Gene C01C4.3 (Nematode worm)

C01C4.3

Species: Nematode worm
Alias: C01C4.3, aSWK232, C01C4.3a, YWY3_CAEEL, CE30845
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 3710539-3717124, WormBase Genetic Map location: X:-9.93,

Classification

Group: Other
Family: NKF1

Sequence

Name Sequence Type Origin Length Description Download
C01C4.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
C01C4.3.AA Protein Genbank 407 None Fasta, JSON

Protein domain

Protein domains of C01C4.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C01C4.3.AA NKF1 126-391 44 3.9e-179 601.4 In-house 1-269 (269) Show / Hide 
Range on Protein: 126-391
Range on HMM: 1-269/269
Sequence Identity: 44% (119 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFPRPQTKQADFVREYNYSFFLSPHQNIIDTYEGMFQSSDDTAYFFVQEFCPRASLREAVEATNQAGIGE
|....|||.|..|.|.|.||.||..|.|.||.|.||||..||.||..|...||.|..|..||..|||..|||.|.|.||..|...|.|....|||.|..|
YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE

ANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKVDTTVKYLEYVNNYHAAELCDTVV-NEKLVVNKSTDIWALGIIFFYC
...|...|...||..|||..|||||..|.||.|.||.||...||..|||.||....||........|.|.|.|.... ||......|.|.|..|...|.|
NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC

MKGKFPWQKASIMCKPYWEWEQWLKRKN--PALPKKFNPFSEKALKLFKKSLTPRFKDRWTAKDMRKCL
..|.||||||..||.|..||..|..|..  |..|.....|...|...|.|.|||....||..|.|.|..
LTGCFPWQKADWMCDPCYEWFMWWQRRKQPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM
Kinase C01C4.3.AA S_TKc 126-397 19 6.2e-33 116.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 126-397
Range on HMM: 1-231/231
Sequence Identity: 19% (56 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFPRPQTKQADFVREYNYSFFLSPHQNIIDTYEGMFQSSDDTAYFFVQEFCPR--ASLREAVEATNQAG-
|.. ...| | ||  ... || .... |||  .       .. || .       | ||.  |. .      . ...| |.|.    .|..  .  .  | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IGEANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKVDTTVKYLEYVNNYHAAELCDTVVNEKLVVNK-STDIWALG
   . |  ...... ...|.|..|. . .|| || ||||. .      .|..|||| |..    . .    .| | |..          .| . |.|..|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCG

IIFFYCMKGKFPWQKASIMCKPYWEWEQWLKRKNPALPKKFNPFSEKALKLFKKSLTPRFKDRWTAKDMRK-C--LAKEKLL
.|.. .. |. |..        . .  . ..             |. |. . .| |.   ..|.|| .  . .   ..   .
CILYEMLCGYPPFP-------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C01C4.3.AA Ciliate-E2 126-372 18 8.4e-31 102.96 In-house 1-339 (365) Show / Hide 
Range on Protein: 126-372
Range on HMM: 1-339/365
Sequence Identity: 18% (66 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRI------------------AIKFFPRPQTKQAD---FVREYNYSFFLSP---------------HQNIIDTYEG
| ..|..|.| || ........ ....                  .||..   . |. .   . .| .    . .               | |||  || 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE-

MFQSSDDTAYFFVQEFCPRASLREAVEATNQAG---------IGEANTKKVFAAVLS---------------AIEFMHDEN-LVHRNLKAENILIFDAND
 ||. ||. ...| |.|   .|..  .  ..           . |   |.... .|.               |.|..| .|  .||..| ||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

YSKVKVTDFGLTRKVDTT---------VKYLEYVNN----------------------YHAAELCDTVVNEKLVVN--------KSTDIWALGIIFFYCM
   .|..|||| .|.|.           | . . .|                      . . ...  ..| |   |        .. |||.||.|.....
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

KGKFPWQKASIMCKPYWEWEQWLKRKNPALPKK---------------FNPFSEKALKLFKK
 ||.|.             .|  | ..  .|..               ..  |...  |.||
FGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK
Kinase C01C4.3.AA CAMK 131-280 20 8.5e-29 89.34 In-house 1-247 (425) Show / Hide 
Range on Protein: 131-280
Range on HMM: 1-247/425
Sequence Identity: 20% (52 aa)

QLGTGRFGFIKLAEHKQSK------------QRIAIKFFPR-----------------------------PQTKQADFVREYNYSFFLSP---------H
.||.|.||  ||..||...            |. |||. ..                              . ... . ||..    ..          |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEI---MKKLQGIGNKLDH

QNIIDTYEGMF------------QSSD-----DTAYFFVQ---EFCPRA----SLREAVEATNQ-------------AGIGEANTKKVFAAVLSAIEFMH
 |||  || .               |.     |. ...|    |.|.       | . . .  .               . |. ....|  ..||....|
PNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

DENLVHRNLKAENILIFDANDYS--------------KVKVTDFGLTRKVD
. | ||| || ||||. | || |              ..|..|||. .|.|
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD
Kinase C01C4.3.AA CAMKL 126-275 24 6.7e-28 86.0 In-house 1-175 (297) Show / Hide 
Range on Protein: 126-275
Range on HMM: 1-175/297
Sequence Identity: 24% (43 aa)

YTVNKQLGTGRFGFIKLAEH-KQSKQRIAIKFFPRPQTKQADFVR----------------EYNYSFFLS-P-HQNIIDTYEGMFQSS----DDTAYFFV
|.. |.||.| ||  |||.| .  ... |||.  .  ..  ....                |..    |. . |.|||  || .  ..      . .. |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

QEFCPRAS--LREAVEATNQAG--IGEANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGL
 | |.  .  | . ...    .  . |  ... |  ..||....|. . ||| .|.||||. . ..  ..|..|||.
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGF
Kinase C01C4.3.AA Pkinase 126-332 21 8.2e-27 95.89 Pfam 1-213 (293) Show / Hide 
Range on Protein: 126-332
Range on HMM: 1-213/293
Sequence Identity: 21% (49 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFPRPQTKQADFVR-----EYNYSFFLSPHQNIIDTYEGMFQSSDDTAYFFVQEFCPRA----SLREAVE
|.. ...| | ||  ... || . .. |.| .... .|    ..     |  .   |  | ||. .. ..|..  .. . .|.|.|.      .| . ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIV-RLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

ATNQAGI--GEANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDY-SKVKVTDFGLTRK--VDTTVKYLEYV--NNYHAAELCDTVVNEKLVVN
. .. ..   |   |...  .|...|..|... .|| || ||||| . ..  ..||..|||| ..      . .  ..   .| | |.    ...     
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IRGGQYYG

KSTDIWALGIIFFYCMKGKFPWQ
.. |.|..|.|... . |..|..
PKVDMWSCGCILYEMLCGRPPFP
Kinase C01C4.3.AA Ciliate-E2-Unclassified 126-330 19 2.1e-25 85.07 In-house 1-269 (352) Show / Hide 
Range on Protein: 126-330
Range on HMM: 1-269/352
Sequence Identity: 19% (56 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRI-----AIKFFPRP----QTKQADFVRE---YNYSF-------------FLSPHQNIIDTYEGMFQSSDDTAYF
|...||.|.| || .....||. |  .     ..|.  .     ..|. ....|    |                 |. |....  .  ...  |.   .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPF-IVKMFYCFQDKQNIY

FVQEFCPRASLREAVEATNQ---------------AGIGEANTK-----KVFAAVLSAIEFMHDEN-LVHRNLKAENILIFDANDYS--KVKVTDFGLTR
.| |.|.  .|..  .  ..                 . | ..|     . || .|...|..| .|  .||..| ||||.   |. .  ..|..|||. .
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF--DNNGKNYYIKIIDFGISK

KVDT-------------------------TVKYL------EYV--NNYH--AAELCDTVVNEKLVVNKSTDIWALGIIFFYCMKGKFP
| ..                         |  |.      |.   .||   .|              .. |||.||.|..... |..|
KYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA--------------YKCDIWSLGVILYEMLFGYYP
Kinase C01C4.3.AA CAMK-Unique 126-330 20 1.9e-19 60.68 In-house 1-292 (363) Show / Hide 
Range on Protein: 126-330
Range on HMM: 1-292/363
Sequence Identity: 20% (59 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFPR--PQ-TKQAD------------------FVREYNYSFFLSPHQNIIDTYEG---MFQSSDDT----
|. .. .|.| || .. .  .  .   |.| .    ..  ||                    . || .   ... |.|||  |.    .|.  |..    
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVD-HPNIIKLYDWNNPIFC--DRKYPLC

-----------AYFFVQEFCPRASLREAVEA------------------TNQAGIGE--ANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDA-ND-
           ... |.|.|.   | ... .                    |    |  . |  ... .|||...||. . |||.||.|||..    .| 
DLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDN

-----------YSKVKVTDFGLTRKVDTTVKYL---EYV--NNYHAAELC----------DTVVNEKLVVNKST---DIWALGIIFFYCMKGKFP
            ...|..|||| .....  ..    ...    | | |            | |.|.   . ..    |||.|| | .|   |. |
NHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPP
Kinase C01C4.3.AA STE 126-275 16 5e-19 63.91 In-house 1-193 (359) Show / Hide 
Range on Protein: 126-275
Range on HMM: 1-193/359
Sequence Identity: 16% (33 aa)

YTVNKQLGTGRFGFIKLAEHK------QSKQR---------IAIKFFPRPQ------------------TKQADFVREYNYSFFLSP-HQNIIDTYEGMF
..  ...| | ||   .| ..      ....          .|||  .  .                  ... .. .| .    ... |.||.  |   |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

Q----SSDDTAYFFVQEFCPRASLREAVEATNQAGIG------------EANTKKVFAAVLSA-IEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFG
.    ...|.  . . |...  ||.. .. .   | .            |   ...  ..| .  .. |. . .|| .|. |||.        || .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

L
.
V
Kinase C01C4.3.AA MARK 126-279 27 8.4e-19 58.25 In-house 1-156 (262) Show / Hide 
Range on Protein: 126-279
Range on HMM: 1-156/262
Sequence Identity: 27% (43 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFP---RPQ-TKQADFVREYNYSFFLSPHQNIIDTYEGMFQSSDDTA-YFFVQEFCPRASLREAVEATNQ
| . |..|.| ..  ||| || .... |||. .        .   . || ..   |. | |||  .. ...  . .   ... | ... .|.. ..|   
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLD-HPNIIKLFH-VIEQDTEQHQIYLIMEYASGGELYDYIKAHPN

AGIGEANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKV
  . |  ... |  ..||....|. | ||| .|.||||| |.|   ..| .|||. ...
GRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI-DENGNHNIKIIDFGFSICI
Kinase C01C4.3.AA QIK 225-275 43 5e-12 43.1 In-house 117-164 (272) Show / Hide 
Range on Protein: 225-275
Range on HMM: 117-164/272
Sequence Identity: 43% (22 aa)

EANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGL
|  ....|  ..||... |. | ||| ||||||| .|.|  . .|. |||.
ENEARRWFWQICSAVHYCHKRNIVHRDLKAENIL-LDNN--MNIKIADFGF
Kinase C01C4.3.AA TyrKc 126-391 20 1.4e-09 -67.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 126-391
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFPRPQTKQADFVREYNYSFFL-SPHQNIIDTYEGMFQSS----DDTAYFFVQEFCPRASLREAVEATNQ
 | .|.|| | || . ... |   .  |.|        ..|| || .    |   |.||.  |    |..     .  .. | |..|  .|..   ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

AGIGEANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKVDTT-VKYLEYVNNYHAAE--LCDTVVN---------EKLVV
  .  .   .    . .  |. |. |..|| | | |.|. . .    ||..||||.|...    .  |    |...|   ..|..           . . 
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NKSTDIWALGIIFF-YCMKGKFPWQK---ASIMCKPYWEWEQWLKRKNPALPKKFNP-------FSEKALKLFKKSLTPRFKDRWTAKDMRKCL
.  .|.|. |.  .  .  |. |.        |.... |  ...|. .  .|.  |.        ...  .. |.      .|| | .. ..|.
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQ-EVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase C01C4.3.AA CAMKL-Unclassified 225-274 28 7.1e-09 26.25 In-house 99-155 (290) Show / Hide 
Range on Protein: 225-274
Range on HMM: 99-155/290
Sequence Identity: 28% (16 aa)

EANTK-------KVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFG
| | .       . |  .  |. ..| ....|| || ||.|.      . .|. |||
ENNARRQPWEIQQYFQQIVDAMQYCHKNCIIHRDLKLENVLLRQQDSSPVIKIFDFG
Kinase C01C4.3.AA CAMKL-Unclassified 126-156 48 9.1e-08 22.43 In-house 1-31 (290) Show / Hide 
Range on Protein: 126-156
Range on HMM: 1-31/290
Sequence Identity: 48% (15 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIKF
| . . .| | || . |||||| . ..||||
YNIVQVIGEGGFGQVQLAEHKQTQEKFAIKF
Kinase C01C4.3.AA QIK 126-155 40 2e-07 25.15 In-house 1-30 (272) Show / Hide 
Range on Protein: 126-155
Range on HMM: 1-30/272
Sequence Identity: 40% (12 aa)

YTVNKQLGTGRFGFIKLAEHKQSKQRIAIK
|.. . .| | |. .||| |.  |...|||
YDIERTIGKGNFAVVKLARHRITKTKVAIK
Kinase C01C4.3.AA CAMK 301-386 16 2.9e-05 12.14 In-house 291-418 (425) Show / Hide 
Range on Protein: 301-386
Range on HMM: 291-418/425
Sequence Identity: 16% (21 aa)

VVNE-------------KLVVNKSTDIWALGIIFFYCMKGKFPWQKASIMCKPYWE----------WEQWLKRKNPALPKKFNP----------------
|.|              |  .....|.|..|.| . .  |..|..  . .. .             .|. .| |    |..| |                
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE

----FSEKALKLFKKSLTPRFKDRWTAKD
    .|. .  | .| |..  ..|.|...
FHHFVSQECKDLIRKMLQVDPEKRMTIEQ
Kinase C01C4.3.AA Pkinase_Tyr 240-279 37 3.8e-05 18.05 Pfam 125-161 (270) Show / Hide 
Range on Protein: 240-279
Range on HMM: 125-161/270
Sequence Identity: 37% (15 aa)

EFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKV
|. .. |..|| | | |.|. .  .  .||..||||.| .
EYLESKNCIHRDLAARNCLVTE--NN-VVKICDFGLARDI
Kinase C01C4.3.AA CAMKL-Unclassified 308-330 39 0.000473 9.59 In-house 189-211 (290) Show / Hide 
Range on Protein: 308-330
Range on HMM: 189-211/290
Sequence Identity: 39% (9 aa)

VNKSTDIWALGIIFFYCMKGKFP
. .|.||||.|.. . |  . ||
IQYSIDIWAMGVMLYMCIVQFFP
Kinase C01C4.3.AA CAMKL 312-346 22 0.00085 7.83 In-house 217-255 (297) Show / Hide 
Range on Protein: 312-346
Range on HMM: 217-255/297
Sequence Identity: 22% (9 aa)

TDIWALGIIFFYCMKGKFPWQKASIM-----CKPYWEWEQ
.|||..|.| .  . |..|.  ...      .. | .|..
VDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKI
Kinase C01C4.3.AA MARK 312-331 40 0.003166 6.59 In-house 187-206 (262) Show / Hide 
Range on Protein: 312-331
Range on HMM: 187-206/262
Sequence Identity: 40% (8 aa)

TDIWALGIIFFYCMKGKFPW
.|||.||.. ..   |.||.
VDIWSLGVVLYFMVCGYFPF
Kinase C01C4.3.AA Pkinase_Tyr 126-155 32 0.949495 3.16 Pfam 1-34 (270) Show / Hide 
Range on Protein: 126-155
Range on HMM: 1-34/270
Sequence Identity: 32% (11 aa)

YTVNKQLGTGRFGFIKLAEHK----QSKQRIAIK
 | .|.|| | || ..... |    . |.  |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK