Gene Wnk2 (Mouse)
Wnk2
Sequence
Protein domains of Wnk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | Wnk2.AA | WNK | 195-453 | 85 | 1e-231 | 755.98 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-261/261 Sequence Identity: 85% (223 aa) LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMK .|||.|.|||||||||.|||||||||||||||||.||.| |||||||||||||.|||||||||||.|||...||.||||||||||||||||||||||.|| MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMK PKVLRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS ||||||||||||||| |||||.| ||||||||||||||||.|||||||||||| |||..||||||||||||||||||||||||||||||||||||||||| PKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS EYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFF ||||||||||||||||||.||||.||.|...||.|||| .||..|||||..|..||.|.|| EYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF |
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Kinase | Wnk2.AA | S_TKc | 195-453 | 25 | 5.8e-66 | 226.37 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-231/231 Sequence Identity: 25% (70 aa) LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTS--GTLKTYLKRFKV .. ..|.|.| .|||. ...| .|| .. .... | ..|| .|||||..||.... .. .|.|.. |.|..|.|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR ------MKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDE-SVDVYAFGMC . . . |....||...| ..| . ||||||| .||... .||.| |||.. ....|||..||||. .|. ..|....| . HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI MLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLS-------HAFF . ||.. . |.. . .....|. .|| |..| | .|. |.|. . ..| | .| LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | Wnk2.AA | FRWNK_Wnk1 | 454-545 | 78 | 8.3e-61 | 208.33 | In-house | 1-92 (92) | Show / Hide |
Range on Protein: 454-545 Range on HMM: 1-92/92 Sequence Identity: 78% (72 aa) AEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIDSGFFHESDVKIVAKSIRDRVALIQWRRER .|||||||||||||.|.||.|.|.||.|||||||||.|||.||||.|||||..|.||||||..||||.|.|.||||||||||||||.|.||| QEDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER |
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Kinase | Wnk2.AA | Pkinase | 195-453 | 26 | 2.2e-60 | 211.69 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-293/293 Sequence Identity: 26% (81 aa) LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKE--EAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSG----TLKTYLK ... .|.||| .|||. . | .|| .. |. . ..|. |....| |.||||||.||..|. |. | .|.|.. | |..|.. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS --RFKVM--KPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSV----KIGDLGLAT---LKRASFAKSVIGTPEFMAPEM--YEEHYDE | ... .........|||.|| ..| . ||||||| .||.| .| . ||.| ||| . . | .... |||..|||| ..|. TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP SVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTCGIKPASFEKVHD-------------------PEIKEIIGECICKNKEERYEIKDLLSHA .||....| . ||.. . |.... . |..... ... . .... .. .| |..| |.||. ..|. ....| | KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP FF .| WF |
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Kinase | Wnk2.AA | STE | 195-453 | 20 | 4e-56 | 192.76 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-359/359 Sequence Identity: 20% (77 aa) LKFDIELGRGSFKTVYKGLDT-----------------ETWVEVAWCELQD-------------RKLTKLERQRFKEEAEMLKGLQ--HPNIVRFYDFWE ... ..|.|.| ||||... ... . .|.. .. . |.|....| ...| .. |||||..|. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF SS---AKGKRCIVLVTELMTSGTLKTYLK-RFKVMKP-------------KVLRSWCRQILKG-LLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLG | . . .. |.| |.| .| .... || .... ||||||| | .|| |||||.|..||.. ||. | | KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG LATLKRAS------------------FAKSVIGTPEFMAPEMYEE-------HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCG------- ... | ....||| .||||. . .||...|.. .| ...|||| ..|... .. .... . . VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE ------IKPASFEKVHD-------------------PEIKEIIGECICKNKEERYEIKDLLS--HAFF .| ... . || |. | | |. ..| ..||. | |. QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | Wnk2.AA | Ciliate-E2 | 195-453 | 20 | 4.8e-48 | 163.01 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-365/365 Sequence Identity: 20% (77 aa) LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRK--------------------LTKLERQRFKEEAEM---------------LKGLQHPNIVRFYD || .|.|.| .|||. . .. ..| . .| . .| ..|. .| |. |.||||...|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE FWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKP-----------KVLRSWCRQILK---------------GLLFLHTRTPPIIHRDLKCDNIFITG .... | . .| ||.|. |.|. |.| .| .. | . .|||. .| .|| . . |||||.| .||.. CFQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-- PTGSVKIGDLGLAT-----------------LKRAS-----------------FAKSVIGTPEFMAPEMYE----------EHYDESVDVYAFGMCMLEM .|| |.||.. .. . .....|||..||||... ..||...|....|... || ----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM ATSEYPYSECQNAAQIYRKV-TCGIKPASFE---------------KVHDPEIKEIIGE----CICKNKEERYE-IKDLLSHAFF . ..|. ... | |. ..| | ...| | .| ...|. |.|. ....| | .| LFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | Wnk2.AA | CAMK | 200-453 | 16 | 5.4e-48 | 152.33 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 200-453 Range on HMM: 1-425/425 Sequence Identity: 16% (72 aa) ELGRGSFKTVYKGLDTETW------------VEVAWCELQDRKLT--------------------------KLERQRFKEEAEMLKGLQ-------HPNI .|||||| .|... ...| ..|| . .||. |.... | |..| || |||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VRFYDFWES-----------SAKG-----KRCIVLVT---ELMTSG----TLKTYLKRF---------------KVMKPKVLRSWCRQILKGLLFLHTRT ...|...|. . . ......|. |... | | |... . .. . | . |||. .. ..| . IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN PPIIHRDLKCDNIFITGPT----------------GSVKIGDLGLATLKRAS-------------------------FAKSVIGTPEFMA-PEMYE---- |.|||||..|| .. . .|| | |.|. .. . | . ||||.|| ||. . --IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH -----------EHYDESVDVYAFGMCMLEMATSEYPYSEC------------QNAAQIYRKVTCGIKPASFEKVHD----------------------PE . |....|. . | . | . ..|. . .| ....|.. | ... . .| CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE IKEIIGECICKNKEERYEIKDLLSHAFF | | . ... |.|. |.. |.| .. CKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | Wnk2.AA | TKL | 201-441 | 19 | 1.8e-46 | 160.68 | In-house | 1-354 (364) | Show / Hide |
Range on Protein: 201-441 Range on HMM: 1-354/364 Sequence Identity: 19% (72 aa) LGRGSFKTVYKG-LDTET-------WVEVAWCELQDRKLTKLER-------------------------QRFKEEAEMLKGLQHPNIVRFYDFWESSAK- .|.|.| .|||| . .. .|| . . . .. ....||. |.. |.|||||.|. . .. . IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG --------GKRCIVLVTELMTSGT-LKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRT------PPIIHRDLKCDNIFITG-------------PTGSV .. . .|.|.. |. | ... . .. .|...| .|. .||... ||||||||| .||.. .. . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KIGDLGLATLKRASF---------------------AKSVIGTPEFMAPEMYE-----------------EHYDESVDVYAFGMCMLEMATSEYPYSECQ ||.|.||.. . |. ...||| .||||. . . |.|..|||.||... |..| . ||.. KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP NAAQIYR-------KVTC--GIKPASF-----------EKVHDPEIKEIIGECICKNKEER . .| . .. | | .| .. .|..|... .| . |.| YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR |
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Kinase | Wnk2.AA | NRBP | 200-454 | 33 | 1.1e-41 | 144.31 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 200-454 Range on HMM: 1-261/261 Sequence Identity: 33% (88 aa) ELGRGSFKTVYKGLDTETWVEVAWCELQ--DRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFK----VM ...| .|||. ||| | |.| .|| |.. . .. . | |.|.|||.| .| . . | .. .|| | || .| .||. | | QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM KPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRA-SFAKSVIGTPEFMAPEMY---EEHYDESVDVYAFGMCMLEM . | . || ||| | .||. ||||| | || ||| | .||| .... .. |.||| .. ||.|.|||| ||| NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQH-NGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM ATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFFA | | | |||. | || . . . . || ...| .|. |. ..| ..|| | AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF |
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Kinase | Wnk2.AA | ULK | 195-453 | 23 | 1.2e-39 | 136.07 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-329/329 Sequence Identity: 23% (77 aa) LKFDIELGRGSFKTVYKGLDTETW---VEVAWCELQDRKLTKLERQR---------FKEEAEMLKGL--------QHPNIVRFYDFWESSAKGKRCIVLV . .|| ||| .|||| . .| .|. | |.. . . . .| | . .| | .|||||..||. |.| .| .. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYII TELMTSGTLKTYLK----------RFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATLKRAS- .|. |.|..|.| . | . .. ..||| |. .|| . |||||.| .|| |. .... .||.| |.| . MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN ----FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI---YRK-----VTCG----IKPASFE----- ... ||| .|||. ... |... .|.. .|. . || . ..|.... . |. ..| ... .| |. MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND KVHDPEIKEIIGECICKNKEERYEIKDLLSHAFF .. ||.|..| ..... ..| .. .|..| .| PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | Wnk2.AA | ULK | 195-453 | 23 | 3e-39 | 136.72 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-324/324 Sequence Identity: 23% (77 aa) LKFDIELGRGSFK-TVYKGLDTET---WVEVAWCELQDRKLTKLERQ--------RFKEEAEMLKGLQ---HPN--IVRFYDFWESSAKGKRCIVLVTEL . .|| ||| .|||| . .| . || . |. | . . .| | . .| | ||| ||..||. |.| | ...|. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY MTSGTLKTYLK---------RFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATL-----KRAS |.|..|.| . | . .. ..||. |. .|| . |||||.| .|| |. .... .||.| |.| . . CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI------------YRKVTCGIKPASFEKVH-----D .. ||| .|||. ... |... .|.. .|. . || . .||.... . |. . ... .| | |. MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQ-QIYIKNQPIQFPKPPKDPKIS PEIKEIIGECICKNKEERYEIKDLLSHAFF ||.|..| ..... ..| .. ....| .| PECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | Wnk2.AA | Ciliate-E2-Unclassified | 196-453 | 20 | 4.1e-37 | 126.3 | In-house | 2-352 (352) | Show / Hide |
Range on Protein: 196-453 Range on HMM: 2-352/352 Sequence Identity: 20% (74 aa) KFDIELGRGSFKTVYKGLDTETWVEV----AWCELQDRK----LTKLERQRFKEEAEMLKG---------------LQHPNIVRFYDFWESSAKGKRCIV |. .|.|.| .||| . .. .. . |..| ..| . ....... | |.||.... ..|.. | . | KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IY LVTELMTSGTLKTYLKRFKV-----------------MKPKVLR-----SWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTG--SVKIGDLGLAT- .|.|.. |.|. |.| .| . . ...|||.|| .|| |||||.|..||... . .|| |.|.. IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKK ----------------LKRASFAKSVIGTPEFM----APEMYEE-HYDES----VDVYAFGMCMLEMATSEYPYS-EC------------------QNAA . .....|||..| |||.... .||.| .|....|... || . .||.. .. | YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ QIYRKVTCGIKPAS--FEKVHDPEIKEIIG----ECICKNKEERYEIKDLLSHAFF .|. | .. | . | .|| |..| .. || ..|. ....| | .| NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | Wnk2.AA | STE11 | 201-453 | 24 | 1.2e-35 | 124.81 | In-house | 7-303 (303) | Show / Hide |
Range on Protein: 201-453 Range on HMM: 7-303/303 Sequence Identity: 24% (75 aa) LGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKL------ERQR------FKEEAEMLKGLQHPNIVRFYDFWE-SSAKGKRCIVLVTELMTSGTLKTYL .|.|.| ||||.... | ...| . . .. ... | | ..|| ...|.|.|.||||.|.. ..... .| . | . |.|. | IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFM--EYCPGGSLSSML K-RFKV--MKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRAS------------FAKSVIGTPE--------FM . .. . .| | .|||.|| .|| |||||.| .||.. ...|..| | |. .. . ||. ||| .| RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWM APEMYE-EH---YDESVDVYAFGMCMLEMATSEYPYSECQN--AAQIYRKVTC-GIKPASFEKVHD-----PEIKEIIGECICKNKEERYEIKDLLSHAF |||.. | |. ..|. ..| ...|||| |...... .|.... .. . | |.. .| .... | .....|. .|| | | APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPF F . I |
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Kinase | Wnk2.AA | Pkinase_Tyr | 195-346 | 34 | 1.7e-21 | 73.39 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 195-346 Range on HMM: 1-158/270 Sequence Identity: 34% (56 aa) LKFDIELGRGSFKTVYKGLDT----ETWVEVAWCELQDRKLTKLE--RQRFKEEAEMLKGL-QHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYL ..|. .||.|.| .|||| . .| ..|| | . . .. . |. | .||...| | .||||||.| . . . | .|.|.| | |..|| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL KR----FKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA .. . ..| | ..|.|| ||. .|. . .||||| . |. .| . |||.| ||| RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA |
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Kinase | Wnk2.AA | TyrKc | 195-453 | 24 | 2.1e-19 | 71.69 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 195-453 Range on HMM: 1-280/280 Sequence Identity: 24% (74 aa) LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGL--QHPNIVRFYDFWESSAKGK-------RCIVLVTELMTSGTLKT .... .||.| | .|||| . ..|| |.. . |. | .||.... | .||||||.| . . . .|.|.| | || ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY----GVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YLKRFKV-MKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRAS----FAKSVIGT-----PEF------MAPEMY ||.. . ..| | |.| || .| .|| . ..||||| . |. .. . |||.| ||. .|... . . |||| YLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI EEH-YDESVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTCGIKPASFEKV-------HDPEIKEIIGECICKNKEERYEIKDLLSHAFF .. . . ||..|| || |. | . . ........| | . . . .|. .|. .| . |.| ... | .| NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | Wnk2.AA | OSR1_C | 474-511 | 63 | 2.5e-19 | 73.77 | Pfam | 1-38 (38) | Show / Hide |
Range on Protein: 474-511 Range on HMM: 1-38/38 Sequence Identity: 63% (24 aa) IALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEVA |.|.|...||||.|||.|.|.||.|.||.||.||.||| INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA |
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Kinase | Wnk2.AA | FRWNK_Wnk2.hmm | 498-534 | 37 | 0.000377 | 11.43 | In-house | 18-54 (63) | Show / Hide |
Range on Protein: 498-534 Range on HMM: 18-54/63 Sequence Identity: 37% (14 aa) FTFDLEKETPDEVAQEMIDSGFFHESDVKIVAKSIRD | |||. ..|.|.|| |... | ||. . . .|| FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRD |
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Kinase | Wnk2.AA | Pkinase_Tyr | 364-409 | 32 | 0.504548 | 4.09 | Pfam | 181-228 (270) | Show / Hide |
Range on Protein: 364-409 Range on HMM: 181-228/270 Sequence Identity: 32% (16 aa) MAPE--MYEEHYDESVDVYAFGMCMLEMAT-SEYP-YSECQNAAQIYRKV |||| .| . . . ||..|| .| |. | | | | .. ...|... MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYI |
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FRWNK_Wnk2.hmm | Wnk2.AA | FRWNK_Wnk2.hmm | 1147-1209 | 77 | 1.6e-42 | 140.6 | In-house | 1-63 (63) | Show / Hide |
Range on Protein: 1147-1209 Range on HMM: 1-63/63 Sequence Identity: 77% (49 aa) DKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDML |.|||||||||||||||||||||||.|.|||.||||.||||..|||.|||||.|...|||.|. DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM |
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FRWNK_Wnk1 | Wnk2.AA | FRWNK_Wnk1 | 1164-1211 | 29 | 2e-05 | 16.98 | In-house | 45-92 (92) | Show / Hide |
Range on Protein: 1164-1211 Range on HMM: 45-92/92 Sequence Identity: 29% (14 aa) FKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDMLSE | |||. |.|.|.| ||| |.. |. .. ..| . . . FSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER |
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OSR1_C | Wnk2.AA | OSR1_C | 1164-1177 | 50 | 0.219478 | 8.79 | Pfam | 25-38 (38) | Show / Hide |
Range on Protein: 1164-1177 Range on HMM: 25-38/38 Sequence Identity: 50% (7 aa) FKFDLDGDAPDEIA |.||. |.|.|.| FEFDIEKDTPEEVA |
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Wnk.CR4 | Wnk2.AA | Wnk.CR4 | 1823-1899 | 65 | 4.2e-48 | 166.11 | In-house | 1-80 (80) | Show / Hide |
Range on Protein: 1823-1899 Range on HMM: 1-80/80 Sequence Identity: 65% (52 aa) SYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFH---TAPPMGRRRKTSKSKL ||.||||||||||.|..|||..|||||.|||.|||.|||.|||.||.|.|||.||.....| |||. ||||..||.|. SYMSSDNDSEFEDEDMWKELQRLREKHMKEIQELQAQQKKEIEELYTRMGKPPPPGIVSPHAMLTAPMSGRRRRPSKHKS |