Gene C50F4.10 (Nematode worm)

C50F4.10

Species: Nematode worm
Alias: aSWK124, C50F4.10, CE05474
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 9534090-9532640, WormBase Genetic Map location: V:2,

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
C50F4.10.AA Protein Genbank 332 None Fasta, JSON
C50F4.10.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of C50F4.10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C50F4.10.AA Worm6 34-301 43 2.3e-148 499.19 In-house 1-279 (279) Show / Hide 
Range on Protein: 34-301
Range on HMM: 1-279/279
Sequence Identity: 43% (123 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQFALKCES--AQSPLQMLKVEAFVLQTIAKRGSRHFCDIEDIGKFQG--IHYIVMHMIGRALVDYMKTSMSG
|...|||..|.|...|... .|.... ||||.|||.  .... ||||.|..||........||||.||| ||..    .||||...|. | |..|... .
WKVTKKIGEGGFGAVYKVEDKSDKKK-KQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDR

AISVNCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGR---KDRNELGKLYLLSFGISR--RYLDSKNQMRKPR-DNVEFRGTVRYASLNCHQLQELN
..|....|...|| .||.||||||||||||.||.| |.||   |..||. ..|.| ||..|  .|.. .|..|.|| ....||||||||.|.||. ||..
KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQC

RKDDLESAFYVIVEMITGQLPWKGLPDGAAVA-RVKQQSRHP-SAIALFLRAPCPMEELREVMILIDSYNYFTAPDYVNI
||||.|| ||..||||.|.|||... |  .|. . |.. |.  .... .. .|||.||....|  ||.|.|...||| .|
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase C50F4.10.AA CK1 34-301 29 3.1e-103 349.26 In-house 1-339 (339) Show / Hide 
Range on Protein: 34-301
Range on HMM: 1-339/339
Sequence Identity: 29% (100 aa)

WTIEKKIAQGDFN-FIYMC-----NGSSNMSNY--KQFALKCESAQSPLQ-MLKVEAFVLQTIAKRG---------SRHFCD----------IEDIGKFQ
|...|||..| |   ||..       ..| ..|  ...|.|.|...|  | ... |..... . ..|         ..|||.          ... |. .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

GIH-YIVMHMIGRALVDYMK--TSMSGAISVNCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKD-----------RNELGKLYLLSFGISR-RYL
. . |.|| . |. | |..|  . . . .|....| ..||..||||..|.|||||||.||.|.|.||..           .||. ..|.. ||..| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DS------------KNQMRKPRD---NVEFRG-TVRYASLNCHQLQELNRKDDLESAFYVIVEMITGQ--LPWKGLP------DGAAVARVKQQSRHP-S
|.            ..|.| ||.   .. ||| |.||.|.|||. .|. |.|||.| ||...|.. |.  |||...       | . | . |.....   
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKK

AIALFLRAPCPME------ELREVMILIDSYNYFTAPDYVNI
   .|. ..||..      |. ..|  |.|..|...||| .|
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase C50F4.10.AA TTBK 34-301 39 2.1e-66 226.89 In-house 1-257 (257) Show / Hide 
Range on Protein: 34-301
Range on HMM: 1-257/257
Sequence Identity: 39% (105 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNY-KQFALKCESAQSPLQMLKVEAFVLQTIAKRGSRHFCDIEDIGKFQGIHYIVMHMIGRALVDYMKTSMSGAIS
|.. ||| .| |  ||      .| |   | |.| |||| | | || |  ||.     |  | |     |      |.||.. |. | |       |. |
WKVVKKIGGGGFGEIYEAK---DMINHHEQVAIKVESAQQPKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFS

VNCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRRYLDSKNQMRKPRDNVEFRGTVRYASLNCHQLQELNRKDDLESAF
.  .| .|.|.....|  |. || ||| ||||   ||   .   | |.| ||  |.|. .. . | ||    ||||||||| | |. .|. |.||| | |
LSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST-CRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLF

YVIVEMITGQLPWKGLPDGAAVARVKQQSRHPSAIALFLRAPCPMEELREVMILIDSYNYFTAPDYVNI
|. || . |||||  . |   | ..|..  |.      |   || .|..  |  | | ||.. |||. |
YMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHR-----MLLKHCP-HEFHQFMDHIKSLNYEDRPDYQLI
Kinase C50F4.10.AA TTBKL 34-305 32 8.7e-65 217.66 In-house 1-288 (288) Show / Hide 
Range on Protein: 34-305
Range on HMM: 1-288/288
Sequence Identity: 32% (95 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQ-FALKCESAQ-SPL-QMLKVEAFVLQTIAKRGSRHFCDIEDIGKFQGIHYIVMHMIGRALVDYMKTSMSGA
|.|.|.|..| |  .|.    ..|.. |. .|.| |. . .   . .| |. ||   ...||.||. . . || .. ...||.. |. | | .|..  . 
WMIVKMIGEGGFGQVYHV---WDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKK

-ISVNCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELG--KLYLLSFGISRRYLDSKN-----------QMRKPRD---NVEFRGTVRYAS
 .|.  .. .|||...|| ..| |||||||.||.|.|.| .|....    .||. ||..|.|... .           .||.||.    ..||||.||.|
RFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCS

LNCHQLQELNRKDDLESAFYVIVEMITGQLPWKGLPDGAAVARVKQQSRHPSAIALFLRAP----CPMEELREVMILIDSYNYFTAPDYVNICNIL
.| |. .|. |.||| |..|.|.|.  | |||... |   .. .|... .    .||   |    ||. |. ..|  . | .|   |||  | ...
PNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDE---DLFKDMPRDHDCPS-EFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C50F4.10.AA Dual 61-305 27 5.2e-43 142.41 In-house 29-282 (282) Show / Hide 
Range on Protein: 61-305
Range on HMM: 29-282/282
Sequence Identity: 27% (72 aa)

KQFALKCESAQSPLQML--KVEAFVLQTIAK-------RGSRHFCDIEDIGKFQGIH--YIVMHMIGRALVDYMKTSMSGAISVNCALSVGIQLIEALED
| ..|| ||      ||  |||. |  ..|         | ..| .  |.|| .  .  |.||   |  | . ..  . |. |. |.  |.|| ..|. |
KCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQD

LHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRRYLD-SKNQMRKPRDNVEFRGTVRYASLNCHQLQELNRKDDLESAFYVIVEMI-TGQ-LPWK
||. |..||. ||.|   |  ..    ..|.. |.| | |.| .  . | .| .| . |. |||.  |   ..  ||||||.  | .  ..  .  ..|.
LHSIGYLHRNIKPANFHCGLGMDET--TVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWR

GLPDGAAVARVKQQSRHPSAIALFLRAPCPMEELREVMILIDSYNYFTAPDYVNICNIL
 ..|   .   |.      .   . ..|   ..|.   .....| | ..||| .. | |
KECDCNMMIKQKDNFMYHFDKHQYSHIP---RRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase C50F4.10.AA CK1-Unique 34-246 29 4.2e-37 126.16 In-house 1-233 (337) Show / Hide 
Range on Protein: 34-246
Range on HMM: 1-233/337
Sequence Identity: 29% (68 aa)

WTIEKKIAQGDF---NFIYMCNGSSNMSNYKQFALKCE--SAQSPLQMLKVEAFVLQTIAKRG-----SRHFCDIEDIGKFQGIHYIVMHMIGRALVDYM
| . |.|  |..   ....  |     .  . .. | |  ..| . | |..|  |.  | |       .|||| ..|..  .   .||| |.|. ..   
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEE-C

KTSMSG-AISVN------CALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRR--YLDSKNQMRKPRDNVEFRGTVRYASL
.  | . ..  |      ||.  | |  ...|  |  ||.||..|| |.| .     ..  .| | .||.||   ..  .|.|.||  . |||. .|.. 
CMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPC

NCHQLQELNRKDDLESAFYVIVEMITGQ--LPWK
 |||..|. |.||.|| || ..  . .   | ||
SCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase C50F4.10.AA CK1-Unclassified 34-248 32 9.9e-34 96.94 In-house 1-219 (244) Show / Hide 
Range on Protein: 34-248
Range on HMM: 1-219/244
Sequence Identity: 32% (73 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQFALKCESAQSPLQMLKVEAFVLQTIAKRG-----SRHFCDIEDIGKF--QGIHYIVMHMIGRALVDYMKTS
  ...|| || |  || |    || . . .|.| |.. |   .|. || ..|   ..      ....  .   |.   ... ..||   |. | |...  
YRVIEKIGQGSFGEIYKC---INMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM-

MSGAISVNCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFG-RKDRNELGKLYLLSFGISRRYLDS-KNQMRKP-RDNVEFRGTVRYASLNCHQLQELN
. .  |.   |  . |.|. .| |||..|||||.|| |.. | .   ..  ..|.  ||.| ||.|. |..   | |.|  . || ||||.| |.  |  
CNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLG--KNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQS

RKDDLESAFYVIVEMITGQLPWKGL
|.|||||  ||..  . |.||| ..
RRDDLESLGYVLIYFLKGSLPWQNI
Kinase C50F4.10.AA CK1-A 34-248 31 4.3e-27 92.7 In-house 1-208 (261) Show / Hide 
Range on Protein: 34-248
Range on HMM: 1-208/261
Sequence Identity: 31% (69 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQFALKCESAQSPLQMLKVEAFVLQTIAKRGSRHFCDIEDIGKFQGIHYIVMHMIGRALVDYMKTSMSGAISV
. . .||  | |  ||.   . |. | .. |.| ||..     |  || | . ..  |   .  ..  |. .    .|| ..| .| |      .   ..
YRLVRKIGSGSFGDIYL---GINITNGEEVAIKMESNKARHPQLIYEAKVYRILQ--GCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNF-CKRRFTM

NCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRRYLDSKNQMRKP-RDNVEFRGTVRYASLNCHQLQELNRKDDLESAF
   | .  |.|  .| .|. .|||||.|| |   |  .|    ||.|. ||....| ||. .   | |.  .  ||.||||.| |.  |  |.||.||  
KTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI-GR-HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMG

YVIVEMITGQLPWKGL
||..    |.|||.|.
YVMMYFNRGKLPWQGM
Kinase C50F4.10.AA CK1 139-248 42 5.2e-27 90.13 In-house 110-219 (271) Show / Hide 
Range on Protein: 139-248
Range on HMM: 110-219/271
Sequence Identity: 42% (47 aa)

VGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRRYLDSKNQMRKP-RDNVEFRGTVRYASLNCHQLQELNRKDDLESAFYVIVE
.. |.|. .| .||..|||||.|| |.. ||   ..  ..|.  ||.. ||.|.|..   | |.|  . ||.||||.| |.  |  |.||.||  ||.. 
IADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMY

MITGQLPWKGL
 . |.||| ||
FLRGSLPWQGL
Kinase C50F4.10.AA CK1-D 34-248 32 8.2e-27 91.52 In-house 1-208 (261) Show / Hide 
Range on Protein: 34-248
Range on HMM: 1-208/261
Sequence Identity: 32% (70 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQFALKCESAQSPLQMLKVEAFVLQTIAKRGSRHFCDIEDIGKFQGIHYIVMHMIGRALVDYMKTSMSGAISV
. | .||  | |  ||.     |...    |.| |....    |..|. . ...  .|      |  .|.      .|| ..| .| |      .   |.
YRIGRKIGSGSFGDIYHGT---NIQTNEEVAIKLECIKTKHPQLHIESKFYKMM--QGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNY-CHRKFSL

NCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRRYLDSK-NQMRKPRDNVEFRGTVRYASLNCHQLQELNRKDDLESAF
   | .. |.|  .| .|   |||||.|| |   |   | ..   |.. ||...|| |..  |    |.| .  || ||||.| ||  |  |.|||||  
KTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLG

YVIVEMITGQLPWKGL
||..    | |||.||
YVLMYFNRGSLPWQGL
Kinase C50F4.10.AA S_TKc 34-293 19 1.4e-12 7.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-293
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQFALKCESAQSPLQMLKVEAFVLQTIAKRGSRHFCDIEDIGKFQGIHYIVMHMIGR---ALVDYMKTSMSGA
..| .|| .| |   | |   .     ...|.|. .     .... |  .|.     .  . . . |.    .  |.|| ...     | ||.|   .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----ISVNCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRRYLDSKNQMRKPRDNVEFRGTVRYASLNCHQLQELNR-K
    ..   | ..  |...||| .|. |.|||||||.|| . .        . .  ||..|..               | ||  | .         .. |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCK

DDLESAFYVIVEMITGQLPWKGLPDGAAVARVKQQSRHPSAIALFLRAPCPMEELREVMILIDS-------YNYF
 |  |   .. ||..|. |.    . ... ..      |.|. .  .  .   | |     .           .|
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C50F4.10.AA Pkinase 142-165 58 2e-06 23.55 Pfam 116-139 (293) Show / Hide 
Range on Protein: 142-165
Range on HMM: 116-139/293
Sequence Identity: 58% (14 aa)

QLIEALEDLHNCGFIHRDLKPSNI
|....|| .|..|.|||||||.||
QILRGLEYCHSMGIIHRDLKPENI
Kinase C50F4.10.AA TyrKc 34-305 17 0.000162 -149.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-305
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQFALKCESAQSPLQMLKVEAFVLQTI-------------AKRGSRHFCDIEDIGKF---QGIHYIVMHMIGR
 | .||.  | |  .| .  .       | | |.  . . ....  || ..  .             .  ..|          |   . .  .. .| . 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---------FMYIEPLMIVMEYMPHG

ALVDYMKTSMSGAISVNCALSVGIQLIEALEDLHNCGFIHRDLKPSNICFGRKDRNELGKLYLLSFGISRRYLDS-------KNQMRKPRDNVEFRGTVR
.| || . .    ...   ||  .|  .  | ||  ..|||||   |.  |..            || ||   |        .  . | ...  .   .|
DLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YASLNCHQLQELNRKDDLESAFY----------VIVEMIT-GQLPWKG-----LPDGAAVARVKQQSRHPSAIA----LFLRAPCPMEELREVMILIDSY
  .. |            .. |           .. |. | || |. |     ...  ....|||  | |         |   .|  .|. ..|     .
WMAPECI----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHE

NYFTAPDYVNICNIL
.    |   .|. ..
DPEDRPTFSEIHECF
Kinase C50F4.10.AA CK1 34-81 31 0.058997 2.76 In-house 1-47 (271) Show / Hide 
Range on Protein: 34-81
Range on HMM: 1-47/271
Sequence Identity: 31% (16 aa)

WTIEKKIAQGDFNFIYMCNGSSNMSNYKQF---ALKCESAQSPLQMLKVEA
  ...|| || |  || .    || . ...   | | |.. |  ..|. ||
YRVGRKIGQGSFGDIYLGI---NM-TNGEENHVAIKLEKNKSKHPQLHYEA