Gene B0261.2 (Nematode worm)

B0261.2

Species: Nematode worm
Alias: B0261.2, B0261.2a, aSWK446, CE07705, B0261.2A
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 5245784-5263401, WormBase Genetic Map location: I:-0.16,

Classification

Group: Atypical
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
B0261.2.AA Protein Genbank 2697 None Fasta, JSON

Protein domain

Protein domains of B0261.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT B0261.2.AA HEAT 240-270 16 0.006289 14.0 Pfam 1-31 (31) Show / Hide 
Range on Protein: 240-270
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

FFKYIFNAVRDKNPAVRIAGIDALHVVLTIV
.. ..... .|... || | . .| ... ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT B0261.2.AA HEAT 654-681 32 0.692321 6.93 Pfam 1-27 (31) Show / Hide 
Range on Protein: 654-681
Range on HMM: 1-27/31
Sequence Identity: 32% (9 aa)

VLRAVCSVIVNDQDVRVRMQVISCFGQM
.| ...    ||.| .||.....|.||.
ILPHLL-KCLNDPDWEVREAACWCLGQL
HEAT B0261.2.AA HEAT 701-724 33 12.819686 2.54 Pfam 8-31 (31) Show / Hide 
Range on Protein: 701-724
Range on HMM: 8-31/31
Sequence Identity: 33% (8 aa)

ALHDEKLEMQQACVTLLGRLAELN
.|.|.  | ..|..  ||.|.|  
CLNDPDWEVREAACWCLGQLCEHC
HEAT B0261.2.AA HEAT 820-851 28 0.002966 15.13 Pfam 1-31 (31) Show / Hide 
Range on Protein: 820-851
Range on HMM: 1-31/31
Sequence Identity: 28% (9 aa)

LFEKLTHMINDSSSLHKREAALRAIGGICRST
... | ...||. . . ||||....| .|.  
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
DUF3385 B0261.2.AA DUF3385 854-1028 29 4.4e-31 111.13 Pfam 1-181 (181) Show / Hide 
Range on Protein: 854-1028
Range on HMM: 1-181/181
Sequence Identity: 29% (59 aa)

VVDPYRDYPSLLDDLLRILKTV-MSNTMRREAIKTLGILGAIDPYTHK--VFTGSVQ------------SSTAISTALSLPISETDSKDPRQDIIHWFNY
|.||| |||.||. |..||||   .  .|||.||..|||||.||| ||    .....            ......|  .|.. .  .             
VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMNEIERHSDKHHIKFRDDQHQNQNNPCTDIMLMMQGYSP-L-----------

EKCTLEEFYPAITIANLML-MMQDEDSQSYAE--IAQAI----VTIF--RSLGDMA-PLYTEQVIPRLIEVCRRATESSNRA-NLREFFLQQLANFVAII
    ..|.||.. | .||    .|   .|.      |||    ..||  ...|      . .|.|| .. | | .      . .|||| .|||. .| |.
---SNDEYYPTVVINSLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCP-----PCSLREFYFQQLCTLVSIV

R
.
K
HEAT B0261.2.AA HEAT 951-981 9 44.101823 0.68 Pfam 1-31 (31) Show / Hide 
Range on Protein: 951-981
Range on HMM: 1-31/31
Sequence Identity: 9% (3 aa)

TIANLMLMMQDEDSQSYAEIAQAIVTIFRSL
 .  |. ...|.|..  .  ....... . .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
FAT B0261.2.AA FAT 1615-1866 26 1.6e-56 189.46 Pfam 1-310 (408) Show / Hide 
Range on Protein: 1615-1866
Range on HMM: 1-310/408
Sequence Identity: 26% (82 aa)

AVIAARGAWAVDNWER--MADYVSVIS------------ENTQ-----DGAMLRAVVAV--HNDENT--KAMGLIEKVREMIDSELTA-MANESYERAYI
| .||  || . .|.   | .|.||.             |...     |..  .|. ..  | .. .   |  .|.|.|.  | |.|| ...|||.|.| 
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

PMVSVQQMAELEEAIEYK-TR-----------PERRPRIALLWSRRLQGC-RRNVEQWQRLIMLRGLVLS--------------PQEMHPLRVKFSSMCR
 ||.||. |||||.|.||              ||.. ..   | .||.||  |||| |||....| .|.|              |.|      ||.. ||
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCR

KQGKNSMSRAVLRELL-SLPANSDLVRAKAPFDKPLLVLALAKQLYQDDHKDEAIRALEDLAN-HWNKRINPIPK---ATGR----ELIPPST--KEPAR
|.|  . .  .|..|. . |...|  .      .|  . | .| ... ....||.. |.. .. |  ....  ..   . |     | | ..   .. ..
KHGRMQLCEKTLKMLYTYDPSEEDWHP----RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTYNLEVINNTNLEYFYTK

ICA-KVLLKLGEWTE
  | .. .|.|.| .
LLAMRCYHKQGMWQW
FAT B0261.2.AA FAT 1908-2076 12 4.2e-12 40.77 Pfam 329-408 (408) Show / Hide 
Range on Protein: 1908-2076
Range on HMM: 329-408/408
Sequence Identity: 12% (23 aa)

INYYQQATQYDPGWHK-VWHKLASTHFYAVCRER--------PHPTTVISPPQQPQQPKKMHIPPVTRATSPPPPAQKSPQPAPFHSITEPLSVIIDYPV
...|..||..|| | |  || .|  .| ..  ..        .                                                         
LQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN---------------------------------------------------------

PPPLGSLVGLPPMPAYLSSNSSLPPQHHHVSPLSNDSPSNSAEN-KLYLKHAAHAVRCFAKALMCSPG-SRLEDTLRLMQ
                                           .  ... |.  ||.|| ...  | | . ..||||| .
-------------------------------------------YTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Rapamycin_bind B0261.2.AA Rapamycin_bind 2186-2290 44 2.5e-61 195.52 Pfam 1-100 (100) Show / Hide 
Range on Protein: 2186-2290
Range on HMM: 1-100/100
Sequence Identity: 44% (47 aa)

ELVRCAILWHEQWHDALDDASRVYFHRRLQDNNVQAMFDALRNMNDLMQKGAPTTMKEHSFQQTYSSDLKEAGRYVQAFESSGNVKDLNQAWEIYCSVFK
||.|.||||||.||..|..||| ||    .|.|...||..|. ......| .|.||.|.||.|....||.||  ..|.....|....||||| ||..||.
ELIRVAILWHEMWHEGLEEASRQYF----GDHNIEKMFNILEPLHEMLEK-GPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFR

KLRDQ
..|.|
RIRKQ
Kinase B0261.2.AA FRAP 2357-2608 64 4.2e-166 558.13 In-house 1-251 (251) Show / Hide 
Range on Protein: 2357-2608
Range on HMM: 1-251/251
Sequence Identity: 64% (162 aa)

DYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKIPLSIEHKTLQKLSLETEHLT
.| |||||||| ||||||||||||.|.||.|| || ..|| ||||||. || ..||||||..||||| |...||.|. .| . ||.. ...   . .||.
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKY-HIRYNIEYNIMDRMCNDYDHLP

LMQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRL
||.|  .|. ..  |.||||. .||||||.||.||.|||||||| | |||.|||||||||||||.||.|.|||.||||||||||||| ||||||..||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRL
||||.||||..|..| |. | | |.| .| . ||..|||||||||| ..|||
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase B0261.2.AA PIKK 2328-2598 42 2.3e-137 462.62 In-house 1-290 (290) Show / Hide 
Range on Protein: 2328-2598
Range on HMM: 1-290/290
Sequence Identity: 42% (122 aa)

SIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVK
 |...     |...||.|.|..|||..|  | .|.||||| |||.||||||.|.||.|....|. .|.|.|..||....|  .|||.||.||.||... |
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYREKKA---KIPLSI----------------EHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVG
....||.    ....                  .  .|. .... |..|..|...|. ... | .....  .|.|.|..| |..||.|||||.| |.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAF
||||||||||.|.|.|..||..||||||.|||.|| |...|| |||||||...|||...|..||.  . | |.. .| ..|.|..|.|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase B0261.2.AA PI3Kc 2359-2676 26 8.3e-121 408.56 SMART 1-336 (336) Show / Hide 
Range on Protein: 2359-2676
Range on HMM: 1-336/336
Sequence Identity: 26% (95 aa)

QFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVK-----------------------EYREKKAK
....|...| |||.|.||.|.|.|.......|..||.|....|.........|.|.|||||.|||.. |                       |.. | ..
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM

IPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSS-EVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHID
. ..|.|...... ....|.|.|..|..|| |........|.. .| ..|.. |.|...|.|.|||.|...||.||||.||||..|.|||. ||...|||
Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID

FGDCFEVAMLREKFP----ERVPFRLTRMLINAME----VTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPV-INWRLVEGMKKDPKTRKDTGGR
||..|. ......|.    ||||||||......|.    ..|..| .  ...|.....| .........|..||||. ..||               . .
FGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-------------EKD

QNMAGAVLPSS-STTDSIMETIKRKLDGTEFVHTD-GSTPPEPLQVTEQLAML
 .. .. .. .  . . ... .... ..|.. . . .| ...  .. . .|..
IKYLRQRFRLDHLSDEEAAQYFMQT-MCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase B0261.2.AA PI3_PI4_kinase 2357-2608 31 2e-110 377.98 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2357-2608
Range on HMM: 1-300/300
Sequence Identity: 31% (94 aa)

DYQFLLKGHEDPR--QDERVMQLF-----------------------GLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYRE
.|.|..||..| |  ||.|.||..                       .|.|... ......|||...| |.........|.|.|||||.|.|.. ..|..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

KKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSS-EVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLML--DRLTG
|.. ... .|||   |. ....||..|||...||.....|....|....| ..|.  | |...|.|..||.|.|..|.||||.||||..|.|.  |. ||
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

KVVHIDFGDCFE-VAMLREKFPERVPFRLTR------MLINAM------EVTGLDGVYNYTAERVLKMLRTNQESLLAVL-------EAFVYDPVINWRL
...|||||.||. ..| ....|||||||.|.      ....||      ...| .| .  . ....  || ........|       |..|.|....|| 
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase B0261.2.AA ATR 2327-2598 29 1.2e-52 177.52 In-house 1-267 (267) Show / Hide 
Range on Protein: 2327-2598
Range on HMM: 1-267/267
Sequence Identity: 29% (81 aa)

VSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHT-L
  |  |   .....| |.|.|. ..||.|  |  . | ..| |.| | |.   |.| ..    |  || . .. |... |  ....| || |  ||.. |
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

VKEYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDR
 | ..||| .      ..  .|.| |     . .|.. |   |        .     . | .. |.  | || || | ..|||||.||||||  |...|.
DKLWKEKKQYMQFYQLRQCMDKKSRE-----EWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDK

LTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAF
..| .||.|.   |      |  || ||||||. ....|   . .|..    | .....| ... ...|...|
INGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase B0261.2.AA ATM 2489-2606 45 6.7e-39 121.67 In-house 132-248 (304) Show / Hide 
Range on Protein: 2489-2606
Range on HMM: 132-248/304
Sequence Identity: 45% (54 aa)

VWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQ
.||..|  ||||||  |.|||||||||||  |...      .|||| |  ||   .    || ||||||| ..  | .|| .||.    |. . ..|  |
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

ESLLAVLEAFVYDPVINW
| || . |  .|||.  |
ETLLTIVEVLLYDPLFDW
Kinase B0261.2.AA DNAPK 2508-2608 33 2.7e-19 66.74 In-house 201-301 (301) Show / Hide 
Range on Protein: 2508-2608
Range on HMM: 201-301/301
Sequence Identity: 33% (34 aa)

GYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWR
..||| ||||  | |    .| .. ||||  |  | .    ||  ||||||  || |   .  |..       .. .|     |.   . |. || . | 
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

L
 
N
Kinase B0261.2.AA DNAPK 2327-2435 34 3.4e-18 62.68 In-house 2-111 (301) Show / Hide 
Range on Protein: 2327-2435
Range on HMM: 2-111/301
Sequence Identity: 34% (38 aa)

VSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHT-L
| |  |  .. |. |  ||....|||    .  |. || || ||| |. |||   |  ..  .    | |    |.|. .    ||| || |  .|   |
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

VKEYREKKAK
 .|. .|  |
NNEMQQKMGK
Kinase B0261.2.AA SMG1 2497-2540 65 8.5e-18 55.4 In-house 190-233 (242) Show / Hide 
Range on Protein: 2497-2540
Range on HMM: 190-233/242
Sequence Identity: 65% (29 aa)

YTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFE
| || | |||||||.||||||  | ..|  || |||||.  |||
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase B0261.2.AA FATC 2665-2697 60 1.3e-17 59.48 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2665-2697
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

EPLQVTEQLAMLTEQATSPLNLCQSYIGWCPFW
||| |..|  .| ..||.| |||| ||||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase B0261.2.AA SMG1 2336-2434 37 2.6e-17 53.74 In-house 1-99 (242) Show / Hide 
Range on Protein: 2336-2434
Range on HMM: 1-99/242
Sequence Identity: 37% (38 aa)

MNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLA--NNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKK
. ..  | .|.|..  || |  | .| || ||   |||.||   .|||. |  |  || |       ||.  |   |||| ||     |  | | .  . 
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPR--FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQRE

A
|
A
Kinase B0261.2.AA ATM 2359-2415 47 1.3e-15 45.94 In-house 1-57 (304) Show / Hide 
Range on Protein: 2359-2415
Range on HMM: 1-57/304
Sequence Identity: 47% (27 aa)

QFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGW
  | || .| |||  . | | . ||||  | || .| |||  | .| ||. || . |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW