Gene TYK2 (Mouse)

TYK2

Species: Mouse
Alias: TYK2, Tyk2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: TK, Secondary Family: JakB,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
TYK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
TYK2.AA Protein Sugen 1184 None Fasta, JSON
TYK2.NA RNA Sugen 4733 None Fasta, JSON
TYK2.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 275 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of TYK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 TYK2.AA B41 29-278 15 3.6e-39 137.37 SMART 1-232 (232) Show / Hide 
Range on Protein: 29-278
Range on HMM: 1-232/232
Sequence Identity: 15% (42 aa)

PTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQA---KVWL-PPNHILDTSQD------MNLYFRMRFYFRNWHGM
.  .. .  . .  .   ..  ... | |....| |.....||.| . ..|.|. ..    . || ....|..   .      ..|.||..||...||| 
SPKPRFCRVYFMDGT---TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHG-

NPQEPAVYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLCHLALSRGVP-------LEEMARE
                      ..... .| ....|...| .|.....   ..          ...|.|..| |......     .       ..... .
----------------------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----------HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKY

ISFKNCIPHSFRQ-------HIRQHNVLTRLRLHRVFRRFLRAFRPGHLSQQVVMVKYLATLERLAPRFGSERI
.| | ..| . ..       |...|.  .| |. ......        ...   ..|||....|..|..|.|  
KSYKRFLPKQWIDSIKQSFMHYQMHHKEWRKRIMEWHKNH------CGMTPEEAKLKYLQICQRWPPMYGVEHF
SH2 TYK2.AA SH2 447-539 22 5.1e-05 19.21 SMART 1-87 (87) Show / Hide 
Range on Protein: 447-539
Range on HMM: 1-87/87
Sequence Identity: 22% (22 aa)

QNGIHGPLMDPFVQAKLWPE---DGLYLIQWSTSHLHRLILTVAHRNPAFSNGPRGLRLRKFPITQQP-GAFVLDG-WGRSFASLGDLRLALQGCSLR
|.  ||..    ....|  .   || .|. .| |.   ..|.| ..           . . . | ... | ...|. |.|.| || .|    | ..|.
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase TYK2.AA Jak 589-865 36 5.2e-135 454.83 In-house 1-299 (299) Show / Hide 
Range on Protein: 589-865
Range on HMM: 1-299/299
Sequence Identity: 36% (112 aa)

ITQLSHLGQGTRTNVYEGLLRVGG---PDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVC--VRGSENIIV
.....|||.|....||.. ... .   .||.....           |...||.||..|.|......|....|.|||.||.|. ..||||  ... |...|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHE-----------QKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMV

TEFVEHGPLDVWLR----RQRGQVPM--TWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLE-EGTNPFIKLSDPGVGQGALSREER--VERIP
.|....|||| .|.    |....|..   ||| .|.|......|||||...||.||.||||..| |.. ....||.||.||........||..  .||||
MEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIP

WTAPECLSGGTSSLGTATDMWGFG-ATLLEIC----------------FDGEAPLQGRGPSEKERFYTKKHQLPEPS--SPELATLTRQCLTYEPAQRPS
|.|||||. ....| .|.|.|.|| .|| |||                ..|..|.. . ...|..||...|.||.|.   .|...|..||..|.| ||||
WYAPECLTNCKFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPS

FRTILRDLTR
||||.|||  
FRTIIRDLNQ
Kinase TYK2.AA Pkinase_Tyr 589-863 27 1.8e-62 212.22 Pfam 1-270 (270) Show / Hide 
Range on Protein: 589-863
Range on HMM: 1-270/270
Sequence Identity: 27% (80 aa)

ITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIA---LAFYETASLMSQV-SHMHLAFLHGVCV-RGSE--NI
|| .  ||.|   .||.| ..                    ..... |  |.| ..... .    .| . |..|.|  .| ..  |.|||. .|     .
ITFGKKLGEGAFGEVYKGTWKG-----------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIY

IVTEFVEHGPLDVWLRRQ---RGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGA-------LSREERVE
||.|...|| |.  ||..   .....| ..   ..| |....|||.||..|  .. ||.|...       | ..| .| |             .|..   
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGGGKL

RIPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAP-LQGRGPSE-KERFYTKKHQLPEPS--SPELATLTRQCLTYEPAQRPSFRTILRDL
 |.|.||||.. |     |..| | || .. ||.  || |  .|  ..| .|..| . ...| |   ..|. .| .||  |.|..||.|. |...|
PIKWMAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TYK2.AA TK 589-863 17 1.5e-59 197.95 In-house 1-486 (486) Show / Hide 
Range on Protein: 589-863
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)

ITQLSHLGQGTRT---NVYEGLLRVGGPDEGKVD---NGCP--PEPGGTSGQQLRVVLKVLDPSHHDIALAFYE--------------TASLMSQVS---
|| .  ||.|       ||.|..| ..|..||..   .. .    ..|..|.. .|  |.| . ... . .| .               |. |.. .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMT-VTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSL

--HMHLAFLHGVCVRG------------SENIIVTEFVEHGP----LDVWLRRQRG--------------------------------------------
  | ..  |.|||..|               .||.|...||     |. .||. |.                                            
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

-------------------------------QVPMTWKMVVAQQLASALSYLEDK------NLVHGNVCGRNILLARLGLE----EGTNPFIKLSDPGVG
                               |..| ...  ..|.|....||..|      |.||.... ||.|... .      .|. |..|..| |  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

-QGA--LSREER-----------------------------------VERIPWTAPECLSGG-------TSSLGTATDMWGFGATLLEICFDGEAPLQGR
 ||   |.|.                                        | |.||||| ..       .    |..|.| || .. ||.  |..|  | 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

GPS---------EKERFYTKK---------------HQLP--EPSS--------------PELATLTRQCLTYEPAQRPSFRTILRDL
 ..         .    | ..               ...|  .  .              .|.. | .||  |.|..||.|..... |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TYK2.AA UTK 656-863 24 3e-26 86.82 In-house 57-296 (296) Show / Hide 
Range on Protein: 656-863
Range on HMM: 57-296/296
Sequence Identity: 24% (59 aa)

AS---LMSQVS-HMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVP-------MTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGL
|    .|.|.. |.... | |||....  .||||. | | |.  |||.| ..|       .. ..  | . |....||. ...||.... ||.|... . 
ARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRM

EEGTNP--FIKLSDPG-------VG---------QGALSREERVER--IPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFY
  ..    ..|..| |       |.         .  ...   ..|  | |.|||.|  .|    |..|.| || .. ||.  | .|  | .  .   . 
-MWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHT-RFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQV

TKK--HQLPE--PSSPELATLTRQCLTYEPAQRPSFRTILRDL
...  ...|     . .. .| ..| .|.|. ||.|....  .
CNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TYK2.AA TK-Unique 589-863 23 1.9e-23 77.76 In-house 1-294 (294) Show / Hide 
Range on Protein: 589-863
Range on HMM: 1-294/294
Sequence Identity: 23% (75 aa)

ITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDI-ALAFYETASLMSQVS-HMHLAFLHGVCVRGS-ENIIVTE
.. .. .|.|    |. | .. .                .....| .|..| |  ...|    .|   ...|...  | ..  . |.|.. .    |. |
LEVGDVIGEGAFGQVWRGEVWGIW---------------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIME

FVEHGPLDVWLRRQRGQ-----------------------VPMTWKMVV--AQQLASALSYLED--KNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPG
... | |.  ||. |..                        | . | ..  | |.|....||.   |. ||...| ||.||..       .  .|..| |
YCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-------DKVCKICDFG

VGQ-----GALSREERVERIP--WTAPECLS--GGTS-SLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEP---SSPELATLTRQC
        |..|.... .|||  | ||| |.  .|.  .  | .| | || .. ||.  |. |  |  ... ..  .. . .| |   .|.|.  | ..|
MARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHT--TKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSC

LTYEPAQRPSFRTILRDL
...|| .|||||.|.  |
WQWEPEERPSFRQIKHRL
Kinase TYK2.AA Frk 652-867 27 1.9e-21 70.84 In-house 41-260 (260) Show / Hide 
Range on Protein: 652-867
Range on HMM: 41-260/260
Sequence Identity: 27% (62 aa)

FYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLR---RQRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGT
|   | .| .. |  |  |. || .    .|.|| ..|| |  .|.   ..  |. |.  . .| |.|. . |||..| .|  .  ||.|.       | 
FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV-------GE

NPFIKLSDPGVGQGALSREE-----RVE-RIP--WTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSS--PEL
.  .|. | |.    .  .|     |.. |.|  |||||     ...  .  |.| ||  | ||   |  |  |    |      .   .|.|.   ..|
HNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAAN--YNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQL

ATLTRQCLTYEPAQRPSFRTILRDLTRLQ
  .  .|   .| .|| | |.   |    
YEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TYK2.AA TyrKc 589-863 22 2.7e-17 56.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 589-863
Range on HMM: 1-280/280
Sequence Identity: 22% (72 aa)

ITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQV--SHMHLAFLHGVCVRG-------SE
|| .  || |    ||.| ..                        . |  |.| ...     .|.. |..|...  .| ..  |.|||. .         
ITLGKKLGEGAFGEVYKGTWK------------------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP

NIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSR--------EERV-
  ||.|...|| |.  ||. |....|  .   . | |.  .||..||..|     ||.|... .        .| || |      .           |. 
LMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKK

----ER--IP--WTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQG-----RGPSEKERFYTKKHQLPEPSS----------PELATLTRQCLT
    ..  .|  |.||||.  |. .  |..| | || .. ||. .|. |  |       ..|  ..  . . .| | .          .|. .. .||  
EHKGGKTMLPIRWMAPECINYGKFT--TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

YEPAQRPSFRTILRDL
..|..||.|..| ...
EDPEDRPTFSEIHECF
Kinase TYK2.AA S_TKc 589-864 17 1.6e-16 62.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 589-864
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

ITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVE
 . | ..|.|.   || .  .                       . .| .|...         ..   .....  | ..  |..|..  ..  .|.|...
YEILRKIGKGAFGKVYKCRHKK---------------------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCD

H--GPLDVWLRRQRGQ-----VPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECL
.  | |   .......      |  .   ...|...|| |. ... .|  .   |||| .          ||..| |.          .    . ||| |
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---TTFCGTPWYMAPEVL

SGGTSSLGT-ATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELATLTRQCLTYEPAQRPSFRTILR--------DLT
     . |. . |.| .| .| | .  |. | .     . .. . |        |||.  . |.||...|..||.   .|.           
-----GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TYK2.AA TKL 595-863 14 9.2e-16 53.25 In-house 1-364 (364) Show / Hide 
Range on Protein: 595-863
Range on HMM: 1-364/364
Sequence Identity: 14% (58 aa)

LGQGTRTNVYEGLLR----VGGPDEGKVDNGCPPEPGGTSGQQ----LRVVLKVL---------------------------DPSHHDIALAFYETASLM
.|.|.   || | .|    ..                            |. |..                           ||  . .   . | . .|
IGSGGFGEVYKGKWRGWGGKC---------------------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMM

SQVSHMHLAFLHGVCVRGSE-------------NIIVTEFVEHGP-LDVWLRRQRGQVPMTWKMVVAQQLASALSYLED--------KNLVHGNVCGRNI
|. .| ..  . |.| ...                ||.|....|  |.. .        .  ..  |.. |....||          ....| .   .||
SRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI

LLARLGL-------EEGTNPFIKLSDPG---VGQGALS--------------------REERVERIPWTAPECLSGGT--------------SSLGTATD
|. . .         .  . ..|..| |   . ..  .                    .  ..  . | |||.| | .              ..  ...|
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

