Gene Wnk3 (Mouse)
Wnk3
Sequence
Protein domains of Wnk3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | Wnk3.AA | WNK | 146-404 | 86 | 7.4e-234 | 762.97 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-261/261 Sequence Identity: 86% (226 aa) LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKVMK .|||.|.|||.|||||.|||||||||||||||||.||.|.|.|||||||||||.|||||||||||.|||.|.|||||||||||||||||||||||||.|| MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMK PKVLRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS |||||||||||||||.|||||.| ||||||||||||||||.|||||||||||| ||...||||||||||||||||||||||||||||||||||||||||| PKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF ||||||||||||||||||.||||.||.|...||||||||.|||.||.|| ||..||||.|| EYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF |
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Kinase | Wnk3.AA | S_TKc | 146-404 | 25 | 2.9e-70 | 240.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-231/231 Sequence Identity: 25% (69 aa) LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTS--GTLKTYLKRFKV .. ..|.||| .|||. ...| .|| .. .... | ..|| .|||||..||.... ... .|.|.. |.|..|.|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR ------MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDE-SVDVYAFGMC . . . |....||...|...| . ||||||| .||... .||.| |||... ....|||..||||. .|. ..|....| . HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI MLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLN-------HAFF . ||.. . |.. . .....|. .||.|..|..| . . ..|... ..|. | .| LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | Wnk3.AA | Pkinase | 146-404 | 25 | 6.3e-63 | 220.16 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-293/293 Sequence Identity: 25% (78 aa) LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKE--EAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSG----TLKTYLK ... .|.|.| .|||. . | .|| .. |. . ..|. |....| |.||||||.||..|. |. | .|.|.. | |..|.. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS --RFKVM--KPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSV----KIGDLGLAT---LMRTSFAKSVIGTPEFMAPEM--YEEHYDE | ... .........|||.||...| . ||||||| .||.| .| . ||.| ||| . . | .... |||..|||| ..|. TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP SVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGIKPASFNKVTD-------------------PEVKEIIEGCIRQNKSERLSIKDLLNHA .||....| . ||.. . |.... . |..... ... . .. . . .| |..|..|.... ..|......|.| KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP FF .| WF |
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Kinase | Wnk3.AA | STE | 146-404 | 20 | 7.9e-61 | 208.4 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-359/359 Sequence Identity: 20% (77 aa) LKFDIELGRGAFKTVYKGLDT-----------------ETWVEVAWCELQD-------------RKLTKAEQQRFKEEAEMLKGLQ--HPNIVRFYDSWE ... ..|.||| ||||... ... . .|.. .. . |.|....| ...| .. |||||..|.. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF ST---LKGKKCIVLVTELMTSGTLKTYLK-RFKVMKP-------------KVLRSWCRQILKG-LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLG | . . .. |.| |.| .| .... || .... ||||||| |..|| |||||.|..||.. ||. | | KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG LATLMRTS------------------FAKSVIGTPEFMAPEMYEE-------HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG------- ... . | ....||| .||||. . .||...|.. .| ...|||| ..|... .. .... ... VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE ------IKPASFNKVTD-------------------PEVKEIIEGCIRQNKSERLSIKDLLN--HAFF .| .. .. || |. |. | . . ..| . ..||. | |. QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | Wnk3.AA | FRWNK_Wnk1 | 405-496 | 73 | 5e-59 | 202.41 | In-house | 1-92 (92) | Show / Hide |
Range on Protein: 405-496 Range on HMM: 1-92/92 Sequence Identity: 73% (68 aa) AEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREK .||||.|||||||||...|...|.||.|||||||||.||||||||||.|| |.|||||.|||.||||.|.|.|.|||||||||.|||. ||. QEDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER |
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Kinase | Wnk3.AA | CAMK | 151-404 | 16 | 8.1e-54 | 171.43 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 151-404 Range on HMM: 1-425/425 Sequence Identity: 16% (72 aa) ELGRGAFKTVYKGLDTETW------------VEVAWCELQDRKLT--------------------------KAEQQRFKEEAEMLKGLQ-------HPNI .||||.| .|... ...| ..|| . .||. ..... | |..| || |||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VRFYDSWES-----------TLKG-----KKCIVLVT---ELMTSG----TLKTYLKRF---------------KVMKPKVLRSWCRQILKGLQFLHTRT ...|. .|. | . .|....|. |... | | |... . .. . | . |||. .....| . IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN PPIIHRDLKCDNIFITGPT----------------GSVKIGDLGLATLMRTS-------------------------FAKSVIGTPEFMA-PEMYE---- |.|||||..|| .. . .|| | |.|. .. . | . ||||.|| ||. . --IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH -----------EHYDESVDVYAFGMCMLEMATSEYPYSEC------------QNAAQIYRKVTSGIKPASFNKVTD----------------------PE . |....|. . | . | . ..|. . .| ....|...| .... .| CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE VKEIIEGCIRQNKSERLSIKDLLNHAFF .| | .. . . ..|..|.. ||| .. CKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | Wnk3.AA | Ciliate-E2 | 146-404 | 19 | 1e-50 | 172.28 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-365/365 Sequence Identity: 19% (74 aa) LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE---------------------QQRFKEEAEM---------------LKGLQHPNIVRFY || .|.|.| .|||. . .. ..| . .|. . .| ..|. .| |. |.||||...| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY DSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKVMKP-----------KVLRSWCRQILK---------------GLQFLHTRTPPIIHRDLKCDNIFIT ..... | ...| ||.|. |.|. |.| .| .. | . .|||. .|..|| . . |||||.| .||.. ECFQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF- GPTGSVKIGDLGLAT----------------LMRTSF------------------AKSVIGTPEFMAPEMYE----------EHYDESVDVYAFGMCMLE .|| |.||.. .. . .....|||..||||... ..||...|....|... | -----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE MATSEYPYSECQNAAQIYRKVTSGIKPASFN-------------KVTDPEVKEIIEG----CIRQNKSERLS-IKDLLNHAFF | . ..|. |. . . .. .. | ..|.| .| .. . ..|.. ....||| .| MLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | Wnk3.AA | TKL | 152-402 | 19 | 5.1e-49 | 169.17 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 152-402 Range on HMM: 1-364/364 Sequence Identity: 19% (73 aa) LGRGAFKTVYKGLDTE----------TWVEV--------AWCELQDRK---------------LTKAEQQRFKEEAEMLKGLQHPNIVRFYD-SWESTL- .|.|.| .|||| ..| | ....... .. ......||. |.. |.|||||.|. . ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -------KGKKCIVLVTELMTSGT-LKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRT------PPIIHRDLKCDNIFITG-------------PTGSV ... . .|.|.. |. | ... . .. .|...| .|...||... ||||||||| .||.. .. . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KIGDLGLATLMRTSF---------------------AKSVIGTPEFMAPEMYE-----------------EHYDESVDVYAFGMCMLEMATSEYPYSECQ ||.|.||.. | .|. ...||| .||||. . . |.|..|||.||... |..| . ||.. KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP NAAQI---------YRKVTSGIKPASF-----------NKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHA . .| . . | .| .. ..|..|.... | .. ..|.| ...| . YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | Wnk3.AA | ULK | 146-404 | 22 | 1.8e-44 | 153.15 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-329/329 Sequence Identity: 22% (76 aa) LKFDIELGRGAFKTVYKGLDTETW---VEVAWCELQDRKLTKAEQQR---------FKEEAEMLKGL--------QHPNIVRFYDSWESTLKGKKCIVLV . .|| |.| .|||| . .| .|. | |.. . ... .| | . .| | .|||||..|| |.. ..| .. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYII TELMTSGTLKTYLK----------RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATLMRTS- .|. |.|..|.| . | . .. ..||| |...|| . |||||.| .|| |. .... .||.| |.| . . MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN ----FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI----YRKVTSG--------IKPASFN----- ... ||| .|||. ... |... .|.. .|. . || . ..|.... . |. .. . . .| |. MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND KVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF .. ||.|..| ... . ..| |. .|.|| .| PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | Wnk3.AA | STE11 | 152-404 | 25 | 1.6e-43 | 150.94 | In-house | 7-303 (303) | Show / Hide |
Range on Protein: 152-404 Range on HMM: 7-303/303 Sequence Identity: 25% (77 aa) LGRGAFKTVYKGLDTETWVEVA--WCELQDRK----LTKAEQQR------FKEEAEMLKGLQHPNIVRFYDSWESTLKG-KKCIVLVTELMTSGTLKTYL .|.||| ||||.... | ...| |.|. . .. | | ..|| ...|.|.|.||||.|.. . .. .... | . |.|. | IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLH--DNQNDHVNIFMEYCPGGSLSSML K-RFKV--MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS------------FAKSVIGTPE--------FM . .. . .| | .|||.|||.|| |||||.| .||.. ...|..| | |. . .. . ||. ||| .| RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWM APEMYE-EH---YDESVDVYAFGMCMLEMATSEYPYSECQN--AAQIYRKVTS-G--IK-PASFNK--VTDPEVKEIIEGCIRQNKSERLSIKDLLNHAF |||.. | |. ..|. ..| ...|||| |...... .|.... ... . . | .. . .| .... | .....| . .||.| | APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPF F . I |
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Kinase | Wnk3.AA | Ciliate-E2-Unclassified | 178-404 | 19 | 5.8e-43 | 146.85 | In-house | 38-352 (352) | Show / Hide |
Range on Protein: 178-404 Range on HMM: 38-352/352 Sequence Identity: 19% (63 aa) QDRKLTKAEQQRFKEEAEMLKGLQ-----------------HPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKV----------------- ...|. . .. ... |.. .. .. ||.... .. .. . |..| .|.|.. |.|. |.| .| YKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC--FQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKI MKPKVLR-----SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTG--SVKIGDLGLAT-----------------LMRTSFAKSVIGTPEFM---- . . ...|||.||..|| |||||.|..||... . .|| |.|.. . .....|||..| FTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYT APEMYEE-HYDES----VDVYAFGMCMLEMATSEYPYS-EC------------------QNAAQIYRKVTSGIKPAS--FNKVTDPEVKEIIE----GCI |||.... .||.| .|....|... || . .||.. .. | .|. | .. | . | .||.|..|. .. APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKML RQNKSERLSIKDLLNHAFF | ..|......||| .| KKNPNKRITFEQILNHPWF |
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Kinase | Wnk3.AA | NRBP | 151-405 | 33 | 8.1e-43 | 148.33 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 151-405 Range on HMM: 1-261/261 Sequence Identity: 33% (90 aa) ELGRGAFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFK----VM ...| .|||. ||| | |.| .|| ||. . .. . | |.|.|||.| | | . | .. .|| | || .| .||. | | QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM KPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMY---EEHYDESVDVYAFGMCMLEM . | . || ||| | .||. ||||| | || ||| | .||| .. . .. |.||| .. ||.|.|||| ||| NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQH-NGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM ATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFA | | | |||. | || . . . . || ...|. |.... .| | ..|| | AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF |
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Kinase | Wnk3.AA | ULK | 146-404 | 23 | 1.8e-42 | 147.41 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-324/324 Sequence Identity: 23% (78 aa) LKFDIELGRGAFK-TVYKGLDTET---WVEVAWCELQDRKLTKAEQQ--------RFKEEAEMLKGLQ---HPN--IVRFYDSWESTLKGKKCIVLVTEL . .|| |.| .|||| . .| . || . |. | ... .| | . .| | ||| ||..|| |.. . | ...|. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY MTSGTLKTYLK---------RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATL-----MRTS |.|..|.| . | . .. ..||. |...|| . |||||.| .|| |. .... .||.| |.| | CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI---YRKVTSG------IKPASFNKV-------TDP .. ||| .|||. ... |... .|.. .|. . || . .||.... . |. .. . | || ... | MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP EVKEIIEGCIRQNKSERLSIKDLLNHAFF |.|..| ... . ..| |. ...|| .| ECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | Wnk3.AA | TyrKc | 146-404 | 25 | 2.6e-25 | 91.34 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 146-404 Range on HMM: 1-280/280 Sequence Identity: 25% (75 aa) LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGL--QHPNIVRFYDSWESTLKGK-----KCIVLVTELMTSGTLKTYL .... .||.||| .|||| . ..|| |.. . .. | .||.... | .||||||.| | .| . . .|.|.| | || || ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLMIVMEYMPHGDLKDYL KRFKV-MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS----FAKSVIGT-----PEF------MAPEMYEE .. . ..| | |.| || .| ..|| . ..||||| . |. .. . |||.| ||. .|... . . |||| . RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY H-YDESVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGIKPASFNKV-------TDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF . . . ||..|| || |. | . . ........| .| . . .|. .|.. | . . ..| . ... | .| GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | Wnk3.AA | OSR1_C | 425-462 | 65 | 2e-20 | 77.8 | Pfam | 1-38 (38) | Show / Hide |
Range on Protein: 425-462 Range on HMM: 1-38/38 Sequence Identity: 65% (25 aa) LALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVA ..|.|...||||.|||||.||||.|.|..| ||||||| INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA |
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Kinase | Wnk3.AA | Pkinase_Tyr | 224-297 | 37 | 2.5e-12 | 42.35 | Pfam | 84-158 (270) | Show / Hide |
Range on Protein: 224-297 Range on HMM: 84-158/270 Sequence Identity: 37% (29 aa) LVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA .|.|.| | |..||.. . ..| | ..|.|| ||...|. . .||||| . |. .| . |||.| ||| IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA |
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Kinase | Wnk3.AA | Pkinase_Tyr | 146-209 | 36 | 1.3e-09 | 33.13 | Pfam | 1-70 (270) | Show / Hide |
Range on Protein: 146-209 Range on HMM: 1-70/270 Sequence Identity: 36% (26 aa) LKFDIELGRGAFKTVYKGLDT----ETWVEVAWCELQDRKLTKAE--QQRFKEEAEMLKGL-QHPNIVRFY ..|. .||.||| .|||| . .| ..|| | . . .. . .. | .||...| | .||||||.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLY |
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Kinase | Wnk3.AA | FRWNK_Wnk2.hmm | 449-494 | 32 | 3e-06 | 18.47 | In-house | 18-63 (63) | Show / Hide |
Range on Protein: 449-494 Range on HMM: 18-63/63 Sequence Identity: 32% (15 aa) FSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIR | | |. |.|||.| ||.. | ||. .. . .|| .. ... FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM |
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Kinase | Wnk3.AA | Pkinase_Tyr | 315-404 | 22 | 0.000733 | 13.7 | Pfam | 181-270 (270) | Show / Hide |
Range on Protein: 315-404 Range on HMM: 181-270/270 Sequence Identity: 22% (21 aa) MAPE--MYEEHYDESVDVYAFGMCMLEMAT-SEYP-YSECQNAAQIYRKV-TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF |||| .| . . . ||..|| .| |. | | | | .. ...|... .| . . . .|. ... | ... ..| . ... | .. MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL |
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FRWNK_Wnk2.hmm | Wnk3.AA | FRWNK_Wnk2.hmm | 759-821 | 66 | 3.5e-40 | 132.69 | In-house | 1-63 (63) | Show / Hide |
Range on Protein: 759-821 Range on HMM: 1-63/63 Sequence Identity: 66% (42 aa) DNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEIL |.||||||||||.||||||||.|||.||.||.||||..|.||.|.|||.|..|.|. .|.|.. DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM |
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FRWNK_Wnk1 | Wnk3.AA | FRWNK_Wnk1 | 770-823 | 27 | 0.00067 | 11.42 | In-house | 39-92 (92) | Show / Hide |
Range on Protein: 770-823 Range on HMM: 39-92/92 Sequence Identity: 27% (15 aa) NNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEILHV .| . | || . |.||..| ||| .|..| . . |. | .. . DNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER |
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OSR1_C | Wnk3.AA | OSR1_C | 776-789 | 50 | 0.393861 | 7.87 | Pfam | 25-38 (38) | Show / Hide |
Range on Protein: 776-789 Range on HMM: 25-38/38 Sequence Identity: 50% (7 aa) FKFDVDGDAPEDIA |.||. |.||..| FEFDIEKDTPEEVA |
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Wnk.CR4 | Wnk3.AA | Wnk.CR4 | 1523-1599 | 47 | 8.6e-39 | 135.2 | In-house | 1-80 (80) | Show / Hide |
Range on Protein: 1523-1599 Range on HMM: 1-80/80 Sequence Identity: 47% (38 aa) SPMSSDNESEIEDEDLKVELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDNKAQS-SEVP--LSPASPRRPRSFKS |.|||||.||.||||...|||||||||..|...||.||.||..|||.|.. ... ...| .... . ....|||...|| SYMSSDNDSEFEDEDMWKELQRLREKHMKEIQELQAQQKKEIEELYTRMGKPPPPGIVSPHAMLTAPMSGRRRRPSKHKS |