Gene C16A11.3 (Nematode worm)

C16A11.3

Species: Nematode worm
Alias: C16A11.3 or Y73B3A.16, C16A11.3, CE19353, aSWK172
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 4229543-4234315, WormBase Genetic Map location: II:-4.08,

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
C16A11.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 336 Kinase domain by global Sugen HMM Fasta, JSON
C16A11.3.AA Protein Genbank 726 None Fasta, JSON

Protein domain

Protein domains of C16A11.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SPK C16A11.3.AA SPK 106-222 26 1.4e-35 125.48 SMART 1-118 (118) Show / Hide 
Range on Protein: 106-222
Range on HMM: 1-118/118
Sequence Identity: 26% (32 aa)

YIQRFLDFLSDKSEN-IKS---PLPLTKFFQDYKTKSNCSQSLATAKKKLLANLFEHIVMSAKYNDDRKAEMLFAIGLRVEDEFLERLRGR--ATVEVDD
.. ||.||| .|... |.    .. ..|.|..|....|. .| .|  |.   .|.... ....|.......|.|| . .|||.|||...    .||..|.
ELTRFMDFLVEKTKDAIEPMVVTTKVFKEFSKYENHVNGCRSYTTYYKRFHNKLAPNMHKWNNYSIEERIRMMFALSGKVEDDFLEQIQTHHIGTVQLDE

CQRITFYKSKTSTSSPETVSFVL
..||..|.|.      .....  
KRRICKYTSND-----GKLKLEG
SPK C16A11.3.AA SPK 105-210 28 6.4e-19 72.25 Pfam 1-107 (112) Show / Hide 
Range on Protein: 105-210
Range on HMM: 1-107/112
Sequence Identity: 28% (30 aa)

LYIQRFLDFLSDKSENIKS-PLPLTKFFQDYKTKSNCSQSLATAKKKLLANLFEHIVMSAKYNDDRKAEMLFAIGLRVEDEFLERLRGRATVEVDDCQRI
  . ||.||| .|....   |. ..| |...... .   |  .  |.   .|   . . . |... .. |.|| . .|||.|||..|  .||..|. .||
AEMTRFMDFLVEKTKDAVEKPMVACKVFEEFSRREGDGLSYDMYYKRFHNKLAPNMHKWNNYSIEERIRMMFALSGKVEDDFLEQIRTHGTVQLDEKKRI

TFYKSKT
..|.|..
CKYTSND
Kinase C16A11.3.AA CLK 390-725 35 2.1e-204 619.67 In-house 1-350 (350) Show / Hide 
Range on Protein: 390-725
Range on HMM: 1-350/350
Sequence Identity: 35% (124 aa)

LKIIAKLGEGVFGAVYKVVDHSN-KKYAVKLFKEEHSEVGEQSWARETAIMKAVTAINSANLIRMEDSWRINESVPNGFLKIAISFELKGRSVFEVMDST
..|...||||.||.|....||.| |||.............|..|.....|||........|....|..|..|.....|...|.|.|||.|.|....|.|.
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

KGKMPAGSEISFEINAIRVMGKQLLEAMEKLESVKIVHLDLKPENICFSSS------CTFKTTVTGN--------VCFIQPS-IFHVCVVDFGNARTIRQ
..|||. ..|...|..||.|..||.||...|...|..|.|||||||||..|      ||||......        ||..... ..|.||.|||.|..||.
NSKMPN-KYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRF

DKPPKYALVQTQNYRAPEIFLGLPFSVKSDIWSFGCILSELYTGDLLFYGNSKSDTEELQFELMQMIVQQPPSCAMLREAEKIKSTKIRIENGNVYMKRK
|.......|.|..|||||..|||..|...|.||.||||.|||||..||...............|.|...|.......|...|.|........... ....
DHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDW-HNSD

SKSSFEPPKPLHKQRRPKDLEAIPLFDLLECILIVDPSRRPSLRDISSRTFF
.....|..|||......||.|...||||....|..|||.|....|.....||
GRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase C16A11.3.AA CMGC 390-725 18 2.7e-66 216.52 In-house 1-513 (513) Show / Hide 
Range on Protein: 390-725
Range on HMM: 1-513/513
Sequence Identity: 18% (97 aa)

LKIIAKLGEGVFGAVYKVVDH---------------SNKKYAVKLFKEEHSEVGEQ----------SWARETAIMKAV--------------TAINSANL
 .|| |.||| .| ||| .|.               .|...|.| .|... | ...          .  ||  |.| .               . .  |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IRMEDSWRINESVPNGFL----------KIAISFELKGRSVFEVMDSTKG-----KMPAGSEIS---------------FEINAIRVMGKQLLEAME--K
... |. . ..| .|..           .. . ||. . . .........     .    ||                 | | .|| . .|.|....   
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LESVK--IVHLDLKPENICFSSSCTFKTTVTG------NVCFIQPSIFHVCVVDFGNARTIRQDKPP---------------------KYALVQTQNYRA
. | .  |.| ||||||| ... |. .|..        |.|    . ... . |||.|| . . . .                      .  |.|  |||
CHSHWGNIIHRDLKPENILINHNCELITRM-MWKSEDWNPC---QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRA

PEIFLGLP----------FSVKSDIWSFGCILSELYTG--------DLLFYGNSK-----------SDTEELQFELMQMIVQQPPSCAMLR-------EA
||| || .          .. . |.||.|||. |.|||        . || |.|             |  .. |... ..  .  .... |       | 
PEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFNFCKHEE

EKIKSTK------------------IRIENGNVYMKRKSKSSFEPPKPLHKQRRPKDL--------------------------------EAIPLFDLLE
| .. .|                  .  | .  | ... .    ||||....  ...                                 .   ..|||.
EWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLK

CILIVDPSRRPSLRDISSRTFF
 .|. ||..|..  .. .  .|
KMLQYDPDKRITAEQALQHPYF
Kinase C16A11.3.AA S_TKc 390-725 18 2.9e-44 154.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 390-725
Range on HMM: 1-231/231
Sequence Identity: 18% (66 aa)

LKIIAKLGEGVFGAVYKVVDHS-NKKYAVKLFKEEHSEVGEQSWARETAIMKAVTAINSANLIRMEDSWRINESVPNGFLKIAISFELKGR---SVFEVM
 .|. |.|.| || |||..... ....|.|  |        ..  || .|.|     .  |.... |...          .. . .|. .    ..|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYI

DSTKGKMPAGSEISFEINAIRVMGKQLLEAMEKLESVKIVHLDLKPENICFSSSCTFKTTVTGNVCFIQPSIFHVCVVDFGNARTIRQDKPPKYALVQTQ
.. ...   |    |    .| . .|...|.| . | .|.| ||||||| ...                    |. . ||| || .       . .. | 
KKRGRH---GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------------HIKICDFGLARQL-------TTFCGTP

NYRAPEIFLGLPFSV-KSDIWSFGCILSELYTGDLLFYGNSKSDTEELQFELMQMIVQQPPSCAMLREAEKIKSTKIRIENGNVYMKRKSKSSFEPPKPL
.|.|||..   ...  |.|.||.|||| |...|  .|.          .......|.                                           
WYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG-------------------------------------------

HKQRRPKDLEAIPLFDLLECILIVDPSRRPSLRDISS-------RTFF
            .. |... .| .||..||.  ..           .|
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C16A11.3.AA Pkinase 390-725 20 3.7e-39 139.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 390-725
Range on HMM: 1-293/293
Sequence Identity: 20% (73 aa)

LKIIAKLGEGVFGAVYKVVDHSNKK-YAVKLFKEEHSEVGEQSWAR---ETAIMKAVTAINSANLIRMEDSWRINESVPNGFLKIAISFELKGRSVFEVM
..|. |.|.| || ||| ..... | .||| .| .| . ...  .|   | .||| .    . | .|. |...                   ....  ||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED------------------KDHIYMVM

DSTKG-----KMP----AGSEISF--EINAIRVMGKQLLEAMEKLESVKIVHLDLKPENICFSSSCTFKTTVTGNVCFIQPSIFHVCVVDFGNARTI-RQ
.   |            . .. .|  . . .. . .|.|...| . | .|.| ||||||| ... .. ..              .|.. ||| |. .   
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--------------CVKICDFGLAKQFDY-

DKPPKYALVQTQNYRAPEIFL-GLPFSVKSDIWSFGCILSELYTGDLLFYGN----SKSDTEELQFELMQ---MIVQQPPSCAMLREAEKIKSTKIRIEN
 ..  . .. | .|.|||. . | . . |.|.||.|||| |...| ..|.|     .  |  .. .. |.   .   . ... ....  ..   .     
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----

GNVYMKRKSKSSFEPPKPLHKQRRPKDLEAIPLFDLLECILIVDPSRRPSLRDISSRTFF
                    . ......   .. |.....| .||..||. ..|    .|
--------------------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase C16A11.3.AA Ciliate-E2 390-725 17 2.2e-29 98.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 390-725
Range on HMM: 1-365/365
Sequence Identity: 17% (78 aa)

LKIIAKLGEGVFGAVYKV-VDHSNKKYA----------------VKLFKEEHSEV---GEQSWARETAIMKAVT-------------AINSANLIRMEDS
 |.| |.|.| || |||. |.  .|..|                || .. .   .   . ... .|  ||. .               .|. |.|.| ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WR---------INESVPNG-FLKIAISFELKGRSVFEVMDSTKGKMPAGSEISFEINAIRVMGKQLLE---------------AMEKLESVK-IVHLDLK
.          . | .  |  ... ... .|  . .|               .| .. |. . ||.|.               |.| | | . |.| |.|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE----------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK

PENICFSSSCTFKTTVTGNVCFIQPSIFHVCVVDFGNARTIRQD-------------KPPK-------------------YALVQTQNYRAPEIFLGLP-
|||| |                       ....|||... . .|             .  |                   . .. | .| ||||. | . 
PENILF-----------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

--------FSVKSDIWSFGCILSELYTGDLLFYGNSKSDTEELQFELMQMIVQQPPSCAMLREAEKIKSTKIRIENGNVY--MKRKSKSSFEPPKPLHKQ
         . |.||||.|.|| |. .| . |                                       . |.....    . . |  .  .. . . 
DNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CK

RRPKDLEAIPLF--DLLEC----ILIVDPSRRPS-LRDISSRTFF
   |. . ...   ||.      .| .||. |..   .|    .|
W--KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase C16A11.3.AA Ciliate-E2-Unclassified 510-725 20 2.9e-26 88.09 In-house 150-352 (352) Show / Hide 
Range on Protein: 510-725
Range on HMM: 150-352/352
Sequence Identity: 20% (53 aa)

KQLLEAMEKLESVK-IVHLDLKPENICFSSSCTFKTTVTGNVCFIQPSIFHVCVVDFGNARTIRQD--------------KPPKYALV-QTQNYR----A
.|.|.. |.| . . |.| |.||||| |....                 ..... |||... . |.              |. ..  . .| ||     |
AQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTA

PEIFLGLPFS----VKSDIWSFGCILSELYTGDLLFYGNSKSD-----TEELQF-----ELMQMIVQQPPSCAMLRE----AEKIKSTKIRIENGNVYMK
||.. |   .     |.||||.|.|| |. .| . ||.|.. .     |. . .     .| | | |....     .        .. |  |.       
PEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN-------

RKSKSSFEPPKPLHKQRRPKDLEAIPLFDLLECILIVDPSRRPSLRDISSRTFF
                            ||| ..| ..|. |... .|    .|
----------------------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase C16A11.3.AA DYRK2 574-638 42 1.4e-18 56.73 In-house 154-215 (318) Show / Hide 
Range on Protein: 574-638
Range on HMM: 154-215/318
Sequence Identity: 42% (28 aa)

DKP-PKYALVQTQNYRAPEIFLGLPFSVKSDIWSFGCILSELYTGDLLFYGNSKSDTEELQFELMQ
... . |  .|.  |||||..||.....  |.||||||. |||||  || |    . |  || .|.
EHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPG----ENENDQFACMM
Kinase C16A11.3.AA DYRK 562-628 44 8.7e-18 63.25 In-house 148-211 (320) Show / Hide 
Range on Protein: 562-628
Range on HMM: 148-211/320
Sequence Identity: 44% (30 aa)

VVDFGNARTIRQDKPPKYALVQTQNYRAPEIFLGLPFSVKSDIWSFGCILSELYTGDLLFYGNSKSD
|.||| .  . |     |  .|   |||||..||.|.... |.||.|||| ||.||  || |..  |
VIDFGSSCFEHQ---RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYD
Kinase C16A11.3.AA TKL 556-723 15 3.6e-15 51.08 In-house 175-364 (364) Show / Hide 
Range on Protein: 556-723
Range on HMM: 175-364/364
Sequence Identity: 15% (35 aa)

SIFH--------------VCVVDFGNARTIRQDKPPKYA-------------------LVQTQNYRAPEIFLGL----------------PFSVKSDIWS
. ..              ... ||| .|.. |..  .                      . | .. |||.. |                 ..| |.|..|
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

FGCILSELYTGDLLFYGNSKSDTE--ELQFELMQMIVQQ---PPSCAMLREAEKIKSTKIRIENGNVYMKRKSKSSFEPPKPLHKQRRPKDLEAIPLFDL
|| .| |..|. . .|..  .. .   . ||.|.|.| .   .| .    .                             .    .  | .    .. .|
FGIVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQN----------------------------HH-K-M-CPCPDCPPSMKKL

LECILIVDPSRRPSLRDISSRT
...    ||. |||  .| .| 
MQDCWDHDPEKRPSFQEILKRL
Kinase C16A11.3.AA DYRK1 549-673 29 1.1e-14 47.6 In-house 134-250 (321) Show / Hide 
Range on Protein: 549-673
Range on HMM: 134-250/321
Sequence Identity: 29% (37 aa)

NVCFIQPSIFHVCVVDFGNARTIRQDKPPKYALVQTQNYRAPEIFLGLPFSVKSDIWSFGCILSELYTGDLLFYGNSKSDTEELQFELMQMIVQQPPSCA
|.  . |    . ..||| .    |     |  .|   ||.||. ||...... |.|| |||| |. ||. || | .  |  .   | . |    ||. .
NILLCNPKRSAIKIIDFGSSCQLGQR---IYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGM----PPK-H

MLREAEKIKSTKIRIENGNVYMKRK
|. .| | .    . ... .|.|..
MIDQAPKAHKYFEKDPDNTWYCKKT
Kinase C16A11.3.AA STE 505-645 21 6.2e-14 45.69 In-house 153-300 (359) Show / Hide 
Range on Protein: 505-645
Range on HMM: 153-300/359
Sequence Identity: 21% (37 aa)

IRVMGKQLLEA-MEKLESVKIVHLDLKPENICFSSSCTFKTTVTGNVCFIQPSIFHVCVVDFGNARTIRQDKP----------------PKYALVQTQNY
|... .|.|.. .. |.| .|.| |.|| || .                       |  .||| .  . .. .                  . .| |. .
IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-W

RAPEIFLG------LPFSVKSDIWSFGCILSELYTGDLLFYG-NSKSDTEELQ--------FELMQMIVQQPP
 |||. ..       . ..|.||||.|| . |. ||   .   .  .   . .        ||.. .||..||
MAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPP
Kinase C16A11.3.AA CAMK 510-642 20 2.8e-12 35.17 In-house 186-361 (425) Show / Hide 
Range on Protein: 510-642
Range on HMM: 186-361/425
Sequence Identity: 20% (39 aa)

KQLLEAMEKLESVKIVHLDLKPENICFSSSC----------TFKTTVTGNVCFIQPSIFHVCVVDFGNARTIRQDK-----------------------P
.|...|.. . | .|||.||||||| ....            |             . . . ..||| |. .....                       .
RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIF-D----------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ

PKYALVQTQNYRA-PEIFLG--------------LPFSVKSDIWSFGCILSELYTGDLLFYGNSKSDTEE------LQFELMQMIVQ
. .  . |  | | ||...|               . . |.|.|| |.||  . .| . ||| . ....|       . ||...| .
KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMK
Kinase C16A11.3.AA TyrKc 390-725 18 1.5e-10 -52.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 390-725
Range on HMM: 1-280/280
Sequence Identity: 18% (69 aa)

LKIIAKLGEGVFGAVYKVVDHSNKKYAVKLFKEEHSEVGEQSWARETAIMKAV--TAINSANLI----RM-------EDSWRINESVPNGFLKIAISFEL
.. . ||||| || ||| .     . |||  ||..    ..   ||  ||. .     |  .|.             |  . . | .|.| ||  .    
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

KGRSVFEVMDSTKGKMPAGSEISFEINAIRVMGKQLLEAMEKLESVKIVHLDLKPENICFSSSCTFKTTVTGNVCFIQPSIFHVCVVDFGNARTIRQD--
.                      .       .  |  . || |.| ...| ||   |.  ..                    .| . ||| .| |  |  
PK---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------TVKISDFGLSRDIYDDDQ

--KPPKYALVQT-QNYR--------APEIFLGLPFSVKSDIWSFGCILSELYTGDLLFYGNS----KSDTEELQFELMQMIVQQPPS----CAMLREAEK
     .|  ... .. .        ||| .    |. |||.||||  . |..|     | .     .|..| ...    .   |||.             
QGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------

IKSTKIRIENGNVYMKRKSKSSFEPPKPLHKQRRPKDLEAIPLFDLLECILIVDPSRRPSLRDISSRTFF
                                          .... ..    ||. ||. ..|  . .|
-----------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase C16A11.3.AA DYRK 500-534 41 1.1e-09 32.58 In-house 100-135 (320) Show / Hide 
Range on Protein: 500-534
Range on HMM: 100-135/320
Sequence Identity: 41% (15 aa)

FEINAIRVMGKQLLEAMEKLESV-KIVHLDLKPENI
| .|..|....|.|... .|..  .|.| |||||||
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENI
Kinase C16A11.3.AA DYRK2 500-534 37 3.2e-08 22.48 In-house 99-133 (318) Show / Hide 
Range on Protein: 500-534
Range on HMM: 99-133/318
Sequence Identity: 37% (13 aa)

FEINAIRVMGKQLLEAMEKLESVKIVHLDLKPENI
|  . .| .....|.... |   .|.| |||||||
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENI
Kinase C16A11.3.AA CAMK 395-455 15 1.5e-07 19.65 In-house 1-105 (425) Show / Hide 
Range on Protein: 395-455
Range on HMM: 1-105/425
Sequence Identity: 15% (16 aa)

KLGEGVFGAVYKVVDH-SN------------KKYAVKLFK---------------------------EEHSEVGEQSWARETAIMKAVTA----INSANL
.||.| || |.....  ..            .|.|.|  .                           ...... ...  || .||| . .    ..  |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRMED
|.. .
IKLYE
Kinase C16A11.3.AA STE 390-426 24 1e-06 19.61 In-house 1-53 (359) Show / Hide 
Range on Protein: 390-426
Range on HMM: 1-53/359
Sequence Identity: 24% (13 aa)

LKIIAKLGEGVFGAVYKVVDH----------------SNKKYAVKLFKEEHSE
...| |.|.| || ||| ..|                ... .|.|  . |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCN
Kinase C16A11.3.AA TKL 396-438 23 8e-06 17.04 In-house 1-73 (364) Show / Hide 
Range on Protein: 396-438
Range on HMM: 1-73/364
Sequence Identity: 23% (17 aa)

LGEGVFGAVYKVVDHS---------NKKYAVKLFKEEHSEVG---------------------EQSWARETAI
.|.| || ||| . .          .|  ||| ||....                        |.||.|.. .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEE
Kinase C16A11.3.AA Ciliate-E2-Unclassified 391-426 27 4.1e-05 13.72 In-house 2-48 (352) Show / Hide 
Range on Protein: 391-426
Range on HMM: 2-48/352
Sequence Identity: 27% (13 aa)

KIIAKLGEGVFGAVYKVVD------------HSNKKYAVKLFKEEHSE
||| ..|.| || |||...            .....|..|. .... |
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-E
Kinase C16A11.3.AA CAMK 700-725 26 0.000269 8.96 In-house 400-425 (425) Show / Hide 
Range on Protein: 700-725
Range on HMM: 400-425/425
Sequence Identity: 26% (7 aa)

DLLECILIVDPSRRPSLRDISSRTFF
||. ..| |||..|... .. .  ..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase C16A11.3.AA DYRK1 390-421 39 0.00047 9.57 In-house 1-33 (321) Show / Hide 
Range on Protein: 390-421
Range on HMM: 1-33/321
Sequence Identity: 39% (13 aa)

LKIIAKLGEGVFGAVYKVVDHSNKKY-AVKLFK
..|.. .| | || | |  || ...| |.|. |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIK
Kinase C16A11.3.AA RIO1 403-426 23 0.000548 12.9 Pfam 1-26 (200) Show / Hide 
Range on Protein: 403-426
Range on HMM: 1-26/200
Sequence Identity: 23% (6 aa)

AVYKVVD-HSNK-KYAVKLFKEEHSE
.||....  ..| ..|||...  ...
NVYHAYSMEDGKDECAVKIYRTGTTC
Kinase C16A11.3.AA Pkinase_Tyr 589-616 46 0.000559 14.1 Pfam 182-209 (270) Show / Hide 
Range on Protein: 589-616
Range on HMM: 182-209/270
Sequence Identity: 46% (13 aa)

APEIFLGLPFSVKSDIWSFGCILSELYT
||| .    |..|||.||||  . |..|
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase C16A11.3.AA Pkinase_Tyr 390-440 34 0.001716 12.45 Pfam 1-58 (270) Show / Hide 
Range on Protein: 390-440
Range on HMM: 1-58/270
Sequence Identity: 34% (20 aa)

LKIIAKLGEGVFGAVYKVVDH-----SNKKYAVKLFKEEHSEVG--EQSWARETAIMK
.... ||||| || ||| . .      . . |||  || ...     ..  || .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMK
Kinase C16A11.3.AA TKL 508-534 28 0.01112 5.49 In-house 137-171 (364) Show / Hide 
Range on Protein: 508-534
Range on HMM: 137-171/364
Sequence Identity: 28% (10 aa)

MGKQLLEAMEKLES--------VKIVHLDLKPENI
. ..   .|. | |         .|.| |||..||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI
Kinase C16A11.3.AA DYRK1 502-534 37 0.011895 4.56 In-house 101-135 (321) Show / Hide 
Range on Protein: 502-534
Range on HMM: 101-135/321
Sequence Identity: 37% (13 aa)

INAIRVMGKQLLEAMEKLES--VKIVHLDLKPENI
.| .| . .|.. |.  . .  ..|.| |||||||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENI
Kinase C16A11.3.AA DYRK 391-419 36 0.012457 5.99 In-house 2-31 (320) Show / Hide 
Range on Protein: 391-419
Range on HMM: 2-31/320
Sequence Identity: 36% (11 aa)

KIIAKLGEGVFGAVYKVVDHSNK-KYAVKL
.|.  .| |.|| | |. || .. . |.|.
EILEYIGKGSFGQVVKCWDHKTNEMVAIKI
Kinase C16A11.3.AA DYRK2 391-415 40 0.013006 3.94 In-house 2-26 (318) Show / Hide 
Range on Protein: 391-415
Range on HMM: 2-26/318
Sequence Identity: 40% (10 aa)

KIIAKLGEGVFGAVYKVVDHSNKKY
 |   .| | || | |. || .|..
EILEVIGKGSFGQVVKCYDHKTKQH