Gene ark-1 (Nematode worm)

ark-1

Species: Nematode worm
Alias: aSWK328, ark-1, C01C7.1, CE26967, rok-1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 12630943-12622460, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: Ack

Sequence

Name Sequence Type Origin Length Description Download
ark-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
ark-1.AA Protein Genbank 1043 None Fasta, JSON

Protein domain

Protein domains of ark-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SAM_Ack ark-1.AA SAM_Ack 9-73 38 6.2e-33 114.44 In-house 1-65 (65) Show / Hide 
Range on Protein: 9-73
Range on HMM: 1-65/65
Sequence Identity: 38% (25 aa)

TADATLNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPS
.....|...|..|.|..|....|..||........||...||...|||||||.||...|.||.|.
EECQWLYEFLREAQLEQYYNQIRDHLKVTRLDHFDYVKDEDLECIGMSRPEQRRLWEAYKKMCPH
Sam7 ark-1.AA sam7 9-71 17 2.8e-08 27.38 In-house 1-70 (70) Show / Hide 
Range on Protein: 9-71
Range on HMM: 1-70/70
Sequence Identity: 17% (12 aa)

TADATLNKLLQAADL---SGYESDLRRKLK---LRNAADLQYVEEVDLLSVGMSRP-EQKRLRKEYTKMF
. . ..   |.....   . |.. .|. .    . . ..|....| ||.. |..||  .|.. ..  .| 
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
Kinase ark-1.AA Ack 113-376 57 1.5e-194 652.59 In-house 1-266 (266) Show / Hide 
Range on Protein: 113-376
Range on HMM: 1-266/266
Sequence Identity: 57% (154 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLAT--SSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALR
||||..||.|.||.||...|.| .|...|||||||..|||. ..  ...||.|.|||....|.|.|||||||||....|.|.|||.|||||.||.| ..|
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK-HCR

DSFP-VHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSP-KLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYG
..|. .|.|||...||||||.|||..|.|||||||||.|.||. ..|||.||||.|.||..|||||.||..|||.|.|||||||.....|...||||..|
TAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFG

VTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKF
||.||||||||.||.|..|.|||...|...|.|.||..||||||.|....|.|...||||||.|....
VTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase ark-1.AA Pkinase_Tyr 113-376 41 3.5e-125 424.59 Pfam 1-270 (270) Show / Hide 
Range on Protein: 113-376
Range on HMM: 1-270/270
Sequence Identity: 41% (114 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCV--GSDKL-LATSSSFLQEAAIMTRM-RHEHVVRLYGVVL-DTKK--IMLVSELATCGSLLECLH
||. |.||.|.||.|... || . ... |.||||..  |...  .  . .|..||.||. . .|...||||||.. . .   |..| |.. .|.||. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KP-ALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDV
|.   ....... |.... |||.||.||| ...|||||||||.|| ... |||.||||.| .   .||| .  . . |||| |.||||||. |||.||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

WAYGVTIWEMFSYGEMP-WKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKF
|..||..||.|.|||.| ..| | ....|..... . . .|. ||..|||..|. | .. .||||||.|. ..
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ark-1.AA TyrKc 113-376 39 1.1e-113 384.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 113-376
Range on HMM: 1-280/280
Sequence Identity: 39% (116 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRM--RHEHVVRLYGVVLDT-------KKIMLVSELATCGSLLEC
||| |.|| |.|| |... ||       ||||||.. .|.       |..|| ||..   .|...||||||...        . .|.| |..  |.|.. 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIG------EDYYRSEFTPNLK--LPIAWCAPECINF
|.|.  .  ...  |.... ||| ||.||. ...|||||||||.|| ... |||||||||| .. .      .||||.  . . |  ||| |.||||||.
LRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

LKFTSKSDVWAYGVTIWEMFSYGEMPWKG-----RSGAQILELVDRKKELLTRPKA-------CPEDIYDMLKETWTHQVQDRPTFSDIVAKF
 |||.|||||..||..||.|.||..|. |      | ....|.|.. . .   | .       ||...|.. |. | ..  ||||||.|. .|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ark-1.AA TK 113-376 22 1.3e-104 351.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 113-376
Range on HMM: 1-486/486
Sequence Identity: 22% (108 aa)

ITLCKELGQGEFG---SVWQA------GWKNSAGSD---------------VIQVAVKCVGSDKLLATSSSFL-------------QEAAIMTRMR----
||| |.||.|.||    |...      .|... ...               ...||||.. ..   .    |.             .||..|  |.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HEHVVRLYGVVLDTKK------------IMLVSELATCGS----LLECLHKPALRDS------------------------------------------
 |...||||||... .             .|.| |.. .|.    |.. |.|   . .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FPVHVLCDYAEQIAMGMSYLELQ------RLIHRDLAARNVLVFSPKL-----------VKISDFG---
                               ...| |. .. ||| ||.||. .      ...||||||||.||.. .            .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRSLGIGEDYYRSEFTP---------------------NLKLPIAWCAPECIN---------FLKFTSKSDVWAYGVTIWEMFSYGEMPWKG-R
     |.| .. ..||||..                        . |||| |.||||.|         . |||.|||||..||..||.|.||..|. |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SG---------AQILELVDRKKEL-----------LTRP--KACP--------------EDIYDMLKETWTHQVQDRPTFSDIVAKF
|          ....|.. |   |           . .|  . ||              |..||.... | .. .||||||... ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ark-1.AA UTK 113-376 30 2.1e-87 296.65 In-house 1-296 (296) Show / Hide 
Range on Protein: 113-376
Range on HMM: 1-296/296
Sequence Identity: 30% (90 aa)

ITLCKELGQGEFGSVWQAGWKNSA--GSDVIQVAVKCVGSDKLLATSSS----FLQEAA---IMTRMR-HEHVVRLYGVVLDTKKIMLVSELATCGSLLE
. | ..||||.|| |  | ... .  . ... ||||   ...   ...     |. ||.   .| . . |..|.||.||... . .|.|.|..  |.|. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMD-VAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

--CLHKPALR---DSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSP-------KLVKISDFG---LSRSLG------IGEDYYRSEFTPNL
  . |.|...   ...  | . ..| .|| ||.||. ....||||||||.||..         ..||.|||   .|| ..      . ...| .  ... 
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

KLPIAWCAPECINFL-KFTSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKK-ELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKF
..||.|.|||...   .||.|||||..||. ||....| .|..| | .|... | ..   .. .|..||...|..... |.  .|.||.| |.|...
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ark-1.AA Src 113-376 38 2.1e-84 286.64 In-house 1-255 (255) Show / Hide 
Range on Protein: 113-376
Range on HMM: 1-255/255
Sequence Identity: 38% (103 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDS
|.||..|||| || ||.. |...     ..||||   ..        ||||| ||. .|||..|.|| |. . . |  | |. . ||||. |.|     .
IKLCRKLGQGQFGEVWMGYWNGN-----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

FPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIW
 ..  | | | |.| ||.||| ...||||||||||||    ..|. |||| | .  ..| | ..     |.|| | |||.||. .|| ||||| .|. ..
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH--GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

EMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYD-MLKETWTHQVQDRPTFSDIVAKF
|...|| .| .| . .. |. |.|    . .|. ||. .|.  ... |  . ..||||  .  ..
EIVTYGRVPYPGMTNHEVLQQVERGYR-MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ark-1.AA Syk 113-370 37 2e-83 283.5 In-house 1-257 (257) Show / Hide 
Range on Protein: 113-370
Range on HMM: 1-257/257
Sequence Identity: 37% (99 aa)

ITLCKELGQGEFGSVWQAGWKNS--AGSD-VIQVAVKCVGSDKLL-ATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPA
. . .|.|.|.|||| .   .    || . .|.||.|    | .  |    |. || .| .  | ..||. |. .     |.| |.|  |...  | .  
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICH-AEMMMMVMEMAELGPMHKYLQQH-

LRDSFPV-HVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAY
 |.. ..  ||   . |.|||| ||| .  .||||||||||       ||||||.|..|| ...||.  .|   | |. | |||||.. || .||||| .
-RHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQ--ATTHGKWPVKWYAPECIYYYKFSHKSDVWSF

GVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFS
|||.|||||||  | .. .|. ...... . . . .|  ||...|.  .. |. .. |||||.
GVTMWEMFSYGQKPYGEMKGQEVMKFIE-NGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase ark-1.AA SFK-Src 113-369 41 7.1e-82 242.31 In-house 1-248 (259) Show / Hide 
Range on Protein: 113-369
Range on HMM: 1-248/259
Sequence Identity: 41% (109 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSS-FLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRD
| | | ||.| || ||.  | |.      .||||     |  |.|.  |||||..| ..||.  ..|| |  |   |  ..||   ||||  || |. | 
IRLEKKLGSGQFGDVWKGRWNNTT-----EVAVKTL---KPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGR-

SFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGED-YYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVT
|  .  | | | |.| || ||| |  .|||||||||||     .|. |||.|| |.  .  |   |     | || | |||  |  .|  |||||..|. 
SLRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGA---KFPIKWTAPEAMNMNRFSIKSDVWSFGIL

IWEMFSYGEMPWKGRSGAQILELVDR-KKELLTRPKACPEDIYDMLKETWTHQVQDRPTF
. |.  || .|. | . . .|  ||| ... .  |. ||.  | .. . | |.  |||||
MMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTF
Kinase ark-1.AA EGFR 113-377 37 6.3e-72 238.06 In-house 1-258 (258) Show / Hide 
Range on Protein: 113-377
Range on HMM: 1-258/258
Sequence Identity: 37% (99 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDS
. . | || | || |.   |   . .  | ||.| .        .  .|.|| .| ...|.|.||| || .  . ..||  .   |.||. ...   .| 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQ--HKDN

FPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIW
   . |  .. ||| ||.||| .|..||||||||||| ||. ||| ||||.. | . |. |. .     |.|| | | ||| . ..|..||||.||||.|
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGG---KMPIKWMALECIHHRCYTHQSDVWSYGVTCW

EMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFP
|.  .|. |..| . ..| .|.. | | |  |. |  |.| ..   |    . ||||  ....| 
ELMTFGQKPYDGIPAREIPDLLE-KGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ark-1.AA Fer 113-377 32 2.6e-67 228.27 In-house 1-283 (283) Show / Hide 
Range on Protein: 113-377
Range on HMM: 1-283/283
Sequence Identity: 32% (93 aa)

ITLCKELGQGEFGSVWQA----GWKNSAGSDV--IQVAVKCVGSDKLLAT-SSSFLQEAAIMTR-MRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECL
.|| | || | || |...      |.. ...|  . |.|| . .... .     |..|| ||   . | .||..|||  |   ||.| |....|||.. |
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

HKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVK---ISDFGLSRS-LGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTS
 |   . . ..  . ... |.| || ||. .  ||||.||||.|.   |..|   |||||.||   ..|.||.  |  .  |.|| | |||....  ...
KKNKNK-TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE--KACKVPIRWLAPETWQTGIYSP

KSDVWAYGVTIWEMFSYGEMPWKG----RSGAQI----LELVDRKKELLTRPKACPEDIYDMLK-ETWTHQVQDRPTFSDIVAKFP
|.|||..||..|| |. |. |. |       ...     . . .|   .. |. .|..|.  ..   |..   ||||...|. |. 
KTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase ark-1.AA Frk 113-380 38 6.7e-67 228.57 In-house 1-260 (260) Show / Hide 
Range on Protein: 113-380
Range on HMM: 1-260/260
Sequence Identity: 38% (104 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLH-KPALRD
| | ..|| | || ||   | |      . |||| . .  .  .   ||.|| || ..||  ...|| |    . |... ||   |||.| |        
IQLIRRLGSGQFGEVWEGLWNN-----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR

SFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGED-YYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVT
.  .. | | | |.| || ||| |  ||||||||||||   . .|| |||| | |   .   | |    . ..|| | ||| .|  ||| |||||..|. 
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRH--GARFPIKWTAPEAANYNKFTIKSDVWSFGIL

IWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPERR
. |.  || ||. |  .|..|. ||.    . .|  ||. .|... | | .. . ||||  .  |. .  
LTEIITYGRMPYPGMTNAEVLQMVDHGYR-MPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase ark-1.AA Tec 113-378 36 1.3e-65 224.28 In-house 1-254 (254) Show / Hide 
Range on Protein: 113-378
Range on HMM: 1-254/254
Sequence Identity: 36% (98 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCV--GSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALR
.|. ||||.| || |  . |...     ..||.| .  ||         |..|| .|.   |.  |.|||| .  . | .| |  . |.||. | .   .
LTFMKELGSGQFGVVHLGKWRHQ-----YDVAIKMIKEGS----MSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLRE--HK

