Gene TRRAP (Mouse)
TRRAP
Sequence
Protein domains of TRRAP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FATC | TRRAP.AA | FATC | 1815-1826 | 41 | 30.697681 | 0.56 | Pfam | 1-12 (33) | Show / Hide |
Range on Protein: 1815-1826 Range on HMM: 1-12/33 Sequence Identity: 41% (5 aa) KVLDPEKQADML . |..| |.|.| EPLSVEQQVDRL |
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| FAT | TRRAP.AA | FAT | 2849-3204 | 20 | 4.7e-104 | 348.63 | Pfam | 1-408 (408) | Show / Hide |
Range on Protein: 2849-3204 Range on HMM: 1-408/408 Sequence Identity: 20% (90 aa) PYLVLECAWRVSNWTA--MKEALVQVE------------VSCPKEMAWKVNMYRGYLAI--CHPEEQQLSFIERLVEMASSLAIREWRR-LPHVVSHVHT | .|.|||...| |.| . .. ..|.|. |. . ....|.. .| ..... .|....| .| ..||.. ||. ... | APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTACLPGESYNRHY PLLQAAQQIIELQEAAQINAGLQPTNLG-RNNSLHDMKTVVKTWRNRLPIV-SDDLSHWSSVFMWRQHHYQ---GKPTWSGMHSSSIVTAYENSSHHDPS |... |...||.|..|. ... ..|.. ..||....|....||..|||.. .....|.. ..||||... . . PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM---------------------- SNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHT------------IPTVPI------------VDCFQKIRQQVKCYLQLA-GVMGKNECMQG .. ...| | . .|.. ...||.|. ... . |....| .| . . ...||..|....|..| || .||.. | NSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-G L----EVIESTNLKYFTKEMTA-EFYALKGMFLAQI----------NKSEEANKAFSAAVQMHDVLVK-AWAMWGDYLESIFVKER-------------Q | |||..|||.|| ... | ..|...||..... ....|.......|.. .. . | ||..|. | . .| ... . LTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMI LHLGVSAITCYLHACRHQNESKSRKYLAKVLW ... | |..|..|.......|.||......|| IQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW |
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| Kinase | TRRAP.AA | PIKK | 3514-3791 | 29 | 2.8e-141 | 475.66 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 3514-3791 Range on HMM: 1-290/290 Sequence Identity: 29% (85 aa) IARFMPRVEIVQKHNTAARRLHIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVE ..|||.|...|..|....... ||||.||.||||.. .....|...||.||..|.|.||.|..|..||||......|...|....|.|.......|.| RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCK---GHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKE IYKQRCAKKGIEHDNPISR---------------YYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIG ||||.|.||.|.|...... ||......|....|..... .......|....|..|.|.|....||.....|..|...|...|... IYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMC FAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGVLKTV .....|.|....||...|...||......|......|...|.....||||||.|........||.|........|..|..|.......|.... MVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | TRRAP.AA | TRRAP | 3514-3559 | 86 | 4.5e-36 | 125.06 | In-house | 1-46 (46) | Show / Hide |
Range on Protein: 3514-3559 Range on HMM: 1-46/46 Sequence Identity: 86% (40 aa) IARFMPRVEIVQKHNTAARRLHIRGHNGKIYPYLVMNDACLTESRR ||||||||||||||||||||| ||||||||||||||||.|....|| IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDICKINARR |
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| Kinase | TRRAP.AA | PI3_PI4_kinase | 3557-3704 | 16 | 8.3e-16 | 60.15 | Pfam | 14-181 (300) | Show / Hide |
Range on Protein: 3557-3704 Range on HMM: 14-181/300 Sequence Identity: 16% (30 aa) SRREERVLQLL-----------------------RLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDN----- .|...|..|.. || |.|. |.... .|.. .. .|... .|.....|. |..... || . . |....|.| CRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHKHFNKEHKM PISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNA-TDYWTFRKMFTIQLALIGFAEFVL . ...|... . .. . ...| .....|. | .| . ..|.| ...|..|. |. ..| .. . ..| WMKMWPDWWHLM---------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYIL |
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| Kinase | TRRAP.AA | PI3Kc | 3557-3846 | 16 | 1.8e-10 | 3.04 | SMART | 10-336 (336) | Show / Hide |
Range on Protein: 3557-3846 Range on HMM: 10-336/336 Sequence Identity: 16% (56 aa) SRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLAT----------------- |...|..|..|| | .. | ||. .|.| .. .......|.....|. |.. .| .| | .. .|... | . .. |.| . LRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMYMMIWHQQAC VQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNA-TDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGD . . .| ... . .. | . .... |..| . .||.. |.|..|. || ..| . ..| . .. . . .||.. | . . . . HWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKK LDA----NRPVPFRLTPNISEFLT----TIGVSGPLTASMIAVARCFAQPNFKVDGVLKTVLRDEI-IAWHKKTQEDTSSPLSAAGQPE---------NM . . ||||||... . |. | . . | . .. .. .. . ..|.| . |... |.. .| .. ... . PGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDHLSDEEAAQYF DS----QQLVSLVQKAVTAIMTRLHNLAQF . . ...... |.... .||.||. MQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | TRRAP.AA | ATR | 3513-3791 | 17 | 1.8e-05 | 14.1 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 3513-3791 Range on HMM: 2-267/267 Sequence Identity: 17% (49 aa) KIARFMPRVEIVQKHNTAARRLHIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLV || | |||. ... ..| .||.| .| . |.. | . |.| |. | | .| . |. . | ..| ..| YIAGFDDMVEILASLQ-KPKKISLKGSDGKFY---IMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLR EIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPR--SMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLN | .. |.. | . .. . | . . . .| .. ..|| .. ..| ...|| ...... |. . | . ... | PILDKLWKEKKQ---------YMQFYQLRQCMDKKSRE-EWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRH PEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGVLKTV . . | . .| . . | .. |||||| |. . .. | .. . .|. . . .|... TDNILIDKINGECVHVDYNC-IFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | TRRAP.AA | PI3_PI4_kinase | 3743-3801 | 14 | 7.036294 | 1.25 | Pfam | 223-300 (300) | Show / Hide |
Range on Protein: 3743-3801 Range on HMM: 223-300/300 Sequence Identity: 14% (11 aa) RPVPFRLTP------NISEFL------TTIGVSGPLTASMIAVARCFAQPNFKVDGVL-------KTVLRDEIIAWHK ..||||.|. .... . .| | . .. . | . .. . .| . ..|... | . ERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| FATC | TRRAP.AA | FATC | 3850-3877 | 39 | 2.5e-05 | 20.08 | Pfam | 6-33 (33) | Show / Hide |
Range on Protein: 3850-3877 Range on HMM: 6-33/33 Sequence Identity: 39% (11 aa) ESKVNTLVAAANSLDNLCRMDPAWHPWL | |. |.. | . .|||.|.. | ||. EQQVDRLIQEATDPENLCQMYIGWCPWW |
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