Gene C56C10.6 (Nematode worm)

C56C10.6

Species: Nematode worm
Alias: aSWK094, CE29490, C56C10.6
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 6581252-6579643, WormBase Genetic Map location: II:-0.14,

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
C56C10.6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
C56C10.6.AA Protein Genbank 422 None Fasta, JSON

Protein domain

Protein domains of C56C10.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C56C10.6.AA TTBKL 24-290 39 1.4e-151 509.84 In-house 1-288 (288) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-288/288
Sequence Identity: 39% (115 aa)

WQVIRKLGEGGCGSVYLVKNLED-ETEAAMKAESNG-AAGGCVLKLEVAILKKLS--GKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQ--IT
|......||||.|.||.|....| ...||||.|.|  . |....|.|| .|.||.  |.||....... .  |.....|||.|..| .. |.. ..  ..
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

VSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTN-NDECRFFHVLDFGLARQFVVSQSDQP-----SKLMMRRPRE---RSLFRGTTRYCSIRM
.....||.  .|..|||.||.||||||.||.|...||... ...|| ....|||.|||.........     .|.||||||.   .. |||||||||..|
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HDRAEQGRVDDLWSMVYLLAELRGPLPWSSQSDKRVVGEMKRLHSDEVVLQN------SPMEFLEIAKYLRSLTYFHRPDYHKIFMLL
|||.||||.|||||. | ..||...|||.. .||  ...||. ..||.. ..      .|.||....|.||||.| .||||..|....
HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C56C10.6.AA CK1 24-286 32 3.4e-106 359.1 In-house 1-339 (339) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-339/339
Sequence Identity: 32% (109 aa)

WQVIRKLGEGGCG-SVYLV-----KNLEDE-----TEAAMKAESNGAAGGCVLKLEVAILKKL---------------------SGKPHVCQFLFAARLT
|.|..|.||||.|  .|.|     |....      .|.|||.|.. ..|.  ...|.....|.                     .|.||.|.. .. .  
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

DFT-YVIMTLLGESLNKIVK--RI-ARQITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTN----------NDECRFFHVLDFGLAR-QFV
|.  |..|||||..| .. |  |   | ..... ..||   |. |...||.||||||.||.|...|....          |.|.| ....|||.|| ...
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

VSQSDQ------PSKLMMRRPRE---RSLFRG-TTRYCSIRMHDRAEQGRVDDLWSMVYLLAELR-GP--LPWSSQSDKRV-----VGEMKRLHSDEVVL
 .. ..       .. ..|.|||   .  ||| |.|||||..|.. ||||.|||||. |.|.|.  |   |||.  .|.       |..||. . ||  .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

QN------------SPMEFLEIAKYLRSLTYFHRPDYHKI
..            .| || .|.||.|||.|..||||..|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase C56C10.6.AA TTBK 24-286 40 1.2e-75 257.57 In-house 1-257 (257) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-257/257
Sequence Identity: 40% (108 aa)

WQVIRKLGEGGCGSVYLVKNLEDE-TEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQI-TVSSQ
|.|..| | || | .|  |..  .  . |.| ||   .   |||.|||.|||| |..|||.|    |  .| |..|.|.|..|        |.  ..|. 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESA-QQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT

VRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLW
.|.   .|  ...||..|| ||| || | |.|    .  ||    ||||||||.. .. .       | |||   |||| || ||  |   | || ||||
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST--CRKCYMLDFGLARQYTNACGE------VRPPREVAGFRGTVRYASINAHRNREMGRHDDLW

SMVYLLAE-LRGPLPWSSQSDKRVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKI
|. |.| | . | |||    ||  |||||      . |.. | ||    . ..||.|. ||||  |
SLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase C56C10.6.AA Worm6 24-286 30 8.7e-61 208.26 In-house 1-279 (279) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-279/279
Sequence Identity: 30% (88 aa)

WQVIRKLGEGGCGSVYLVKNLEDET--EAAMKAESN-GAAGGCVLKLEVAILKKLSGKP--HVCQFLFAARLTD--FTYVIMTLLGESLNKIVKRIA-RQ
|.| .|.||||.|.||.|.. .| .  . |||.|.    .   .||.|...||..  ..  |.|..  ...     | |..|||.|..|  . |  . | 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

ITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYK--TNNDECRFFHVLDFGLAR-QFVVSQSDQPSKLMMRRPR-ERSLFRGTTRYCSIRMHDR
....   .||   |  . . | .||||||.||.| . |     ...| .    ||||..|  .   .  .     .| || ..  ||||.||...  |..
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNE-----LRTPRWTACGFRGTVRYAPLACHKG

AEQGRVDDLWSMVYLLAEL-RGPLPWSSQSDKRVVG---EMKRLHSD----EVVLQNSPM-EFLEIAKYLRSLTYFHRPDYHKI
 ||.| ||. |  |...|. .| |||   .|.  |.   . .| . .    . .... |. || .| .|. .. |. |||| .|
QEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase C56C10.6.AA CK1-A 24-286 29 1.3e-31 108.95 In-house 1-261 (261) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-261/261
Sequence Identity: 29% (80 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQITVSSQVR
....||.| |  | .||  |...  | |.| |||  |    |  |  . . |.| . . . ..  .  |.  ..| ||| ||  .     |. |.   . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESN-KARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLM

IAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLWSM
.|  ..  .  .|  .|||||.|| |  .|    .  |   ...|||||...  |.. |   .  |  ..     || || ||  |   || | ||. ||
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGI---GRHCNKLFLIDFGLAKKYRDSRTRQ--HIPYREDKN---LTGTARYASINAHLGIEQSRRDDMESM

VYLLAEL-RGPLPW------SSQSDKRVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKI
 | .    || |||        .     . | |   . |.. . .| ||  . .| |.| .   |||  .
GYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase C56C10.6.AA CK1-D 24-286 29 6.3e-27 91.95 In-house 1-261 (261) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-261/261
Sequence Identity: 29% (79 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQITVSSQVR
. . ||.| |  | .|. .|.. . | |.| |.  .     |..|  . | ..|   . .  .  .  |.  ..| ||| ||  .     |.  .   . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK-HPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLM

IAANVLFCLKQIHDIGFIHRDLKPAN--MALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLW
.|  ..  .. ||   |||||.|| |  | || . |       ...|||||...  ... |   .     ||     || || ||  |   || | ||| 
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGN-----MVYIIDFGLAKRYRDARTHQ--HIPY---RENKNLTGTARYASINTHQGIEQSRRDDLE

SMVYLLAEL-RGPLPW-----SSQSDK-RVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKI
|. |.|    || |||       . .|   . | |   . ... .  | || .   | |.| . ..|||  .
SLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase C56C10.6.AA CK1-Unique 24-230 25 1.1e-26 89.58 In-house 1-223 (337) Show / Hide 
Range on Protein: 24-230
Range on HMM: 1-223/337
Sequence Identity: 25% (58 aa)

WQVIRKLGEGGCGSVYLVKNLEDE------TEAAMKAESNGAAGG----CVLKLEVAILKKLS--GK--PHVCQFLFAARLTDFTYVIMTLLGESLNKIV
|.|| ..| || | |. |  . ..       . .|| |  ...       ..... . . |..   |   |.|.        |  . .||..| |.  . 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KRIAR-QITVS------SQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNN-DECRFFHVLDFGLARQ-FVVSQSDQPSKLMMRRPRERSLFRGT
   .. |.| .        .. .  .|. .   |  ||.||..||.|  ..  ...  . . . .||.|  |  | || . |     .| ||..  |||.
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYM--APSQQHQHCYYMLDYGICRRVFFVSNNHQ-----IRQPRPITPFRGC

TRYCSIRMHDRAEQGRVDDLWSMVYLLAEL
 .||..  |   |.|| ||. | .|.|  |
KDYCPCSCHQCREHGRRDDMESWFYMLYHL
Kinase C56C10.6.AA CK1-G 24-286 28 2.6e-22 72.36 In-house 1-266 (266) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-266/266
Sequence Identity: 28% (78 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKP-HVCQFLFAARLTDFTYVIMTLLGESLNKIVKRIARQITVSSQV
..| .| |.|  | ... ||.      | | |         |..|    | |.|.|  . |  .      .   .| ||| ||        |. .| . .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSR-APQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVC

RIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQGRVDDLWS
 .|   .  ....|.   | || || |   | . |.|. .  |. |||.|.|..  .  |         ||.    || || ||  |   || | ||. .
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQ-HVIHIIDFGMAKQYIDPETKQHIPY-----REHKSLTGTARYMSINTHLGREQSRRDDMEA

MVYL-LAELRGPLPW------SSQSDKRVVGEMKRLHSDEVVLQN--SPMEFLEIAKYLRSLTYFHRPDYHKI
.  . .  ||| |||              .|. ||    |. .||   | .|    .| |.| .|  |||  .
LGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase C56C10.6.AA CK1-Unclassified 24-176 25 7.4e-18 49.3 In-house 1-159 (244) Show / Hide 
Range on Protein: 24-176
Range on HMM: 1-159/244
Sequence Identity: 25% (41 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKP-------HVCQFLFAARL--TDFTYVIMTLLGESLNKIVKRIAR
 .||.|.| |  | .|...|.....|.|.| |.. .     |. |. |.. | .         ..      ..    |. ...|.|||.|| .. .   |
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNR

QITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALG-YKTNNDECRFFHVLDFGLARQFV
. ..     ||   .  . ..|  .|||||.|| |   | .  | . .   .  ||||.  ..
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQV---YIIDFGLSKRYI
Kinase C56C10.6.AA Pkinase 24-180 22 7.2e-17 60.72 Pfam 1-167 (293) Show / Hide 
Range on Protein: 24-180
Range on HMM: 1-167/293
Sequence Identity: 22% (39 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKL-----EVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGE-----SLNKIVK-RI
....||.|.|. |.||. ..  .. . |.|  .   .  ....      |..|.|.| . |...... . .  |  |..| ...      .|  ... . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

ARQI--TVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQF-VVSQS
 . .  .     ...  .|  |. .|. |.|||||||.|  .  . ..|.  .... |||||.||   ..|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS
Kinase C56C10.6.AA CK1 24-176 28 2.9e-16 52.64 In-house 1-160 (271) Show / Hide 
Range on Protein: 24-176
Range on HMM: 1-160/271
Sequence Identity: 28% (46 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEA---AMKAESNGAAGGCVLKLEVAILKKLSG------KPHVCQFLFAARL--TDFTYVIMTLLGESLNKIVKRI
 .|.||.|.|  | .||..|. ...|.   |.| |.| .     |. |. |.| | |       ... .    ..    |. ...|.|||.|| .  .  
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC

ARQITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFV
 |. ..   . ||   .  .  .|  .|||||.|| |   |    . .|   .. ||||| ...
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR--YGKHCHQVYIIDFGLAKRYR
Kinase C56C10.6.AA S_TKc 24-294 19 7e-15 41.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-294
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKLEVAILKKLSGKPHVCQFLFAARLTDFTYVIMTLLGE---SLNKIVKRIARQ-----
....||.|.|. |.||.... ..  . |.|  .      . .. |..||||  . |...... . .  |. |..| ...    .| .. |.  |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVSQSDQPSKLMMRRPRERSLFRGTTRYCSIRMHDRAEQG
..     .... ..  |. .|. |.|||||||.|  |             . |||||||.                   . | ||  |..  .      |
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL---GYG

R-VDDLWS---MVYLLAELRGPLPWSSQSDKRVVGEMKRLHSDEVVLQNSPMEFLEIAKYLRSLTYFHRPDYHKIFM-----LLISVM
.   | ||   ..| ..  . | |        .   .|..          . |.... . .      .||   ...       .   .
KCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C56C10.6.AA CK1-Unclassified 199-236 53 7e-08 19.37 In-house 178-216 (244) Show / Hide 
Range on Protein: 199-236
Range on HMM: 178-216/244
Sequence Identity: 53% (21 aa)

GTTRYCSIRMHDRAEQGRVDDLWSMVYLLA-ELRGPLPW
||.|| ||..|   ||.| ||| |. |.|   |.| |||
GTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW
Kinase C56C10.6.AA CK1 246-284 30 3e-06 17.58 In-house 232-271 (271) Show / Hide 
Range on Protein: 246-284
Range on HMM: 232-271/271
Sequence Identity: 30% (12 aa)

GEMKRLHSDEVVLQN-SPMEFLEIAKYLRSLTYFHRPDYH
.|.|.  . |.  ..  | || .  .| |.| .. .||| 
MEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase C56C10.6.AA CK1 199-236 53 1.9e-05 14.9 In-house 178-216 (271) Show / Hide 
Range on Protein: 199-236
Range on HMM: 178-216/271
Sequence Identity: 53% (21 aa)

GTTRYCSIRMHDRAEQGRVDDLWSMVYLLA-ELRGPLPW
||.|| || .|   ||.| ||. |. | |   ||| |||
GTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW
Kinase C56C10.6.AA TyrKc 24-248 13 2.5e-05 -136.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-248
Range on HMM: 1-280/280
Sequence Identity: 13% (41 aa)

WQVIRKLGEGGCGSVYLVKNLEDETEAAMKAESNGAAGGCVLKL--EVAILKKL-SGKPHVCQFLFAARLT-------DFTYVIMTLL-GESLNKIVKRI
 . ..|||||  | ||. .     .. | |   ..|    .  .  |  |..||    |.. ... ...         .  ...| .  . .|..  .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ARQITVSSQVRIAANVLFCLKQIHDIGFIHRDLKPANMALGYKTNNDECRFFHVLDFGLARQFVVS------QSDQPSKL--MMR--RP--------RER
 ......  . ..  .      .|. ..|||||   |  .| .     ..   . ||||.|           ..   .|     .   |           
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVK---ISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

SLF------------------RGTTRYCS--------IRMHDRAEQGRVDDLWSM------------VYLLAELRGPLPWSSQSDKR-----VVGEM
. |                  .| . |          .... . .||.  .                .| . .      |  . ..|     .. ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK----QCWHEDPEDRPTFSEIHECF