DSFPVHV--LCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEF-TPNLKLPIAWCAPECINFLKFTSKSDVWAY
  |   .  | .   ..  || ||| .  ||||||||| || . . ||.||||..|   .  | | | . |   | |. ||.||  .. .. |||||||.
HHFQKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRY--VLDDQYTSSVGT---KFPVKWCPPEVFHYSRYSSKSDVWAF

GVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPE
||  || || | ||.  .|  .. | | .    | ||. |.. ||.  .. | ..  .||||..   .  |
GVLMWEVFSCGKMPYENMSNSEVVEHVSQG-HRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase ark-1.AA S_TKc 113-377 21 3.4e-45 157.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 113-377
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATC--GSLLECLHKPALR
 .. ...|.| ||.|... .|.    .  .||.|..          ....| .|. . .|...|.||.|  | ... .| |..    |.|.. ..|   .
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

DS---FPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTS-KSDVWA
     ||  . . |. ||. .. |.  .. |||||   |.|. .   .||.||||.| |              .     ..||| .   ...  |.|.|.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWS

YGVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVA--------KFP
 |....||.. |. |.      |. .. .. .         ...  |...  ..   ..|||  .. .         . 
CGCILYEMLC-GYPPFP-----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ark-1.AA Pkinase 113-376 23 2.7e-41 147.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 113-376
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

ITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQ------EAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCG----SLLE
... . .|.| ||.|... .|..      .||||..   |.  ..|...|      |..|| |..|...||||... | ..| .| |.. .|    .| .
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKII---KKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

CLH---KPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLV----KISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECIN-
 ..   . ..   |. .....|. ||. |. |.  .. |||||   |.|. .   .    ||.||||.. .     | ... .  .   . ..||| |. 
YISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRG

FLKFTSKSDVWAYGVTIWEMFSYGEMPWKGR----SGAQILELVDRKKE---LLTRPKACP-------------------EDIYDMLKETWTHQVQDRPT
  . ..|.|.|..|....||.. |. |..|.    . .  .....|...      .|. |.                   |.  | .|  ..   ..|||
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

FSDIVAK--F
. .|.    |
AEQILQHPWF
SH3 ark-1.AA SH3 382-443 28 4.8e-07 30.64 SMART 1-58 (58) Show / Hide 
Range on Protein: 382-443
Range on HMM: 1-58/58
Sequence Identity: 28% (18 aa)

QSVRAVVDCKDSAADHLHFKKDDLIVVISRSPAQYPDGYYWFGSLR-NGKLGLFRPTDTVAHL
. |||. |.. . .|.| |||.| | |....     |.  | | .. .|. |.|  .      
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 ark-1.AA SH3_2 383-434 23 1.4e-05 22.44 Pfam 1-60 (68) Show / Hide 
Range on Protein: 383-434
Range on HMM: 1-60/68
Sequence Identity: 23% (15 aa)

SVRAVVDCKD-SAADH-----LHFKKDDLIVVI---SRSPAQYPDGYYWFG-SL-RNGKL--GLF
 .|.. |..  . ...     |||||.|.|.||   ....     .. |..     .|.   |.|
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD----NW-WWCWETIWGGRRMRGWF
PBD ark-1.AA PBD 483-548 21 2.2e-13 49.4 Pfam 1-60 (60) Show / Hide 
Range on Protein: 483-548
Range on HMM: 1-60/60
Sequence Identity: 21% (15 aa)

LISEPVGDVRHTCHVGIDGTAF---GLLQLDKKAMCPTSSSPSTSRGSQASPAPSHTSSSTTSSVHLRE
 || |.....||.|||.||  .   |...  .| ....         .  .|...|........|....
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSS---------GISKPEQKHNPQAVFDVVQFYQ
PBD ark-1.AA PBD 484-518 31 1.7e-12 48.72 SMART 1-38 (38) Show / Hide 
Range on Protein: 484-518
Range on HMM: 1-38/38
Sequence Identity: 31% (12 aa)

ISEPVGDVRHTCHVG-IDG--TAFGLLQLDKKAMCPTS
|| | |...|..||| .||  . |. |... .......
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC