Gene C14A4.13 (Nematode worm)
C14A4.13
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| C14A4.13.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 261 | Kinase domain by global Sugen HMM | Fasta, JSON |
| C14A4.13.AA | Protein | Genbank | 471 | None | Fasta, JSON |
Protein domains of C14A4.13.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | C14A4.13.AA | TTBKL | 26-286 | 37 | 2.4e-133 | 449.27 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 26-286 Range on HMM: 1-288/288 Sequence Identity: 37% (108 aa) FMAVQMIGKGAYGVVYEVVRRNSPNTRFACKAELAI-DHNN--LKTEWDLMTLLKDNKSKHNIIGVELGSERNFNYIVMHLVGPSLSDLRKTVPNKT-FT .|.|.|||.|..|.||.|. ........|.|.|. .... .| |......| .|.|.| .. .. | . ..|..||.|.||.|.||||. ||| |. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLG--SEEEKLVYVLDFGLCRNMFNKQKEL-----------RKPRM---KAPFRGTILYCSLNI .|.....|||...| .. ..|.|||||||.|...|. . .|....||..|||..| ...|..|. |.||. |||||||. |||.|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HQRMEPGRHDDFWSLLYMMIEFHLSDLPWENMS-KEDTKKAKETKLDGLLAR-------CPPEFRMIRCYLLTLTYSKEPDYVKLREVL |.|.| |||||.||..||.||.|.. |||.||. |... ..|. ..| .|. ||.|| .. ..| .|.| ..||| ...|.. HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | C14A4.13.AA | CK1 | 26-282 | 28 | 7.5e-99 | 334.71 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 26-282 Range on HMM: 1-339/339 Sequence Identity: 28% (96 aa) FMAVQMIGKGAYG-VVYEV-----VRRNSPN----TRFACKAELA-ID--HNNLKTEWDLMTLLKDNKS-----------------KHNIIGVELGSERN .. |..||.|..| .|.| .. .... ...|.|.| . | |. | .. .|...|. .. .. .. . |.. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --FNYIVMHLVGPSLSDLRK--TVPNKTFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGS-----------EEEKLVYVLDFGLCR-NMF .||.|| |.||.|.|||| . .|. |.. |. .|||. ..| .. ..|.||||.||.||..|. .| .|.. ||..|||..| DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR NKQK------------ELRKPRM---KAPFRG-TILYCSLNIHQRMEPGRHDDFWSLLYMMIEFHLSD--LPWENMS---------KEDTKKAKETKLDG .|.. ..| || |..||| |. |||.| |...|.||.|| ||..||.||.. ||| ||. |. |... .. DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM LLAR----------CPPEFRMIRCYLLTLTYSKEPDYVKL .. ||.|| .| .|. .|.|...||| .. STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | C14A4.13.AA | Worm6 | 26-282 | 35 | 4.8e-77 | 262.28 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 26-282 Range on HMM: 1-279/279 Sequence Identity: 35% (99 aa) FMAVQMIGKGAYGVVYEVVRRNSPNT-RFACKAEL--AI-DHNNLKTEWDLMTLLKDNKSKHNIIGVELGSERN--FNYIVMHLVGPSLSDLRKTVPNKT . .. ||.|..| ||.| .. . .||.|.| . ...|| | ....| |..| .. | .| ||||||.|||..|.||||. |.. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGV---LGSEEEKLVYVLDFGLCR--NMFNKQKELRKPR-MKAPFRGTILYCSLNIHQRMEPGR |.. |. .|||| ... . ..|.|||||||.||.||. ..|.. .| ||||.|| . ||..|||.|| ...|||| |..|. |...| .| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR HDDFWSLLYMMIEFHLSDLPWENMSKEDTKK-AKETK---LD----GLLAR-CPP-EFRMIRCYLLTLTYSKEPDYVKL || | .|||.|. . .||| .|...| .. |. . .. .. . ||. ||. | |.... | .||| .. KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | C14A4.13.AA | TTBK | 96-282 | 43 | 4.5e-58 | 199.25 | In-house | 70-257 (257) | Show / Hide |
Range on Protein: 96-282 Range on HMM: 70-257/257 Sequence Identity: 43% (83 aa) FNYIVMHLVGPSLSDLRKTVPNKTFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRNMFNKQKELRKPRMKAPFR |||.||.| | .|.||| | .|.| || .| .|. .| .|. |||.||||||.| . |. | .| ||||| | | . | | || | || FNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRK-CYMLDFGLARQYTNACGEVRPPREVAGFR GTILYCSLNIHQRMEPGRHDDFWSLLYMMIEFHLSDLPWENMS-KEDTKKAKET-KLDGLLARCPPEFRMIRCYLLTLTYSKEPDYVKL ||. | | | |. | ||||| ||| ||..|| ||| . |.. . || . || ||.||.. . |.| |||. . GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | C14A4.13.AA | CK1-D | 90-282 | 34 | 2.7e-27 | 93.25 | In-house | 63-261 (261) | Show / Hide |
Range on Protein: 90-282 Range on HMM: 63-261/261 Sequence Identity: 34% (70 aa) LGSERNFNYIVMHLVGPSLSDLRKTVPNKTFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRNMFNKQKELRKP- .|.| ..| .|| |.|||| || .. | | | . | | . . | .||||.|| || .|. ..||..|||| . . . | CGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGL--GKRGNMVYIIDFGLAKRYRDARTHQHIPY RMKAPFRGTILYCSLNIHQRMEPGRHDDFWSLLYMMIEFHLSDLPWENMSKEDTKKAK---------ETKLDGLLARCPPEFRMIRCYLLTLTYSKEPDY | . || | |.| || .| | ||. || |... | . ||| . | ||. | .||.| | . | || | .| . . ||| RENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGL-KAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDY VKL . | CYL |
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| Kinase | C14A4.13.AA | CK1-A | 91-282 | 34 | 6e-27 | 92.15 | In-house | 64-261 (261) | Show / Hide |
Range on Protein: 91-282
Range on HMM: 64-261/261
Sequence Identity: 34% (70 aa)
GSERNFNYIVMHLVGPSLSDLRKTVPNKTFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRNMFNKQKELRKP-R
|.|...| .|| |.|||| || .. ||. | . | | . . ..||||.|| || .|. | || ...|||| . .. . | |
GCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI-GRHCNKL-FLIDFGLAKKYRDSRTRQHIPYR
MKAPFRGTILYCSLNIHQRMEPGRHDDFWSLLYMMIEFHLSDLPWENMSKEDTKKAK---------ETKLDGLLARCPPEFRMIRCYLLTLTYSKEPDYV
||. | |.| |. .| | ||. |. |.|. | . ||| | | ||| | | .. | | || |. | | . .|||.
EDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGM-KAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYM
KL
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YL
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| Kinase | C14A4.13.AA | Dual | 28-197 | 27 | 4.3e-21 | 67.55 | In-house | 3-186 (282) | Show / Hide |
Range on Protein: 28-197 Range on HMM: 3-186/282 Sequence Identity: 27% (51 aa) AVQMIGKGAYGVVYEVVRRNS---PNTRFACKAELAIDHN---NLKTEWDLMTLLKD----NK---SKHNIIGVELG--SERNFNYIVMHLVGPSLSDLR |...| | ..|| | | . |. .. | | || | .| . . .| |. | |. | .. .|.|| ..|||| . | VVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIR KTVPNKTFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRNMFN-KQKELRKPRMKAPFRGT . .. .. . . ||| ... |||.||..||.||..|. ..| || .||.. | . |. | .| | . |. RKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGL--GMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGC |
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| Kinase | C14A4.13.AA | CK1-Unique | 26-225 | 26 | 8.8e-21 | 68.8 | In-house | 1-221 (337) | Show / Hide |
Range on Protein: 26-225
Range on HMM: 1-221/337
Sequence Identity: 26% (59 aa)
FMAVQMIGKGAYGVVYEVVRRNSP-----NTRFACKAE-LAIDHN--NLKTEWDLMTLLKDNK-----SKHNIIGVELGSERNFNYIVMHLVGPSLSDLR
. ||.| || |..| | . ... | | .. .|. | | . ..| . | .||| ..|||. ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC
KTVPNKTFTLF------TTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRN--MFNKQKELRKPRMKAPFRGTILYCSLN
| ||| . |. || . . |..||. || |. . ... |.||.| || . . ..|.|| ..||||. ||.
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS
IHQRMEPGRHDDFWSLLYMMI
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CHQCREHGRRDDMESWFYMLY
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| Kinase | C14A4.13.AA | CK1-G | 91-282 | 29 | 3.6e-17 | 54.66 | In-house | 65-266 (266) | Show / Hide |
Range on Protein: 91-282 Range on HMM: 65-266/266 Sequence Identity: 29% (60 aa) GSERNFNYIVMHLVGPSLSDLRKTVPNKTFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRNMFNKQKELRKP-R | . .| .|| | |||| || . . .|.. |.. ||| . . .. | ||||| || || .......... |||. . . . | | GQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYR MKAPFRGTILYCSLNIHQRMEPGRHDDFWSLLYMMIEFHLSDLPWENMSKEDTKKAK---------ETKLDGLLAR--CPPEFRMIRCYLLTLTYSKEPD . || | | | | | | || .| | . | ||| . | |. | . .| . |. | .| | | . .|| EHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGL-KADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPD YVKL | | YDYL |
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| Kinase | C14A4.13.AA | CK1 | 26-174 | 28 | 1.6e-15 | 50.05 | In-house | 1-155 (271) | Show / Hide |
Range on Protein: 26-174 Range on HMM: 1-155/271 Sequence Identity: 28% (45 aa) FMAVQMIGKGAYGVVYEVVRRNSPNTR--FACKA-ELAIDHNNLKTEWDLMTLLKDNKSKHN--IIGV----ELGSE--RNFNYIVMHLVGPSLSDLRKT .. .. || |. |..|.. . . . . |.| . | |. | ... |... .. . .|. | | ...|..|| | |||| || . YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGH-NC-DNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FN VPNKTFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGL |. |.| |. | | . . . ..||||.|| || .|. . ... ||. |||| FCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGL |
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| Kinase | C14A4.13.AA | S_TKc | 26-291 | 18 | 2.1e-13 | 19.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-291 Range on HMM: 1-231/231 Sequence Identity: 18% (51 aa) FMAVQMIGKGAYGVVYEVVRRNSPNTRFACKAELAIDHNNLKTEWDLMTLLKDNKSKHNIIGVELGSERNFNYIVMHLVGP---SLSDLRKTVPN----K . .. |||||.|.|| .. .. . ..|.| .... | ... . . ....| .. |.|| ... .| |. | . . YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF TFTLFTTAVCAIQCFDSLVEIQRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRNMFNKQKELRKPRMKAPFRGTILYCSLNIHQRMEPGR-HDDF |. ... . | .. | . . | ||||.||.| . . . ||||.| . | || |.. . |. | PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDW WSLLYMMIEFHLSDLPWENMSKEDTKKAKETKLDGLLARCPPEFRMIRCYLLTLTYSKEPDYVKLRE----VLCQIMT ||. ...|. |.. .. . | . .||.. . . .|. .| | .. . . | WSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | C14A4.13.AA | CK1 | 200-280 | 34 | 1.2e-05 | 15.63 | In-house | 182-271 (271) | Show / Hide |
Range on Protein: 200-280 Range on HMM: 182-271/271 Sequence Identity: 34% (31 aa) YCSLNIHQRMEPGRHDDFWSLLYMMIEFHLSDLPWENMSKEDTKKAK---------ETKLDGLLAR-CPPEFRMIRCYLLTLTYSKEPDYV | |.| |. .| .| || || |... | ||| .. | .||| | | .. | . .| || | .| | . ..||| YASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGL-KANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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| Kinase | C14A4.13.AA | TyrKc | 26-286 | 17 | 1.5e-05 | -132.85 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 26-286
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)
FMAVQMIGKGAYGVVYEVVRRNSPNTRFACKAELAIDHNNLKTEWDLMTLL-KDNKSKHNIIGVELGSERNF-----NYIVMHLVGP-SLSDLRKTVPNK
...| ||.|.||. . . . | | . . . | .|. | .... ...|| . ..||| .||| .. .| | . .|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK
TFTLFTTAVCAIQCFDSLVEI-------QRIGYIHRDVKPSNFAIGVLGSEEEKLVYVLDFGLCRNMFNK------QKELRK---PRMK--APFRGTILY
.| . . . | . ..|||| | .| . | . ||||.|. .. .. || | | |
--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR----W
CSLNIHQRMEPGRHDDFWS---LLYMMIEFHLSDLPWEN-----MSKEDTKKAKETK-LDGLLAR--------CPPEFRMIRCYLLTLTYSKEPDYVKLR
... . . | || ... . | . . |... || .. . .. . ||.| .| .. | ..
MAPECINYGKFTTKSDVWSFGVCMWEI--FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH
EVL
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ECF
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