Gene TRKB (Mouse)

TRKB

Species: Mouse
Alias: TRKB, Ntrk2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Trk

Sequence

Name Sequence Type Origin Length Description Download
TRKB.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
TRKB.NA RNA Sugen 4695 None Fasta, JSON
TRKB.AA Protein Sugen 848 None Fasta, JSON

Protein domain

Protein domains of TRKB.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT TRKB.AA LRRNT 31-60 25 6.5e-07 28.36 Pfam 1-31 (31) Show / Hide 
Range on Protein: 31-60
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

ACPTSCKCS--SARIWCTEPSPGIVAFPRLEP
.|| .|.|.    ...|.... . ...||  |
QCPRPCHCHHDHTHVYCSDRNLT-NHVPRDLP
LRRNT TRKB.AA LRRNT 31-65 21 1e-06 29.57 SMART 1-38 (38) Show / Hide 
Range on Protein: 31-65
Range on HMM: 1-38/38
Sequence Identity: 21% (8 aa)

ACPTSCKCS---SARIWCTEPSPGIVAFPRLEPNSVDP
.|| .|.|.     ...|.... .....||  |. .. 
QCPRPCHCHPDFHTHVYCDDRNLTWNEVPRDIPPDTTY
LRRCT TRKB.AA LRRCT 148-195 21 4.7e-12 47.3 SMART 1-55 (55) Show / Hide 
Range on Protein: 148-195
Range on HMM: 1-55/55
Sequence Identity: 21% (12 aa)

NPFTCSCDIMWLKTLQET---KSSPDTQ-DLYCLNESSKNM-PLANLQ--IPNCG
||. |.|...|......    .  .| | |..| . .. .. ||. ..     |.
NPWNCDCHLRWFQRWLQQQHNRHVQDPQSDMRCASPEHMRGQPLFHYLHSDFKCP
IG TRKB.AA IG 203-284 25 8.2e-12 46.48 SMART 1-58 (58) Show / Hide 
Range on Protein: 203-284
Range on HMM: 1-58/58
Sequence Identity: 25% (22 aa)

APNLTVEEGKSVTLSCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDS--GKQISCVAENLVGEDQD--SVNLTVH
 | .|| || .|||.| |      ...|                   |.| |.. .||  .    |.|.   |...   ...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set TRKB.AA I-set 249-283 45 4.3e-08 29.99 Pfam 59-92 (92) Show / Hide 
Range on Protein: 249-283
Range on HMM: 59-92/92
Sequence Identity: 45% (16 aa)

SLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV
.|.|.|. .||.||  .|||.| .||.. ...|||
TLTISNVQPDDEGK-YTCVATNSFGEAECTAELTV
IGc2 TRKB.AA IGc2 209-273 32 2.3e-07 31.74 SMART 1-56 (56) Show / Hide 
Range on Protein: 209-273
Range on HMM: 1-56/56
Sequence Identity: 32% (21 aa)

EEGKSVTLSCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVG
.|| |||| | . |.| |.  |      .....    . ..|.|.|.. .|||.  .|.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP----WNWTLTIKNVTPEDSGY-YTCYARNPWG
I-set TRKB.AA I-set 197-230 32 0.000126 18.21 Pfam 1-34 (92) Show / Hide 
Range on Protein: 197-230
Range on HMM: 1-34/92
Sequence Identity: 32% (11 aa)

PSARLAAPNLTVEEGKSVTLSCSVGGDPLPTLYW
|.      ...| ||......| | ||| |.  |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSW
I-set TRKB.AA I-set 306-330 34 0.030102 10.14 Pfam 23-48 (92) Show / Hide 
Range on Protein: 306-330
Range on HMM: 23-48/92
Sequence Identity: 34% (9 aa)

TVRGNPKPALQWFYNGAILNE-SKYI
.|.|.|.|  .||..|. |.. |...
QVTGDPPPQVSWFKDGQPLRPDSDRH
I-set TRKB.AA I-set 357-371 46 1.838048 4.08 Pfam 71-85 (92) Show / Hide 
Range on Protein: 357-371
Range on HMM: 71-85/92
Sequence Identity: 46% (7 aa)

GDYTLMAKNEYGKDE
| ||  |.|..|..|
GKYTCVATNSFGEAE
Kinase TRKB.AA Trk 564-833 80 3.7e-225 754.29 In-house 1-275 (275) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-275/275
Sequence Identity: 80% (222 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
||||.||||||||||||||||||||||||..||||||||||.||||||.|||||||||||.|||||||||...|||.|||||||||||||.||.|||||.
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAM

LMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS-TDYYRVGGHTMLPIRWMPPESIMYRKFTTE
..|...|   |..||..|||.||.|||.||||.|||||||||.||||||||.||.|||||||||||||| |||||||.||||||||||||||||||||.|
CYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYE

SDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLL
|||||.|||.||.|||||||||||||.||||||.|||. |.|||.||||||..|||||||||..|.|||.||...
SDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase TRKB.AA Pkinase_Tyr 564-833 47 2.7e-148 502.85 Pfam 1-270 (270) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-270/270
Sequence Identity: 47% (132 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA---RKDFHREAELLTNL-QHEHIVKFYGVCV-EGDP--LIMVFEYMKHGDLNKFLR
|.. ..|||||||.|......  .|...|| ||||.||. ..     |.|| |||.....| .|..||..||||. .|.|  ...|.|||.|||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY-RVGGHTMLPIRWMPPESIMYRK
.|          ...  || ...|....|||.|| ||.|....|||||.|||||.||. |||.|||..||.|..||| |..|...|||.||.||.|.|.|
KHR---------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

FTTESDVWSLGVVLWEIFTYGKQP-WYQLSNNEVIECI-TQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLL
|||.||||| ||..|||||||.|| .. .||.||.| |  .|. . .|. ||.|.|.||. ||. .|  |   . ||  |
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TRKB.AA TyrKc 564-833 44 7.6e-145 488.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-280/280
Sequence Identity: 44% (136 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNL--QHEHIVKFYGVCVEG-------DPLIMVFEYMKHGDLNKF
|.|...|||||||.|.... .        | ||||.||. .   |.||.|||.....|  .|..||..||||...       .|| .|.|||.||||...
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST-------DYYRV----GGHTMLPI
||.|.|.            |. ...|... |||.|| ||.|....|||||.||||||||. |||.|||.|||.|.        ||||.    ||.|||||
LRKHRPK------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-----LSNNEVIECITQGRVLQRPRT--------CPQEVYELMLGCWQREPHTRKNIKSIH
|||.||.|.|.||||.||||| ||..|||||||.||..      .|| ||||.. ||. . .|          ||.|.|..|. ||...|. | . . ||
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

TLL
 ..
ECF
Kinase TRKB.AA TK 564-833 26 8e-125 420.65 In-house 1-486 (486) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

IVLKRELGEGAFG---KVFLAECYNLCP--------------------EQDKILVAVKTLK---DASDNARKD--------------FHREAELLTN--L
|.| ..||||.||   .|...| ... |                    |. |. ||||.||   ..|.....|              . .|.... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHEHIVKFYGVCVEG------------DPLIMVFEYMKHGD----LNKFLRAHGPDAVLMAEGNP-----------------------------------
.|..||..||||..|             |...| |||.|||    | ..||.. |..  ......                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------PTELTQSQMLH-------------------IAQQIAAGMVYLASQ------HFVHRDLATRNCLVGENLL-----------VKIGDFGMS--
        |..||....|.                   ...|||.|| ||.|.      .|||||||.||||||||.            .||.|||.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------RDVYSTDYYRVGG------------------------HTMLPIRWMPPESIM---------YRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-LS
      ||.|| |.|.. .                         ..||||||.||...         |.||||.|||||.||..|||||||..|.|  .|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------NEVIECITQG--------------RVLQRPRTCP--------------QEVYELMLGCWQREPHTRKNIKSIHTLL
|          ||.|....|                . .|  ||              .|.|.||. ||...|  | . . .|  |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TRKB.AA Musk 564-833 47 2e-123 409.8 In-house 1-282 (282) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-282/282
Sequence Identity: 47% (133 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA
|.  |..|||||| || |    | |... ..|||| ||| ||.   .|| ||| ..    |  |||  |||  | |. . ||||  |||| ||..  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

VLMAEGNPP-----------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESI
.  .  . .            .|     | .|.|||.|| ||    ||||||||||||..|.  ||| |||.|| .|. |||.  .    ||||||||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

MYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLL
.| .||.|||||. ||.||||| |. ||.| ..  |||  | || .|  |  |||.||.||  |||..|  |   ..||  .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase TRKB.AA Ror 564-834 47 2.4e-116 392.85 In-house 1-276 (308) Show / Hide 
Range on Protein: 564-834
Range on HMM: 1-276/308
Sequence Identity: 47% (132 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA
.    ||||..||||.  . . . . .  ..||.||.|. ||   ..|| .|..|   |.|  ||.  |||    |. |.|||| ||||  ||  . | .
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

VLM----AEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTT
         .     | ..  |||| |||||| ||.| ||||||||.||||||| . ||| ||| .||.|| ||||. .  ..|||||.||.||| ||..
DHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSE

ESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQ
.||.|| |||||||. || ||.|  ||.|||| | .  .|  |  ||. .| ||  ||   |  |   | ||. |.
DSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIHSRLR
Kinase TRKB.AA InsR 564-835 43 8.4e-112 376.83 In-house 1-278 (278) Show / Hide 
Range on Protein: 564-835
Range on HMM: 1-278/278
Sequence Identity: 43% (123 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKI--LVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGP
||| ||.|.|.||.| .    .. |.   .   .|.||... ||.  | .|  ||.   .  . |.|. .|||  | |   | | |..|||  .||.. |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

DAVLMAEGNPPTE-----LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
...     ||. .      . .||.  | .|. || |||.  ||||||| |||.| . . |||||||| ||.| .|||| ||  |||.|||.|||.   .
EEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

FTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECI-TQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQN
||| |||||.||||||. | | ||   ||| .| . |   | ||..|  ||. ..|||  |||  |  |   . |  .|..
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase TRKB.AA DDR 564-833 41 3.1e-103 349.29 In-house 1-306 (306) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-306/306
Sequence Identity: 41% (126 aa)

IVLKRELGEGAFGKVFLAECYNLC-----------PEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQ-HEHIVKFYGVCVEGDPLIMVFEYMKH-G
 . .  .||| || | | |  ..               . .|||||.|.  |...||.|||.|.  .  .  |  ||.  |||.. .|. |. |||   |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNKFLRAHG-PDAVLMAEG------NPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFG--MSRDVYSTDYYRVGG---
||| |. .|  ..  ||.        . || .  .. ..|. |||.|| ||.|  ||||||||||||||... .|| |||  |||  || ||||| |   
DLNQFWMEHEAENSGLMNCKADTQNCQKPT-ISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTG

--HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVY-ELMLGCWQREPHTRKNI
     .||||| .|||.  |||| ||||. || .||.|.  . ||. ||..  ||| .     .||.  .| .|. ||.|.| .||. ||.|..  |   
RQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSF

KSIHTLL
. ||..|
EEIHKFL
Kinase TRKB.AA TK-Unique 564-833 36 4.6e-100 338.73 In-house 1-294 (294) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-294/294
Sequence Identity: 36% (108 aa)

IVLKRELGEGAFGKVFLAECYNLC-PEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQ-HEHIVKFYGVCVEGD-PLIMVFEYMKHGDLNKFLRAHG
.......|||||| |. .|  ..  .. ... ||||.|| .|.|  ..|| .|.... .|  |..||...|.|.. | |  ...||.  |.| ..||  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PD-------AVLM------AEGNPPTELTQSQMLHIAQQIAAGMVYLAS--QHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY-STDYYRVGGHTMLPI
|.       . |        .........  ...|.| ||| || ||||  ...|||||..||.|..|.. .||.||||.||||  ..| . ..  ..||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMPPESIM--YRKF-TTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTC-PQEVYELMLGCWQREPHTRKNIKSIHTLL
|||.|||.   .. . ||.|||||.||..|||||.|..| ..... ...|||..|  ...|  | ..|.|.||  |||.||. | .. .|   |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TRKB.AA UTK 564-836 36 2.6e-99 336.22 In-house 1-296 (296) Show / Hide 
Range on Protein: 564-836
Range on HMM: 1-296/296
Sequence Identity: 36% (112 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK-----DFHREAE---LLTNLQ-HEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKF
. | |.||.|||| |..|.  .  .   . .||||...  .|  ..     || .||    .. ... |.......|||. . |...| |||. ||| ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN-------LLVKIGDFG---MSRDVY---------STDYYRV
|| |.|..       .|. ||  |.|. | .||.|| ||.|..||||||| |||||...       ...||.|||   |||.|.         ...||. 
LRRHRPTPP-----ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

GGHTMLPIRWMPPESIMYR-KFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQG--RVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTL
 . ...||||| ||.. .. .||| |||||.|||.|||.|.|..|.  .|| .|.. .. |  . . .|. || .||.||. ||. .|  |    ....|
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQER---PDFEDL

LQNL
.| .
VQQM
Kinase TRKB.AA Src 564-833 38 2.5e-88 299.73 In-house 1-255 (255) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-255/255
Sequence Identity: 38% (106 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
| |.|.||.| || |. .  .|     ... ||||||| ..  . ..| .||.....|.||..|. | || ...|   | |||.|| | ..|..      
IKLCRKLGQGQFGEVWMG-YWN-----GNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK------

LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS--TDYYRVGGHTMLPIRWMPPESIMYRKFTTESD
   ||    .|   | . .| |.|.|| || |. ..||||| || |||||...|..|||  | .     | |      ..||.|. || | |..||. ||
-DGEGR---HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSD

VWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYE-LMLGCWQREPHTRKNIKSIHTLL
||| |. |.||.|||. |    .| ||.... .|  . .|..||.|.|| .|| ||...|  |   . ..  |
VWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TRKB.AA ALK 564-835 41 7.6e-87 294.83 In-house 1-273 (273) Show / Hide 
Range on Protein: 564-835
Range on HMM: 1-273/273
Sequence Identity: 41% (114 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA
| | | || |||| |. ..   .     .. ||.|||. |.|     ||  ||  . . .|. .|.  |.| .  |.  | |||  ||. .|||   |  
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

V-LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDV-YSTDYYRVGGHTMLPIRWMPPESIMYRKFT
. |      |. || .  |.... .|.|  || ..||.||| | ||||    |    .||.||||.||. | .|||| || .|.|. |||||  |   ||
ESLQ-----PSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFT

TESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQN
. .|||| || .||||  |  |    .| ||.| .|.|  .  || ||| || .|  ||| .|  | .  .|   .| 
SKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase TRKB.AA S_TKc 564-833 22 1e-52 182.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKH--GDLNKFLRAHGPD
  . |..|.||||||...   .     .. .||.| .|       ... || ..| . .|..|||.|.|... | | ||.||. .  ||| .... .|. 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR-

AVLMAEGNPPTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTT-
        ...   ..  .  ....||. .. |. |....||||   | |. |   .||.|||..| .          .      .|.|| .   .... 
--------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKC

ESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHT---------LL
..|.||.|..|.| .. |. |..   . ...  .            ..|. ... .|.|..|  |  .  . .          .
KCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TRKB.AA Pkinase 564-833 20 3.1e-46 164.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 564-833
Range on HMM: 1-293/293
Sequence Identity: 20% (65 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK---DFH-REAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG----DLNKFL
....| .|.|.||.|     |  .   . ..||||..|  ...  |   ... .|.... .|.|..||..|... ..| . ||.||. .|    ||  ..
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV----KIGDFGMSRDVYSTDYYRVGGHTMLP--IRWMPPE
..         .... . ..  .  ... ||. |. |. |. ..||||   |.|. .|  .    ||.||| .. ..   | . .  | .   ...|.||
ST--------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPE

SIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQL----SNNEVIECITQGRVLQRPRTCP-----------------------QEVYELMLGCWQREPH
 |. ... ....|.||.|..|.| .. |. |...     . .. ...| . .  . .. .|                       .|  ... .|... |.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

TRKNIKSIHTL--L
 | ... |     .
KRPTAEQILQHPWF