Gene TYRO3 (Mouse)

TYRO3

Species: Mouse
Alias: Tyro3, TYRO3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Axl

Sequence

Name Sequence Type Origin Length Description Download
TYRO3.AA Protein Sugen 880 None Fasta, JSON
TYRO3.NA RNA Sugen 2844 None Fasta, JSON
TYRO3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of TYRO3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 TYRO3.AA IGc2 45-114 30 6.8e-18 66.68 SMART 1-56 (56) Show / Hide 
Range on Protein: 45-114
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

SQGQPVKLNCSVEGMEDPDIHWMKDGTVVQNASQVSISISEHSWIGLLSLKSVERSDAGLYWCQVKDGEE
 .||.| |.| ..| .||.||| | |. ..             | . |..|.|...|.|.|.|..     
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG TYRO3.AA IG 39-126 23 1.2e-16 62.55 SMART 1-58 (58) Show / Hide 
Range on Protein: 39-126
Range on HMM: 1-58/58
Sequence Identity: 23% (22 aa)

PVKMTVSQGQPVKLNCSVEGMEDPDIHWMKDGTVVQNASQVSISISEHSWIGLLSLKSVERSDA---GLYWCQVKDGEETKIS-QSVWLTVE
|  .||. |..|.|.| |.      |.|.                        | . .|...|.   | |.||..    .. | |...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set TYRO3.AA I-set 33-125 22 2e-11 41.27 Pfam 1-92 (92) Show / Hide 
Range on Protein: 33-125
Range on HMM: 1-92/92
Sequence Identity: 22% (21 aa)

LKLMGAPVKMTVSQGQPVKLNCSVEGMEDPDIHWMKDGTVVQN-ASQVSISISEHSWIGLLSLKSVERSDAGLYWCQVKDGEETKISQSVWLTV
 |    |  ..|. |. ....| |.|  .|.. | |||  ...  . .... .. . .  |  . |...|.| | |...     . . .. |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDG-DGTYTLTISNVQPDDEGKYTCVATNS-FGEAECTAELTV
V-set TYRO3.AA V-set 43-125 19 1.8e-10 37.9 Pfam 17-128 (128) Show / Hide 
Range on Protein: 43-125
Range on HMM: 17-128/128
Sequence Identity: 19% (22 aa)

TVSQGQPVKLNCSVE-GM----EDPDIHWMK-DGT-------------------------VVQNASQVSISISEHSWIGLLSLKSVERSDAGLYWCQVKD
||..|| |.|.|..  .      . .|.|..   .                         . ..  ..| ..|  .    |.......|| | |.|.|..
TVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPS--KNDFSLTISNLQPSDSGTYYCAVWN

GEETKISQSVWLTV
. |    ....|||
CNEDYFGHGTRLTV
IG TYRO3.AA IG 135-212 15 3.5e-05 24.47 SMART 1-58 (58) Show / Hide 
Range on Protein: 135-212
Range on HMM: 1-58/58
Sequence Identity: 15% (13 aa)

PKDLAVPPNAPFQLSCEAVGPPEPVTIYWWRGLTKVGGPAPSPSVLNVTGVTQR-----TEFSCEARNIKGLATS-RPAIVRLQ
|. . | .  . .|.| .       .|.|.               |.. .|.        .. |.|.  .| ..|  .. .. |
PP-VTVKEGETVTLTC-VS------QIWWY---------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 TYRO3.AA IGc2 141-200 19 0.002922 6.16 SMART 1-56 (56) Show / Hide 
Range on Protein: 141-200
Range on HMM: 1-56/56
Sequence Identity: 19% (12 aa)

PPNAPFQLSCEAVGPPEPVTIYWWRGLTKVGGPAPSPSVLNVTGVTQRT--EFSCEARNIKG
 .  ...| |. .   .  .| | .  ...     . . |... ||     . .|.||| .|
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP----WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set TYRO3.AA I-set 129-159 35 0.154449 7.73 Pfam 1-31 (92) Show / Hide 
Range on Protein: 129-159
Range on HMM: 1-31/92
Sequence Identity: 35% (11 aa)

PFFTVEPKDLAVPPNAPFQLSCEAVGPPEPV
| ||  |||. |       ..|.. | |.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQ
FN3 TYRO3.AA FN3 215-297 17 7.9e-08 33.25 SMART 1-69 (69) Show / Hide 
Range on Protein: 215-297
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

PAAPFN---TTVTTISSY------NASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLAPA----TNYSLRVRCANA--LGPS
| .| |    .|| ..|        ... | |       ..                          . ...| |     |.|. |||. |.   |..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TYRO3.AA FN3 313-393 13 0.007271 15.84 SMART 1-69 (69) Show / Hide 
Range on Protein: 313-393
Range on HMM: 1-69/69
Sequence Identity: 13% (13 aa)

ARAPQN---FHAI-RTDS------GLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTRANLTDWDPQ----KDLILRVCASNA--IGDG
  .|.|   ...   |..       . |.|..               ....               . .|.  |     .    || | |.   | |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------------IVGYR---------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase TYRO3.AA Axl 508-774 76 1.9e-209 702.13 In-house 1-267 (267) Show / Hide 
Range on Protein: 508-774
Range on HMM: 1-267/267
Sequence Identity: 76% (205 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA
|.||.|||.||||||.|.||||||||||||||||.|.||...|.|||||.|||||||||||.|..|.||........|.|.||||||||||||||.|||.
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

SRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWA
||.|..||.||||.||.|||||||||||||.|||||||||||||||.|||||||||||||.||||||||||||..|.||||.|.|||||..||..|||||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVWA

FGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRM
||||||||||||||||.|.||.|.|.|||.|.|||||..||.|.||||||||.||||.||||. ||.
FGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase TYRO3.AA Pkinase_Tyr 508-776 42 4.7e-140 474.94 Pfam 1-270 (270) Show / Hide 
Range on Protein: 508-776
Range on HMM: 1-270/270
Sequence Identity: 42% (118 aa)

FTLGRMLGKGEFGSVREAQLK-QEDGSFVKVAVKMLKADIIASSD---IEEFLREAACMKEF-DHPHVAKLVGVSL-RSRAKGRLPIPMVILPFMKHGDL
 |.|..||.|.||.|... .| ..|.  ..|||||||    |...   .|.|.|||. ||.. .||.. .|.|| . ... .     .......|.||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDL

HAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYY-RQGCASKLPVKWLALESLADNLYT
. .| . |  |.. .|....|. . ..||.|||||.|.|.||||||||||...|...| ..||||.| ||. ||| |..  .|||.||.|.|..... .|
LDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

VHSDVWAFGVTMWEIMTRGQTP-YAGIENAEIYNYL-IGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMEL
. ||||.|||.||||.|.|..| |.|. |.|.|.|.   |.|...|. | .|.|||| ||| .||..||.|. .. .|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TYRO3.AA TyrKc 508-776 39 3.7e-128 432.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 508-776
Range on HMM: 1-280/280
Sequence Identity: 39% (119 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF--DHPHVAKLVGVSLRS--RAKGRL---PIPMVILPFMKHGD
 |||..|| |.|| |.....|      ..|||||||.|      .|.|.|||  |...  .||.. .|.|| . .  .        . .|... .|.|||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGD

LHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG-------DYYRQGC--ASK--LPVKWL
|. .| ..|       |....|. |...||||||||.|.|.||||||||||...|. || ..||||||.||..       ||||.     .|  ||..|.
LKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

ALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAG-----IENAEIYNYLIGGNRLKQPPE--------CMEEVYDLMYQCWSADPKQRPSFTCLRMEL
|.|.. .. .|  ||||.|||.||||.|.||.|| |     ..|.|...|.  |.|..|||.        | .|.|..| ||| .||..||.|. .. ..
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TYRO3.AA TK 508-776 25 3.6e-113 380.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 508-776
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

FTLGRMLGKGEFG---SVREAQLKQED----------------------GSFVKVAVKMLKADIIASSD-IEE-----------FLREAACMKEFD----
 |||. ||.|.||    |.........                      |  ..|||||||..  .|..  ..           ||.||. || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHVAKLVGVSLRSRAKGRL------PIPMVILPFMKHGD----LHAFLLASRIGENP-----------------------------------------
 ||.. .|.||..... | ..      . .|... .|.|||    |. .| ..| ....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------FNLPLQTLVRFMVDIACGMEYLSSR------NFIHRDLAARNCMLAEDMT-----------VCVADFG---
                              .|....|. ....||||||||.|.      ||.|||||||||...|...           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRKIYSGDYYRQGC------------------------ASKLPVKWLALESLADNL---------YTVHSDVWAFGVTMWEIMTRGQTPYAG-I
     |.|.|||.|.|.                             |||..|.| |.|.|.          .|  ||||.|||.||||.|.||.||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EN---------AEIYNYLIGG--------------NRLKQPPECM--------------EEVYDLMYQCWSADPKQRPSFTCLRMEL
 |         .|...||  |              .|..||| |               ||.|||| |||..||..||.|. |. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TYRO3.AA Met 509-770 41 4.6e-113 372.11 In-house 1-271 (271) Show / Hide 
Range on Protein: 509-770
Range on HMM: 1-271/271
Sequence Identity: 41% (115 aa)

TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLK-ADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA
 ... .|.| || |  ... ..||   ..|.| |.   |     |..||||.  ||.||||.| .|.|..|..  .     |.|.||.||||||  |   
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGH----MPWVVLPYMKHGDLKTF---

SRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI-YSGDYYRQGCASK---LPVKWLALESLA--------
  |     |.    |. |  ..|.||.|. |. |.|||||.||||| |..|| ||||||.|.. |   || |        |||||.|.|.|         
--IRNPQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCP

DNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIEN-AEIYNYLIGG--NRLKQPPECMEEVY-DLMYQCWSADPKQRPSFT
..  .|  |||| ||| ||| |||| .||  . |   |  .| .|  .|| ||. | . .| |.| .||.|.| .||.| 
TYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase TYRO3.AA UTK 508-776 34 1e-98 334.24 In-house 1-296 (296) Show / Hide 
Range on Protein: 508-776
Range on HMM: 1-296/296
Sequence Identity: 34% (105 aa)

FTLGRMLGKGEFGSVREAQLKQED--GSFVKVAVKMLKADIIASSDIE---EFLREAA---CMKEFD-HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKH
  ||| ||.|.|| |..| ..|..  .  ..|||| ....  |  . |   .|..||.    || |. ||.|..|||| ...        .|... .|. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP------WMIVTEYMEN

GDLHAFLLASRI--GENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAED-------MTVCVADFG---LSRKIY---------SGDYYR
||| ..|  .|   ...|. | | ... ...|||.||.||.|..|.||||||||| ....       |.. .||||   .|| ..         . .||.
GDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

QGCASKLPVKWLALESLADN-LYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGG--NRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRM
.  . ..|..| | |.|...  .| .||||.|||..|||.|.|..||.|. |...   .  |   |...|..| ..||.|| .|| .||  ||.|  |. 
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQ

EL
..
QM
Kinase TYRO3.AA TK-Unique 508-776 33 6.7e-87 295.0 In-house 1-294 (294) Show / Hide 
Range on Protein: 508-776
Range on HMM: 1-294/294
Sequence Identity: 33% (100 aa)

FTLGRMLGKGEFGSVREAQLKQ---EDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD-HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHA
...|. .|.|.|| |  .....   ... ...|||||||..     |  .||.|.. ||| . ||.. ...|.. .|   ..   .| |....  |.|  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDT-DKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EP---WMIIMEYCPCGNLQH

FLLASRIG----------------ENPFN----LPLQTLVRFMVDIACGMEYLSS--RNFIHRDLAARNCMLAEDMTVCVADFGLSRKIY-SGDYYRQGC
.|  .| .                .....    . ...|..|...||||||||.|  ....||||.|||..|.|| .. ..|||..|..|  |.| ... 
YLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCS

ASKLPVKWLALESLA--DNLY-TVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC-MEEVYDLMYQCWSADPKQRPSFTCLRMEL
 ...|..|.|.|||   .. | |  ||||.|||.||||.| |..|| |. ...| . .  | |..||..|  .|.| ||..||. .|..||||. .. .|
QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TYRO3.AA InsR 508-778 37 6.3e-83 278.36 In-house 1-278 (278) Show / Hide 
Range on Protein: 508-778
Range on HMM: 1-278/278
Sequence Identity: 37% (108 aa)

FTLGRMLGKGEFGSVREA---QLKQEDGSFV-KVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHA
 .|.| .|.| || | |     . .. ..   ..|.| ....  .. .  ||| ||  ||||.. || .| ||  |       |  .|.  .|..|||  
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNEN-ASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQ-----PM-YVVMEMMTYGDLKS

FLLASRIGEN----PFN-----LPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESL
.|.. |  |     . |      .|. ..    .|. || || ...|.|||||.|||| ..| || ..|||. | ||  |||| |  ..||| | | |||
YLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESL

ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYL-IGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELEN
 |  .| ||||| ||| .||. | |  || |  |... .|  ..|| |..|  | | ...|| .||   || ||.|. .   | .
KDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase TYRO3.AA HMTK 508-775 36 8e-80 271.5 In-house 1-291 (291) Show / Hide 
Range on Protein: 508-775
Range on HMM: 1-291/291
Sequence Identity: 36% (110 aa)

FTLGRMLGKGEFG-----------------SVREAQLK------QEDGSFVK-VAVKMLKADIIASS-DIEEFLREAACMKEFDHPHVAKLVGVSLRSRA
 . .. .| | ||                  |  | ..      ..|.  .. .|||||..|  ||. |.|||||||  | ...||.. .||||.. .| 
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGD--ASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQR-

KGRLPIP-MVILPFMKHGDLHAFLLASRIGENPFNLPLQTL--VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIY-SGDYYRQ
      | .. | .|. ||| ..| . | .    |..|...    |.| .| ||.|..|  ..|.|||||||....   | .|||||.|..    ||...
------PWLCVLEYMQYGDLRNVLKTCREK----NIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHL

GCAS-KLPVKWLALESLA--DNLYTVHSDVWAFGVTMWEIMTRGQTPYA--GIENAEIYNYLIGGNRLKQPPE--CMEEVYDLMYQCWSADPKQRPSFTC
  .. |||.||.| | ..  .      |||||||||||||.. | .||.  .|.| |.  ... |.|| |||.  | ....|||..|| .|| |||.|  
RKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQ

LRME
|...
LQKM
Kinase TYRO3.AA Src 508-776 38 1.1e-76 260.02 In-house 1-255 (255) Show / Hide 
Range on Protein: 508-776
Range on HMM: 1-255/255
Sequence Identity: 38% (103 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA
..| | ||.| || | ..  ...    .||||| ||..     . | ||.||  ||...|... .|  |  .       ||   .  .|.|| | ..| .
IKLCRKLGQGQFGEVWMGYWNGN----TKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-----PI-YIVTEYMSHGSLLDYLKK

SRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG-DYYRQGCASKLPVKWLALESLADNLYTVHSDVW
.. |    .|.|..|. .   .| ||.||.|.|.|||||||||    |.  . |||||| | |  . | |     .|.|.|| | | .  . .|. ||||
DGEGR---HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVW

AFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYD-LMYQCWSADPKQRPSFTCLRMEL
 ||. ..||.|.|..|| | .|.|    .  | |. .|..| .|.|. .| ||| .||.||| |  |.  |
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TYRO3.AA Fer 508-777 33 1.9e-75 256.36 In-house 1-283 (283) Show / Hide 
Range on Protein: 508-777
Range on HMM: 1-283/283
Sequence Identity: 33% (97 aa)

FTLGRMLGKGEFGSVREAQ----LKQEDGSFV---KVAVKMLKADIIASSDIEEFLREAACMKE-FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHG
.||| .||.| || |. ..    .| . ...|   .|.||..|..      |.||..||  |.  .|||.| |. ||.       . || |... |...|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCV-----DEQPI-MIVMEFCNGG

DLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC---VADFGLSRK--IYSGDYYRQGCASKLPVKWLALESL
.|  .|  .       .... ...|.  ..||||||| |.| ||||.||||| . .| ...   ..|||.||.   |  ||.    | |.|..||| |..
SLDSYLKKNKNK----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETW

ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAG----IENAEI-----YNYLIGGNRLKQPPECMEEVYDLMY-QCWSADPKQRPSFTCLRMELE
 . .|.  .|||.|||..|||.|.|..||.|    . ....      ..  .|.... |... .|.. .|  ||| .||..||... .. .|.
QTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase TYRO3.AA FGFR 616-776 48 8.2e-69 233.66 In-house 132-293 (293) Show / Hide 
Range on Protein: 616-776
Range on HMM: 132-293/293
Sequence Identity: 48% (78 aa)

NLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEI
||    ||..   .| ||||| ||  |||||||||    .|    ..||||.| | . ||||      ||.|| |.|.| |. ||. |||| .|| .|||
NLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

MTRGQTPYAGIE-NAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMEL
|| |..|| .|    |.| ||. | |.  |..| .|.| .| ||| . |.|||.|. |  .|
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TYRO3.AA S_TKc 508-779 22 8.6e-43 149.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 508-779
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKH--GDLHAFL
....| .||| ||.|. .. |    .  .||.|..|         | ..|| ...|. .||.. || .|              ... .. .  |||. ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYI

LASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTV-HSD
   . . ..| .|  .  ..|  |.|..||. |...|||||   | .| |  .. ..||||.|..                 ..| | |    |.   .|
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCD

VWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRME-----LENI
.|..|....| .. |..|.   . ..... .             .|. |.. .|.  ||..||.  .|..|      . .
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase TYRO3.AA Pkinase 508-783 21 3.5e-41 146.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 508-783
Range on HMM: 1-293/293
Sequence Identity: 21% (68 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLR--EAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHG----DL
...|| .|.| ||.|.... | .     .|||| .| . . |.  .. .|  |.. ||...||.. .| ..  .   |...    ...... .|    ||
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY---MVMEYCEGGLYVMDL

HAFLLASRIGENPFNL--PLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTV----CVADFGLSRK--IYSGDYYRQGCASKLPVKWLALES
.... .    ..  ..  . ... ..|  |..|.||. |...|||||   |... .....    ...||||...  . ..  .   | .     ..| | 
FDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEV

LA-DNLYTVHSDVWAFGVTMWEIMTRGQTPYAGI-----ENAEIYNYLIGGNRLKQPPECM---------------------EEVYDLMYQCWSADPKQR
.  .. |.  .|.|..|....| .. |..|. |       .     ..|.| .|. . .                       ||  |... |.  |||.|
IRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PSFTCLRMELENILGH--L
|.        | || |  .
PT-------AEQILQHPWF
Kinase TYRO3.AA FGFR 508-545 47 4.8e-08 23.47 In-house 1-42 (293) Show / Hide 
Range on Protein: 508-545
Range on HMM: 1-42/293
Sequence Identity: 47% (20 aa)

FTLGRMLGKGEFGSVREAQLKQEDGS----FVKVAVKMLKAD
 ||| ||| | || |  |  |  | .     ..|||||||..
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMN