Gene ZAP70 (Mouse)
ZAP70
Sequence
Protein domains of ZAP70.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SH2 | ZAP70.AA | SH2 | 10-87 | 39 | 1.6e-34 | 103.19 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 10-87 Range on HMM: 1-81/81 Sequence Identity: 39% (32 aa) FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDV---RFHHFPIERQLNGTYAIAGGKAHCGPAELCQFY ...|.|||.|||..|. |. || ||.|.. .. |.|.||...| |..|. | |. ||.| |.|.. .| .||...| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
|||||||||
| SH2 | ZAP70.AA | SH2 | 8-93 | 37 | 2.8e-27 | 97.89 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 8-93 Range on HMM: 1-87/87 Sequence Identity: 37% (33 aa) LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAG--GKAHCGPAELCQFYSQDPDG |...| |||.|||. || || || ||.|.. .. |.||||. .. ...|. |.|. .| | |.. .. .. || ..|.. |.| QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
|||||||||
| SH2 | ZAP70.AA | SH2 | 163-239 | 38 | 1e-36 | 109.63 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 163-239 Range on HMM: 1-81/81 Sequence Identity: 38% (31 aa) WYHSSLTREEAERKLYSGQQTDGKFLLRPRK-EQGTYALSLVYGK---TVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYL ||| ...|.|||| |......|| ||.|.. ..| |.||.... |.|| | ... |.|.| ...||..|..|||. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
|||||||||
| SH2 | ZAP70.AA | SH2 | 161-245 | 38 | 6.4e-29 | 103.32 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 161-245 Range on HMM: 1-87/87 Sequence Identity: 38% (34 aa) MPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKE-QGTYALSLVYGKTVYHYLISQDKAGKYCIPE--GTKFDTLWQLVEYLKLKADG .|||| ..|||||..| .. . || ||.|.. | |.||. ... |.||.| ... |||.| | ..||..| .||.. . ..| QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
|||||||||
| Kinase | ZAP70.AA | Syk | 337-586 | 66 | 2.7e-209 | 701.58 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 337-586 Range on HMM: 1-257/257 Sequence Identity: 66% (172 aa) LVADIELGCGNFGSVRQGVYRMR-----KKQIDVAIKVLK-QGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKE ||.|.|.||||||||..|.|.|. |..|.||||.|| .....|||.|.|||||.|.|||.|.|||.||.|.||..|.|||||..||.||.|..... LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH EIPVSNVAELLH-QVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMW ||...||.||.| ||||||.|||||.|||||||||||||||||||||||||.|||||||..||.|...||||.||||||||...|||..|||||.||||| EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW EAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFL |.||||||||..|||.||..||..|.||.||..||.|||.||..||||||.|||.|. EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV |
|||||||||
| Kinase | ZAP70.AA | Pkinase_Tyr | 337-592 | 43 | 4.4e-132 | 447.96 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 337-592 Range on HMM: 1-270/270 Sequence Identity: 43% (117 aa) LVADIELGCGNFGSVRQGVYR--MRKKQIDVAIKVLKQGTEKAD--KDEMMREAQIMHQL-DNPYIVRLIGVCQ--AEA--LMLVMEMAGGGPLHKFLLG .. . .|| |.||.|..|... . ...|.||.|.||.|. . . ....||||.||.|| ..| ||||.||| | ...||| . .| |...| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK K---KEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY-TARSAGKWPLKWYAPECINFRKFSSRSDVWS . |. .... . .|.|.|| |||.||..||||||||.|. . . .||.||||.... .|.|| ..|. ||.| ||.||||||..||.. ||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS YGVTMWEAFSYGQKP-YKKMKGPEVLDFI-KQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRM .||.||| |.||..| |. |. ||...| ..| ||.||. ||.|.| || .|| |. |||| | . ... FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| Kinase | ZAP70.AA | TyrKc | 337-592 | 40 | 3.1e-131 | 443.21 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 337-592 Range on HMM: 1-280/280 Sequence Identity: 40% (117 aa) LVADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQL--DNPYIVRLIGVCQA--------EALMLVMEMAGGGPLHKFLL .. . .||.|.|| |..|... |.||.|.|| .. . ..||||.||..| ..| ||||.||| | ||.||| . .| |...| ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR GKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD------DSYYTARS--AGK--WPLKWYAPECINFRKFS ........ . .|.| || ||..||..||||||||.|. ..| .||||||||.... | ..||.... || .|..|.||||||..||. KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT SRSDVWSYGVTMWEAFSYGQKPYKK-----MKGPEVLDFIKQGKRMECPPE--------CPPEMYALMSDCWIYKWEDRPDFLTVEQRM . |||||.||.||| |.|||.|| |. ||. ..|||.||..||. ||.||| .|..|| .. |||| | .. ... TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | ZAP70.AA | TK | 337-592 | 22 | 1.7e-105 | 354.72 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 337-592
Range on HMM: 1-486/486
Sequence Identity: 22% (111 aa)
LVADIELGCGNFG---SVRQGVYRMR-----------------------KKQIDVAIKVLKQGTEKADKDEMM-------------REAQIMHQLD----
.. .|| |.|| |..| .|.| .....||.|.|| |.. ....... .||..| ...
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-NPYIVRLIGVCQAEA-------------LMLVMEMAGGGP----LHKFLLGKKEE--------------------------------------------
| ||||.||| .. .|.|||.. .| |...| ....
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------IPVSNVAELLHQVAMGMKYLEEK------NFVHRDLAARNVLLVNRHY-----------AKISDFG---
... .|.| || ||..| |||||||||||.|. ... .||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LSKALGADDSYYTAR-----------------------SAGKWPLKWYAPECIN---------FRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMK
|..... || ||... | ||.|..|.||||.| ..||.. |||||.||.||| |.|||.|| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
G----------PEVLDFIKQG--------------KRMECPPECP--------------PEMYALMSDCWIYKWEDRPDFLTVEQRM
||......| ||..|| || .|.| || .|| |. ||||.| .. ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
|||||||||
| Kinase | ZAP70.AA | Ack | 337-592 | 39 | 2.7e-94 | 318.46 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 337-592 Range on HMM: 1-266/266 Sequence Identity: 39% (104 aa) LVADIELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKAD--KDEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLLGKKE-- . .|| | ||.|..|. . | | ||.|.|. . ... |. .||..|||.|| | .||| || . . |.|.|.| .| |. | . ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA EIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNR-HYAKISDFGLSKALGADDSYYTARSAG--KWPLKWYAPECINFRKFSSRSDVWSYGVT ... . . |.|||| ||| |...||||||||.|| . .||.||||. ||| . ||. | |. | ||||...|.||. ||||..||| FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT MWEAFSYGQKPYKKMKGPEVLDFIK-QGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRM .|| ||||..|.. . | ..| | | | . |. ||.. |..| || . .||| | .. . LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
|||||||||
| Kinase | ZAP70.AA | UTK | 342-592 | 33 | 1.2e-88 | 300.81 | In-house | 6-296 (296) | Show / Hide |
Range on Protein: 342-592 Range on HMM: 6-296/296 Sequence Identity: 33% (98 aa) ELGCGNFGSVRQGVYRMRK---KQIDVAIKVLK-QGTEKADKD---EMMREAQ---IMHQLD-NPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLLGKK .|| |.|| |. . .. . .. |||.||.. .. ... . |.||. .| |.. |...||.||| | | .|.|.|.. .| | ..| . QLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHR EEIP-----VSNV--AELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRH--------YAKISDFG---LSKALGA--------DDSYYTARSAGKWPLK .. | ... . ..| || ||....||||||||||. ||..| .||.||| .|..... .. ||.|.....||.. PTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNC-LVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIR WYAPECINFR-KFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQG--KRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRM |.|||... . .|.. |||||.||..|| ...|..||. | ..|. .. | ||.||..|| ..| || .|| | ..|||| ...|.| WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
|||||||||
| Kinase | ZAP70.AA | Fer | 337-593 | 35 | 2.7e-86 | 293.02 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 337-593 Range on HMM: 1-283/283 Sequence Identity: 35% (100 aa) LVADIELGCGNFGSVRQG---VYRMRKKQIDV---AIKVLKQGTEKADKD---EMMREAQIMHQ-LDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFL . . ||.|.|| |..| ......|...| |.|| | .|.|.|. |.|.||.|| . .| |..|...||| . ...|.|||.. || | ..| VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL LGKKEE-IPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVN-RHYAK--ISDFGLSKALGADDSYYTAR-SAGKWPLKWYAPECINFRKFSSRSD .|.. ... . ..|.| ||.||..|| .|||.||||.|. . .. | |||||.|... . . |. . | | | .| |||..... .|. .| KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD VWSYGVTMWEAFSYGQKPYKK----MKGPEV-----LDFIKQGKRMECPPECPPEMYALMS-DCWIYKWEDRPDFLTVEQRMR |||.||..|| |. |..|| || .| || |..| .|...|||.. .| .|| .. |||| . .. |... VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
|||||||||
| Kinase | ZAP70.AA | FAK | 337-597 | 38 | 6.9e-86 | 287.77 | In-house | 1-285 (285) | Show / Hide |
Range on Protein: 337-597 Range on HMM: 1-285/285 Sequence Identity: 38% (111 aa) LVADIELGCGNFGSVRQGVYRMRKK-------------------------QIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALML . .| | || | |||| | .|.|||| |. ... |.. | || ||.|.| | ||.|||.|. . . ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI VMEMAGGGPLHKFLLGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN .||.. | | ..| .|.. . |..| | ||| |.||||| |||||| . . | ||||| . |.||| | || | || .|| || IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKWMSPESIN FRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYY || | . |||| .|| ||| .|| ||. .| .| | .| |. || ||| .| ||. || | .|| | . .... | FRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ |
|||||||||
| Kinase | ZAP70.AA | Eph | 337-592 | 41 | 3.2e-84 | 282.8 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 337-592 Range on HMM: 1-264/264 Sequence Identity: 41% (109 aa) LVADIELGCGNFGSVRQGVYRMR-KKQID----VAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLLGKKE . . .| | || |..| ... .|. |||| ||.| .. . .|| || | | | |.|| || ... .| | | |.| .|| . . IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG EIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS---YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVT .. | ..| .| ||||| . |.|||||||||.|. . |.|||||| | |.| || | || |..| ||| | .|||.| |||||||. QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV MWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRM ||| ||| .|| | . .|. | || | |..||. .. || ||| . ..|| | .. . MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL |
|||||||||
| Kinase | ZAP70.AA | EGFR | 337-593 | 40 | 1.1e-83 | 277.78 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 337-593 Range on HMM: 1-258/258 Sequence Identity: 40% (105 aa) LVADIELGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKEEIPV | . || | || | |.. . .| ||||||.. |.. ..||..|| .| .|.|..|||.||| .. ..|| . | | .. |..| LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS SNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSY . |.| ||.||||. |||||||||||. || ||||.| | .|. |.| . || | || | ||| .|.. ..|||||||||.|| . QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTF GQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMR |||||. .. |. |....|.|.. || | .| .| ||. . || | .... GQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
|||||||||
| Kinase | ZAP70.AA | Src | 337-592 | 38 | 8.7e-82 | 277.65 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 337-592 Range on HMM: 1-255/255 Sequence Identity: 38% (101 aa) LVADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLL--GKKEEIP . .|| |.|| | .|.. .....||.|.||.|| . . .||||| .|. . .|.| || | | | | | ..| |. ... IKLCRKLGQGQFGEVWMGYW---NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLH VSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFS . . .. ||| ||.|||..|..|||||||||| . .|. |||| . . || |.||. | | || |||.||...|. |||||.|. ..| .. LPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVT YGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYA-LMSDCWIYKWEDRPDFLTVEQRM ||. ||. |. .|||. ...| || ||..||.|.| .| || . |.|| | . . . YGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
|||||||||
| Kinase | ZAP70.AA | TK-Unique | 337-592 | 32 | 2.4e-79 | 269.94 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 337-592
Range on HMM: 1-294/294
Sequence Identity: 32% (97 aa)
LVADIELGCGNFGSVRQGVYRMRK----KQIDVAIKVLKQGTEKADKDEMMREAQIMHQLD-NPYIVRLIGVCQAEA--LMLVMEMAGGGPLHKFLLGKK
|. ....| |.|| | | .. .. ||. ||.| || . . ||.....|.|.| .|. |.||...|.|. |..|| . .| | ..| ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR
-------------------------EEIPVSNVAELLHQVAMGMKYLEE--KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL
|.| .. . |.|.||.||.. |..|||||.|||||| ... .||.|||... . .. | . .| |. |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI
KWYAPECIN--FRKF-SSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPEC-PPEMYALMSDCWIYKWEDRPDFLTVEQRM
.| ||| . . . ...|||||.||.||| |..|. || .|. ..... |..|.||. |..| ..||| ||. || .. |.||.| .. .|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
|
|||||||||
| Kinase | ZAP70.AA | S_TKc | 337-596 | 22 | 9.2e-45 | 155.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 337-596
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)
LVADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGG--GPLHKFLLGKKEE---
..| | ||.|.... . . ||||..| . ..|| ||... . |.||.|..|.| . | .|||...| | |.... .. .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
--IPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-RSDVWSYGVTM
.| .. ...|.. ...|. .....|||| |.|| . ||.||||.. | . . . ||| . ... ..|.|| |...
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL
WEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQ-----RMRNYY
.| .. |. |. .. .|. . .||. ... |. . |.|| . | .. .
YEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | ZAP70.AA | Pkinase | 337-583 | 23 | 2.9e-31 | 111.63 | Pfam | 1-282 (293) | Show / Hide |
Range on Protein: 337-583 Range on HMM: 1-282/293 Sequence Identity: 23% (69 aa) LVADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADKDEMMR---EAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGG----PLHKFLL .. .| |.||.| |. ..| ||.|..| .|| .||. | |.|||. |. |.||||..... . .||| ..|| |. .. YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS -GKKEEI--PVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYA----KISDFGLSKAL-GADDSYYTARSAGKWPLKWYAPECIN-FRKFSS .. . . . . |.. |..|. .....|||| |.|..|. . ||.||||.| . .| .| . | . ||| |. .. .. TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGP RSDVWSYGVTMWEAFSYGQKPYKKM----KGPEVLDFIKQGKRMECPPECP-----------------------PEMYALMSDCWIYKWEDRP ..|.||.|....| .. |. |.. . . . |.. .. . . ..| .|. ....|. .. ..|| KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP |
|||||||||