Gene C18H7.4 (Nematode worm)

C18H7.4

Species: Nematode worm
Alias: C18H7.4, CE17429, aSWK375
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:-23.34, WormBase Physical Map location: IV: 592491-595173,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
C18H7.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 251 Kinase domain by global Sugen HMM Fasta, JSON
C18H7.4.AA Protein Genbank 445 None Fasta, JSON

Protein domain

Protein domains of C18H7.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 C18H7.4.AA SH2 71-153 26 1.6e-11 45.51 SMART 1-87 (87) Show / Hide 
Range on Protein: 71-153
Range on HMM: 1-87/87
Sequence Identity: 26% (24 aa)

LPYFHGALMNIDADQLLVN----DGDFMVTTRIVADLNKLQFHLAVRLKKGIRRYEIKRNQ-NSAKLGN---RSASNIGKLIDSLKAETIE
 |..|| .   .|.||| |    ||||.|  .     |. .. | || |.... | |.||. ..  ..    |. ...  |..  .   . 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES---NPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase C18H7.4.AA Fer 177-428 39 1.7e-135 456.47 In-house 1-283 (283) Show / Hide 
Range on Protein: 177-428
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

VNFKKQIGSGAYGTVYRGR----------LVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQL-YDHPNIVKFYGYILDDVPYLLVLEFCNGGSVEDLL
|...|..|.||.|.||.||          .|.... |.|||...|....| . ..|.|||.|.  |||||.|||||.. |. |...|.|||||||... |
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RDKPE--IKINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIHNGVVK----MADFGMCRATAVYKVDLSKP-----LNVRWLAPEVWTNGETRYNTD
. ...  ...| .....|.|||||.|||.|||||||||.||||.|...||    ..||||.|....|..| ...     ...||||||.|..|.....||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VYAFGVMIWEFFITPYQSPYT--------EWKGYTVKQKVRGGYRMQPPEGMPKDVASLLA-ECWNHDPEKRPNAEKLKEKLE
|..||||.||.|  .......        ..|....|.....||.|..|..||........  ||..|||.||.. ....||.
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase C18H7.4.AA Pkinase_Tyr 177-427 36 6.2e-99 335.68 Pfam 1-270 (270) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-270/270
Sequence Identity: 36% (99 aa)

VNFKKQIGSGAYGTVYRGRLV----KTNAIVAVKKLDTEGTDEEG--LTDMMKEARVMQLY-DHPNIVKFYGYIL-DDVP--YLLVLEFCNGGSVEDLLR
. | |..|.||.|.||.|..     .|.  ||||.|  ||...|   . |.|.||..|  . .|||||..|| .. .. |  ...|.|.. .|.  | ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

D----KPEIKINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIH-NGVVKMADFGMCRAT---AVY-KVDLSKPLNVRWLAPEVWTNGETRYNTDVYA
.    |. ... . .|. .  |.||.||. |||||||.| ||||.. |.||| .|||..|.      | ..  . .| ..|.|||.. .|.    .||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVMIWEFFITPYQSP-YTEWKGYTVKQKV-RGGYRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKEKL
||| .|| |     .| | ... . |.... . |||| .||. |... .|. .||..|||.||  . . |.|
FGVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase C18H7.4.AA TyrKc 177-427 31 3.2e-93 316.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-280/280
Sequence Identity: 31% (92 aa)

VNFKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQLY--DHPNIVKFYGYILDD-------VPYLLVLEFCNGGSVEDLLRD
. ..|..|.||.|.||.|..      ||||.|  .      . |.|.|||.|  .  .|||||..||.....        |...|.|.. .|.  | ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KPE-IKINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIHNGV-VKMADFGMCRAT----------AVYKVD---LSK-PLNVRWLAPEVWTNGETRY
. . ..    ... . .||||.|||.|||||||.| ||||....  || .|||..|.            .|..     .| .| .||.|||..  |.   
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

NTDVYAFGVMIWEFFITPYQSPYTE----WKGYTVKQKVRGGYRMQPPEG--------MPKDVASLLAECWNHDPEKRPNAEKLKEKL
 .||..|||..|| |    | .. .     . . | ..|. |||| .|.         .|... ..  .||..|||.||. . ..|..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase C18H7.4.AA TK 177-427 18 5e-82 274.66 In-house 1-486 (486) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)

VNFKKQIGSGAYG---TVYRGRLVKTN-------------------------AIVAVKKLD--TEGTDEEGLTDMMK----------EARVMQLYD----
. . |..|.|..|   .||.|..   |                           |||| |   .. ..|| . ..|.          ||..|.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVKFYGYILDDVP------------YLLVLEFCNGGS----VEDLLRDKPE---------------------------------------------
 |||||..||......|            ...|.|....|.      | ||....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IKINRRVQYTYMAACGMDYLHKK------NCIHRDIASRNCLIH-NGV-----------VKMADFGMCR
                               .   ... . . .|||| |||.|      |..|||.| ||||.. |.|           .| ||||..|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----------------------------------ATAVYKVDLSKPLNVRWLAPEVWTNGETRYN---------TDVYAFGVMIWEFFITPYQSPYTEW
                                   ... |. . .  | .||.|||... .. .           .||..|||..|| |    . .| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KG---------YTVKQKVRGG--------------YRMQPPEGMP--------------KDVASLLAECWNHDPEKRPNAEKLKEKL
             | ...| |              .|| .|...|              .... |. .||..|||.||. . |.|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase C18H7.4.AA UTK 177-427 29 1.1e-67 230.62 In-house 1-296 (296) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-296/296
Sequence Identity: 29% (87 aa)

VNFKKQIGSGAYGTVYRGRLVK-----TNAIVAVKKLDTEGTDEEGLT---DMMKEAR---VMQLYD-HPNIVKFYGYILDDVPYLLVLEFCNGGSVEDL
| . .|.|.||.|.|...|...     . ..||||.........   .   | |.|||   .|.  . |||.....|. ... | ..|.|.. .|.  ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRDKPE--------IKINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIHNG--------VVKMADFG---MCRATA------------VYKVDLSKP
||. ..         .  .|... .  |.|| ||| ....|||.| ||||.|          |.| ||||   |.|. .             |. .  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LNVRWLAPEVWTNGETRY--NTDVYAFGVMIWEFFITPYQSPYTEWKGYTVKQKVRGG--YRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKEKL
. .|| |||. |... |.   .||..|||  || .    . || ..    | . |. |  ||| .|...| .|  |. .||. ||..||..| | ...
WPIRWMAPEALTHHT-RFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase C18H7.4.AA TK-Unique 177-427 30 2.7e-61 209.93 In-house 1-294 (294) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-294/294
Sequence Identity: 30% (91 aa)

VNFKKQIGSGAYGTVYRGRLVKTN------AIVAVKKLDTEGTDEEGLTDMMKEARVMQLYD-HPNIVKFYGYILDDV-PYLLVLEFCNGGSVEDLLR--
......||.||.|.|.|| .....       .||||.|  . ||..   |..||...|.  . |||||...|.  ..  | ....|.| .|. ...||  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTD-KQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

---------------------DKPE---IKINRRVQYTYMAACGMDYLHK--KNCIHRDIASRNCLI-HNGVVKMADFGMCR---ATAVYKVDLS-KPLN
                     |||.   |.  . ... .  |||| ||..  |...|||...||.|. ...|.| .|||| |   .. ||    | ... 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VRWLAPEVWT--NGET-RYNTDVYAFGVMIWEFFITPYQSPYTEWKGYTVKQKVRGGYRMQPPEGM-PKDVASLLAECWNHDPEKRPNAEKLKEKL
.||.|||.     |   .. .||..||| .|| | |  . ||.. .   . ...| ||||. ||.  .... .|. .||...||.||. ...| .|
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF-TLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase C18H7.4.AA TKL 183-427 22 7.5e-60 205.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 183-427
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

IGSGAYGTVYRGRLVKTN--------AIVAVKKLDTEGTDEEGLTD-----------------------MMKEARVMQLYD--HPNIVKFYGYILDDVP-
||||..|.||.|..  ..          |||||. ..  ||. ...                         .|  .|..    |||||.|.|| ..  . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YLLVLEFCNGGSVEDLLRDKPEIKINRRVQYTYMAACGMDYLHK--------KNCIHRDIASRNCLIH-NGV--------------VK
            . .| |.| ||| ...|       ...|..  . .|.||.|||         .. ||||. |.|.|.. |.               .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

MADFGMCR--------------------ATAVYKVDLSKPL-NVRWLAPEVWTNGETRYNT----------------DVYAFGVMIWEFFI--TPYQ-SP
 .||| .|                    .  ...  ....  . ||.||||  . .   .                 |||.||...|| .   .||.  |
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

YTEWKGY-----TVKQKVRGGYRMQPP------------EGMPKDVASLLAECWNHDPEKRPNAEKLKEKL
| ....        .. .  |.|  .|            . .|.....|. .||.|||||||........|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase C18H7.4.AA S_TKc 177-435 23 1.2e-53 185.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 177-435
Range on HMM: 1-231/231
Sequence Identity: 23% (63 aa)

VNFKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQLYDHPNIVKFYGYILDDVPYLLVLEFCNG--GSVEDLLRDKPE----
  . ..||.||.|.||..| .||. |||.|...          ....| ....  .||||||.|... |   . .|.|.|.|  |.. |......     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IKINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIHNGVVKMADFGMCRATAVYKVDLSKPLNVRWLAPEVWTNGETRYNT---DVYAFGVMIWEF
  .   .   |.|  .|...|.|... ||||.   | |. . ..| .|||..|         .      ..||||       |..   |....|....|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEM

FI--TPYQSPYTEWKGYTVKQKVRGGYRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKE-KLEDLNQKYE
.   .|..        ... .|..           .... ...  |.. |||||| | .. .  ..  .  . 
LCGYPPFP------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C18H7.4.AA Abl 177-427 34 2.1e-52 172.85 In-house 1-252 (252) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-252/252
Sequence Identity: 34% (88 aa)

VNFKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQLYDHPNIVKFYGYILDDVPYLLVLEFCNGGSVEDLLRDKPEIKINRR
.  |...| | || || |   . . .|||| |  .  .   . . .||| .|.   |||.|.  |    . |. .. ||   | . | ||.  . ...  
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTME---VHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELP-A

VQYTYMA---ACGMDYLHKKNCIHRDIASRNCLI-HNGVVKMADFGMCR--ATAVYKVDLSKPLNVRWLAPEVWTNGETRYNTDVYAFGVMIWEFFITPY
|   |||   | ||.|| |.. ||||.| ||||.  . .||.||||. |     .|         ..| |||     .     ||.||||..||   |  
VVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWE-IATYG

QSPYTEWKGYTVKQKVRGGYRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKEKL
 |||       | .|.  ||||. ||| |..|  |. .||. ..  ||  ... ...
MSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase C18H7.4.AA Frk 177-431 31 4.9e-47 160.93 In-house 1-260 (260) Show / Hide 
Range on Protein: 177-431
Range on HMM: 1-260/260
Sequence Identity: 31% (83 aa)

VNFKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQLYDHPNIVKFYGYILDDVPYLLVLEFCNGGSVEDLLR----DKPEIK
. . ...||| .| |. | |   .. ||||.| .   |    .|...||..|.   || ... |     . | ... |    ||. . |.       ...
IQLIRRLGSGQFGEVWEG-LWNNTTPVAVKTLKPGTMDP---NDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQ

INRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIHNG-VVKMADFGMCR-----ATAVYKVDLSKPLNVRWLAPEVWTNGETRYNTDVYAFGVMIWEFF
..  |. .   | || || ..| ||||.| || |. .. ..|.||||. |        .|       . ..| |||     .     ||..||... |  
MQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE-I

ITPYQSPYTEWKGYTVKQKVRGGYRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKEKLEDLN
||  . ||    .  | | |  ||||  | . |. . ... |||..||.|||  | |. ||||  
ITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase C18H7.4.AA Pkinase 177-427 21 5.1e-47 167.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-293/293
Sequence Identity: 21% (63 aa)

VNFKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDMMK--EARVMQLYDHPNIVKFYGYILDDVPYLLVLEFCNGG----SVEDLLR--DK
  ....||||..|.||... ..|. |||||... ...... .    .  |...|.  .|||||..|..  |.  . .|.|.|.||    .  |...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PEI--KINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLIH-NGVV----KMADFGMCRATAVYKVDLSKPLNV-----RWLAPEVWT-NGETRYNTDV
  .    .    | |  ..|..|.|....||||. . |.||. ||..    | .||| ..         .  ...     ...||||   . .  .  |.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YAFGVMIWEFFI--TPYQSP----YTEWKGYTVKQKVRGGYRMQPPEG-------------------MPKDVASLLAECWNHDPEKRPNAEKLKEK--L
...|....|..   .|...         . . .... .. .. . |.                    ....  ...  |.. ||.|||.|| ...   .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase C18H7.4.AA Src 177-427 31 1.4e-44 149.3 In-house 1-255 (255) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-255/255
Sequence Identity: 31% (81 aa)

VNFKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQLYDHPNIVKFYGYILDDVPYLLVLEFCNGGSVEDLLR---DKPEIKI
. .....|.| .| |. | . . |  |||| |  .||     ..  .|| .|   .|...|. |    .. |.. | |. . ||  | |.   .  ....
IKLCRKLGQGQFGEVWMG-YWNGNTKVAVKTL-KPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHL

NRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLI-HNGVVKMADFGMCRATA----VYKVDLSKPLNVRWLAPEVWTNGETRYNTDVYAFGVMIWEFFIT
.. .  .   | ||.|| ..| |||| | || |. .| |.| ||||  | .     .|       . ..| |||  . |     .||  ||. ..|  .|
PQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE-IVT

PYQSPYTEWKGYTVKQKVRGGYRMQPPEGMPKDVAS-LLAECWNHDPEKRPNAEKLKEKL
  . ||  ..   | |.|  ||||  |.. |. .   .. .||. |||.||  | | ..|
YGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase C18H7.4.AA TKL-Unique 179-427 29 3.3e-41 143.07 In-house 1-290 (290) Show / Hide 
Range on Protein: 179-427
Range on HMM: 1-290/290
Sequence Identity: 29% (87 aa)

FKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDT-EGTDEEGLTDMMKEARVMQLYD-HPNIVKFYGYILD---DVP-YLLVLEFCNGGSVEDLLRD-----
| . ||.|.||.||.|   ..  .||.|..   |.   | . .  .| ..|   . |||||...||  |   . | . .|.|.|.|||  |.| .     
FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KPEIKIN--RRVQYTYMAACGMDYLHKKN--CIHRDIASRNCLIHNG------VVKMADFGMCRATA-VYKVDLS------KPLNV---RWLAPEVW
   ....|.|  .||.    .| ||.||| ..   ||||. |.| |. |.       .| .||| ..  .   |  ..      .. ..   ||.|||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

TNGETRYNT--DVYAFGVMIWEFFITPY----QSPYTEWKGYTVKQKVRG---GYRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKEKL
.. .. |..  |||.||.. || . .        || .   . ....|.    .||   |. .||.   |. .||.|||..||. .   ..|
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase C18H7.4.AA MLK 177-364 28 7.4e-40 135.96 In-house 1-228 (291) Show / Hide 
Range on Protein: 177-364
Range on HMM: 1-228/291
Sequence Identity: 28% (66 aa)

VNFKKQIGSGAYGTVYRGRLVKTN---AIVAVKKLDTEGTDEEGLT-----DMMKEARVMQLYDHPN----IVKFYGYILDD-VPYLLVLEFCNGGSVED
 .|.. ||||..| |..||  ...    |||||. ...   . . |     |. .|.|     .|||    |..||| .|..  ....|.|.| |||  .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LL---RDKPE-----------IKINRRVQYTYMAACGMDYLHKKN---CIHRDIASRNCLIH-------NGVVKMADFGMCRATAVYKV---DLSKPLNV
.|   |.|..           ..    ..  .  | ||.|||..     ||||. |.| ||.       .|..| .|||   .. ...      |.. ..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT--SRDWHQMCTNMMSNAGTY

RWLAPEVW---TNGETRYNTDVYAFGVMIWE
.| ||||     ..      ||. .||..||
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWE
Kinase C18H7.4.AA MLK 395-427 36 6.6e-07 20.14 In-house 259-291 (291) Show / Hide 
Range on Protein: 395-427
Range on HMM: 259-291/291
Sequence Identity: 36% (12 aa)

PEGMPKDVASLLAECWNHDPEKRPNAEKLKEKL
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PSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL