Gene C54G4.1 (Nematode worm)

C54G4.1

Species: Nematode worm
Alias: C54G4.1, aSWK021, C54G4.1N, CE05507
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 8022500-8027629, WormBase Genetic Map location: I:2.42, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: MSKb

Classification

Group: AGC
Family: RSK
Subfamily: MSK

Sequence

Name Sequence Type Origin Length Description Download
C54G4.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
C54G4.1.AA Protein Genbank 785 None Fasta, JSON
C54G4.1.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 289 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of C54G4.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C54G4.1.AA AGC 17-284 33 9.90000000001e-174 453.68 In-house 1-395 (395) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-395/395
Sequence Identity: 33% (134 aa)

FALLRVLGKGAYGKVFLVRKVGGK---DHNTIYAMKVLRKTR-VLTKQK-TLEHTMAE------------RQVLERLRG---------TPFLVN-LFYAF
| .|.|.|||..|||.||||..|.   | . .||||||.| . .. |.| ..||||.|            |..||....          ||.|. |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTDTK--LHIVME----YVR-----GG-ELFTHLC---SRGHFDLEAARFVIAE-------LVVAIDSLHQ-RKVIYRD-LKLENILLDEEGHVKLTDFG
|....  |..|||    ||.     || |||.||.    .|.|| |.||| .||       .| |...||. ...|.|| ||.|||||||.||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKLFLPGE-------------------------------------------------LDRANSYCG--TIEYMSPEVINRPEGGYSDVVDWWS--LGVI
|.| .  ..                                                  ||... ||  | |||.||..      |.  .||||  ||..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

SFELLTGCSPFTVDG------AQNSSKDIAKRIM------TKKVPFP----------KTMDVDARDFIGQLLEKKLEKRLGYN-------GVDEIKNHKF
 .|.|||..||. |        ... ... ..||      ..||.||          . ....|.|.| .||.|  |||||..       |..|||||..
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

M
 
F
Kinase C54G4.1.AA MSK 20-279 48 1.4e-162 546.45 In-house 1-277 (277) Show / Hide 
Range on Protein: 20-279
Range on HMM: 1-277/277
Sequence Identity: 48% (133 aa)

LRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGHFDL
|.|||.|.|||.|..||....|....||||.|.|..|..|.|| |||..|||.||.....|..|||.||||.......||||..|||||||...|.|||.
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEE---GHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINR---PEGGYSDVVDWWSLGVIS
...|....|||.|.|..||...|.||||.||||.|.|   |||||.|||...||...| .|..|.|.|..||.||...|   ..|||....||||||||.
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FELLTGCSPFT--VDGAQ---NSSKDIAKRIMTKKVPFP----KTMDVDARDFIGQLLEKKLEKRLGYN--GVDEIK
...|||..||.  .|..|   ||...|.|||......||    ..|..||.|.|..||.|...||||.|  ...|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase C54G4.1.AA RSK 20-284 47 7.1e-153 514.18 In-house 1-278 (278) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-278/278
Sequence Identity: 47% (132 aa)

LRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGH---
|.|||.|.||||||.||....|...|||||||.|  . ..||...|||.||..||| .. ||.|.|.|||||..||...|||.|||||||||. ..|   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDE---EGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINR--PEGGYSDVVDWWSLGV
|. . |.|..||.|.|.. |||...|.||||.||||.|.   |||.||||||..|.| . .  .....|.||||| ||...|  ..||..  .|||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

ISFELLTGCSPFTVDGAQNSSKDIAKRIMTKK--VPFP--KTMDVDARDFIGQLLEKKLEKRLG--YNGVDEIKNHKFM
. .|.||||.||.  ...|..|.| |||...|  ...|  ...  .|.|.| ..|..  .||||   ....|||.|...
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase C54G4.1.AA Akt 17-284 43 1.3e-115 371.1 In-house 1-264 (264) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-264/264
Sequence Identity: 43% (121 aa)

FALLRVLGKGAYGKVFLVRKVGGKDHNTIY-AMKVLRKTRVLTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRG
| .|.|||||..||||||.|   ||.. .| |||||.| . . |   .|||..|| .|.. .  ||.||| |.||| .|| .||.|. |||||.||. ..
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYIIQKN-QVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR

HFDLEAARFVIAELVVAIDSLHQRKVIYRD-LKLENILLDEEGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINRPEGGYSDVVDWWS-LGVIS
 |. . ||| .||.. ||. ||.. .|||| ||.||||.|..||..||||||.|  .  . |.... ||| ||..||..|    |..  ||||. ||.. 
RFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG--NGHTKAVDWWGSLGCVM

FELLTGCSPFTVDGAQNSSKDIA---KRIMTKKVPFP--KTMDVDARDFIGQLLEKKLEKRLG--YNGVDEIKNHKFM
.|...|  ||        ..|.    | |....| ||  .. . ...|.| .||.|  .||||  .|...|||.| . 
YEMMCGRPPF-------YNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase C54G4.1.AA AktR 17-284 43 1.2e-106 360.57 In-house 1-268 (268) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-268/268
Sequence Identity: 43% (121 aa)

FALLRVLGKGAYGKVFLVRKVGGK-DHNTIYAMKVLRKTRVLTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRG
| ....|||||.|||.||.|   | | . .||||...|   . ...  .||  ||...| .   ||.|.|.|.|||..|| ..|||..|||||.|| ...
FHVYKCLGKGAFGKVYLVQK---KRDNQKQYAMKMIKK-KKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKK

HFDLEAARFVIAELVVAIDSLHQR-KVIYRDLKLENILLDEEGHVKLTDFGLSK-LFLPGELDRANSYCGTIEYMSPEVINRPEGGYSDVVDWWSLGVIS
.|. | ||| .|. . |.. |||. ..|||||| |||||||.||||.||||||| .|   . ..|.| ||| |||.||.|..   |.   ||||..|.  
KFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-KGHNKSVDWWAFGIFI

FELLTGCSPFTVDGAQNSSKDIAKRIMTKK-VPFPKTMDV--DARDFIG-QLLEKKLEKRLG--YNGVDEIKNHKFM
.|..||| ||.    ... ... ..| .|  ..||.....   ..|.|  .|| |  .||||   || .|||.|.. 
YEMVTGCPPFY----HKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase C54G4.1.AA S_TKc 17-284 33 2.2e-100 340.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

FALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRG--GELFTHLCSR
. .||..||||.|||...|...    . |.|.|...           ||.. |.|.|..  . |..|.|...||. ..|..||||. |  |.||.....|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

GH------FDLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINRPEGGYSD-VVDWW
|.      |.   |||...... |.. .|....|.|||| |||||||  |.|..||||....        ...||| .||.|||.     ||.   .|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCDWW

SLGVISFELLTGCSPFTVDGAQNSSKDIAKRIMTKKVPFPKTMDVDARDFIGQLLEKKLEKRLGYNGVDE----IKNHKFM
|.|.| .|.|.|. ||         . . |.|.          . .|.||| ..|.|  |||..   . .    ||.| ..
SCGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C54G4.1.AA RSK 17-284 34 2.5e-85 289.76 In-house 1-271 (271) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-271/271
Sequence Identity: 34% (97 aa)

FALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGH
. |....|.|...||....|. .|| |. ||||...|  .  | .    . .|| .| |    || | |.|.||. .|. ..|.  |||.||..|   . 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIIL-RYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FDLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEE----GHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINRPEGGYSDVVDWWSLGVI
|  . ..|. ||.  | . ||. ....|||| ||||.|.|    ||.|..|||..|  | .|   . . |.|..|| |||..|   |..  .||||.||.
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQ--GHDQACDWWSFGVL

SFELLTGCSPFTVDGAQNSSKDIAKRIMTKK----VPFPKTMDVDARDFIGQLLEKKLEKRLGY--NGVDEIKNHKFM
 .| |||| || . .  .. ..| .||   .     . . .    | | . ..|.   ..|||   ||| .||.|.. 
MYEMLTGCTPF-QNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase C54G4.1.AA Ciliate-E2 17-284 22 1.7e-76 260.48 In-house 1-365 (365) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

