Gene C49C3.10 (Nematode worm)

C49C3.10

Species: Nematode worm
Alias: C49C3.10, C49C3.10A, CE19749, C49C3.10a, aSWK197, C49C3.10HRDcorrected
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 17338944-17336805, WormBase Genetic Map location: IV:29.36,

Classification

Group: CMGC
Family: MAPK
Subfamily: JNK

Sequence

Name Sequence Type Origin Length Description Download
C49C3.10.AA Protein Genbank 384 None Fasta, JSON
C49C3.10.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 298 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of C49C3.10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C49C3.10.AA JNK 20-324 49 9.69999999999e-218 729.64 In-house 1-309 (309) Show / Hide 
Range on Protein: 20-324
Range on HMM: 1-309/309
Sequence Identity: 49% (152 aa)

RYVNVQPFQFDKPFVVHAFDQVLGRPVVIKKVMLPDSLHDRQPWRRAQRELNCMLNIEDDNVVKMYSTFTPAENPLKMTEFYIVREYMHGTMKNLSASTF
...   ..|.....|..|||||....|.|||.|.||.......|.||.||..||..|...|..|||..|||.|........|||.|||.........|||
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

NEGGHRTVKSIFFDICRGVQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKEDPT-SNTPYIVQRFYRAPEIICETTDNNKTNVDIWSLGCILAEL
.|..|......|...|.|...||.|.|.||||||.||..||....|.|||||...|||| ..|||.|.|.|||||.||...||.|.||||||.|||.||.
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

LTGHVLFRGKDHIDQFILMVQFLGNAGPSFYSQMNEHARNFLLRYNLDQYQAPINFYSRFPDTVFQGVLQFEPK---ECDMSRDLLFRMLVINPDDRLNI
...||||.|||||||......|||...|.|..||..|.||.....|.|.|..|.||...||||.|..|.|.|||   .|.|.|||||||||||||||...
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRISV

QMVLSHPYL
...|.|||.
DDALQHPYI
Kinase C49C3.10.AA MAPK 21-324 29 8.10000000001e-123 414.33 In-house 1-328 (328) Show / Hide 
Range on Protein: 21-324
Range on HMM: 1-328/328
Sequence Identity: 29% (100 aa)

YVNVQPFQFDKPFVVHAFDQVL-------GRPVVIKKVMLPDSLHDRQPWRRAQRELNCMLNI-EDDNVVKMYSTFTP-----AENPLKMTEFYIVREYM
|....| ..    ||.......       |. |.|||.. | . .  .   |..||. ..  . ...|..|..  |||     .... .. ..|||.|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

HGTMKNLSASTFNEGGHRTVKSIFFDICRG--VQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKEDPTSN----------------TPYIVQRFY
.  . ..  |   .  .  .......|.||  ..|.| ... ||||||.|||.|...|.|.||||.. ..||...                |.|...|.|
ETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWY

RAPEIICET-TDNNKTNVDIWSLGCILAELLT-GHVLFRGKDHIDQFILMVQFLGNAGPSFYSQMN--EHARNFLLRYNLDQYQAPINFYSRFPDTVFQG
|||||.. . .......||.||.|||.||.|| ...||.|||.|||. |....||.  . |....   |||||.. ........ ...... ||...|  
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF--

VLQFEPKECDMSRDLLFRMLVINPDDRLNIQMVLSHPYL
      . ... .|||..|||..||.|..... |.|||.
------NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase C49C3.10.AA CMGC 34-324 19 3.2e-88 289.93 In-house 15-513 (513) Show / Hide 
Range on Protein: 34-324
Range on HMM: 15-513/513
Sequence Identity: 19% (98 aa)

VVHAFDQVLGRP--------------VVIKKVMLPDSLHDRQP--------WRRAQRELNCMLNIE----------------DDN-VVKMYSTFTPAE--
|. ..|.  ...              | |||...|   .. .         ..||.||. .. ..                 ..| .||.|  |.. .  
VYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSD

NPLK---------MTEFYIVREYMHGTMKNLSASTF----------NEGGH----------RTVKSIF------FDICRGVQ--YLHAMR--ISHRDLKP
....         . ..|.| |||  . ...  ..            .  |          ...|...      . |.||.   |.| ..  | ||||||
GNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKP

ENILMNQEGDV--------------------KLCDFGHSNKEDPTS-----------------------NTPYIVQRFYRAPEIICETT--------DNN
||||.|.....                    |.|||| . ...| |                       .|.|.| |.||||||..  .        .. 
ENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHY

KTNVDIWSLGCILAELLTG--------HVLFR-----------GKDHIDQFILMVQFLGNAG---------------PSFYSQMNE--------------
 | .|.||.|||.||..||        . ||            ||.||||  .... ||.                 .  . .|..              
TTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQ

--------HARNFLLRYNLDQYQAPINFYSRFPDTVFQGVLQFEP-------------------------KECDMSRDLLFRMLVINPDDRLNIQMVLSH
        .|||.. . |  . . |... . ||.  ...  . ..                         ....  .||| .||...||.|. ..  |.|
TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQH

PYL
||.
PYF
Kinase C49C3.10.AA S_TKc 27-324 20 2.3e-53 184.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-324
Range on HMM: 1-231/231
Sequence Identity: 20% (65 aa)

FQFDKPF-------VVHAFDQVLGRPVVIKKVMLPDSLHDRQPWRRAQRELNCMLNIEDDNVVKMYSTFTPAENPLKMTEFYIVREYMHG---TMKNLSA
... ..        |  . .   || | ||..            ....||.... .   .|.||.| .|         ...|.| ||. |   ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIK

STFNE-----GGHRTVKSIFFDICRGVQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKEDPTSNTPYIVQRFYRAPEIICETTDNNKTNVDIWSL
.   .         ......  ||....|.| ..| ||||||||||...   .|.|||| . .      | ... ..|.|||..      .|  .|.||.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCILAELLTGHVLFRGKDHIDQFILMVQFLGNAGPSFYSQMNEHARNFLLRYNLDQYQAPINFYSRFPDTVFQGVLQFEPKECDMSRDLLFRMLVINPDD
||||.|.|.|  .|.      |  .| . .|                                                    .  .|.. ..|. .|..
GCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------------------SPEAKDFIRKCLQKDPEK

RLNIQMVLS-------HPYL
|. .  .|        ||..
RPTA-EALQDEWDIKCHPWF
Kinase C49C3.10.AA GSK 126-324 29 1.4e-50 152.35 In-house 117-328 (328) Show / Hide 
Range on Protein: 126-324
Range on HMM: 117-328/328
Sequence Identity: 29% (64 aa)

TVKSIFFDICRGVQYLHAMRISHRDLKPENILMN-QEGDVKLCDFGHSNKEDP---TSNTPYIVQRFYRAPEIICETTDNNKTNVDIWSLGCILAELLTG
..| ... ..|| .||| . | |||.||.|||.. . | .|.|||| . . .|   ..|..||. |.||||| |   |. . . .|.||.||..||.|.|
HIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYT-CQIDVWSCGCVMAEMLKG

HVLFRGKDHIDQFILMVQFLGNAGPSFYSQMNEHARNFLLRYNLDQYQAPINFYS--------------RFPDTVFQGVLQFEPKECDMSRDLLFRMLVI
..|| |....|| .. .. ||       . ||..  .|   |  .|.  |...                .     .. ... ...   .. ||. ..||.
QPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYR-TVYMFKWCHTDMQ---DWIDLISKCLVY

NPDDRLNIQMVLSHPYL
.|  ||.  ....||. 
DPKKRLSPLEACAHPFF
Kinase C49C3.10.AA Pkinase 43-324 25 2.5e-49 175.0 Pfam 24-293 (293) Show / Hide 
Range on Protein: 43-324
Range on HMM: 24-293/293
Sequence Identity: 25% (76 aa)

GRPVVIKKVMLPDSLH--DRQPWRRAQRELNCMLNIEDDNVVKMYSTFTPAENPLKMTEFYIVREYMHGT---MKNL------SASTFNEGGHRTVKSIF
|. |..|.. ...  .  |.. .|.  .|.  |...  .|.|..| .|.        .. |.| ||. |.   |         .  .|  .  ...|...
GKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYM

FDICRGVQYLHAMRISHRDLKPENILMNQEGDV----KLCDFGHSNK--EDPTSNTPYIVQRFYRAPEIICETTDNNKTNVDIWSLGCILAELLTGHVLF
  |.||..|.|.|.| ||||||||||....|..    |.|||| . .  . . |.| . . ..|.|||.|  .     . ||.||.||||.|.|.|. .|
YQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPF

RGK----DHIDQFILMVQFLGNAGPSFYSQMNEHARNFLLRYNLDQYQAPINFYSRFPDTVFQGVLQFEPKECDMSRDLLFRMLVINPDDRLNIQMVLSH
.|.    . .||  .... .|   .. ... ..  . | .|.                 . .. .    ..||   .|.. ..|  .| .|.... .| |
PGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEEC---KDFIKWCLCKDPKKRPTAEQILQH

PYL
|..
PWF
Kinase C49C3.10.AA p38 34-260 34 1.5e-44 150.06 In-house 15-240 (289) Show / Hide 
Range on Protein: 34-260
Range on HMM: 15-240/289
Sequence Identity: 34% (80 aa)

VVHAFDQVLGRP---VVIKKVMLPDSLHDRQPWRRAQRELNCMLNIEDDNVVKMYSTFTP-AENPLKMTEFYIVREYMHGTMKNLSAST-FNEGGHRTVK
|  |.|.  |     | ||| | |    .    .|. |||     .. .||...   ||| |..   ....|.| . |    .|.. .  ...     ..
VCKAEDRRTGQKRRYVAIKKLMRP--FQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKCQRLSD---DHIQ

SIFFDICRGVQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKEDPTSNTPYIVQRFYRAPEIICETTDNNKTNVDIWSLGCILAELLTGHVLFRGK
 . . | ||  | |.  | |||||| ||  | . ...  ||| . . | .. | |.. | ||||||.    . ..| |||||.|||.|||.|| .||.|.
FLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCD-DEMTGYVATRWYRAPEIMLNWMHYTQT-VDIWSVGCIMAELITGRTLFPGD

DHIDQFILMVQFLGNAGPSFYSQM-NEHARNFL
|||||   ... .|   . | . . .|.|||..
DHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYI
Kinase C49C3.10.AA CDK 66-324 25 7.5e-44 138.07 In-house 55-284 (284) Show / Hide 
Range on Protein: 66-324
Range on HMM: 55-284/284
Sequence Identity: 25% (72 aa)

AQRELNCMLNIEDDNVVK---MYSTFTPAENPLKM---TEFYIVREYMHGT----MKNLSASTFNEGGHRTVKSIFFDICRGVQYLHAMRISHRDLKPEN
| || ... ..  .|.||    . | ... |  |    . .|.| |||.      |.              .|.... . ||. |.|  .| |||||| |
AIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEYMDHDLKKYMD--------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQN

ILMNQEGD-----VKLCDFGHSNKED-------PT-SNTPYIVQRFYRAPEIICETTDNNK-TNVDIWSLGCILAELLT---GHVLFRGKDHIDQFILMV
||.|  |      .|. ||| . .         |.   |. .| . |||||.   ... .  | .|.||.|||.||..|   .  || |.  |||  .  
ILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIF

QFLGNAGPSFYSQMNEHARNFLLRYNLDQYQAPINFYSRFPDTVFQGVLQFEPKECDMSRDLLFRMLVINPDDRLNIQMVLSHPYL
...|   ..    . .                                            ||| .||. .|. |.. .  |.|||.
RICGTPTEDNWPGVTKLPDY----------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase C49C3.10.AA ERK 136-324 34 5.3e-38 132.56 In-house 119-307 (307) Show / Hide 
Range on Protein: 136-324
Range on HMM: 119-307/307
Sequence Identity: 34% (70 aa)

RGVQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKEDP--TSN--------TPYIVQRFYRAPEIICETTDNNKTNVDIWSLGCILAELLTGHVLF
.|. |.|   . |||||| ||| |  .| | |||| ....|.   .|        | |.. | ||||||.  .....|  .|||| |||.||.| .  ||
CGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTK-AMDIWSCGCIFAEMLGRKPLF

RGKDHIDQFILMVQFLGNAGP-SFY---SQMNEHARNFLLRYNLDQY--QAPINFYSRFPDTVFQGVLQFEPKECDMSRDLLFRMLVINPDDRLNIQMVL
.|||...|. .  | .|   | |..    . .| |....  .   ..  ..|......||..        .|. .    ||| .|||..||.|...   |
PGKDYVHQINRIFQIIGT--PHSEEDLQYICSENAWKYIKNL---PNPVRPPKPWENIFPNAN------CNPQAI----DLLEKMLVFDPDKRITVEECL

SHPYL
.|||.
EHPYF
Kinase C49C3.10.AA Ciliate-E2-Unclassified 68-324 23 2e-37 127.39 In-house 69-352 (352) Show / Hide 
Range on Protein: 68-324
Range on HMM: 69-352/352
Sequence Identity: 23% (74 aa)

RELN-CMLNIEDDNVVKMYSTFTPAENPLKMTEF-------YIVREYMH-----------------GTMKNLS---ASTFNEGGHRTVKSIFFDICRGVQ
....  .||. . ..|||. .|.  .|.   .|.       .. .....                  | .. .   |           | .|  |. | .
KIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA-----------KFYFAQILQGLE

YLHAM-RISHRDLKPENILMNQEG---DVKLCDFGHS----------------------NKEDPTSNTPYIVQRFYRAPEIICETTDNNK--TNVDIWSL
|||    | |||.||||||....|    .|..||| |                      .. . .. ||.    .| |||....   ...    .|||||
YLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-QYTAPEVLQGQNYDHSKAYKCDIWSL

GCILAELLTGHVLFRGKDHIDQFILMVQFLGNAGPSFYSQMNEHARNFLLRYNLDQYQAPINFYSRFPDTVFQ---GVLQFEPKECDMSRDLLFRMLVIN
|.|| |.|.|   | ... .....|  |.. |              |.   |.. .||  ..    ||   .|     ...| |..    ||| .||. |
GVILYEMLFGYYPFYDNNCEQHQQLITQWI-N--------------NA---YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN--DLLQKMLKKN

PDDRLNIQMVLSHPYL
|. |.... .| ||..
PNKRITFEQILNHPWF
Kinase C49C3.10.AA DYRK 119-242 39 5e-36 126.01 In-house 96-221 (320) Show / Hide 
Range on Protein: 119-242
Range on HMM: 96-221/320
Sequence Identity: 39% (51 aa)

FNEG-GHRTVKSIFFDICRGVQYLHAM-RISHRDLKPENILMNQE---GDVKLCDFGHSNKEDPTSNTPYIVQRFYRAPEIICETTDNNKTNVDIWSLGC
|...   . |... . |. .  .||   .| | |||||||...|.    ..|..||| |  |.    ..||..|||||||.|. .     . .|.|||||
FQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGC--PYCYAIDMWSLGC

ILAELLTGHVLFRGKDHIDQFILMVQFLG
|||||.||..|| |..  ||. .....||
ILAELFTGWPLFPGENEYDQLACIMEVLG
Kinase C49C3.10.AA ERK1 21-260 32 8.9e-29 101.92 In-house 1-240 (289) Show / Hide 
Range on Protein: 21-260
Range on HMM: 1-240/289
Sequence Identity: 32% (81 aa)

YVNVQPF-QFDKPFVVHAFDQVLGRPVVIKKVMLPDSLHDRQPW-RRAQRELNCMLNIEDDNVVKMYSTFTPAENPLKMTEFYIVREYMHGTMKNLSAST
|.|.|   .    .|. | |.| .. | |||.    |  . | .  |  ||.. ..  . .|....      |.   .| . ||| . |   .  |  . 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI----SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQ

FNEGGHRTVKSIFFDICRGVQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKEDPTSN-----TPYIVQRFYRAPEIICETTDNNKTNVDIWSLGC
     |  .    . | ||..|.|.  . |||||| |.|.|.  |.|.||||     ||        | |.  |.||||||.       |  .|||| ||
HLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS-IDIWSVGC

ILAELLTGHVLFRGKDHIDQFILMVQFLGNAGPS-FYSQMNEHARNFL
||||.|    .| ||  .||  ...  ||          .|| |||.|
ILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYL
Kinase C49C3.10.AA TyrKc 36-260 17 3.6e-09 -74.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-260
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

HAFDQVLGR-------------PVVIKKVMLPDSLHDRQPWRRAQRELNCMLNI--EDDNVVKMYSTFTPA-------ENPLKMTEFYI---VREYMHGT
  ....||.             .| .|..            .   ||.. | ..  . .|.|..|   |         | ..  .|.      ..| . .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

MKNLSASTFNEGGHRTVKSIFFDICRGVQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKEDPT----SNTPYIVQRF---YR--------APEII
 ..          ...  |. ..|..| .||| ... ||||   |.| . .. || .||| | . .       .. |....     .        ||| |
RPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

CETTDNNK---TNVDIWSLGCILAELLT-GHVLFRG-----------KDHIDQFILMVQFLGN-------AGPSFYSQMNE-------------HARNFL
     | .   |  |.|| |  . |..| |     |             ...|   | |   .       . .  |. | .               . ..
-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase C49C3.10.AA ERK1 299-324 50 2.5e-07 23.56 In-house 264-289 (289) Show / Hide 
Range on Protein: 299-324
Range on HMM: 264-289/289
Sequence Identity: 50% (13 aa)

DLLFRMLVINPDDRLNIQMVLSHPYL
||| .||  ||. |...   | ||||
DLLDKMLTFNPHKRITVEEALAHPYL
Kinase C49C3.10.AA p38 299-324 42 5e-06 16.34 In-house 264-289 (289) Show / Hide 
Range on Protein: 299-324
Range on HMM: 264-289/289
Sequence Identity: 42% (11 aa)

DLLFRMLVINPDDRLNIQMVLSHPYL
||| .||.. || |.  .  ..|||.
DLLEKMLELDPDKRITAEEAMQHPYF
Kinase C49C3.10.AA DYRK 299-324 26 0.000237 12.49 In-house 295-320 (320) Show / Hide 
Range on Protein: 299-324
Range on HMM: 295-320/320
Sequence Identity: 26% (7 aa)

DLLFRMLVINPDDRLNIQMVLSHPYL
|.. ..|...|. |.  .  | || .
DFIKKCLQWDPHKRITPSQALQHPWF