Gene TEC (Mouse)

TEC

Species: Mouse
Alias: TEC, Tec
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
TEC.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 250 Kinase domain by global Sugen HMM Fasta, JSON
TEC.AA Protein Sugen 630 None Fasta, JSON
TEC.NA RNA Sugen 2676 None Fasta, JSON

Protein domain

Protein domains of TEC.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BTK TEC.AA BTK 113-149 54 1.1e-23 85.95 SMART 1-37 (37) Show / Hide 
Range on Protein: 113-149
Range on HMM: 1-37/37
Sequence Identity: 54% (20 aa)

NNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLF
||..|.||||.|| ||...||.||.|.||||.... .
NNHRMQKYHPCFWMDGHWLCCQQTCKNAPGCCPCHPH
PH TEC.AA PH 5-111 22 3.8e-20 75.3 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5-111
Range on HMM: 1-92/92
Sequence Identity: 22% (24 aa)

TILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLSYYEGRAEKKYRKGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDAN-TLYIFAPSPQSRDRWV
 |.|  | |..      .  ..|.| |||. ..|.||. .   .  ||.|..|.........|        ... ||...  . |.|..|.|......|.
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDN-------KRPHCFQIRT-DRRTYYFQAESEEEMNDWM

KKLKEEIK
. ... ..
QAIQSACR
PH TEC.AA PH 5-113 24 6e-20 73.51 SMART 1-82 (82) Show / Hide 
Range on Protein: 5-113
Range on HMM: 1-82/82
Sequence Identity: 24% (27 aa)

TILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLSYYEGRAEKKYRKGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVK
.|.|  | |.|         ..|.| |||. ..|.||. .      ||.|..|.....| .              |...|  .|.|....|......|..
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK----KPKGSIPLSDCTVRE-P-------------CFEIHH-DRTYYFQCESEEEMQEWMQ

KLKEEIKNN
 ... |.||
AIQKAIHNN
BTK TEC.AA BTK 118-149 50 1e-14 60.02 Pfam 1-32 (32) Show / Hide 
Range on Protein: 118-149
Range on HMM: 1-32/32
Sequence Identity: 50% (16 aa)

IKYHPKFWADGSYQCCRQTEKLAPGCEKYNLF
.||||.|| .|...||.||.|.|||| .... 
QKYHPCFWMNGHWSCCHQTDKNAPGCQPCHHW
SH3 TEC.AA SH3 181-237 39 2.7e-19 71.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 181-237
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

EIVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARDK-YGSEGYIPSNYVTGKK
. |.|.||.||... .| ...|. ...|||.| .||..| .  | ||..|||||. ..
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 TEC.AA SH3_1 184-230 38 3.1e-19 67.77 Pfam 1-49 (49) Show / Hide 
Range on Protein: 184-230
Range on HMM: 1-49/49
Sequence Identity: 38% (19 aa)

VAMYDFQATEAHDLRLERGQEYIILEKNDL-HWWRARDKY-GSEGYIPS
|| ||.||... .| ...| .....||.|  .||..|..  | ||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 TEC.AA SH3_2 182-233 18 1.5e-05 22.33 Pfam 1-65 (68) Show / Hide 
Range on Protein: 182-233
Range on HMM: 1-65/68
Sequence Identity: 18% (12 aa)

IVVAMYDFQA-TEAHD-----LRLERGQEYIIL---EKNDLHWWRA-RD-KYGSE--GYIPSNYV
 .... |... | . .     |....|.   ..   .|.. .||.. .  . | .  |..||..|
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWV
SH2 TEC.AA SH2 246-329 32 2.8e-35 105.42 Pfam 1-81 (81) Show / Hide 
Range on Protein: 246-329
Range on HMM: 1-81/81
Sequence Identity: 32% (28 aa)

WYCRNTNRSKAEQLLRT-EDKEGGFMVRDSS-QPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYH
||... .|..||.||.  . ..| |.||.|. .|| ||.|....     .. ..||.|..|..   .||....| |.|..|..|..
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---GDRVKHYRIQRTDNG--GYYITGRHKFCSLQELVEHY
SH2 TEC.AA SH2 244-335 34 4.1e-30 107.28 SMART 1-87 (87) Show / Hide 
Range on Protein: 244-335
Range on HMM: 1-87/87
Sequence Identity: 34% (33 aa)

YGWYCRNTNRSKAEQLLRTE-DKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAE--KHAFGSIPEIIEYHKHNAAG
. ||  | .|..|||||...  ..| |.||||.. || |..|. .|      ....||.|.....  .|||..|  .. | |. |......||. |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK------GKVKHYRIRRNDD--GKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase TEC.AA Tec 369-620 72 1.9e-215 722.05 In-house 1-254 (254) Show / Hide 
Range on Protein: 369-620
Range on HMM: 1-254/254
Sequence Identity: 72% (185 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDM--LL
||||.|||||.||||.|||||.||.||||.|.||.|.||||||||||||||.|||||||||||.||.|||||||.||.|||||.||....||...|  ||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

SMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFE
.|||||||||.||||..|||||||||||||....|||||||||.|||||||||||.|.||||||||||||.|||.|||||||.|||||||.|..|.||.|
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

KNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDE
...|.|||..|..||||.||.|.|...|..| .||.|.||.||.|..|||.| |
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase TEC.AA Pkinase_Tyr 369-618 46 6.5e-147 498.18 Pfam 1-270 (270) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-270/270
Sequence Identity: 46% (125 aa)

LTFMRELGSGLFGVVRLGKWR-----AQYKVAIKAIREGAMCE----EDFIEEAKVMMKL-THPKLVQLYGVCT-QQKP--IYIVTEFMERGCLLNFLRQ
.||...||.| ||.|..|.|.      ...||.| ..|||| |    |||..|||.|..|  ||..|.|||||| |..|  ||||.|.|. |.||..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---QGHFSRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYV-LDDQY-TSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSF
.   .....  .||.||.....||||||.. .||||||||||||.| .|||..|||.||..  ||.| ....|.|.|.||..||..||..|..|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLMWEIFTEGRMP-FEKNTNYEVVTMV-TRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTI
||||||||| |..| ..  .|.||. ..  .|.|. .|..... .|..|..||.. || ||.|..... .
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TEC.AA TyrKc 369-618 41 6.4e-135 455.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-280/280
Sequence Identity: 41% (117 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL--THPKLVQLYGVCTQQ-------KPIYIVTEFMERGCLLNFLRQRQGH
.|. ..||.| ||.|..|.|.  ..||.| ..|.|  .|||..||..|.||   || .|.||||||||       .|..||.|.|. |.|...|| ....
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FSRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDD-------QYTSSS---GAK--FPVKWCPPEVFNYSRFSSKSDV
.. . |||.| ....|||||... .||||||||||||.| ..||.||||..|.. ||       .| ...   |.|  .|..|..||..||..|..||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGVLMWEIFTEGRMPFEK-----NTNYEVVTMVTRGHRLHRPKL--------ASKYLYEVMLRCWQERPEGRPSFEDLLRTI
|||||.|||||| | .| .       .|.||.  | .|.|. .|.         ... .|..|..||.| || ||.|... . .
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TEC.AA Src 369-618 50 2.4e-124 419.38 In-house 1-255 (255) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-255/255
Sequence Identity: 50% (128 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLR-QRQGH-FSRDMLL
... |.||.| || |  |.|. . |||.| ...| |  |.| .||..| || |.|||||| ||.| .|||||||.|..|.|| .|. ...|.  .   |.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

SMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVL--DDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMP
.|   | |||.|||.. .||||||||| ||.|  |.|| ||| || .   || |....|||||.||  || .|| ||. ||||||||.|..||.| ||.|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

FEKNTNYEVVTMVTRGHRLHRPKLASKYLYE-VMLRCWQERPEGRPSFEDLLRTI
 .  || ||...| || |. .|.   ..||| .||.||...|| || || |    
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TEC.AA SFK-Src 369-622 47 3.2e-118 352.1 In-house 1-259 (259) Show / Hide 
Range on Protein: 369-622
Range on HMM: 1-259/259
Sequence Identity: 47% (124 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DMLLS
    . |||| || |  |.|  .  ||.|  . ||| .| | .|| || || ||.|.||| |||   ||||.|| |  | || .|.. .|.  |   |  
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQ--YTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPF
|  .|  || ||| . |.|||||||| || .  |.|| ||||.| . .|.  ||   |||||.||  ||  |..||| ||||||||.|| || | ||.|.
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

EKNTNYEVVTMVTR--GHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELV
.  || ||.  | |  | |.  |.     .|..|. |||..|. || || |.  ...  
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase TEC.AA TK 369-618 24 1.1e-116 392.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

LTFMRELGSGLFG---VVRLGKWRAQ--------------------------YKVAIKAIREG-AMCEEDFIE--------------EAKVMMKLT----
.|. ..||.| ||   .|..|.|| .                           .||.| ..|| || .|.|..              || .|...     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLVQLYGVCTQQ------------KPIYIVTEFMERGC----LLNFLRQRQGH--------------------------------------------
 || .|.|||||||.            .|..||.|.|. |.    |...||.. ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FSRDMLLSMCQDVCEGMEYLERN------SFIHRDLAARNCLVNEAGV-----------VKVSDFG---
                               ..   || ||.....|||||...       |.|||||||||||.| .|           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----MARYV-LDDQYTSSS------------------------GAKFPVKWCPPEVFN---------YSRFSSKSDVWSFGVLMWEIFTEGRMPFEK-N
     .||..  || |...|                        |.|.|..|..||..|         | .|..|||||||||||||||| |..|.    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------YEVVTMVTRG--------------HRLHRPKLAS--------------KYLYEVMLRCWQERPEGRPSFEDLLRTI
.|          ||. ...||              .|. .|....              . .|..|..||.. || ||.|..|.. .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TEC.AA UTK 369-618 35 8.60000000001e-102 344.47 In-house 1-296 (296) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-296/296
Sequence Identity: 35% (105 aa)

LTFMRELGSGLFGVVRLGKWRA------QYKVAIKAIREGAM---CEE---DFIEEAK---VMMKLT-HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNF
. ..|.||.| ||.|......       . .||.|. ...|.    .|   ||.|||.   .|...  ||....|.|||||..|..||||.||.| |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------QRQGHFSRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG-------VVKVSDFG---MARYVL----------DDQYTSSSGAK
||       ... ... . .|.|. |. .||.||..  |.|||||||||||.. .       |.|..|||   |.|.|           .. |....  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPVKWCPPEVFNYS-RFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRG--HRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTI
 |..|. ||....  ||..|||||||||..|||.| ||.|..  .| .|.. |..|  .|. .|.  .  .|..|.|||.  |. ||.||||. ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TEC.AA Frk 369-622 46 4.2e-99 335.54 In-house 1-260 (260) Show / Hide 
Range on Protein: 369-622
Range on HMM: 1-260/260
Sequence Identity: 46% (121 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLR--QRQGHFSR-DML
. ..|.|||| || |  |.|  .  ||.| .. |.|  .||. ||..| || ||||.||| ||| ..||||.|| |..| |...|.  ...|.  .  .|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMAR-YVLDDQ--YTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGR
. |   |  || |||   .||||||||| ||.|  ..|. |||.||  . |..  | |  ||.||.||  ||  ||..|. ||||||||.|. || | ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPFEKNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELV
||.   || ||..|| .| |. .|    . |||.|| ||.. |. || || |   ...  
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TEC.AA Src-Unclassified 369-618 40 6.7e-97 328.23 In-house 1-284 (284) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-284/284
Sequence Identity: 40% (114 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREG---AMCEEDFI--------EEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQ
.   |.|| | || | .||||    ||.|  |.|    |  | |         .||..| |. |..||.||.||.| .|.||.||.|  | || .||   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GHFSRDMLL-------------SMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG-----VVKVSDFGMA--RYVLDDQYTSSSGAKFPVKWCPPEVFN
|      ..             ..   |  ||.||| .  .|||||||| |. .       |||| ||| |  . . || |    ||.||.||  || | 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLHRP--KLASKYLYE-VMLRCWQERPEGRPSFEDLLRTI
|  || ||||||.|.| |||.| |. |     | ||.  | || |. .|  ..   |.|| .|..|| ..|. || |. |    
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase TEC.AA SrcA 369-618 47 1.2e-96 305.95 In-house 1-250 (250) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-250/250
Sequence Identity: 47% (119 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DMLLS
..  | || | || | .| | .. ||||| .. | |  | |.|||..| || | |||||| |     |||||||.| .| || ||....|.  .   |  
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

MCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEK
|   | ||| |.||  .||||| | | || |  . |. |||.|| . |. ||.  |||||.||  ||   | ||  ||||||||.|. |. | ||.|.  
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG

NTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTI
  | ||.  | || ..  |.   . |.|.| .||.  || || || |   .
MNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase TEC.AA SrcB 369-619 47 1.3e-96 327.32 In-house 1-251 (251) Show / Hide 
Range on Protein: 369-619
Range on HMM: 1-251/251
Sequence Identity: 47% (119 aa)

LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRDMLLS
| . . ||.| || | .| .. . |||.|....|.|  | |..|| || .| | .||.|| | |.  ||||.||.|..|||| ||.  .| . | . |. 
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEK
|   . ||| |.||  .||||| | | || |. . |. |||.|| . |. ||   |||||.||  ||  |.  |  ||||||||.|. || | ||.|.  
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

NTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTID
 || ||.. . || |. ||    . ||..| .||.|||| || |. |   .|
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase TEC.AA Abl 369-618 46 1.7e-94 315.64 In-house 1-252 (252) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-252/252
Sequence Identity: 46% (116 aa)

LTFMRELGSGLFGVVRLGKW-RAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDMLL
..    || | .| |  | | | .  ||.|...| .|  ..|..|| .| .. || |||| ||||.  | ||.||||  | ||..||.  . . .  .||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

SMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFE
 |   .  ||.|||...||||||||||||| |  .||| |||.|| . || ||   |||||.||  ||   | .|||||||| ||||.||| | |  |. 
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

KNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTI
     .|   . .|.|. ||.   .  ||.|..||| ..  ||||... ...
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase TEC.AA S_TKc 369-622 24 8.3e-57 195.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 369-622
Range on HMM: 1-231/231
Sequence Identity: 24% (65 aa)

LTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMER--GCLLNFLRQRQGH-----F
 ...|..|.| ||.|......  . .|||| |.      |... | ....|  || .|.||.|.   . .|.|.|...   | |. ....|..|     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSS-KSDVWSFGVLMWEIFT
.  .  .... .|...||. .. .|||||   | |..|  ..|..|||.|| .        .       ...|||.    ..  |.|.||.|....| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

EGRMPFEKNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLR-----TIDELV
 |. ||.   .....  . .          |. . . . .|.|  || ||.  ..|.      ... .
-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TEC.AA Pkinase 369-618 23 1.4e-46 165.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 369-618
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

LTFMRELGSGLFGVVRLGKWRAQYK-VAIKAIREGAMCEEDFIE-----EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERG----CLLNFLR-QRQ
... | .||| ||.|......   | ||.| |.     ..  ..     |...| .| ||  |.||....  . ||.|.|..| |     |  ... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GHF--SRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVV----KVSDFGMAR---YVLDDQYTSSSGAKFPVKWCPPEVFN-YSRFSSKSDV
| |  | . . ...  ...|.||. ....|||||   |.|... |..    |..||| |.   |  .  .|.  |  .   ...||| . ..  ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGVLMWEIFTEGRMPFEKN------TNYEVVTMVTR-GHRLHRPKLAS-------------------KYLYEVMLRCWQERPEGRPSFEDLLRT--I
||.|....| .. || ||         . .... .. .   . ..|.. |                   . . ... .|..  |. ||..|..|    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF