Gene YES (Mouse)

YES

Species: Mouse
Alias: YES, Yes
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
YES.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 250 Kinase domain by global Sugen HMM Fasta, JSON
YES.NA RNA Sugen 4537 None Fasta, JSON
YES.AA Protein Sugen 541 None Fasta, JSON

Protein domain

Protein domains of YES.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3_1 YES.AA SH3_1 95-142 46 5.9e-25 86.99 Pfam 1-49 (49) Show / Hide 
Range on Protein: 95-142
Range on HMM: 1-49/49
Sequence Identity: 46% (23 aa)

VALYDYEARTTEDLSFKKGERFQIINNTEG-DWWEARSIATGKSGYIPS
||||||.|.. ..||||||. ...|. ... |||..|.. ||. |..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3 YES.AA SH3 92-149 41 2e-24 88.41 SMART 1-58 (58) Show / Hide 
Range on Protein: 92-149
Range on HMM: 1-58/58
Sequence Identity: 41% (24 aa)

TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPAD
  ..|||||.|.. ..||||||. ..... ....||..|   ||. |..||||| . |
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 YES.AA SH3_2 93-148 23 4.9e-13 48.53 Pfam 1-68 (68) Show / Hide 
Range on Protein: 93-148
Range on HMM: 1-68/68
Sequence Identity: 23% (16 aa)

IFVALYDYEA-RTTED-----LSFKKGERFQII---NNTEGDWWEA-RSIATGKS--GYIPSNYVVPA
 .... ||.. . ...     |.||||. . .|   .   ..||.. ..|..|.   |..||..| . 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 YES.AA SH2 156-238 62 1.6e-51 153.1 Pfam 1-81 (81) Show / Hide 
Range on Protein: 156-238
Range on HMM: 1-81/81
Sequence Identity: 62% (52 aa)

WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
||.||. |..|||||.||||..| |||||||.|.| |.|| ||...  ||.||||.|...||||||||.| .|..|| || ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 YES.AA SH2 154-244 45 3.5e-37 130.75 SMART 1-87 (87) Show / Hide 
Range on Protein: 154-244
Range on HMM: 1-87/87
Sequence Identity: 45% (42 aa)

EEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITT--RAQFDTLQKLVKHYTEHADG
..||.|.. |..||.||.|||.. | ||||.||...|.|.||.|.      . ||||.||..|.|.|||..  | .|..|  || ||. ...|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase YES.AA SrcA 275-524 90 6.6e-227 724.78 In-house 1-250 (250) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-250/250
Sequence Identity: 90% (227 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDM
.|||..||||||||||||||||||||||||||||||.|||||.||||||||||||||.|||||||||||||||.|.|||||||||...||||||||||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM
|||.|.||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL
.||||||||||||.|||||.|||||||||. ||.|||.|||||||.||||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase YES.AA Src 275-524 75 9.69999999999e-204 683.14 In-house 1-255 (255) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-255/255
Sequence Identity: 75% (193 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLK-EGDGKYLKLPQLV
..|. |||||.|||||||.|||.||||.|||||||| ||||||||||||||||.||| ||||.|.| |||||||.||.|||||.|| .|.|..|.||||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVP
|||||.|.||||.|.||||||||.|.|.|||||..||.|||||||||.  |.||.||.|||||||||||||..|||||||||||||||| ||.||.||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMVNREVLEQVERGYRMPCPQGCPESLHE-LMNLCWKKDPDERPTFEYIQSFL
|||| |.|||.|||||||||||..||..|.| .|  ||.|||..||||||.|.||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase YES.AA SFK-Src 275-528 62 2e-186 558.15 In-house 1-259 (259) Show / Hide 
Range on Protein: 275-528
Range on HMM: 1-259/259
Sequence Identity: 62% (162 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVD
 ||| |||.| ||.|| |.||.|| ||.||||||.|  | ||||||.||||||..|. ||||    |||||.|| |  |||||.|.|  |. |..|||||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE-DNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPY
||||.| |||| |  |..|||| | |.|||.| .||..|||..| .. |.| |||..|||||||||||||... || ||||||||||| .|.|| ||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMVNREVLEQVER--GYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYF
||| | ||| ||.|  |||||||..||. ....|  ||.. ||.|||||  .  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase YES.AA SrcB 275-525 70 4.5e-166 558.02 In-house 1-251 (251) Show / Hide 
Range on Protein: 275-525
Range on HMM: 1-251/251
Sequence Identity: 70% (178 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDM
|.|. ||| | |||||||..|. .|||.||.|.||| |||||.|| .||.| ||.|| |||||. |||||.||.| ||.||||||  .|  |.||.|.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM
.||||.|||||||||||||||||||||| | |.||||||||||.||||||||| |||||||||||||  .| ||||||||||||| .|.|| ||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE
 | ||....|||||||.|. ||| | ..| .|||. |.|||||.|.|| |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase YES.AA Src-Unclassified 275-524 52 5.9e-156 524.4 In-house 1-284 (284) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-284/284
Sequence Identity: 52% (150 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPG---TMMPEAFL--------QEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGD
..|  |||.| ||||| | | |   ||.||..||   || |||||        ||||||||.|| .|| |||| | |||.||.||.|..||||..|.||.
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GKYLKLPQL------------VDMAAQIADGMAYIERMNYIHRDLRAANILVGENL-----ICKIADFGLA--RLIEDNEYTARQGAKFPIKWTAPEAAL
|.|| .. .            ||.|||.| || | |   |.|||| | |.|.|.|      . |..|||||  .|..| .| .|.||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCP--QGCPESLHE-LMNLCWKKDPDERPTFEYIQSFL
|| |.|||||||.|||  |. |||..||||| ||||||.|||||||| |  ..||... | .|  || |||. ||||.    ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase YES.AA Pkinase_Tyr 275-524 50 2.7e-150 509.66 Pfam 1-270 (270) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-270/270
Sequence Identity: 50% (135 aa)

LRLEVKLGQGCFGEVWMGTWN-----GTTKVAIKTLKPGTMMP----EAFLQEAQIMKKL-RHDKLVPLYAVVS--EEP--IYIVTEFMSKGSLLDFLKE
...  |||.|.||||..|||.     ....||.|.||.|.| .    |.|..||.|||.| .|...| ||.|..  .||  ||||.|.| .|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G--DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSF
   |.. |....|..|..|||.||.| |..|.|||||.| |.||.||...||.||||||.| .| .| ..|.|.|.||||.|||.  ||.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILQTELVTKGRVP-YPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL
|.|  |..| |. | |||| | ||.|.. |.|||||||..||. ...|| .||..||..||||..|...|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase YES.AA Frk 275-528 65 1.1e-143 483.67 In-house 1-260 (260) Show / Hide 
Range on Protein: 275-528
Range on HMM: 1-260/260
Sequence Identity: 65% (169 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLK--EGDGKYLKLPQL
..|  .|| | ||||| | || || ||.|||||||| |. ||.|||||||||| ||. ||||   ||||||.|| | .|||...|.  .. |. ....||
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR-LIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR
||||||.| ||||.| .||||||| | |.||||..||||||||||| |. |||  | .|.||.||||||||||| | .||||||||||||| ||..| ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYF
.||||| |.|||..|..|||||.| .||. | |.|  ||..||..||||| .|  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase YES.AA Src-Echino1 275-524 61 8.60000000001e-139 467.39 In-house 1-252 (252) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-252/252
Sequence Identity: 61% (155 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVD
||.. |.|.| .|||| | ||| |.||.||||..|| | .|| || .|||.||. .| .||| |.. ||||||| ||.|.|.|.||.|..| .|...|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPG
| |.|| || |... |..|||| | |.|||.  .||||||||||......| ..||||.||||||||||||||||||||||||||| ||.|| ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MVNREVLEQVERGYRMPCPQGCPESLHEL-MNLCWKKDPDERPTFEYIQSFL
| |||||.||.|||||| .. ||.||... |  || |||  |||||.. .|.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase YES.AA TyrKc 275-524 43 2.6e-133 450.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-280/280
Sequence Identity: 43% (123 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKL--RHDKLVPLYAVVSE--------EPIYIVTEFMSKGSLLDFLKEGDGK
..|. ||| |.||||. |||.  ..||.|.||...   |.|..||.||.||  .|. .| ||.|...        ||..||.|.|..|.|.|.|..  .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

YLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN--------EYTARQ--GAK--FPIKWTAPEAALYGRFTIKSD
 |....|.... |||.||.|....|.||||| | |.|||||...||.||||.| |.|          |....  |.|  .||.|.|||.  ||.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILQTELVTKGRVPYPG-----MVNREVLEQVERGYRMPCPQG--------CPESLHELMNLCWKKDPDERPTFEYIQSFL
|||||..  |. | |  ||||     | |.||.|.|..|||||.|.         ||. ....|  ||. ||..||||. | ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase YES.AA SRM 275-525 51 1.5e-123 415.23 In-house 1-253 (253) Show / Hide 
Range on Protein: 275-525
Range on HMM: 1-253/253
Sequence Identity: 51% (131 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGT-MMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLV
  |  |||.| ||||| | | |  .||||  |    |  . . .| | |||||| ... |.||.|  .|.||.|| | ||.|. .|.. |.| |..|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYP
|.| |.| ||.| |  ||||||| | |.|||.|..||..|||||||| |  |    . . |.|||||||| |. . .||||||||||  |. |.| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE
|| | | . |..||||||||  || . | ||  ||..||..||.|      | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase YES.AA TK 275-524 26 5.4e-121 407.58 In-house 1-486 (486) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-486/486
Sequence Identity: 26% (128 aa)

LRLEVKLGQGCFG---EVWMGTWNGT--------------------------TKVAIKTLKPG-TMMPEA--------------FLQEAQIMKKLR----
..|. |||.| ||   ||..|.|.|                           |.||.|.||.| .| .|.              ||.||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVPLYAVVSEE-------------PIYIVTEFMSKGS----LLDFLK--EGDGKY-----------------------------------------
 |. .| ||.|....             |..||.|.|..|.    |.|.|.   ....                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKLPQLVDMAAQIADGMAYIERM------NYIHRDLRAANILVGENLI-----------CKIADFG---
                               | ..||. |..|||.||.|....      |..|||| | |.|||||..           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-EDNEYTARQ------------------------GAKFPIKWTAPEAAL---------YGRFTIKSDVWSFGILQTELVTKGRVPYPG-M
     ||| | .| .|....                        |.|.||.|.|||. .         ||.||.||||||||.|  |..| |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

VN---------REVLEQVERG--------------YRMPCPQGCP--------------ESLHELMNLCWKKDPDERPTFEYIQSFL
 |         .||.|...||              .|||.|..||              | ...||  ||..||..||||. ....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase YES.AA Tec 275-526 44 2e-106 359.9 In-house 1-254 (254) Show / Hide 
Range on Protein: 275-526
Range on HMM: 1-254/254
Sequence Identity: 44% (112 aa)

LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLP-QLV
| .   ||.| || | .| | .  .||||..| |.|  | |..||..|.|| | ||| || | |.. |||||||.|..|.||..|.|  ..  |    | 
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYP
.|  ..  |||| || ..||||| | | |||.. . |..|||..| . | .||   |.|||.|| .||   | |.  |||||.||.|  |  . |..||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED
 | | || |.| .|.|.  |. |.... . |. ||.  |.|||||.   . ...
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase YES.AA S_TKc 275-528 25 3.4e-55 190.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 275-528
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSK--GSLLDFLKEGDG----KYLK
 ..  |.|.| ||.|. .....   .|||| .|      | ...| ||.|| .|. .| || |  .. .|.|.|...   |.|.|..|.  .    ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI-KSDVWSFGILQTELVTK
  .   ...||.....|. ... |||||  .|||. |    ||.||||||..                . |||      ..  |.|.||.|..  |... 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQS-----FLEDYF
|. |.|     ......            .... .... |..|||..|||   .        .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase YES.AA Pkinase 275-524 26 2.9e-45 161.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

LRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQ-----EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKG----SLLDFLKEGDG
.... |.|.| ||.|. ... || | ||.|..|  .  ..   .     |.||||.|.|.  | || .. ..  ||.|.|.. .|    .| |...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLIC----KIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVW
. .     .. ... ||. |..|. .|. |||||  .|||. .|  .    ||.|||||..  .  |..| . |  .   . |||  . .   . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDMW

SFGILQTELVTKGRVPYPGM------VNREVLEQVER-GYRMPCPQGCP-------------------ESLHELMNLCWKKDPDERPTFEYIQSF--L
|.|..  |... || |.||         ....... .  .. ..|. |.                   |.. .... |..||| .|||.| |     .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF