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| Kinase | D2024.1.AA | AGC | 139-215 | 16 | 0.000814 | 4.16 | In-house | 169-276 (395) | Show / Hide |
Range on Protein: 139-215 Range on HMM: 169-276/395 Sequence Identity: 16% (19 aa) MHD-CGFLHHD-LKPANFVWGQSDEVLTSRVFYLIDFGISSKFIRH------------------------IKGTPINQQNGFEFRTENK----------- .|. |. | | ||| | . . | ||| . .... . . |. .... .|. LHSHMGIIHRDYLKPENILLDED------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMD--T-NK-CNPNNWQRNNMSQEDDTTRKK --KVHSLVG--TPKYTSP . ....| || | .| RDRTWTFCGPCTPEYMAP |
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| Kinase | D2024.1.AA | NDR | 177-215 | 20 | 0.006798 | 4.03 | In-house | 193-250 (350) | Show / Hide |
Range on Protein: 177-215 Range on HMM: 193-250/350 Sequence Identity: 20% (12 aa) SKFIRHIKGTPINQQN-----------------GFEFRTENK--KVHSLVGTPKYTSP ..|.. .. .| || ..... .|. . .|.|||| |. | QDFMDNWNSNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAP |
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