Gene HGK (Mouse)

HGK

Species: Mouse
Alias: ZC1, HGK, Map4k4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MSN

Sequence

Name Sequence Type Origin Length Description Download
HGK.AA Protein Sugen 1392 None Fasta, JSON
HGK.NA RNA Sugen 7711 None Fasta, JSON
HGK.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of HGK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HGK.AA MSN 25-289 91 5.5e-211 703.29 In-house 1-265 (265) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-265/265
Sequence Identity: 91% (242 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT
||||||||||||||||||||||||||||||||||.||||||||.||||||||||||||||||||||||||||||.|||.|||||||||.|||||.|||..
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAI
|||||||||.|||||||||||.|.||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
|||||.|||||||||||||||||||||.|||||||||| .|.| ||.|||.|||.|||.||||||
EMAEGQPPLCDMHPMRALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase HGK.AA STE20 25-289 52 4.3e-170 571.37 In-house 1-288 (288) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-288/288
Sequence Identity: 52% (153 aa)

FELVEVVGNGTYGQVYKGRHVKTGQL----AAIKVMDVTE-----DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD
.||.|..|.|.||.|||..|..||..    .|||.|.. .     ||.|.|. ||...|..  | || .|||...|....  ||.||.|||.||.||.||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTC--DDELWIVMEYCGGGSLTD

LVKN--TKGN-----TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR----TVG-RRNTFIGTPYWMAPEVIACD
..|.  ..|.     ...|..|||| ||.|.||..|| .|.||||||..|.||||..||||.||||.|||..    | . .||||.|||||||||||.|.
IMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

ENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP--RNPPPRLK---SKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
|.||  |||..| || |||||||||| ||..|||||||.|.||  .||||.||   ..|||..|  |.. ||.|.. .||...||||||||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase HGK.AA STE 25-289 37 1.6e-139 469.84 In-house 1-359 (359) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-359/359
Sequence Identity: 37% (137 aa)

FELVEVVGNGTYGQVYKGRHVK---------------TGQLAAIKVMDVTE------------------DEEEEIKLEINMLKKYSH-HRNIATYYGAFI
.|..|..|.|..|.|||....|               ||.. |||.|.. .                  .|...|. ||...||..| | || .|||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KKSPP-GHDDQLWLVMEFCGAGSITDLVKN--TKGNTLK----------EDWIAYISREILRG-LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSA
|.... . ||.||..||....||..|..|.   .|..|.          |..|||| |.||.| |..|| ||.||||||..|.||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLDR---------------TVG-RRNTFIGTPYWMAPEVIACDENP-DATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN-----------
||.                | . .||||.||| ||||||| ..... |  ||...| || |.|.||||.| ||..|||||||.|.||.|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPRLKS------------------KKWSKKFFSFIEGCLVKNYMQRPSTEQLLK--HPFI
    |||.|..                  .|||..|  ||. ||.|.. .||...||||  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase HGK.AA NinaC 25-289 52 1.3e-131 443.49 In-house 1-267 (267) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-267/267
Sequence Identity: 52% (142 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKG
.| .| .| |||| |.|    . ||.||.|...  .| .|||  | | |..|. | |.  .|| . || . .  ||||.|||.|  ||.||.||     |
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCN-GDQLWFVMEYCNGGSVTDMVKGLLKCG

NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGIT
  ..|. |||| .| ..|| ||| .||||||.|| |.||| .  |||.||||||||| | .|||| .|||.||||||||| .  | .|| | | || |||
RRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGIT

AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
|||.. | ||. |||||||.| |||||||.|    .|...|  ||  || |.| .||.  ..|.||||
AIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase HGK.AA YSK 25-289 48 5.70000000001e-128 387.54 In-house 1-257 (257) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-257/257
Sequence Identity: 48% (131 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE--EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG
|   |..| | .| ||||  ..|..  |||. |  ..|.  | |  ||. |       .|  |||.. |      |  || .||.|| ||. || |    
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSP-YITKYYGSYLK------DTKLWIIMEYCGGGSCLDLMKPKYV

NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC--DENPDATYDYRSDLWSCG
. . |  || | |||| ||  ||   .||||||  ||||.|. .||| ||||..|.  |. .||||.||||||||||| .  ..     ||.  | || |
GQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSY-----YDFKADIWSLG

ITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
|||.||| | ||.||.||||..|||| |.||.|. ...|| |  |.|.||.|.  |||| ..|||| ||
ITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase HGK.AA MST 25-289 49 2.4e-114 364.86 In-house 1-254 (254) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-254/254
Sequence Identity: 49% (132 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSHHRNIATYYGAFI--KKSPPGHDDQLWLVMEFCGAGSITDLVKNTK
|..||  | | ||.|||  | .||.. |||.. |  .|  .||. ||....      .| .||| ..  |      . ..|.|||.||.||. |..| |.
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQC-KSKYIVKYYGSYFDAK------NNHCWIVMEYCGMGSVCDIMKITQ

GNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGI
  || |. || |..  |.||. ||  . ||||||  | || .  | || |||||.||  | . |||.||||||||||||         ||.  | || ||
-RTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ-----EIKYDCKADIWSLGI

TAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
|||||||| ||. | |||||.|.|| .||| .|   .||  |  |.  ||.||  ||.. ||||.||||
TAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase HGK.AA KHS 25-289 47 3.4e-104 351.39 In-house 1-258 (258) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-258/258
Sequence Identity: 47% (128 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN
.||.  || ||||.||| |......|||.||. .  ... . |. || |.|.  .| ||  |.|.....      |.||..||.||.||. |. . |   
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKD-CRHPNIVAYFGSYLRR------DKLWICMEYCGGGSLQDIYHVT--G

TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITA
 |.|  |||..||.|.||..|| .  .|||||| |.|||.. .||| |||||||.  |...|  |||||||||||| | . .    |.   |.|..||||
PLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERK--GGYNQLCDIWAVGITA

IEMAEGAPPLCDMHPMRALFLIPRNP--PPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
||.||  ||. |.||||||||. .    ||.|| | |||..|  |.  .|.||  .||. |.||.|||.
IELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase HGK.AA PAKA 25-289 40 4.5e-99 335.45 In-house 1-260 (260) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-260/260
Sequence Identity: 40% (110 aa)

FELVEVVGNGTYGQVYKGRHVKTGQL--AAIKVMDVTEDEEE-EIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTK
.. .| .| |  |.||..  .||.|    |||.|.. ..     |. || ..|. ..| ||  |. ...       ||.||.|||. ..|. ||..... 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKE-CKHKNIVNYIDSYLV------DDELWVVMEYMEGGCLTDVITQCC

---GNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWS
    |...|. |||. ||.|.||  .| .|.||||||  |.||  ...||. |||  ||| .   .|||  |||||||||||   .     ||.  | ||
NIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ-----YDEKVDIWS

CGITAIEMAEGAPPLCDMHPMRALFLIPRN-PPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
 || ||||.|| ||  .. | ||..||  |  |...   |||..|  | . || ..  .|.|...||.|||.
LGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase HGK.AA PAKL 25-289 44 1.6e-97 330.33 In-house 1-256 (256) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-256/256
Sequence Identity: 44% (119 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTED-EEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN
||. |  | | || |||. |  |.   ||||. ..|  | ..|  ||..|||     ||  |.|    |      ...|  |..| .||| |. . . . 
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKK-CKCPNIVSYFGSIQQKL-----NHYWILMDYCSLGSINDMMESC-CK

TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG-RRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGIT
||.|  |. | .  |.||  ||   .||||||  |.||.| . ||. ||||| ||. . .   |  ||||||||||.|       . |..  | || |||
TLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINK-----QNYNNKCDIWSLGIT

AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
|||||.| ||. || ||||.  ||. ||| ..  |.||. | .|.  |.||   .|.|  .|| ||||
AIEMADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase HGK.AA S_TKc 25-289 32 4.3e-97 329.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-231/231
Sequence Identity: 32% (90 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGA--GSITDLVKNTKG
.|.....| |..|.|||.||.|||.. |||...      | |. ||..|||  || || ..|..|         | |..|||.|.   |.  |. |. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR

NT----LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDY-RSDLW
.     . | ..... ..|...|...| |..||||.| .|.||.|  ..|. |||...||       .||.|||..|||||.         |.. ..| |
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWW

SCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLK-------HPFI
|||.. .||. | || .  .... . .|             |. . .||..||.|.  .||.  ..|.       ||..
SCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HGK.AA SLK 25-289 41 3.2e-89 301.14 In-house 1-259 (259) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-259/259
Sequence Identity: 41% (110 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN
.|..  .|.| .|.||| .|  ....|| |.... ..|| |.   ||..| .   | ||   |.|.       .|..||...|||. | . | .    . 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYY------YDNKLWMMIEFCDGGAV-DNIMVELEH

TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITA
.|.|| |.|...... .| .|| ..|||||.|  |.|.| . .|.| ||||||.. .|. .| |||||||||||||..|.   |. |||..|.|| ||| 
PLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITL

IEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
||||.. ||  .| ||| |. | .  ||.|.   .|||.|  |.. ||||.  .|..|.||..|...
IEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase HGK.AA Pkinase 25-289 27 9.8e-83 285.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL-----EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAG----SITD
.......| |..|.|||..|..||.. |.|.... ...... .      || ..|.  .| || ..|..|        .| ...|||.|. |    .  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

LVKNTKGNTL--KEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEV----KLVDFGVSAQL-DRTVGRRNTFIGTPYWMAPEVIACDENPDA
...  .....   |. .  . ..|||||...| . .||||.| .|.|. .| ..    |. |||...|.     .  .|| |||..||||||      . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQ

TYDYRSDLWSCGITAIEMAEGAPPLCDM----HPMRALFLIPRNPPPRLKSKKW----------------------SKKFFSFIEGCLVKNYMQRPSTEQ
 |....| ||||.. .||. | || ..     . .. ...| |. .|.|..  .                      |. . .||..|| |.  .||. ||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLKHPFI
.|.||..
ILQHPWF
Kinase HGK.AA Pkinase_Tyr 25-245 26 2.2e-32 110.33 Pfam 1-228 (270) Show / Hide 
Range on Protein: 25-245
Range on HMM: 1-228/270
Sequence Identity: 26% (62 aa)

FELVEVVGNGTYGQVYKGRHV----KTGQLAAIKVM--DVTEDE--EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDL
 .. .. | | .|.||||.      .|..  |.|..  . ....   |.   |....|.. || ||  .||. .... |.   |...|||..  |.  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDY

VKNT--KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRT-VGRRNTFIGTPYWMAPEVIACDENPDATY
 ..    .. |.  ..  ....| .|...|. .. ||||.   |.|.|||  ||  ||| .  .   |   . | ..      |||||.|.  .     .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGK-----F

DYRSDLWSCGITAIEMAE-GAPP-LCDMHPMRALFLI
   || || |..  |.   |. |   .| . . . .|
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase HGK.AA TyrKc 25-289 22 8.1e-17 49.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKY-SHHRNIATYYGAFIKK-----SPPGHDDQLWLVMEFCGAGSITDLVK
 .| .. |.| .|.||||.     .  |.|..      .|..  |.....|.  || ||   ||. ...     .    ...|..|||..  |.  |  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMY----IEPLMIVMEYMPHGDLKDYLR

NTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT--------VGRRNTFIGTP-----YWMAPEVIACDEN
..... |. .   ...  | .| ..|| ...||||.   |.|..||  ||  ||| |  ..          . |  .  |.       |||||.|     
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----

PDATYDYRSDLWSCGITAIEMAE-GAPPLCD-----MHPMRALFLIPRN---PPPRL----KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
 . ..   || || |..  |.   |..|  .     | . ... .. .    |.|       .   ... .. .. |   .  .||. ...  | ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
CNH HGK.AA CNH 1066-1372 27 5.1e-125 422.55 SMART 1-375 (375) Show / Hide 
Range on Protein: 1066-1372
Range on HMM: 1-375/375
Sequence Identity: 27% (105 aa)

YKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQ------GKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNK------------IL
........|.|..|||..||||||.|...|....|      |...... ||....|.|.|..|.|..|||||..|....|.||..|             .
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

HNDPEVEKKQGW-TTVGDLEG-CVHYKV-VKYER--IKFLVIALKSSVEVYAWAPKPYHKFMAFKS----------------FGELVHKPLLVDLTVEEG
.|.  |..|..| |...|..| |.|..| ....|  |.||. |...||..|.....|.|||| .||                |.|... |..|...... 
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

QRLKVIYGSCA------GFHAVDVD-------------SGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDG---MELLVCYEDEGVYVNTYG---
.|.....|..       |||.|...             . ...|..|.....   |    |  |||........||   ...|.||...||.||.||   
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTC--KPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEW

RITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHL-DGVFMHK---RAQRLKFLCE---RNDKVFFASVR
| .....|.|..||...||.. ...|......|.||...||.. ....|..   .......||.   |..|.|..| .
RRWRNPILHWEFMPEYFAYHY-PYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH HGK.AA CNH 1075-1363 23 3.3e-88 304.14 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1075-1363
Range on HMM: 1-336/336
Sequence Identity: 23% (80 aa)

LCAALWGVNLLVG-TESGLMLLDR------SGQGKVYPLINRRRFQQMDVLEGLNVLVTI--SGKKDKLRVYYLSWLRNKILHNDPEVEKKQ--------
.|.. ||..|||| |..||.....      ....... ...| |..|..|.| .|.|..|  ..|  .|.|..|.|| .|...... . .|.        
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSR-RVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIER

-------GWTTVGDLEGCVHYK--VVKYERIKFLVIALKS-----SVEVYAWAP--KPYHKF-------MAFKSFGE-LVHK----PLLVDLTVEEGQRL
       .|....|. .| ...  ...|.....|..|.|.     .. .| |..  |..||.       ..|. | | . .     .. ..... . ...
IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKP

KVIYGSCAGFHAVDVD-SGSVYDIYLPTHVRKNPHSMIQCSI-------KPHAIIILPNTDGMELLVCYEDEGVYVNTYGR-ITK--DVVLQWGEMPTSV
|...|.. |||.|..| .|. .... | .         |...       ||.... ...  . |.|.||....||||..|. ...  |....| .||.|.
KLCVGCQKGFHIVNLDGTGQPWWLHDPADHSV------QQDFMARRENCKPICMHRINDD-E-EFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSF

AYIRSNQTMGWGEKAIEIRSVETG-HLDGVFMHKRAQRLKFLCERN
|. .... ... ...||||.|||| ..|..... ..|...||....
AC-CYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS