Gene abl-1 (Nematode worm)

abl-1

Species: Nematode worm
Alias: aSWK326, M79.1, M79.1a, M79.1A, CE31570, abl-1, M79.1x=(nlenl..pqqn)
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 10593251-10574901, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: Abl

Sequence

Name Sequence Type Origin Length Description Download
abl-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
abl-1.AA Protein Genbank 1196 None Fasta, JSON

Protein domain

Protein domains of abl-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 abl-1.AA SH3 118-187 27 6e-18 66.88 SMART 1-58 (58) Show / Hide 
Range on Protein: 118-187
Range on HMM: 1-58/58
Sequence Identity: 27% (19 aa)

PLFVALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFIAPYN
| ..||||. . ... ||..||| ...|  . ...|...|. .            |..||.|||......
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNR-----------TGQEGWFPSNYVEEID
SH3_1 abl-1.AA SH3_1 121-180 30 2.7e-14 51.24 Pfam 1-49 (49) Show / Hide 
Range on Protein: 121-180
Range on HMM: 1-49/49
Sequence Identity: 30% (18 aa)

VALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPS
|||||. ..... ||..|||.. ..  .....|...|. .|           |. ||.||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNT-----------GQEGWFPS
SH3_2 abl-1.AA SH3_2 119-186 14 4.4e-09 34.71 Pfam 1-68 (68) Show / Hide 
Range on Protein: 119-186
Range on HMM: 1-68/68
Sequence Identity: 14% (12 aa)

LFVALYDFHG-VGEEQ-----LSLRKGDQVRIL--GYNKNNEWCEA-RL--YSTRKNDASNQRRLGEI--GWVPSNFIAPY
..... |. .  ...      |...|||.....  |  ....|... .                 |.   ||.||......
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG-------------GRRMRGWFPSQWVEEC
SH2 abl-1.AA SH2 194-269 50 4.4e-45 134.19 Pfam 1-81 (81) Show / Hide 
Range on Protein: 194-269
Range on HMM: 1-81/81
Sequence Identity: 50% (41 aa)

WYHGKISRSDSEAILGS--GITGSFLVRESETSIGQYTISVRHDG---RVFHYRINVDNTEKMFITQEVKFRTLGELVHHH
||||||||.. | .| .  .  |.|||||||...|.||.|||.||   || ||||. ..... .|| ..||..| |||.|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 abl-1.AA SH2 192-275 42 7.6e-36 126.33 SMART 1-87 (87) Show / Hide 
Range on Protein: 192-275
Range on HMM: 1-87/87
Sequence Identity: 42% (37 aa)

YTWYHGKISRSDSEAILGS--GITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQ--EVKFRTLGELVHHHSVHADG
. ||||.|||.. |..| .  .  |.||||.||...|.|..|||..|.| ||||. ... | .|..  ..|| .| |||.|.. ...|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase abl-1.AA Abl 311-562 75 8.20000000001e-197 660.13 In-house 1-252 (252) Show / Hide 
Range on Protein: 311-562
Range on HMM: 1-252/252
Sequence Identity: 75% (189 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILV
|.|..||||||||.||||.|||||||.|||.||||.|..||||.||||||...|.|||.||||||.|.||||||||||.||||.|||..|...||...|.
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

QMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYP
.||.||||||||||.|||||||||||||||.||.|||.|||||||.||.|||||||||||||||||||.||.|.||||||||||||||||||||||.|||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

GVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNL
|..||.||..||.|.||..|.||||.||.||.|||.||..|||.|..||...
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase abl-1.AA Pkinase_Tyr 311-562 51 3e-149 506.08 Pfam 1-270 (270) Show / Hide 
Range on Protein: 311-562
Range on HMM: 1-270/270
Sequence Identity: 51% (138 aa)

IIMHNKLGGGQYGDVYEGYWK----RHDCTIAVKALKEDAMPL----HEFLAEAAIMKDL-HHKNLVRLLGVCT-HEAP--FYIITEFMCNGNLLEYLRR
|..  ||| |..|.||.|.||     .... ||| |||.||.      .|..||.||| | ||.|.|||.|||| .. |   ||..|.|..|.||.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T--DKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFM-KEDTY-TAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAF
   ||  |..  |.||. |||.||.|||....||||||||||||.| |.|||.|||||| . ..|.| ... |.|.||||.||| .... |..|||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLLWEIATYGMAP-YPGVELSNVYGLL-ENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNL
|||.||| |||. | |||.  . || .. |.| ||. |..||. .|.||.|||.. |.|||.|..||  |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase abl-1.AA SFK-Src 311-566 50 2.6e-140 418.81 In-house 1-259 (259) Show / Hide 
Range on Protein: 311-566
Range on HMM: 1-259/259
Sequence Identity: 50% (131 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRR-TDKSLLPPIIL
| .  ||| ||.|||. | |      .||| ||  ||   |||.||..|| | | ||..|  |||   | ||||| | .| || ||.    .||  |  |
IRLEKKLGSGQFGDVWKGRWNNT-TEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMP-QL

VQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFM-KEDT-YTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMA
| ||.|.|.|| ||||  |.|||||||| || . |..|..|||..| . ..|  |||| ||||||||||||    |.|| |||||.||.|. || |||  
VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYPGVELSNVYGLLEN--GFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLI
||||     |   ..   | ||. |..||.  | .|..||   |.||| |    . .|.  
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase abl-1.AA TyrKc 311-562 42 5.4e-137 462.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 311-562
Range on HMM: 1-280/280
Sequence Identity: 42% (122 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDL--HHKNLVRLLGVCTHE-------APFYIITEFMCNGNLLEYLRRTDK
| .  ||| |..| ||.| ||    . ||| |||||  . .|. || ||. |  ||.|.|||.||||..        | .|..|.|..|.|..|||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKED--------TYTAHA--GAK--FPIKWTAPEGLAFNTFSSKS
  |..  |.... |||.||.||. ...||||||||||||.| ..|||.||||.|. ..|        .|..    |.|  .||.|.||| . ...|..||
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWAFGVLLWEIATYGMAPYPG-----VELSNVYGLLENGFRMDGPQG--------CPPSVYRLMLQCWNWSPSDRPRFRDIHFNL
|||.|||..||| |||. ||||     .. . |. ....|.||. |.         ||. .|..|.|||.  |.|||.|..||  .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase abl-1.AA Src 311-562 50 9.40000000001e-136 457.3 In-house 1-255 (255) Show / Hide 
Range on Protein: 311-562
Range on HMM: 1-255/255
Sequence Identity: 50% (129 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLR-RTDKSLLPPIIL
| .  ||| ||.|.|..|||. .    ||| ||.. |  . ||.|| ||| | |..||.|. ||. | |.||.||.|..|.||.||. ... . |.  .|
IKLCRKLGQGQFGEVWMGYWNGN-TKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL

VQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMK--EDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMA
. || |.|.||.|||.. .||||||||| ||.|.|..|.||||||| .|  .| |.|. |||||||||||| . ...|. ||||| ||.||.|| |||  
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGVELSNVYGLLENGFRMDGPQGCPPSVYR-LMLQCWNWSPSDRPRFRDIHFNL
|||| .   |   .|.|.||  |..||...|  .|||||. .| .|| |  ..  |
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase abl-1.AA SFK-Abl 311-562 51 2.7e-131 430.87 In-house 1-251 (251) Show / Hide 
Range on Protein: 311-562
Range on HMM: 1-251/251
Sequence Identity: 51% (131 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLR-RTDKSLLPPIIL
||.   ||.|||| || | |  |  ..|.|  |...|   .|. || ||| . | |||||.|||| | | ||..||| .||||.||.       . .. .
IILGHRLGEGQYGEVYKGIWNNH--RVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSM

VQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPY
   | ||| ||| ||..|||||||||||||| .   .|.||||.|||   | |.|  | |.|||||||| |..  |. |||||.||. |||||||| .||
MHCAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPY

PGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNL
||.. . |   |. |.||  ||.||  .|  |.|||   |  || | |    |
PGIHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase abl-1.AA TK 311-562 26 2.8e-118 398.3 In-house 1-486 (486) Show / Hide 
Range on Protein: 311-562
Range on HMM: 1-486/486
Sequence Identity: 26% (128 aa)

IIMHNKLGGGQYG---DVYEGYWKRHD-------------------------CTIAVKALKED-AMPLHEFLA--------------EAAIMKDLH----
|.. .||| ||.|   .||.| |....                         .. ||| |||. ||   ||..              ||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVRLLGVCTHE------------APFYIITEFMCNGN----LLEYLRRTD----------------------------------------------
 |.|.|||.||||..             |..|..|.|..|.    |..|||. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------KSLLPPIILVQMASQIASGMSYLEAR------HFIHRDLAARNCLVSEHNI-----------VKIADFG---
                            |. |..  |. |. |||.||.||...      .|.|||||||||||.|.|.           .||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARFM-KEDTYTAHA------------------------GAKFPIKWTAPEGLA---------FNTFSSKSDVWAFGVLLWEIATYGMAPYP---
     ||| . ..| |...                         |.|.||.|.||| |.         ...|..|||||.||||.||| ||| .||.   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

--------GVELSNVYGLLENG--------------FRMDGPQGCP--------------PSVYRLMLQCWNWSPSDRPRFRDIHFNL
        | ..  |. .|..|              .||  |..||              . .|.||.|||.. |.|||.|...|  |
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase abl-1.AA Src-Unclassified 311-555 42 5.5e-114 384.98 In-house 1-277 (284) Show / Hide 
Range on Protein: 311-555
Range on HMM: 1-277/284
Sequence Identity: 42% (117 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKED---AMPLHEFL--------AEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRT
.    ||| || | |. | | |    .||| ....    |    ||        .||.||| . | ||| |..||. | |.|||||.| || || .||  
VHLLRKLGRGQFGEVWYGKW-RGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREG

DKSLLPPIIL------------VQMASQIASGMSYLEARHFIHRDLAARNCLVSEHN-----IVKIADFGLA--RFMKEDTYTAHAGAKFPIKWTAPEGL
....|.   .            | .| |.|||| |||..  .|||||||| |. . |     .||..|||||  . | .| | .  ||.||.||.|||  
GGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECF

AFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGP--QGCPPSVYR-LMLQCWNWSPSDRPRF
   .|| ||||| .|.|||||.|.|  ||||     |   .| |.||  |  ..|| ..|  .|..||.  |  || |
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTF
Kinase abl-1.AA Tec 311-564 41 2.1e-112 379.76 In-house 1-254 (254) Show / Hide 
Range on Protein: 311-564
Range on HMM: 1-254/254
Sequence Identity: 41% (106 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPI-IL
. .   || ||.| |  |.|.     .|.|..|| .|   .|. || .|. | | .||.| |||. ..| ||.||.| .| ||.|||.  . .     ||
LTFMKELGSGQFGVVHLGKWRH-QYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAIL

VQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPY
 .|  ..  || |||   |||||||||||||.. ..||..|||..|.   | ||   |.|||.|| .|| . .. .|||||||||||| ||. . | .||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLEN
.  . | |      |.|.  |. |. ..|. | .||  .| .|| |..   ....
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase abl-1.AA Frk 311-566 49 5.2e-109 368.46 In-house 1-260 (260) Show / Hide 
Range on Protein: 311-566
Range on HMM: 1-260/260
Sequence Identity: 49% (130 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLR--RTDKSLLPPII
| .  .|| ||.|.|.|| |      .||| ||  .|  ..||.|| |||.| |  |..|  ||| | | ||||| | .| |.|||.      . .   .
IQLIRRLGSGQFGEVWEGLWN-NTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ

LVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLAR-FMKEDT--YTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYG
||.|| |.|.|| ||| . .||||||||| || ||||.||||||||| .||..   | .. ||.|||||||||    | |. |||||.||.|| || |||
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

MAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLI
  ||||.   .|   ...|.||  | .||. .| .||.||.  |  || |  ... ||. .
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase abl-1.AA Csk 311-562 45 8.49999999999e-104 351.13 In-house 1-251 (251) Show / Hide 
Range on Protein: 311-562
Range on HMM: 1-251/251
Sequence Identity: 45% (116 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKED-AMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEA-PFYIITEFMCNGNLLEYLRRTDKSLLPPII
. .  . | | .|||  | ..     .||| .|.|    .  |||||..|  | |.|||.|.||  |.    ||..|.| .|||..|||   ....    
LHLGECIGHGEFGDVMQGEYQNR--KVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQ

LVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAH--AGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGM
| . |  ...|| |||.. |.|||||||| |||| .. |. |||||   ||.... .  .. |||||||||| |    ||.||||| ||.|||||  .| 
LLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLA---KEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGR

APYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNL
.||| . |. |    | |.||. | ||||.|| .| |||. .| .|| || .   |
VPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase abl-1.AA SrcB 311-563 49 1.4e-101 343.74 In-house 1-251 (251) Show / Hide 
Range on Protein: 311-563
Range on HMM: 1-251/251
Sequence Identity: 49% (126 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILV
. .  ||| ||.|.|. ||...|   .|||..|. .|  . ||||| .|| | |. ||||  | |.| | |||||.| .| ||..|.  . | |.   |.
LKLVKKLGAGQFGEVWMGYYNNH-MKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLI

QMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYP
 |. ||| || |.| . .||||| | | ||||  . ||||||||| . .. |||. |||||||||||| . | .|  |||||.||.|| || |||  |||
DMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

GVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLE
|   ..|   || |.||  |. ||. .|..| .||   | .|| |  ..  |.
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase abl-1.AA S_TKc 311-566 23 7.4e-51 176.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 311-566
Range on HMM: 1-231/231
Sequence Identity: 23% (62 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCN--GNLLEYLRRTDK----SLL
  ...|.| | .| || ...|. .   |.| .|        .. | .|.|  ||.|.|.|..|. .   .|...|.. .  |.|..|...  .    . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSS-KSDVWAFGVLLWEIAT
|.     .. ||.... |.  ...|||||   | |..|   .||.||||||..                . ||| |    ..  |.|.|..|..|.| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGMAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIH-----FNLENLI
 |  |.|  ..  .. ..            .|..  .. .|... |..||   ..       ..   .
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase abl-1.AA Pkinase 311-553 22 1e-38 137.94 Pfam 1-282 (293) Show / Hide 
Range on Protein: 311-553
Range on HMM: 1-282/293
Sequence Identity: 22% (65 aa)

IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFL------AEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNG----NLLEYLR-RT
.  . |.| | .| ||....|   .. ||| .| .    ....      .|..||| |.|.| |||..... .   |...|.. .|     | .|.. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

DKSL-LPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIV----KIADFGLARFMKEDTYTAHAGAKFP---IKWTAPEGLA-FNTFSSKSD
.... ...  .  .. ||..|. |. .. .|||||   |.|..... .    ||.|||||....   |     .. .   . . ||| .   .  ..|.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWAFGVLLWEIATYGMAPYPGV-------ELSNVYGLLENGFRMDGPQGCP-------------------PSVYRLMLQCWNWSPSDRP
.|..|..|.| .. |  |.||        ..  ..  ..  .. | |. |.                   ..   ..  |... |..||
MWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
FABD abl-1.AA FABD 1089-1196 24 3.4e-42 147.4 SMART 1-153 (153) Show / Hide 
Range on Protein: 1089-1196
Range on HMM: 1-153/153
Sequence Identity: 24% (37 aa)

NELKHVVPPRKNRNQ------------DESGSIDEEPVSKDMIVSLLKVIQKEFVNLFNLASSEITDEKLQQFV------------------I-------
....|.|..||.|.|            .....|.....|||||..........|.||||||.........||..                          
PQIMHKVALRKTRTQLTIYATPIAKLTQPAERIPSDKISKDMILECTECLCSAFHNLFNLATHSEQMVSHQQWLQMSDKGHQLHNYCMGYADCGIMQMHN

-----ELLSQLEIYNRQIKF---SHNPRAKPVDDKLKMAFQDCFDQIMRLVDR
     ||...||..|||..|   |...|..|......|....|...|...|.|
KFQFRELVTRLENQNRQLRFCSTSAGSRNSPNNNQDFMNLHSCVKEISDVVQR