Gene C45B11.1 (Nematode worm)

C45B11.1

Species: Nematode worm
Alias: C45B11.1A, aSWK309, C45B11.1a, C45B11.1, CE05425
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 11042917-11039350, WormBase Genetic Map location: V:2.94,

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
C45B11.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
C45B11.1.AA Protein Genbank 542 None Fasta, JSON

Protein domain

Protein domains of C45B11.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD C45B11.1.AA PBD 35-94 37 7.4e-23 82.25 Pfam 1-60 (60) Show / Hide 
Range on Protein: 35-94
Range on HMM: 1-60/60
Sequence Identity: 37% (23 aa)

EISTP-SNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAEL
.|||| .||.|..|.|.|. .|..||.|..|| || .  .||.|.....|.....|.. . 
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSS-GISKPEQKHNPQAVFDVVQFYQ
PBD C45B11.1.AA PBD 36-71 52 1e-16 62.81 SMART 1-38 (38) Show / Hide 
Range on Protein: 36-71
Range on HMM: 1-38/38
Sequence Identity: 52% (20 aa)

ISTPS-NFEHRIHAG-FDARSGTYTGLPKQWQALLGPP
||||. ||.|..|.| .|...|..||||.|||.||. .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase C45B11.1.AA PAKB 251-502 68 4e-212 710.99 In-house 1-252 (252) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-252/252
Sequence Identity: 68% (172 aa)

LTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATI
|..|..|||||||.|..|....|...||||.|.||||||||||||||.|.|.|||||||...||.||.|||||||||||||.||||||.|||.|.||||.
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

SRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQP
.||||.||..|||..|||||||||||||..||.|||.|||||.|.|.|||.|.||||||||.|.|||.|.||.|..||||.|||.||||.||||.||..|
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

FQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
.||||||||.|..|...|.|||..|.|.|....|.|.|.||.|..||||||.
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase C45B11.1.AA STE20 251-502 42 2.3e-141 475.92 In-house 1-288 (288) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-288/288
Sequence Identity: 42% (123 aa)

LTDYKQIGEGSTGVVEAAYKISTKQI----VAVKRMNLRKQ----QRRELLFNEVSILRQYQHPNIVRFFSSHLVD----DELWVVMEFMEGGSLTDIVT
 .....||.||.|.|  ||...|...    ||.|.|||.|.    ...|....|.||..|..|||||... |.|.|    ||||.|||...|||||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

AT----------RMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSE-----EVPRRRSLVGTPYWTAAEVIAR----
..          .|.|.|||.| |.|| .||.||....||||||.| |||  || |||.|||.|.||..     . ..| ..|||||| | |||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-EPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIR--DEHEARFSR--HAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
  .||...||||.||..|||.|||||.|. .|..|| .|   ..   ...   . | | |. .....| .||..||. |..||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase C45B11.1.AA PAKA 252-502 48 4.8e-119 401.78 In-house 2-260 (260) Show / Hide 
Range on Protein: 252-502
Range on HMM: 2-260/260
Sequence Identity: 48% (125 aa)

TDYKQIGEGSTGVVEAAYKISTKQI--VAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATR------MT
. ...||.|..| |  |..|.|.|   ||.|.||. .| . ||. || .......|.|||.. .|.|||||||||||.||||.|||..|...      |.
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEP
| ||| . |..| .|.|.|....|||||||| |||  || ||.|||||| ||..|  .| . |||||| | ||| |  ||   |||| |||.|||.||||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
|. |. |  ||  |  .    .   .|.| |. . |. |  .|| .|. |..||.|||.
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase C45B11.1.AA STE 251-502 29 5.2e-114 385.06 In-house 1-359 (359) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-359/359
Sequence Identity: 29% (108 aa)

LTDYKQIGEGSTG-VVEAAYK--------------ISTKQIVAVKRMNLRKQ-----------------QRRELLFNEVSILRQYQ--HPNIVRFFSSHL
... ..||.|..| |. |...              ..|..|.|.|.|||...                 . .. . .|..|.....  |||||... ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VD-------DELWVVMEFMEGGSLTDIVTA---------------TRMTEPQIATISRQVLGA-LDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCG
..       ||||..||.|.||||.||.                 .|. |.|||.| ||.| . |..||  ..||||||.. |||     |||.|||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLSEEVP----------------RRRSLVGTPYWTAAEVIAR------EPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDE-----------
||.....                .| ..|||| | | ||| .       .|||..||||.|...|||..|.||... .|..|| .| ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----HEARFSRH-----------------AKVSVELSELLSHCIVKDVNKRWPAKDLLR--HPFF
    .  ..  |                  |.| |. . ...| .|| |||. |..||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase C45B11.1.AA S_TKc 251-502 29 8.5e-96 325.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

LTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEG--GSLTDIVTATR-------
 .  ..||.|. |.|  .....|..|||.|...       | . .|..||.. .|||||... .    |.|..|||...|  |.| |.    .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDT-RADIWSFGIMLIEMVE
..| ... . .|.. ||...| ...||||.| . ||| .  ..|..|||.. ||       ....|||.. | ||.   .|.. ..|.||.|..|.||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLR-------HPFF
|.|||   |... .|.|.             | |. .....| .|| .||. | ..|.       ||.|
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C45B11.1.AA Pkinase 251-502 27 2.3e-82 284.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

LTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRREL--LFN--EVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGG----SLTDIVT---A
..  ..||.|| |.|  .....| .|||||....|..   ..  ...  |..|..  .||||||.. .   .|....|||..|||    .| |...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRM--TEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTV----KLTDFGFCGQL-SEEVPRRRSLVGTPYWTAAEVIA-REPYDTRADIWSF
...  .| ..  . .|.| .|...|....||||.|.. ||....|..    |..|||.. |.     .   ...|||.. | |||  ...|....|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMLIEMVEGEPPFFND------QPFQAMKRIRDEHEARFSRHA------------------KVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
|..|.||. |.||| ..       . | ..||..    . .                     ..| |. .... |. || .||. |...| ||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase C45B11.1.AA MST 257-502 39 7.2e-78 247.08 In-house 7-254 (254) Show / Hide 
Range on Protein: 257-502
Range on HMM: 7-254/254
Sequence Identity: 39% (99 aa)

IGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHL--VDDELWVVMEFMEGGSLTDIVTATRMT--EPQIATISR
.|.|| |.|  |  ..|..|||.| ..       . . .| ||. | . ..||... | .   . ..| |||. ..||. ||. .|. |  | |||.|..
LGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACILY

QVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQ
..|  |. || .| ||||||.  |||  .|  || |||  |||..    | ...||||| | |||    ||. ||||| ||  ||| ||.||... .|. 
DTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMR

AMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
||. |       |.   . | |..  ...| .|. ..|| |..|| |||.
AMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase C45B11.1.AA YSK 252-502 38 3.2e-73 219.73 In-house 2-257 (257) Show / Hide 
Range on Protein: 252-502
Range on HMM: 2-257/257
Sequence Identity: 38% (100 aa)

TDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRR-ELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTA---TRMTEPQI
|    || || |.|  ..   |...||.|  .| .     |..  |. .| |   |.| ... | | |  ||..||.  |||. |   .     . |..|
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI

ATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAR--EPYDTRADIWSFGIMLIEMVEGEPPF
|.| | .| .||.||  ..||||||.  .||  .| ||| |||  ||. . . .|   |||||| | |||      ||. ||||| ||  .||  |||| 
AIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY

FNDQPFQAMKRIRDEH----EA-RFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
    |  .| .|  .     |   .|  .|  ||.      | .|| ..|  ||.|| | | 
CDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVEC------CLNKDPEQRPSAKELLKHKFI
Kinase C45B11.1.AA SLK 256-502 35 1.3e-69 234.01 In-house 6-259 (259) Show / Hide 
Range on Protein: 256-502
Range on HMM: 6-259/259
Sequence Identity: 35% (89 aa)

QIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVT--ATRMTEPQIATISRQ
 .|.|  | |. | .  .|.. | | ......   |  . |. || . .|||||. .... .|..||...|| .|| .  |.      .||.||. ....
ELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKH

VLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIARE-----PYDTRADIWSFGIMLIEMVEGEPPFFND
.. ||..|| .||||||.|   ||.  || |.| |||   .. ... .| . .||||| | ||.. |     ||| .|||||.|| |||| ..|||  . 
MCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHEM

QPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
.|   . .|.     .  . .. |.| ...| .|.|||...||....|..|...
NPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase C45B11.1.AA CAMK 256-502 17 2e-65 209.5 In-house 1-425 (425) Show / Hide 
Range on Protein: 256-502
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

QIGEGSTGVVEAAYKISTK------------QIVAVKRMNLRKQQR----------------------------RELLFNEVSILRQ-------YQHPNI
..|.|| |.|  .. ..|.            | ||.| .. .| .                             |. ...|..|...        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFFSSHLV-------------------DDELWVVM---EFMEGG----SLTDIVTAT----------------RMTEPQIATISRQVLGALDFLHARKV
....                        |.... ||   |...||     | | ...                 |.|| . ... ||.. |....| ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKSDSILLKRD-----------------GTVKLTDFGFCGQLSE-----------------------EVPRRRSLVGTPYWTA-AEVIAR------
.|||.| . |||  .                 ...|..||||  .. .                       | .  .  .|||.  |  ||. .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EPYDTRADIWSFGIMLIEMVEGEPPFFND----------------QPFQAMKRIRDE-HEARFSR---------HAKVSVE--------LSE
        ..|.  .|.|| |..|  |. |.|||  |                . |.  .. . .  .  ||            ..| |           
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLSHCIVKDVNKRWPAKDLLRHPFF
|.... ..| .||. ... |.||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase C45B11.1.AA MSN 251-502 36 7.2e-64 209.69 In-house 1-265 (265) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-265/265
Sequence Identity: 36% (97 aa)

LTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQY-QHPNIVRFFSSHL------VDDELWVVMEFMEGGSLTDIVTATR--
    . .| |  | |       | |..|.| |..|.    |.   |. .|..|  | ||. ..   .       |. ||.||||   ||.||.|  |.  
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQ-EINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

-MTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIA-----REPYDTRADIWSFGIML
 . |  || |.| .|  | .||..||||||||   .||. .  ||| |||   ||.  | || . .||||| | ||||     .  || |.|.|| ||  
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
||| ||.||  . .|..|.  |  . . .     | |    . . .|..|.  .|  ....|.||| 
IEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase C45B11.1.AA KHS 254-502 36 3.2e-63 211.44 In-house 4-258 (258) Show / Hide 
Range on Protein: 254-502
Range on HMM: 4-258/258
Sequence Identity: 36% (92 aa)

YKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTAT-RMTEPQIATISR
 ...| |  | |  | .| .....||| . .  ..  ...  |. .... .||||| .| | |  | ||..||.  |||| ||  .|  ..| ||| ..|
LQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCR

QVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREP---YDTRADIWSFGIMLIEMVEGEPPFFNDQ
..| .|..||... .|||||   |||  .| ||| |||  .|..  . .|.| .||||| | || | |    |.   |||. ||  ||. |  ||.|.  
ETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFDLH

PFQAMKRIRDE--HEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
|..|.  .     .  .     | |    . .  ...|.  ||  |. ||.|||.
PMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase C45B11.1.AA TyrKc 251-502 22 3.9e-24 87.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 251-502
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

LTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQY--QHPNIVRFFSSHLVD-------DELWVVMEFMEGGSLTDIVTATR
.|  |..|||  |.|  .  .   . |||| ..  .   || . .| .|....  .||||||..   . .       . |..|||.|..|.| |   ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEE--------VPRRRSLVGTP-----YWTAAEVIAREPYDTRA
   . ..   .. |.    ..|| ...||||.    .|.....||| .||| .  . ..        . | ..  |.       |.| |.|    . |  
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSFGIMLIEMVE-GEPPFFN-----DQPFQAMKRIRDEHEARFSRHAK------VSVELSELLSHCIVKDVNKRWPAKDLLRHPFF
|.||||... |.   |..|  .       .......... .  .   ..        . |. .. . |   | ..|   ...  | .|
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase C45B11.1.AA Pkinase_Tyr 251-390 28 1.8e-22 76.76 Pfam 1-156 (270) Show / Hide 
Range on Protein: 251-390
Range on HMM: 1-156/270
Sequence Identity: 28% (44 aa)

LTDYKQIGEGSTGVVEAAYKI----STKQIVAVKRM--NLRKQQ--RRELLFNEVSILRQY-QHPNIVRFFSSHL-VDDE--LWVVMEFMEGGSLTDIVT
.|  |..|||. |.|  ..      .||. |||| .  .  ..|  |....  |..|..|. .||||||.    .  ..   ...|||.|..|.| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AT-----RMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFG
.      . | ...  ...|.  ....|.... ||||.    .|......|| .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase C45B11.1.AA Pkinase_Tyr 411-459 30 0.000115 16.42 Pfam 180-231 (270) Show / Hide 
Range on Protein: 411-459
Range on HMM: 180-231/270
Sequence Identity: 30% (16 aa)

WTAAEVIAREPYDTRADIWSFGIMLIEMVE-GEPP-FFNDQPFQAMKRI-RD
|.| |.|.   . |  |.||||. . |..  || | . .  ... ...| .|
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