Gene C25H3.1 (Nematode worm)

C25H3.1

Species: Nematode worm
Alias: C25H3.1extended, CE02499, aSWK114, C25H3.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 5700133-5701371, WormBase Genetic Map location: II:-1.15,

Classification

Group: CK1
Family: CK1-Unique

Sequence

Name Sequence Type Origin Length Description Download
C25H3.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 245 Kinase domain by global Sugen HMM Fasta, JSON
C25H3.1.AA Protein Genbank 211 None Fasta, JSON

Protein domain

Protein domains of C25H3.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C25H3.1.AA CK1-Unique 19-211 41 2.9e-110 372.63 In-house 1-215 (337) Show / Hide 
Range on Protein: 19-211
Range on HMM: 1-215/337
Sequence Identity: 41% (90 aa)

YKVTKLLGGGSYGCVHEVIELKTG------DRYAMKSEYSSMKKP--ILLNELKVMKAIYTFS-----SQHVLKVRDMGVHGSTKFIIMQMLEKNMDEVF
..|.|..|.|.|||||.||....|      |.|.||.|...|.|.  .|..|..|||.|....     ..|...|.|...|.....|.|.|....|.|..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

ELLGG-SMTLN------TAVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANSGQGLRTIYIIDYGICKR--FVDNNNVIRQPRKITKFRGTLDFAPIV
..... ..|||      .|....||||...|.|||.||.||..||||||..|.|.|.....|..|||||.|  ||.||..|||||.||.|||..|..|..
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

SHELREHSRGSDLES
.|..|||.|..|.||
CHQCREHGRRDDMES
Kinase C25H3.1.AA CK1 19-211 24 9.8e-68 231.34 In-house 1-256 (339) Show / Hide 
Range on Protein: 19-211
Range on HMM: 1-256/339
Sequence Identity: 24% (63 aa)

YKVTKLLGGGSYG-CVHEV-----IELKTG-----DRYAMKSEYS-SMKKPILLNELKVMKAIYTFS---------SQHVLK----------VRDMG-VH
.||.|..|.|..| ....|     . .|..     ..|||| |   ||... .| |. .|... ..          ..|..|          . . | ..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

GSTKFIIMQMLEKNMDEVFE---LLGGSMTLNTAVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANS-----------GQGLRTIYIIDYGICK-RFV
.  ....|..| .| .....   . .. ....|..   .|.||.||.||..||.|||||| |.|...|.           .. .|..|.||.|... ...
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DNNN------------VIRQPRK---ITKFRG-TLDFAPIVSHELREHSRGSDLES
|...            ..|.||.    ..||| |. ...| .|. .|..|  ||.|
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWS
Kinase C25H3.1.AA Worm6 19-211 32 5.1e-57 195.74 In-house 1-206 (279) Show / Hide 
Range on Protein: 19-211
Range on HMM: 1-206/279
Sequence Identity: 32% (66 aa)

YKVTKLLGGGSYGCVHEVIELKTGD--RYAMKSEY--SSMKKPILLNELKVMKAIYTFSSQHVLKVRDMGVHGS--TKFIIMQMLEKNMDEVFELL-GGS
.||||..| |..| | .| . ...   ..||| |    .||.. |  |. |.||.    . |..|. | |  ..  ...|.|... ||  .  . . .. 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

MTLNTAVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDA---NSGQGLRTIYIIDYGICK--RFVDNNNVIRQPR-KITKFRGTLDFAPIVSHELREHSR
....|.   . ||||..| .|..||.|||.|| |.|       .   ..|||..|.|.|.  .. ...|..|.|| .  .||||. .||. .|  .|..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

GSDLES
  |.||
KDDCES
Kinase C25H3.1.AA TTBKL 19-190 25 6.2e-39 129.12 In-house 1-193 (288) Show / Hide 
Range on Protein: 19-190
Range on HMM: 1-193/288
Sequence Identity: 25% (49 aa)

YKVTKLLGGGSYGCVHEVIELKT-GDRYAMKSEYSSMKK--PILLNELKVMKAIYTFSSQHVLKVRDMGVHGSTKFIIMQMLEKNMDEVFELLGGS--MT
....|..|.| .| | .|. .|. .|..||| |. .. .   ..  |..|... .  .| |..|. . |  ..  |..|... .| . .   .     ..
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LNTAVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANS--GQGLRTIYIIDYGICKRFVDNNN-----------VIRQPRK---ITKFRGTL
  |..  ..|||..|  || .||.|||.|| |.|.....  .   |..|.||.|..........            .| ||.    . ||||.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTT
Kinase C25H3.1.AA CK1-Unclassified 19-175 27 2.1e-28 80.96 In-house 1-165 (244) Show / Hide 
Range on Protein: 19-175
Range on HMM: 1-165/244
Sequence Identity: 27% (45 aa)

YKVTKLLGGGSYGCVHEVIELKTGDRYAMKSEYSSMKKPILLNELKVMKAIYTFSSQ-----HVLKVRDMGVH--GSTKFIIMQMLEKNMDEVFELLGGS
|.|.. .| || | ....| ..|.. .|.| | .  | | |. | |.|..    ..      .. |.   |    |   ...|  | ..... | . .. 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

MTLNTAVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANSGQGLRTIYIIDYGICKRFV--DNNN
 .| |      | .. .|..|  .|.|||||| |..    .|.   ..||||.|. ||..  |...
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGK-LGKNHHQVYIIDFGLSKRYIDMDKTG
Kinase C25H3.1.AA TTBK 19-209 31 3.8e-26 89.43 In-house 1-190 (257) Show / Hide 
Range on Protein: 19-209
Range on HMM: 1-190/257
Sequence Identity: 31% (60 aa)

YKVTKLLGGGSYGCVHEVIELKTG-DRYAMKSEYSSMKKPILLNELKVMKAIYTFSSQHVLKVRDMGVHGSTKFIIMQMLEKNMDEV-FELLGGSMTLNT
 ||.|  ||| .| . |  .. .   . |.| | .  .| .|  |  |.|       .|| .    | .    ...||.. ||. .   . . |  .| |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQG--CDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST

AVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANSGQGLRTIYIIDYGICKRFVDNNNVIRQPRKITKFRGTLDFAPIVSHELREHSRGSDL
..    | |...|  |  ||||||||| |. .  |. .  | .|..|.|   ...     .| ||. . ||||  .| | .|  ||  |  ||
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNP-STCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDL
Kinase C25H3.1.AA CK1-A 19-211 26 2.4e-23 79.27 In-house 1-190 (261) Show / Hide 
Range on Protein: 19-211
Range on HMM: 1-190/261
Sequence Identity: 26% (52 aa)

YKVTKLLGGGSYGCVHEVIELKTGDRYAMKSEYSSMKKPILLNELKVMKAIYTFSSQHVLKVRDMGVHGSTKFIIMQMLEKNMDEVFELLGGSMTLNTAV
|.. . .| ||.| .   |... |.  |.| |    . | |. | || . .       . ..|  |       ..|..|   ....| .     |. | .
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQG--CVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVL

ATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANSGQGLRTIYIIDYGICKRFVDNNNVIRQP-RKITKFRGTLDFAPIVSHELREHSRGSDLES
    | .  .|..|  .|.|||||| |. .    |     ...||.|. |.. |..  .  | |.  .  ||  .| |  |   | ||  |.||
MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMES
Kinase C25H3.1.AA CK1 19-175 26 4.3e-22 72.98 In-house 1-164 (271) Show / Hide 
Range on Protein: 19-175
Range on HMM: 1-164/271
Sequence Identity: 26% (44 aa)

YKVTKLLGGGSYGCVHEVIELKTGDR--YAMKSEYSSMKKPILLNELKVMKAIYT--FS--SQHVLKVRDMGVH--GSTKFIIMQMLEKNMDEVFELLGG
|.|.. .| || | ....| ...| .  .|.| | .  | | |. | |..|      ..  . .. ...  |    |   ...|  | ..... | . ..
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

SMTLNTAVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANSGQGLRTIYIIDYGICKRFVDNNN
  .| | .    | .. .|..|  .|.|||||| |..    .|.   ..||||.|. ||..| ..
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKT
Kinase C25H3.1.AA CK1-D 19-211 29 1.8e-21 72.38 In-house 1-190 (261) Show / Hide 
Range on Protein: 19-211
Range on HMM: 1-190/261
Sequence Identity: 29% (57 aa)

YKVTKLLGGGSYGCVHEVIELKTGDRYAMKSEYSSMKKPILLNELKVMKAIYTFSSQHVLKVRDMGVHGSTKFIIMQMLEKNMDEVFELLGGSMTLNTAV
|.. . .|.||.| .    ...|..  |.| |    | | |  | |. | .       . ..| .|  |    ..|..|   ....|   .    | | .
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQG--GIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVL

ATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANSGQGLRTIYIIDYGICKRFVDNNNVIRQP-RKITKFRGTLDFAPIVSHELREHSRGSDLES
  . | .  .|..|   |.|||||| |. .    |.   ..||||.|. ||. | .     | |      ||  .| |  |   | ||  ||||
MLADQMICRIEYIHCRNFIHRDIKPDNFLMGL--GKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLES
Kinase C25H3.1.AA Pkinase 19-145 24 1.4e-16 59.69 Pfam 1-138 (293) Show / Hide 
Range on Protein: 19-145
Range on HMM: 1-138/293
Sequence Identity: 24% (35 aa)

YKVTKLLGGGSYGCVHEVIELKTGDRYAMKSEYSSMKKPILL------NELKVMKAIYTFSSQHVLKVRDMGVHGSTKFIIMQMLEKNMDEVFELL----
|.. . .| ||.||| . .. .||...|.|    . .|.  .      .|...|| .    . .... .|.   ..   ..|  .|.    |..|     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIS

---GGSM--TLNTAVATSYQCLEGLEFMHWAGFLHRDIKPNN
   .|..  . ...    || |.|||..|  |..|||.|| |
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN
Kinase C25H3.1.AA Ciliate-E2 19-192 18 2.5e-16 52.53 In-house 1-253 (365) Show / Hide 
Range on Protein: 19-192
Range on HMM: 1-253/365
Sequence Identity: 18% (49 aa)

YKVTKLLGGGSYGCVHEVIELKTGDRYAMKSEYSSM--------KKPILLNELKVMKA---IYTFSSQHVLKVRDMGVHGSTKFIIM--QMLEKN-----
||. |..| |..|.| ..   |.. ..|.| ..  .        |  | . ..|.||    ..... .|...  .       |.| .  ..||..     
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY---KKI-NEKNILEQLNHPNI

--MDEVFE-------------LLGG---------------------SMTLNTAVATSYQCLE---------------GLEFMHWAG-FLHRDIKPNNYCL
  | |.|.             . ||                     ..|.. .   ..| |.               .||..|  .  .||||||.|  .
IKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF

DANSGQGLRTIYIIDYGICKRFVDNNNVIRQPRKITK--------------------------FRGTLDF
          | ||| |..|.. |.|. ...  .. |                          . ||. .
----------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGY
Kinase C25H3.1.AA S_TKc 19-210 16 2.6e-10 -25.71 SMART 1-220 (231) Show / Hide 
Range on Protein: 19-210
Range on HMM: 1-220/231
Sequence Identity: 16% (41 aa)

YKVTKLLGGGSYGCVHEVIELKTGDRYAMKSEYSSMKKPILLNELKVMKAIYTFSSQHVLKVRDMGVHGSTKFIIMQMLEK---NMDEVFELLGGS----
|.. ...| |..|.|. ... ||| ..|.|          ...|....|        .. |  |. .. .  ...| ...    .. .. .  |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MTLNTAVATSYQCLEGLEFMHWAGFLHRDIKPNNYCLDANSGQGLRTIYIIDYGICKRFVDNNNVIRQPRKITKFRGTLDFAP--IVSHELREHSR-GS
 ..  .|    || ...||..|  |..|||.|| |  ||        .| |.| |.....             | | ||... .  ..      ...  .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-----GYGKCKC

D-----------------------------------------------------LE
|                                                     |.
DWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