MWGFGATLLEICFDGEAPLQGRGPSEK---------ERFYTKKHQLPEP--------------SSPELATLTRQCLTYEPAQRPSFRTILRDL
.. ||  | ||.   .   .   ....         .  . |....| |                |... |  .|  ..| .|||| .||  |
VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TYK2.AA EGFR 636-739 27 3.8e-12 36.45 In-house 31-134 (258) Show / Hide 
Range on Protein: 636-739
Range on HMM: 31-134/258
Sequence Identity: 27% (29 aa)

VVLKVL-DPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCG
|  ||| . .    . .. . |  |  | | ||  | |||.  .   .|| .  .| |  ..|  ....     .  . | |. ..|||.. .|| .   
VAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAA

RNILL
||.|.
RNVLV
Kinase TYK2.AA Src 651-738 32 1.5e-11 35.47 In-house 40-129 (255) Show / Hide 
Range on Protein: 651-738
Range on HMM: 40-129/255
Sequence Identity: 32% (29 aa)

AFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLR-RQRGQ-VPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNIL
|| . | .| ...| .|  |. || ..    ||||. .|| |  .|. ...|. ....     | | |.  .||| .|..|     ||.|
AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVL
Kinase TYK2.AA Ack 656-741 30 4.8e-09 26.66 In-house 53-140 (266) Show / Hide 
Range on Protein: 656-741
Range on HMM: 53-140/266
Sequence Identity: 30% (27 aa)

ASLMSQVSHMHLAFLHGVCVRGSEN-IIVTEFVEHGPLDVWLRRQRG--QVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLAR
.. | .  | ||  |.|| |...     |||. . | |   || . .    . .     . |.|....||| |...|  .  |||||..
VAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFS
Kinase TYK2.AA Pkinase 773-863 19 1.2e-07 28.13 Pfam 175-293 (293) Show / Hide 
Range on Protein: 773-863
Range on HMM: 175-293/293
Sequence Identity: 19% (23 aa)

IPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGR----GPSEKERFYTKKH-QLPEPSS-----------------------PELATLTRQ
... ||| .  | .  |.. |||..| .| | .. |. | .|.    . ....... ... .|.....                       .|.  . . 
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CLTYEPAQRPSFRTILRD--L
||.. |..||... || .  .
CLCKDPKKRPTAEQILQHPWF
Kinase TYK2.AA Syk 656-739 29 7e-06 16.29 In-house 56-139 (257) Show / Hide 
Range on Protein: 656-739
Range on HMM: 56-139/257
Sequence Identity: 29% (25 aa)

ASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPM-TWKMVVAQQLASALSYLEDKNLVHGNVCGRNILL
|..| |  | .   . |.|  . .   | | .| ||.  .|   |  ..      ... | |.   ||| |. ||     ||.||
AQVMCQLDHPCIVRMIGIC-HAEMMMMVMEMAELGPMHKYLQQHRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLL
Kinase TYK2.AA Ack 773-863 32 0.000339 10.06 In-house 175-266 (266) Show / Hide 
Range on Protein: 773-863
Range on HMM: 175-266/266
Sequence Identity: 32% (31 aa)

IPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEK-ERFYTKKHQLPEPS--SPELATLTRQCLTYEPAQRPSFRTILRDL
..| |||||  .. |   | |.| || || |    || |  |. ...  ..   ..  || |   .... ..  || . .|| ||.|  |  .|
FAWCAPECLRHRQFS--HASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase TYK2.AA Src 775-863 31 0.001631 7.75 In-house 166-255 (255) Show / Hide 
Range on Protein: 775-863
Range on HMM: 166-255/255
Sequence Identity: 31% (29 aa)

WTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSS--PELAT-LTRQCLTYEPAQRPSFRTILRDL
|||||... |. .  . .| | ||  | ||   |  |  |    |  .   .   .| |.   .||   . .||   .| ||| | ..   |
WTAPEAINYGRFT--IKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TYK2.AA Pkinase 589-729 13 0.037069 8.71 Pfam 1-131 (293) Show / Hide 
Range on Protein: 589-729
Range on HMM: 1-131/293
Sequence Identity: 13% (21 aa)

ITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYE-----TASLMSQVSHMHLAFLHGVCVRGSENIIV
.. .. .|.|.   ||..  .  |                      .|..|... . |.     ..      ...|  ..| .   |.... ....  .|
YHIGRKIGSGSFGCVYKCHHKGTGK---------------------IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMV

TEFVEHG----PLDVWLR-RQRGQV--PMTWKMVVAQQLASALSYLEDKNLVH
.|..|.|     |  ... ...| .  ..     .. |....| |. ... .|
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase TYK2.AA Syk 843-857 33 0.241435 0.36 In-house 243-257 (257) Show / Hide 
Range on Protein: 843-857
Range on HMM: 243-257/257
Sequence Identity: 33% (5 aa)

RQCLTYEPAQRPSFR
..| .|..  || | 
NKCWIYKWCDRPTFV
Kinase TYK2.AA Jak 894-1168 41 6.6e-156 524.25 In-house 1-299 (299) Show / Hide 
Range on Protein: 894-1168
Range on HMM: 1-299/299
Sequence Identity: 41% (125 aa)

LKKIRDLGEGHFGKVSLYCYDPTN------DGTGE--MVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRD
||....|||||||.| ...||...      | ..|  .|.|| ..  |.||..  ..|||.|.....|.|||||.|.|....... ..||||...|.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLP----R--HCVGL--AQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRL---VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECK
||.    |  .||..  .....||.|||.|| ||....|||.|..|||.|.|....   |||..|.|........||||...|.|....|||||||..||
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FYY--ASDVWSFG-VTLYELL-TYCDSNQSPHMKFTELIG-HTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQT
||.  |.|.|||| |||.|.. .|||...||...|.. || ..|.||...|.....|.|.|||.||.|..|||.||..||......||.|......|  
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase TYK2.AA Pkinase_Tyr 894-1166 40 5.3e-125 423.98 Pfam 1-270 (270) Show / Hide 
Range on Protein: 894-1166
Range on HMM: 1-270/270
Sequence Identity: 40% (115 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQL--RSGWQREIEILRTL-YHEHIVKYKGCCEDQGEK-SVQLVMEYVPLGSLRDYLPR
..... ||||.||.| .  ...  |.|.  |||| ||||. ..   |    ||..|...| .|..||.. |.| ||||  .. .||||.|.|.|.||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H-----CVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYY-RVREDGDSPVFWYAPECLKECKFYYASDVWS
|      . . .|| ...||..||.||.....|||||||||.|..... |||.|||||... .  .|| |.|..|. |..|.||||....||  .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELL-ERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPIL
|||...|..||...              |   |.  .. |.. |.|.|.|.|. || |||.||| ||. ... ||||. .. .|
FGVLMWEIFTYGEQP-------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TYK2.AA TyrKc 894-1166 35 2e-116 393.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 894-1166
Range on HMM: 1-280/280
Sequence Identity: 35% (107 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTL--YHEHIVKYKGCCEDQGE-----KSVQLVMEYVPLGSLRDY
..... ||||.||.| .  ..       ..|||| |||..    |    ||..|.. |   |..||.  |.| .||.     . . .||||.|.|.|.||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LPRHC--VGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEG------HEYYRVRE--DGD--SPVFWYAPECLKECK
| .|   . ...|| |. ||..||.||| ...|||||||||.|..... |||.||||.... ..      ..|||..|  .|.   |. |.||||....|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDR--------CPCEIYHLMKNCWETEASFRPTFQNLVPIL
|  .||||||||...|..||...  .   .        |  |.  .. |....|.|.|.|.         || |.| .|| ||. ... ||||.... ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQ--------Q-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TYK2.AA TK 894-1166 21 5.1e-96 322.39 In-house 1-486 (486) Show / Hide 
Range on Protein: 894-1166
Range on HMM: 1-486/486
Sequence Identity: 21% (107 aa)

LKKIRDLGEGHFG---KVSLYCYDPTN---------------------DGTGEMVAVKALKEGCGPQLRS----GWQ------------REIEILRT--L
.. .. ||||.||   .| .  . . |                     .|. . |||| ||||.. . .      ..            .|.....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

YHEHIVKYKGCCEDQGEKS----------VQLVMEYVPLGS----LRDYLPRHC----------------------------------------------
 |..||.  |.| ....|.          . .||||.|.|.    ||||| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VGLAQLLLFAQQICEGMAYLHAQ------HYIHRDLAARNVLLDNDRL-----------VKIGDFG---
                               . ..||| ...||..||.|||..      ...||||||||.|....             .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKAVPE-----------------------GHEYYRVREDGDSPVFWYAPECLK---------ECKFYYASDVWSFGVTLYELLTYCDSNQSPHM
     ||.....                       ...||| . .|  |. |.|||||.         . ||  .||||||||...|..||..    . |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KF---------TELIGHTQ-GQMTVLR--LTELLERGERLPRP--DRCPC-------------EIYHL-MKNCWETEASFRPTFQNLVPIL
           .|.. . . |... .|  | .  | |.|...|  . ||              |.|.. |. ||. ... ||||. |.  |
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGL-N--EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TYK2.AA EGFR 894-1167 36 1.1e-63 210.3 In-house 1-258 (258) Show / Hide 
Range on Protein: 894-1167
Range on HMM: 1-258/258
Sequence Identity: 36% (100 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRH--C
|||.. || | ||.|    . |  .     ||.|.|.|  ||.      .|  ..  . |.|.|.  | |  .    .|||  | |.|.| ||.  |   
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ---MQLVTQYMPYGCLLDYVRQHKDN

VGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYEL
.|  .||... ||  || ||  .. .||||||||||.     ||| ||||||  .   . |.. . |  |. | | ||... ..  .|||||.|||. ||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

LTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQ
.|.    |.|.             .      .|||.||||| |. |   .| .|  ||   .  ||||. |.  ..
MTFG---QKPYD-----------GIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase TYK2.AA S_TKc 894-1166 24 3.9e-57 197.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 894-1166
Range on HMM: 1-231/231
Sequence Identity: 24% (73 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPL--GSLRDYLPRHC
 ...| .|.| |||| .         ||. ||.| .|           .|||.||.   |..|||......|   ... .||||..   |.|.||. .. 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

-------VGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYY-ASDVWS
           .   ...|||....|.| .. |||||   |.|||.   .||.|||||. .                 .. ||| |   .. . ..|.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGVTLYELLT----YCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLV--------PIL
.|..|||.|.    ..      ...  ..||                           . |  .....|.. . . ||| . |         | .
CGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase TYK2.AA UTK 894-1094 29 3.7e-55 187.13 In-house 1-236 (296) Show / Hide 
Range on Protein: 894-1094
Range on HMM: 1-236/296
Sequence Identity: 29% (71 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGE-MVAVKALK-EGCGPQLRS---GWQREIE---ILRTLY-HEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLR
..  |.||.|.|| |..  ... ..  .|  ||||... .. ..| .     . .|     ..  .. |.....  | | ...     .|.|| . |.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

DYLPRHCVGLA---------QLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDR-------LVKIGDFG---LAKAVPE--------GHEYYRVRED
.|| ||   .          |.| .| .| .||.||| ....||||||||.|.. .|       ..||.|||   ....|.         . .||. ...
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GDSPVFWYAPECLKEC-KFYYASDVWSFGVTLYELLTY
.  |. |.|||.| .  .|  .||||||||...|..|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase TYK2.AA TKL 900-1166 21 8.9e-55 188.29 In-house 1-364 (364) Show / Hide 
Range on Protein: 900-1166
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

LGEGHFGKVSLYCYDPTNDGTG-----EMVAVKALKEG-----------------------CGPQLRSGWQREIEILRTLY---HEHIVKYKGCCEDQG-
.|.|.||.|    .  ..   .     . |||| .|.                        . | ..   ..|.| .. .    |..||...|.| . . 
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

----------EKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQH--------YIHRDLAARNVLLDND--------------RLVK
          ..   .||||.| |||..||      . |.. .|..|. ||.|||...         |||||  .|.|.|..              . .|
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDFGLAKAVPEGHEYYRVREDGD-------------SPV---FWYAPECLKEC----------------KFYYASDVWSFGVTLYELLTYCDSNQSPHM
|.||||.. . .  .  .   ..              ...    | |||.|..                 ..  ..||.|||. |.|.|| |        
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------

KFTELIGHTQGQMTVL-------RLTELLERGERLPRP------------DRCPCEIYHLMKNCWETEASFRPTFQNLVPIL
       . .. |...        .    ..|.|.|.|            . || ..  ||. ||..... ||.|| .. .|
-----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TYK2.AA Ack 894-1094 40 1.6e-52 175.51 In-house 1-207 (266) Show / Hide 
Range on Protein: 894-1094
Range on HMM: 1-207/266
Sequence Identity: 40% (85 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQL--RSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC
..    ||.| || |     .    |.   |||| |. . ..|    .   ||  |.  | |.|.|.  |   ||  .....|.|  |.||| | |  ||
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQ--PMLMMVTELAPCGSLLDCLRKHC

V----GLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDG--DSPVFWYAPECLKECKFYYASDVWSF
      .. |. |. ||..||.||.... |||||||||.||  | |.|||.||||  | ...  |||  .      |  | |||||.  .|  |||||.|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF

GVTLYELLTY
|||| |  .|
GVTLWEMFSY
Kinase TYK2.AA Frk 894-1170 34 5e-52 178.51 In-house 1-260 (260) Show / Hide 
Range on Protein: 894-1170
Range on HMM: 1-260/260
Sequence Identity: 34% (98 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLP-----
.. || || | ||.|    .. |       |||| || |        . ||  |.. | |  ...    |    |. . .. | .  ||| .||      
IQLIRRLGSGQFGEVWEGLWNNT-----TPVAVKTLKPGT--MDPNDFLREAQIMKKLRHPKLIQLYAVCTV--EEPIYIITELMRHGSLQEYLQAINDK

RHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHE-YYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVT
 . . . ||.  | |.  |||||  | ||||||||||||....  .|| |||||. .    |  |  | .   |. | |||  .  ||   |||||||. 
GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGIL

LYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQ
|.|..||       .| .          ||     . ...| |.|.|  || ..|..| .||. ..  ||||  |   |.   
LTEIITYG------RMPYPG--------MTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TYK2.AA Src 894-1094 39 4e-49 165.01 In-house 1-196 (255) Show / Hide 
Range on Protein: 894-1094
Range on HMM: 1-196/255
Sequence Identity: 39% (81 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLP----R
.| .| ||.|.|| |    .. . .     |||| ||.|         ..|..|. .| ||..|.    | .  |. .  | ||   ||| |||      
IKLCRKLGQGQFGEVWMGYWNGNTK-----VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQ--EEPIYIVTEYMSHGSLLDYLKKDGEG

HCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLY
. . | ||. .| |. |||||| .. |||||||||||| ... ..|..|||||. . |. . |  |..   |. | |||.. . .|   |||||||. |.
RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

ELLTY
|. ||
EIVTY
Kinase TYK2.AA TK-Unique 894-1094 32 1.9e-48 165.16 In-house 1-235 (294) Show / Hide 
Range on Protein: 894-1094
Range on HMM: 1-235/294
Sequence Identity: 32% (76 aa)

LKKIRDLGEGHFGKVSLYCYDPTN--DGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLY-HEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRH
|.  . .||| || |    . ...  ..    ||||.||..  .. ..   .||.... |  |..||.  ||| . .  .....|||.| |.|..|| . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

C---------------------------VGLAQLLLFAQQICEGMAYLHA--QHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP
                            . . .|. || ||. ||.||.   .. .||||.|||||| .|  .||.|||.|. |  ...| . .. |  |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VFWYAPECLK--ECKF-YYASDVWSFGVTLYELLTY
. | ||| ||  .  . .. ||||||||...|..|.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL
Kinase TYK2.AA Syk 894-1094 40 5.5e-47 159.76 In-house 1-205 (257) Show / Hide 
Range on Protein: 894-1094
Range on HMM: 1-205/257
Sequence Identity: 40% (84 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGE----MVAVKALK-EGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLP
| . . .| | || |    |   . | ||     ||.| || ..  | .     || ..   | | .||.  | |  ..| .  .||| ..||.. .|| 
LVQDNEIGCGNFGSVHKGWYM-MKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGIC--HAE-MMMMVMEMAELGPMHKYLQ

RH--CVGL-AQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFG
 |   .   . | | . |.  || ||  .| .||||||||||| |    || |||. ||   . .||. .  |  || ||||||    ||  .|||||||
QHRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFG

VTLYELLTY
||. | . |
VTMWEMFSY
Kinase TYK2.AA Pkinase 894-1163 25 3.1e-43 153.93 Pfam 1-288 (293) Show / Hide 
Range on Protein: 894-1163
Range on HMM: 1-288/293
Sequence Identity: 25% (80 aa)

LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQR-------EIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLG----S
....| .|.| ||.|    |  .. |||..|||| .|     . .. |..       ||.|.. | |..||......||  .... .||||.. |    .
YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIK----KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMD

LRDYLP---RHCV--GLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLD-NDRL---VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK-E
| ||.    . |.     ..  .. ||..|..|.|..  |||||   |.|.| |. .   |||.|||||| .   .  ..   .     .. ||| ..  
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGG

CKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTEL----IGHTQGQMTVLRLTELLERGERLPRPDR---------------CPCEIYHLMKNCWETEA
 .  ...|.||.|..|||.|.           | .       |.| || ....   |.. .  ... .                . |  ...|.|..   
QYYGPKVDMWSCGCILYEMLCGR-------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

SFRPTFQNLV
. |||.. ..
KKRPTAEQIL
Kinase TYK2.AA Syk 1121-1160 40 4.7e-17 55.23 In-house 218-257 (257) Show / Hide 
Range on Protein: 1121-1160
Range on HMM: 218-257/257
Sequence Identity: 40% (16 aa)

LTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQ
.....| |.|...|..|| |.| ||. ||  ..  |||| 
VMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase TYK2.AA Ack 1123-1166 44 1.1e-15 49.36 In-house 222-266 (266) Show / Hide 
Range on Protein: 1123-1166
Range on HMM: 222-266/266
Sequence Identity: 44% (20 aa)

ELLE-RGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPIL
....  |||||||| || .|| .|..||. ..  |||| ...  |
QKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase TYK2.AA Src 1125-1166 44 4.1e-14 44.3 In-house 213-255 (255) Show / Hide 
Range on Protein: 1125-1166
Range on HMM: 213-255/255
Sequence Identity: 44% (19 aa)

LERGERLPRPDRCPCEIYH-LMKNCWETEASFRPTFQNLVPIL
.||| |.|.|. || |.|. .|. ||. ..  ||||  |   |
VERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TYK2.AA UTK 1116-1166 32 9.9e-14 43.36 In-house 244-296 (296) Show / Hide 
Range on Protein: 1116-1166
Range on HMM: 244-296/296
Sequence Identity: 32% (17 aa)

MTVLRLTELLERG--ERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPIL
|.  .... ...|   |.|.|..|| ..| ||. ||... ..||.|. ||  .
MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TYK2.AA TK-Unique 1121-1166 38 2.7e-13 42.31 In-house 248-294 (294) Show / Hide 
Range on Protein: 1121-1166
Range on HMM: 248-294/294
Sequence Identity: 38% (18 aa)

LTELLERGERLPRPDRC-PCEIYHLMKNCWETEASFRPTFQNLVPIL
. |....| |.|.|. | . |.| |||.||  |.. ||.|  .. .|
IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL