Gene TIE2 (Mouse)

TIE2

Species: Mouse
Alias: TIE2, Tek
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Tie

Sequence

Name Sequence Type Origin Length Description Download
TIE2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
TIE2.AA Protein Sugen 1123 None Fasta, JSON
TIE2.NA RNA Sugen 4654 None Fasta, JSON

Protein domain

Protein domains of TIE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ig_Tie2_1 TIE2.AA Ig_Tie2_1 23-118 69 4.8e-77 254.54 Pfam 1-99 (99) Show / Hide 
Range on Protein: 23-118
Range on HMM: 1-99/99
Sequence Identity: 69% (69 aa)

AMDLILINSLPLVSDAET-SLTCIASGWHPHEPI-TIGRDFEALMNQHQD-PLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKM
.||.||||..|.|||||| |||||||.||||||| |||.||...|||||| |.|...|..|.|.||||||.||.|.|.|||.|..||||||.||.||||
IMDVILINPDPVVSDAETPSLTCIASDWHPHEPILTIGQDFPRPMNQHQDLPQEFPHDEPRPWPKKVVWKWEKRSHIFGAYYCQIRVRGQARRIYTMKM
EGF_2 TIE2.AA EGF_2 224-251 32 6.4e-07 25.13 Pfam 1-29 (29) Show / Hide 
Range on Protein: 224-251
Range on HMM: 1-29/29
Sequence Identity: 32% (10 aa)

CTTCKN-NGVCHED-TGECICPPG-FMGRTC
|  | . .|.|  . .| | |..| . | .|
C--CNGHHGTCNNQGCGKCQCDDGWWQGDHC
EGF TIE2.AA EGF 219-252 30 1e-06 29.52 SMART 1-32 (32) Show / Hide 
Range on Protein: 219-252
Range on HMM: 1-32/32
Sequence Identity: 30% (12 aa)

DCSRPCTTCKNN-----GVCHEDTGECICP-PGFMGRTCE
.|.     | ..     |.|.  . .| || ||..| .||
ECA----PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE
EGF_Lam TIE2.AA EGF_Lam 227-264 28 4e-05 24.28 SMART 1-42 (42) Show / Hide 
Range on Protein: 227-264
Range on HMM: 1-42/42
Sequence Identity: 28% (13 aa)

CKNN-----GVCHEDTGECI-CPPGFMG-RTCEKA-CEPHTFGRTC
|  .     | |.  || |. | .. .| | |... |.|. .  .|
CDCHLPPPQG-CDP-TGQCHNCKHNTTGGRHCDDERCAPGYW--GC
Laminin_EGF TIE2.AA Laminin_EGF 230-268 25 9e-05 20.04 Pfam 10-59 (59) Show / Hide 
Range on Protein: 230-268
Range on HMM: 10-59/59
Sequence Identity: 25% (13 aa)

N-GVCHE-------DTGECI-CPPGFMGRTCEKACEPHTFGR---TCKERC
| . |.         ||.|  | ....|| |.  |.| ..|.   .  . |
NDDQCDPDDEHCGKHTGQCHNCKHNVTGRHCDR-CKPGYWGDPWCDPPQGC
EGF TIE2.AA EGF 224-250 27 0.003856 13.56 Pfam 1-36 (36) Show / Hide 
Range on Protein: 224-250
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CTT----CKNNGVCHED--TGECICPPG---FMGRT
|.     |...| |..   . .|.||||   . |..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF TIE2.AA EGF 267-299 23 0.068097 10.62 SMART 1-32 (32) Show / Hide 
Range on Protein: 267-299
Range on HMM: 1-32/32
Sequence Identity: 23% (9 aa)

RCSGPEGCKSYV-----FCLPDPYGCSCA-TGWRGLQCN
 |.   .|          |.   | | |.  |..| .| 
ECA---PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE
EGF_2 TIE2.AA EGF_2 268-298 27 29.072198 1.18 Pfam 1-29 (29) Show / Hide 
Range on Protein: 268-298
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CSGPEGCKS-YVFCLPDPYG---CSCATG-WRGLQC
|     |     .|  .  |   |.|  | | | .|
C-----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF_2 TIE2.AA EGF_2 302-311 36 0.08061 9.18 Pfam 19-29 (29) Show / Hide 
Range on Protein: 302-311
Range on HMM: 19-29/29
Sequence Identity: 36% (4 aa)

CPSG-YYGPDC
|..| ..|..|
CDDGWWQGDHC
EGF TIE2.AA EGF 302-310 41 19.718149 1.17 Pfam 25-36 (36) Show / Hide 
Range on Protein: 302-310
Range on HMM: 25-36/36
Sequence Identity: 41% (5 aa)

CPSG---YYGPD
|| |   | |..
CPPGYLGYTGKR
EGF_2 TIE2.AA EGF_2 315-340 35 3e-06 23.22 Pfam 1-29 (29) Show / Hide 
Range on Protein: 315-340
Range on HMM: 1-29/29
Sequence Identity: 35% (11 aa)

CHCTN-EEICDRFQG---CLCSQG-WQGLQC
| |..  ..|... |   | |..| ||| .|
C-CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF TIE2.AA EGF 329-339 28 4.39081 3.35 Pfam 23-36 (36) Show / Hide 
Range on Protein: 329-339
Range on HMM: 23-36/36
Sequence Identity: 28% (4 aa)

CLCSQG---WQGLQ
| | .|   ..| .
CQCPPGYLGYTGKR
FN3 TIE2.AA FN3 445-526 16 0.008194 15.39 SMART 1-69 (69) Show / Hide 
Range on Protein: 445-526
Range on HMM: 1-69/69
Sequence Identity: 16% (16 aa)

PEPLHA---PNVIDTGHN------FAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIEVTNEIFTLNYLEPR----TDYELCVQLARPGEGGEG
| |      . | |.. .       . .  . .|           . |.               .|.  |.|     | ||  |.    ...|||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP----------IVGYR---------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TIE2.AA FN3 541-624 16 5.5e-07 30.46 SMART 1-69 (69) Show / Hide 
Range on Protein: 541-624
Range on HMM: 1-69/69
Sequence Identity: 16% (16 aa)

LPPPRG---LSLLPKSQT------ALNLTWQPIFTNSEDEFYVEVERRSLQTTSDQQNIKVPGNLTSVLLSNLVPR----EQYTVRARVNTK-AQGEW
 .||..   |.. . . |       ..|.|.|           .|. |                   . ...|.|      .|..| |. .. ..|| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TIE2.AA FN3 638-720 17 6.5e-15 56.78 SMART 1-69 (69) Show / Hide 
Range on Protein: 638-720
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

PPQPEN---IKISNITDS------TAMVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATVTQYQLKGLEPE----TTYHVDIFAENN--IGSS
|. |.|   ......|..      .. .||.          |..|.                     | ..||.|     |.|.. . |.|    |..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase TIE2.AA Tie 831-1091 85 4.4e-230 708.56 In-house 1-267 (267) Show / Hide 
Range on Protein: 831-1091
Range on HMM: 1-267/267
Sequence Identity: 85% (227 aa)

EGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
|||||||.||.||||||.|..|||.||||||.||||||.|||||.||.|||||||||.||||||||||.||||||.||||||||||||.|||||||....
EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHT

T------ASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYG
|      ||||||||.|||||||||||.||||||.||||||||||||.|||..||||||||||.||||||||||||||||||||||||||||.|||||||
TRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYG

VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
|||||||||||||||||||||||||||||||.|.|.|||||||||||||||..|||||.||||.|.|
VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
TyrKc TIE2.AA TyrKc 823-1091 40 6.1e-141 475.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-280/280
Sequence Identity: 40% (122 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLG-HHPNIINLLGACEHR-------GYLYLAIEYAPHGNLLDFLR
|.. ...|||.||.| |.. |     .. |.| .||.|    ..||  |....|||| |||||..|.|.| .        . |..  ||.|||.|.|.||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVY--------VKKT----MGR--LP
|.|                 |. ..||.|. ..|.||.||..|..|||||||||.|||||...||.||||||  . .        ....     |.  ||
KHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG-----MTCAELYEKLPQGYRLEKPLN--------CDDEVYDLMRQCWREKPYERPSFAQI
.||||.|..||...|| |||||.||..||| ..|..|| |     |. .|..|.. ||||...| |        | ||.|..|.|||.|.| .||.|..|
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

LVSL
   .
HECF
Pkinase_Tyr TIE2.AA Pkinase_Tyr 823-1091 43 1.1e-139 473.66 Pfam 1-270 (270) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-270/270
Sequence Identity: 43% (124 aa)

IKFQDVIGEGNFGQVLKARIK--KDGLRMDAAIKRMKEYASKDD--HRDFAGELEVLCKLGHHPNIINLLGACE-HRGY--LYLAIEYAPHGNLLDFLRK
|.|  ..|||.||.| |.. |  .|. ... |.| .||.|....  ..||  |......|||||||..|.|.|  ...   .|.  ||.|||.|||.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQ---EVY-VKKTMGRLPVRWMAIESLNY
 |            .    |. ..||......|.||.||..|..|||||||||.||.|| ..||.||||.|     . | .|.. |.||..||| |..||
HR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

SVYTTNSDVWSYGVLLWEIVSLGGTP-YCGMTCAELYEKL-PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
...|| |||||.|||.|||...|..| | ||. .|.||..  .|||...| || ||.||||.|||...| .||.|..|.  |
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TIE2.AA TK 823-1091 25 5.4e-119 400.77 In-house 1-486 (486) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

IKFQDVIGEGNFG---QVLKARIK-----------------------KDGLRMDAAIKRMKEY--ASKDDHRD--------------FAGELEVLCK-LG
|.. ...|||.||   .| |.. .                       |.| ... |.| .||   .|.....|              .| |....|  ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNIINLLGACEHR------------GYLYLAIEYAPHGN----LLDFLRKSRVLETDPAFAIAN----------------------------------
|||||..|.|.| .             . ...  ||.|||.    |.|.|||.|  .....  ..|                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------STASTLSSQQLLH-------------------FAADVARGMDYLSQK------QFIHRDLAARNILVGENYI-----------AKIADFGLSR-
         ..|. ..||.                   .....|.|| ||..|      .|.||||||||.|||||..           .||||||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----------------------------------GQEVYVKKTMGRLPVRWMAIESLN---------YSVYTTNSDVWSYGVLLWEIVSLG-GTPYCGMT
                                  .|. | ... |.||.|||| |.||         | ..|| |||||.|||.|||...| ...| ||.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

---------CAELYEKLPQG--------------YRLEKPLNCD--------------DEVYDLMRQCWREKPYERPSFAQILVSL
         ..|..|.| .|              .|...| .|               .|.||||.|||...| .||.|.|..  |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TIE2.AA FGFR 823-1091 43 5.6e-113 381.63 In-house 1-293 (293) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-293/293
Sequence Identity: 43% (127 aa)

IKFQDVIGEGNFGQVLKARIK---KD--GLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR
     ..||| |||| .|  |   .|     .  |.| .|. .. .|  |   |.|..   | |.|||||||.|   | ||  .||..|||| ||||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

VLETDPAFAIA-------NSTAST--------LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRG---QEVYVKKTMGRL
  . |  . .         ... .        |.. .|  .|  |||||.||  .  |||||||||.||...|. ||.||||.|.    . | |.| |||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMT-CAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
|. ||| |.|   |||. |||||||||||||  .||.|| .     |||. |  |.|.||| ||  |.| .|.|||..|| .||.|.|.  .|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TIE2.AA TK-Unique 823-1091 39 5.5e-111 375.03 In-house 1-294 (294) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-294/294
Sequence Identity: 39% (117 aa)

IKFQDVIGEGNFGQVLKARIKK----DGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRG-YLYLAIEYAPHGNLLDFLRKSR
....||||||.|||| .. ...    .. .  .|.|  |..|.. |..||  |.... .|| ||||...||.|   .   ....||.| |||...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

VLETDP--------AFAIANSTAST--LSSQQLLHFAADVARGMDYLSQ--KQFIHRDLAARNILVGENYIAKIADFGLSR---GQEVYVKK-TMGRLPV
    ..         |. .... .|  .|...|.||| ..|.|| ||..  |...||||.|||.|..|....||.|||..|     .||... . ||.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAIESLN--YSVY-TTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNC-DDEVYDLMRQCWREKPYERPSFAQILVSL
|||| |||   . .| || |||||.|||.|||..||..|| ||  ... |....|||...| .|  .|.| ||..||...| |||||.||.  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TIE2.AA Src 823-1091 37 2.9e-90 306.17 In-house 1-255 (255) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-255/255
Sequence Identity: 37% (103 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETD
||. . .|.|.|| | ..  ..   ... |.| .|.     .  .|  | ... ||  |.....|.  |      |   ||  ||.|||.|.|       
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-------

PAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQE----VYVKKTMGRLPVRWMAIESLNYSVYTTNS
      ... ..|. .||. .|| ||.||.||.....|||||||||.||||| ..|.||||| |  .    .|. ..  ..|..|.| | .|| ..|. |
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYD-LMRQCWREKPYERPSFAQILVSL
||||.|.||.|||. | .|| ||| .|  ... .|||. .| || ||.|. .|.|||...| .|| |. .   |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TIE2.AA UTK 823-1091 32 1.2e-88 300.82 In-house 1-296 (296) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-296/296
Sequence Identity: 32% (100 aa)

IKFQDVIGEGNFGQVLKARIKKDG---LRMDAAIKRMK-EYASKDDHR---DFAGELE---VLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDF
... . .|.|.||.| ||| ...    . || |.|  . . .. ....   ||  |     .. .. .|||...|.| |   . .....||.. |.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKSRV-LETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGEN-------YIAKIADFG---LSRGQE------------
||..|  ..              |.. |.|..|.|.|||| ||....|.||||||||.||...       ...||||||   .||.              
LRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY

VYVKKTMGRLPVRWMAIESLNYS-VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG--YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQ
 | .   .|.|.|||| |.|..   .|| |||||.||..|||.. | .|| ||. ... . .  |  ||...|  | ..||.||..||.  | |||.| .
YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

ILVSL
..  .
LVQQM
Kinase TIE2.AA RTKB 823-1091 36 4.2e-83 279.99 In-house 1-264 (264) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-264/264
Sequence Identity: 36% (99 aa)

IKFQDVIGEGNFGQVLKARIKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLE
..     |.| ||.| .| ..  .       | |..|  ||  .. ||  |. |.  || |||.| ..| | .   . | .|.. .||| |.||..|  .
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

TDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSR-GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNS-
 .|          .|...||. |. ..|.|| .|.|.. |||||.|||.||. .   ||.|||..|  ..  ...|  |||..|||.||. .. ||| | 
HNPQ---------SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSG

DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
||||.||  ||| |||||||     ... . |  |.||.||     .....|..|| . . .||.|. .. ..
DVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase TIE2.AA VEGFR 935-1091 49 7.2e-72 245.07 In-house 170-332 (332) Show / Hide 
Range on Protein: 935-1091
Range on HMM: 170-332/332
Sequence Identity: 49% (81 aa)

LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRG----QEVYVKKTM-GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE
| .. |. ..  |||||..|. .  |||||||||||. ||.. || ||||.|        ||.|.  |||| .|||.||.   |||| ||||||||.|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IVSLGGTPYCGMT-CAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
| |||| || |     |.. .|  |||...|  |  |.|. | .||.. | |||.|.   . |
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase TIE2.AA Ret 940-1093 50 1.4e-66 226.46 In-house 137-293 (293) Show / Hide 
Range on Protein: 940-1093
Range on HMM: 137-293/293
Sequence Identity: 50% (79 aa)

LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGT
.. ||  . .|| |||    .||||||||.|| |  | || ||||.|       |||.  .|.|| |||||||   |||| |||||.|||.|||| .|. 
IISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGAN

PYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR
|| | .   |.. |  ||| . | ||  |.| .|||||.. |  ||.|. |   . .
PYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase TIE2.AA PDGFR 940-1091 49 3.4e-66 211.38 In-house 203-358 (358) Show / Hide 
Range on Protein: 940-1091
Range on HMM: 203-358/358
Sequence Identity: 49% (77 aa)

LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGT
||.|.  ||.||..|  |  .||||||||.|. .  ..|| |||| |       || |   |||| ||| ||.  .|||| |||||||.||||| ||||.
LLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGGN

PYCGMTC-AELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
|| ||   .. | .  .||| ..|    .|.|. |..|| ..|  ||.| |.   |
PYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase TIE2.AA S_TKc 823-1095 25 1.1e-46 162.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 823-1095
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPH--GNLLDFLRKSRVLE
 .. ..||.| ||.| |.| ||       |||..|        ...  |...| |  |||||..|...... ..||.  ||...  |.|.|...| .   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTT-NSD
..          . ..  .  .... ......|. ....|||||   |||. |    ||.||||.|        |       .|| | |    |..  .|
LR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCD

VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV-----SLNRML
.|| |..|.| .. | .|..  . .....|.            ..|. |..|.|..  | .||.  ..|       .   .
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TIE2.AA Pkinase 823-1091 22 3.9e-46 164.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 823-1091
Range on HMM: 1-293/293
Sequence Identity: 22% (70 aa)

IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKD--DHRDFA-GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHG----NLLDFLRK
...  .||.|.||.| |.. |..|     |.|..|    |.  | ...   |.... .| .||||. |....| ....|.  ||...|     | |... 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

SRVLETDPAFAIANSTASTL--SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIA----KIADFGLSRG--QEVYVKKTMGRLPVRWMAIE
              .   ..  | ... ...  ..||..|. .. .|||||   |||. .|.      ||.||||..      ..  |      ..|| |
--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

SLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM----TCAELYEKLPQGYRLEKPLNCD-----------------------DEVYDLMRQCWREKPY
 .. .. |.. .|.||.|..|.| .. | .|..|     . .. .... .  . . . ...                       .|  |... |.. .|.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

ERPSFAQILVS--L
.||...||| .  .
KRPTAEQILQHPWF
Kinase TIE2.AA VEGFR 823-917 37 1.5e-18 66.68 In-house 1-101 (332) Show / Hide 
Range on Protein: 823-917
Range on HMM: 1-101/332
Sequence Identity: 37% (38 aa)

IKFQDVIGEGNFGQVLKAR---IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEH---RGYLYLAIEYAPHGNLLDFLRKS
.|   ..|.| ||||..|    |.|       | |..|| |  . ||    ||..|  .||| |  |.||.|      | |   .|| ..|||...||  
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

R
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R
Kinase TIE2.AA PDGFR 823-917 36 1.5e-18 55.8 In-house 1-98 (358) Show / Hide 
Range on Protein: 823-917
Range on HMM: 1-98/358
Sequence Identity: 36% (36 aa)

IKFQDVIGEGNFGQVLKAR---IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR
 .|  . | | ||.|  |    . | .  |  |.|  |. |  .       || ..  ||.| ||.|||||| | |  |.  ||   | ||..|.. |
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR
Kinase TIE2.AA Ret 823-917 35 1.4e-16 53.14 In-house 1-100 (293) Show / Hide 
Range on Protein: 823-917
Range on HMM: 1-100/293
Sequence Identity: 35% (36 aa)

IKFQDVIGEGNFGQVLKA---RIKKDGLRMDAAIKRMKEY-ASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRG--YLYLAIEYAPHGNLLDFLRKS
  . |. ||| ||||.||   .|.        |.|  |.  |.    .|   |...| |.  ||..| |.|||   .   . | .||.  | |  ||| |
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLL-KQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
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R