FALLRVLGKGAYGKVFLV--RKVGG------------------KDHNTIYAMKVLRKT------RVLTKQKTLEHTM----AERQVLERLRGTPFLVNLF
. .....|.|..|.|...  .||.                   |. . |||||...|       ...   .....       |...||.|   |......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQL-NHPNIIKMY

YAFQ--TDTKLHIVMEYVRGGELFTHLCSR-----------GHFDLEAARFVIAELVV---------------AIDSLHQRK-VIYRDLKLENILLDEEG
..||  .|... .||||. ||.|| .. ..           . |... .........                |. .||... .|.||.|.||||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

HVKLTDFGLSK----------------LFLPGEL---------------DRANSYCGTIEYMSPEVINRPE-------GGYSDVVDWWSLGVISFELLTG
 .|..||||||                ...                   . .|..||| .||.||..|. .        ||.  .|.|||||| .|.|.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

CSPFTVDGAQNSSKDIAKRIMTKKVPFP------------------KTMDVDARDFIGQ----LLEKKLEKRLGYNGVDEIKNHKFM
  ||             . |. .|. ||                  |  . .. |.| .    .|.|. |||..  | ..|.||...
KPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase C54G4.1.AA CAMK 22-284 20 6.3e-76 243.97 In-house 1-425 (425) Show / Hide 
Range on Protein: 22-284
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

VLGKGAYGKVFLVRKV-GGKDHN--------TIYAMKVLRKTRVLT------------------------KQKTLEHTMAERQVLERLRG------TPFL
.||.|..|||.|..    .....        . .|.|.. |...                          ..|...  . | ... .|.|       | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLFYAFQ------------TDTK--------LHIVM---EYVRGGEL----FTHLCSRGH---------------FDLEAARFVIAELVVAIDSLHQRK
..|. ...            | .|        ...||   ||. ||||    | .....|.               |. . ||...  .. |.. .|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIYRDLKLENILLDEE-----------------GHVKLTDFGLSKLFLPGELDR----------------------ANSYCGTIEYMS-PEVINR-P---
.. ||||.||||||.                  . .|..|||... | ||| ..                       . .||| |||. |||.|. .   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------EGGYSDVVDWWSLGVISFELLTGCSPFTVDGAQN---------SSKDIAKRIMTKKVP-FPKTMDV-----------------------DAR
        . .|.  .| ||.||| . .|.|..||  |  ..         . ... ..||. |    |. ..                        ...
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFIGQLLEKKLEKRLGYNGVDEIKNHKFM
|.| ..|..  |||.    .....||..|
DLIRKMLQVDPEKRM---TIEQCLNHPWM
Kinase C54G4.1.AA Pkinase 17-284 27 1.1e-74 259.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

FALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQ-KTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGG----ELFTHL
. ..|..|.|..|.|.. ...|  .   |.|.|...| .   .. .|. .. .| |.. || . |. | |...|........||||..||    .||...
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

C--SRGHF--DLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEEGHV----KLTDFGLSKLF-LPGELDRANSYCGTIEYMSPEVINRPEGGYSD
   ..| |  . . ..|.. ... ... .|....|.||||.||||.|..||.    |..||||.|.| .      ....|||..||.||||.    .|. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR-GGQYYGP

VVDWWSLGVISFELLTGCSPFTVDG----AQNSSKDIAKRIMTKKVPFPKTMD---------------------VDARDFIGQLLEKKLEKRLGYNGVDE
 ||.||.|.| .|.|.|  ||  .       .. . . .||| ....|.   .                      ...|||  .|.|. .||..    ..
KVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQ

IKNHKFM
|..|...
ILQHPWF
Kinase C54G4.1.AA Ciliate-E2-Unclassified 17-284 25 2.4e-73 250.0 In-house 1-352 (352) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

FALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKT---LEHTMAERQVLERLR------------------GTPFLVNLFYAFQTDTKL
. .....|.|..|||.....   |... .|||| . | ..  ...        | | . ....                     ||.|..||.||.. ..
YKIIKQIGQGGFGKVYKCQH---KKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI

HIVMEYVRGGELFTHLCSRGH-----------------FDLEAAR-----FVIAELVVAIDSLHQRK-VIYRDLKLENILLDEEG---HVKLTDFGLSKL
 |||||..||.|. ....|..                 |. ..|.     | .|........||. . .|.||.|.||||.|..|   ..|..|||.|| 
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

FLP-----GEL---------DRANSYCGTIEYM----SPEVINRPEGGYSDV--VDWWSLGVISFELLTGCSPFT-VDGAQNS-----------SKDIAK
        ..          ..... |||..||    .|||. . . . |    .|.|||||| .|.|.|  ||   .  |.             | . .
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

RIMTKKVPFPK--------TMDVDARDFIGQLLEKKLEKRLGYN-GVDEIKNHKFM
 |. |.. |||        . .  | ||| .|| |.|.|..... . ..|.|| ..
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase C54G4.1.AA CAMKL 17-284 27 1.1e-63 202.05 In-house 1-297 (297) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-297/297
Sequence Identity: 27% (83 aa)

FALLRVLGKGAYGKVFLVRK-VGGKDHNTIYAMKVLRKTRVLTKQKTLEH-----------TMAERQVLERLR--GTPFLVNLFYAFQTDTK------LH
. ....||||..||| | .        .. .|.|.. | .   ..... .              | | ...|.  . |  . |.  ..|...      ..
YRIGKTLGKGSFGKVKLATHIRTT---GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

IVMEYVRGGE--LFTHLCSRGH----FDLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEEG--HVKLTDFGLSKLFLP---GELDRANSYCGTI
.||||. |||  || .....||    .. . ||.    .| |.. .|..... ||.|.||||||| |   .|..|||.| .. |   |. .  .  ||. 
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

EYMSPEVINR-PEGGYSDVVDWWSLGVISFELLTGCSPFTVDG----AQNSSKDIAKRIMTKKVPFP--KTMDVDARDFIGQLLEKKLEKRLGYNGVDEI
.||.||....  .  .   || ||.||| . ...|  ||  |      ..      ..||.    .|  . .. |.||.| ..|... |||     ...|
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRP---TIHQI

KNHKFM
.||..|
MNHPWM
Kinase C54G4.1.AA Pkinase_C 304-347 31 5.6e-12 45.43 Pfam 1-46 (46) Show / Hide 
Range on Protein: 304-347
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

RIGHDLDTQFFSAEFTSQPPLYSP---AESPLNANTLFRGYSYVSPS
.. ...||. |  |||..|| ..|     .. ... .|||..||.|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase C54G4.1.AA S_TK_X 285-345 29 7.2e-12 46.68 SMART 1-79 (79) Show / Hide 
Range on Protein: 285-345
Range on HMM: 1-79/79
Sequence Identity: 29% (23 aa)

SSIDWDAAVK--RTLKPVIVPRIG----HDLDTQFFSAEFTSQPPLYSPAESPLNAN-------TL-----FRGYSYVS
..||||.  .  ....| ..|.|     .. ||  |  |||...| ..|...|| ..       |.     |||..|| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase C54G4.1.AA Pkinase_Tyr 150-169 45 0.000144 16.09 Pfam 141-160 (270) Show / Hide 
Range on Protein: 150-169
Range on HMM: 141-160/270
Sequence Identity: 45% (9 aa)

NILLDEEGHVKLTDFGLSKL
|.|..|...|| .||||...
NCLVTENNVVKICDFGLARD
Kinase C54G4.1.AA Pkinase_Tyr 17-33 35 0.010904 9.73 Pfam 1-17 (270) Show / Hide 
Range on Protein: 17-33
Range on HMM: 1-17/270
Sequence Identity: 35% (6 aa)

FALLRVLGKGAYGKVFL
  ....||.||.|.|..
ITFGKKLGEGAFGEVYK
Kinase C54G4.1.AA MSK 382-666 48 1.9e-169 569.24 In-house 1-277 (277) Show / Hide 
Range on Protein: 382-666
Range on HMM: 1-277/277
Sequence Identity: 48% (144 aa)

KSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVS-------QKFASQAQREARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLERFTE
....| .|.|.|...|.|.....|...|.||.|       .|.|...|.|...|||.|.|||||.||....|..|.|||||...|.||...||| |.|.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

SEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCFTLQYAAPEVLDV
||...|||.||.||...|.|.|.|||||||||||..........|.|||||||.|...|...||                     |||||.|.|||.|..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS---------------------PCFTLHYMAPEMLRR

GDSQPE-YNEQCDLWSLGVVLFTMLSGQVPFH--ARSRQ---ESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWL
|..|.. |.|.||.|||||.|.|||.|||||.  ...||   .|..|||.|||..||||.|.||.|.|.|||.||..|||.||||||.|..|.||.|.
GYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase C54G4.1.AA RSK 382-666 32 1.9e-138 466.25 In-house 1-278 (278) Show / Hide 
Range on Protein: 382-666
Range on HMM: 1-278/278
Sequence Identity: 32% (99 aa)

KSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQ-------REARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLER---
 ...| .|.|.....|.|..   | ..|.|..... . |.|       .| .|||..|.||.||.||... .....||.|| . | ||.....| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSS-ARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCFTLQYAAPE
|.|.||...|...|.||..||.. |.||||||||||..... . ....|.||||.........|....                     .|.|..|.|||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMT---------------------FCYTIEYMAPE

VLDVGDSQPE-YNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLS-----MQELTAHM
.| ... |.. ....||.|||||....||.|..||.. ...... |||.||....||.|...| ..|..||.||...|..||.|||.     ..|. .|.
MLKRAN-QQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHP

WL
|.
WF
Kinase C54G4.1.AA AGC 382-666 22 4.1e-104 269.49 In-house 1-395 (395) Show / Hide 
Range on Protein: 382-666
Range on HMM: 1-395/395
Sequence Identity: 22% (96 aa)

KSDAGLLGKGAFSVVRRCERV------VDGAQFAVKIVSQKF---------ASQAQRE------------ARILEMVQG---------HPNIVQ-LHDVH
     ..|||.|. |. ....        | ..|.|... |            ....|             .|||....         ||.||. ||   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

SDPLH--FYLVMEILT---------GN-ELLERIR---KLERFTESEAADIMRQ-------LVSAVKYLHD-KRIVHRD-LKPENILFESIDSSARLRLV
 |. |   |.||| .          |  ||. ...   |  ||.|..|  .. .       .|.|. |||. . |.||| |||||||. .      ..|.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGFARLLPNSMEQQLKSVQ--------------------------------------------VLRKMYGLIAHNHSLHSETPCFTLQYAAPEVLDVGD
|||..  ..|..|.. .  |                                                . |            || | .| |||.|    
DFGLCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCG------------PC-TPEYMAPEIL----

SQPEYNEQCDLWS--LGVVLFTMLSGQVPFHARSRQ------ESATEIMQRICRAEFSFTGD------------AWTNVSADAKNLITGLLTVDPKKRLS
    |. .|| ||  ||.... ||.|. ||.. ..|      ..  |..|.|.  .. .. .            .. ..| .||.||..||..||.||| 
----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLG

----------MQELTAHMWL
           .|. .| | 
CGGNDFGDKGAEEIKNHPWF
Kinase C54G4.1.AA CAMK 387-666 22 6.2e-102 329.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 387-666
Range on HMM: 1-425/425
Sequence Identity: 22% (102 aa)

LLGKGAFSVVRRCERVVDG------------AQFAVKIVSQKFAS-------------------------------QAQREARILEMVQG------HPNI
 ||.|.|..|..|..  ..             ..|.||.. | ..                               . .|| .|. ..||      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLHDVHSD-------------------PLHFYLVM---EILTGNEL----LERIRKL---------------ERFTESEAADIMRQLVSAVKYLHDKRI
..|..|  |                   . |.|.||   |  .| ||    ...|..                 ||||.||. ..||..|||.|.|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILFESIDSS--------------ARLRLVDFGFARLL-----------PNSMEQQLKSVQVLRKMYGLIAHNHSLH---------SETPCF
|||||||||||. . ...              . . ..|||||. .           ....| . ..                            .|.| 
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN-----------------QWTTPTEGQKMKTFCG

TLQYAA-PEVLD---VGDS-------QPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQE---------SATEIMQRICRAEFSFTGDA-----------
|. |.| ||||     ...       .| |...|| ||.||.|..||.|  || . ...|         .  |....|......|  .            
TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE

-WTNVSAD--------AKNLITGLLTVDPKKRLSMQELTAHMWL
 | ..| .        .|.|| ..|.|||.||.. ..  .| |.
WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase C54G4.1.AA S_TKc 382-666 30 3e-92 313.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 382-666
Range on HMM: 1-231/231
Sequence Identity: 30% (93 aa)

KSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQREARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTG--NELLERIRKLER------FT
     ..|||||..|..|  . .| ..|.||..     ...|| .||..  .|||||.|.||  |  |.|.||| . |   .|...|.|  |      |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

ESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCFTLQYAAPEVLD
| .|. .|.|...|..|.|...|.||||||||||. .     .. . |||.||.|                              | | |. | ||||| 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------------------TTFCGTPWYMAPEVL-

VGDSQPEYNE-QCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTA-------HMW
       |.   || ||.|..|. ||.|. ||.         .....|.              | .||..| ..|..||.||..  |. .       | |
------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase C54G4.1.AA Pkinase 386-666 26 3e-74 257.8 Pfam 5-293 (293) Show / Hide 
Range on Protein: 386-666
Range on HMM: 5-293/293
Sequence Identity: 26% (85 aa)

GLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQR-------EARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTGN----ELLERIR--KLERF
. .|.|.|..|..| .. .| ..||||.. . ..  ..       |..|. .. .|||||.|.|.  |. | |.||| . |     .| ..|.  .  .|
RKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF

--TESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFE-SIDSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCFTLQYAAP
  .| |. ..|.|......|.|...|.||||||||||.    . .|.... |||.|...                      . ..    |.| |. |.||
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------------Y-NNS-MTTFCGTPWYMAP

EVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHAR---SRQESATEIMQRICRAEFSFTGDAWTNVS-----------------ADAKNLITGLLTV
||.    ....|   .| ||.|..|. ||.|. ||  .    .  .  ....|| .....|  . | ..|                  ..| .|...|..
EVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPKKRLSMQELTAHMWL
|||||.. ...  | |.
DPKKRPTAEQILQHPWF
Kinase C54G4.1.AA Ciliate-E2 378-666 22 5.2e-72 245.54 In-house 1-365 (365) Show / Hide 
Range on Protein: 378-666
Range on HMM: 1-365/365
Sequence Identity: 22% (90 aa)

YKLDKSDAGLLGKGAFSVVRRCERVVDGAQFA----------------VKIVSQKFASQAQREARILEMVQG----------------------HPNIVQ
||. |    ..|.|.|..|..|..  .. |||                |||      .. ... .......                       ||||..
YKFIK----KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIK

LHDVHS--DPLHFYLVMEILTGNELLERIRKL-----------ERFTESEAADIMRQLVS---------------AVKYLHDKR-IVHRDLKPENILFES
....    |  ..||||| . |..|...|..            ..||| |...||.|...               |..||| |  |.|||.|||||||  
MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

IDSSARLRLVDFGFARLLPNS---------MEQQLKSVQVLRKMYGLIAHNHSLHSETPCF------------TLQYAAPEVLDVGD-----SQPEYNEQ
      . ..|||... . ..         ..  .   .   ...| ..           .            |. | |||.|  ..      | .|...
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-----------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYK

CDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGD--------------AWTNVSADAKNLITG----LLTVDPKKRLS-MQELTAHMW
||.|||||.|. ||.|. ||            .| |.  ...|                  | ..| ..|.||      .| .||.||.. ....  | |
CDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPW

L
.
F
Kinase C54G4.1.AA Ciliate-E2-Unclassified 378-666 23 6.6e-58 198.69 In-house 1-352 (352) Show / Hide 
Range on Protein: 378-666
Range on HMM: 1-352/352
Sequence Identity: 23% (87 aa)

YKLDKSDAGLLGKGAFSVVRRCERVVDGAQF-------AVKIVSQKF--ASQAQREARILEMVQG--------------------HPNIVQLHDVHSDPL
||. |     .|.|.|..|..|..  .. |.        ..|..||    .. .    ..|| .                     ||.|| ....  |  
YKIIK----QIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ

HFYLVMEILTGNELLERIRKL-----------------ERFTESEAA-----DIMRQLVSAVKYLHDK-RIVHRDLKPENILFESIDSSARLRLVDFGFA
..|.||| . |..|.. |.|                  ..||| .|.     ....|.... .||| |  |.|||.||||||| .  .  .... |||..
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

RLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCFTLQYA----APEVLDV-GDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESAT------
. . .. ... .. |        .. . . .. | | |..|     |||||.  . ...   ..|| |||||.|. || |. || .... .. .      
KKYQQNNNCD-TNQQ------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI

------EIMQRICRAEFSFTGDAW----TNVSADAKNLIT----GLLTVDPKKRLSMQELTAHMWL
      .. | |.  ...|    |     ..|  ||..|.     .| ..|.||......  | |.
NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase C54G4.1.AA CAMKL 378-537 33 4e-51 161.33 In-house 1-191 (297) Show / Hide 
Range on Protein: 378-537
Range on HMM: 1-191/297
Sequence Identity: 33% (65 aa)

YKLDKSDAGLLGKGAFSVVRRCER-VVDGAQFAVKIVS------QKFASQA------------QREARILEMVQ--GHPNIVQLHDVHSDPLH------F
|.. |     ||||.|..|. ..     | . |.||.         ....             .||..|..|..  .||||..|..|  .| |      .
YRIGKT----LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI

YLVMEILTGNE--LLERIRKL----ERFTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLRLVDFGFARL-LP--NSMEQQLK
|||||   | |  |...|.|     .|..|.||  . ||.||||.|.|...|||||.||||||. . ...  . ..||||. .  |  .  .| ||
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLK
Kinase C54G4.1.AA RSK 378-525 33 3e-44 153.34 In-house 1-152 (271) Show / Hide 
Range on Protein: 378-525
Range on HMM: 1-152/271
Sequence Identity: 33% (53 aa)

YKLDKSDAGLLGKGAFS---VVRRCERVVDGAQFAVKIV--SQKFAS---QAQREARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKL
| | .     .|.|.||   |...|..   . ..|.||.  ... ..   ..  |  ||. .. ||.||.||.|  |  . |..|. . | .|. |. | 
YELHEC----IGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGH-HPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQ

ERFTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESI-DSSARLRLVDFGFA
  |.|.|....|. . .|. ||| . ||||||||||||. .   .   ....|||||
KMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFA
Kinase C54G4.1.AA AktR 378-666 26 2.7e-31 110.28 In-house 1-268 (268) Show / Hide 
Range on Protein: 378-666
Range on HMM: 1-268/268
Sequence Identity: 26% (80 aa)

YKLDKSDAGLLGKGAFSVVRRCERV-VDGAQFAVKIVSQ------KFASQAQREARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLE
... |    .||||||. |  ...   .. |.| |...       ........|  |.|| . || ||.||.   .  . ...||.  | ||.  ..| .
FHVYK----CLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKK

RFTESEAADIMRQLVSAVKYLHDK-RIVHRDLKPENILFESIDSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHN-HSLHSETPCFTLQYAA
.|.|..|  .. | . |. |||..  |. |||||||||   .|.   ....||| ..                     |   .  . .  . | | .| |
KFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENIL---LDEDGHVKITDFGLSK---------------------LQFMMHYDEKAYSFCGTPEYMA

PEVLDV--GDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICR-AEFSFTGDAWTNVSADAKNLIT-GLLTVDPKKRLS-----MQE
||..    |     .| ..|.|..|.... |..|. || . ....    ....|..  .| ..    ...|  .|.||. .||  .|.|||       .|
PEMITKKKG-----HNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQ--MFQKIKIKQQNKFPYP----SYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEE

LTAHMWL
.  | | 
IKSHPWF
Kinase C54G4.1.AA RSK 559-666 35 2.9e-30 105.25 In-house 164-271 (271) Show / Hide 
Range on Protein: 559-666
Range on HMM: 164-271/271
Sequence Identity: 35% (40 aa)

TPCFTLQYAAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSM-
|.| | .| |||||    ..  . . || ||.||....||.|  ||... |..   .| |||  . ||.|.  | ..|. || |....|..|| .||.  
TFCYTANYMAPEVL----KRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPM-NIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAG

----QELTAHMWL
    ..   | |.
PNGVEQIKQHPWF
Kinase C54G4.1.AA CAMKL 563-666 26 1.6e-24 75.07 In-house 196-297 (297) Show / Hide 
Range on Protein: 563-666
Range on HMM: 196-297/297
Sequence Identity: 26% (29 aa)

TLQYAAPEVLDVGDSQ--PEYN-EQCDLWSLGVVLFTMLSGQVPFHARS----RQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRL
.. |.|||..    .    .|.  . | ||.||.|..|. |..|| . .     ..   . . .| .  . .  . |  || |...|| ..|.|.|.|| 
SPPYMAPEIF----QGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYP--PIWYHVS-DCRDLIRKMLQVNPEKRP

SMQELTAHMWL
.....  | |.
TIHQIMNHPWM
Kinase C54G4.1.AA Akt 424-507 38 1.4e-13 39.75 In-house 50-133 (264) Show / Hide 
Range on Protein: 424-507
Range on HMM: 50-133/264
Sequence Identity: 38% (33 aa)

EARILEMVQGHPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLERFTESEAADIMRQLVSAVKYLHDKRIVHRD-LKPENIL
| .||.... || ||.||    .. . |.||.   | ||   ... .||.|..|     ....|  .|| | |. || |||||||
ERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENIL
Kinase C54G4.1.AA TyrKc 378-664 20 3.2e-13 -8.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 378-664
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YKLDKSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVS-QKFASQAQREARILEMV-QGHPNIVQLHDVHSDP-------LHFYLVMEILTGNELLERIRK
 .|.|     || ||| .|....      | ||| .   .      |||||. ..   |||||.|. | ...          ..|||   .  |....||
ITLGK----KLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LER-FTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLRLVDFGFARLLPNS----MEQQLKSVQ---VLRKMYGLIAHNHSLHSETP
 .. .. ..  ... |  .   |||.|...||||   |.|   ...  . .  ||| .| . .      ... ....     . |               
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL---VGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM---------------

CFTLQYAAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLS-GQVPFHA-----RSRQESATEIMQR-ICRAEFS-----FTGDAWTNVSADAKNLITGLLT
 . .   |||..       ..... | || ||... ... || |         | ||    ..|.   .   .     |        ...  ....    
-LPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-----VCCPDEMYQIMKQCWH

VDPKKRLSMQELTAHM
 ||..| ...|.   .
EDPEDRPTFSEIHECF
Kinase C54G4.1.AA Akt 584-666 31 9.8e-12 33.71 In-house 182-264 (264) Show / Hide 
Range on Protein: 584-666
Range on HMM: 182-264/264
Sequence Identity: 31% (28 aa)

QCDLWS-LGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRL-----SMQELTAHMWL
..| |. ||.|.. |. |. ||... ..    . .. |  ..  |      ..| ..|.||.|||. ||||||       ||. .| |.
AVDWWGSLGCVMYEMMCGRPPFYNQDHH----QMFKKIKNQPVKFPDK--DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase C54G4.1.AA Pkinase_Tyr 378-501 26 4.4e-11 38.16 Pfam 1-137 (270) Show / Hide 
Range on Protein: 378-501
Range on HMM: 1-137/270
Sequence Identity: 26% (38 aa)

YKLDKSDAGLLGKGAFSVVRRCERV----VDGAQFAVKIVSQKFASQA------QREARILEMVQGHPNIVQLHDVHS-DPLH--FYLVMEILTGNELLE
 ...|     ||.||| .|....       .. . |||.. ..  ...       |||.|.     |||||.|. | . .  .   |.|||   .  ||.
ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

RIRK----LERFTESEAADIMRQLVSAVKYLHDKRIVHRDL
  ||     ...| ..  .. .|  ..  ||..|...||||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase C54G4.1.AA Pkinase_Tyr 568-604 28 6.680442 0.29 Pfam 182-216 (270) Show / Hide 
Range on Protein: 568-604
Range on HMM: 182-216/270
Sequence Identity: 28% (11 aa)

APEVLDVGDSQPEYNEQCDLWSLGVVLFTMLS-GQVP-F
|||..  |     .... | || ||... ... |. | .
APECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTY