Gene SRM (Mouse)

SRM

Species: Mouse
Alias: Srms, SRM
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SRM

Sequence

Name Sequence Type Origin Length Description Download
SRM.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
SRM.NA RNA Sugen 2547 None Fasta, JSON
SRM.AA Protein Sugen 507 None Fasta, JSON

Protein domain

Protein domains of SRM.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 SRM.AA SH3 69-126 29 1.3e-11 45.87 SMART 1-58 (58) Show / Hide 
Range on Protein: 69-126
Range on HMM: 1-58/58
Sequence Identity: 29% (17 aa)

RLFRALYDFTARCAEELSVSRGDRLYALKEEGDYIFAQRLSGPPSTGLVPVTYLAKAT
. .|||||..|. ..|||...|| .. |....|  .  |. .   .|..| .|... .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 SRM.AA SH3_2 70-125 14 7e-06 23.51 Pfam 1-68 (68) Show / Hide 
Range on Protein: 70-125
Range on HMM: 1-68/68
Sequence Identity: 14% (10 aa)

LFRALYDFTA-RCAEE-----LSVSRGDRLYAL----KEEGDYIFA-QRLSGPPST--GLVPVTYLAKA
..|.. |... ....|     |.. .|| .. .    |. ......  ...|   .  |..| ..... 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG-GRRMRGWFPSQWVEEC
SH3_1 SRM.AA SH3_1 72-119 25 1e-05 22.41 Pfam 1-49 (49) Show / Hide 
Range on Protein: 72-119
Range on HMM: 1-49/49
Sequence Identity: 25% (13 aa)

RALYDFTARCAEELSVSRGDRLYALK-EEG-DYIFAQRLSGPPS-TGLVPV
.||||..|. ..|||  .|| .. .. ... |  .......    .|..|.
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNT--GQEGWFPS
SH2 SRM.AA SH2 135-212 43 4e-36 107.89 Pfam 1-81 (81) Show / Hide 
Range on Protein: 135-212
Range on HMM: 1-81/81
Sequence Identity: 43% (35 aa)

WYFSGISRAQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVRAQA---KVCHYRICMAPSGSLYLQEGQLFPSLDALLAYY
||.  |||..|..||..| | .|.||.|.|||..|.|.|||| .    .| ||||.  . | .|. ... |.||  |  .|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SRM.AA SH2 133-218 46 2.2e-34 121.46 SMART 1-87 (87) Show / Hide 
Range on Protein: 133-218
Range on HMM: 1-87/87
Sequence Identity: 46% (41 aa)

QPWYFSGISRAQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVRAQAKVCHYRICMAPSGSLYLQE--GQLFPSLDALLAYYKTNWKL
||||.  |||..|.|||..| . .|.||.|.|||..|.|.|||| . ||.||||.  ..|. |..|  .  ||||  |...|..|   
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase SRM.AA SRM 245-496 70 2.7e-216 724.87 In-house 1-253 (253) Show / Hide 
Range on Protein: 245-496
Range on HMM: 1-253/253
Sequence Identity: 70% (179 aa)

FVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSAD-MKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLL
|.| ||||||.|||||||||.|...||.||||... |....|.|||.|.|.|||...|||||.||.|.||||.||||.|||||.||..|..|||..||||
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

GFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYE
.|||||||||.||||....|||||||||||||...|||.|||||||.|||.||||....||.|||||||||||..|||||||||||||.|.||||||||.
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKLN
|||||||.|||.||||.|.||.||.||..||.|||...||.||.|..||||| 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase SRM.AA Src 245-495 57 4.90000000001e-177 594.43 In-house 1-255 (255) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-255/255
Sequence Identity: 57% (146 aa)

FVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLG-SSEGKALSLPHLL
. | ||||.| |||||.|.| |...||||..|...|. ... .|....|.||||.|..|.|.|| .||.|||||.| .|.|. ||  ..||..|.||.|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

GFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLK--DDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCP
 .|.||||||.|||.....||||||||||||... |||||||||||.|  ||.|....|.|.|.|||||||.||..|..|||||||||||.|..|||..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YEGMTNHETLQQISRGYRLPRPAVCPAEVYV-LMVECWKGSPEERPTFAILREKL
|.||||||.|||..||||.|.|. ||.|.|  .| .||. .||.||||..|...|
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase SRM.AA Pkinase_Tyr 245-495 45 8.9e-142 480.79 Pfam 1-270 (270) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-270/270
Sequence Identity: 45% (122 aa)

FVLRRKLGEGFFGEVWEGLWL-----GSIPVAVKVIKSADMKL----ADLTKEIEALKSL-RHERLIRLHAICS-LGEP--VYIVTELMGKGNLQVYLGS
 .. .||||| ||||..| |      . ||||||..|   |.     .|. .|.. .|.| .|. ..||...|.  |||  .|||.|.| .|.|  || .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S--EGKALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLL-KDDVY-SPSSGSKIPVKWTAPEAANYRVFSQKSDVWSF
   ....|....||... |.|.||.|||... .||||||||.||......|..||||||.. .|| |   ..|.|.|.||.|||. ||..|. |||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLYEVFTYGQCP-YEGMTNHETLQQI-SRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKL
|.|..|.||||. | |.||.|.| ...|  .|||.|.|  ||.|.| || .||.  ||.||||. ..|.|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SRM.AA SFK-Src 245-499 51 1.1e-141 422.95 In-house 1-259 (259) Show / Hide 
Range on Protein: 245-499
Range on HMM: 1-259/259
Sequence Identity: 51% (134 aa)

FVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLG
 .|..|||.| ||.|| | | ..  ||||  |.. |      .|   .| |||..||.|.|.|  |||.||.||||  | |  || . .|..| .| |  
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

FACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLL-KDDV-YSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPY
 | ||| || |||.   ||||||||||||||  .|||.|||..| | .||  | .  | | |.|||||||.|.  || ||||||||||..|. |||  ||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

EGMTNHETLQQISR--GYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKLNAIN
.|||| | |||. |  |||.| |  || | |..| .||.  |..||||  |. ..    
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase SRM.AA TyrKc 245-495 40 8.4e-138 465.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-280/280
Sequence Identity: 40% (116 aa)

FVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSL--RHERLIRLHAICSLG-------EPVYIVTELMGKGNLQVYLGSSEGK
 .| .|||||.||||..| |   |.||||..|.    ..|. .|.. ...|  .|. ..||...|. .       ||..||.|.| .|.|. || ....|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDD--------VYSPSS--GSK--IPVKWTAPEAANYRVFSQKSD
 |....|| |. |.|.||.||......||||||||.|||...|.|..||||.| ..||        .|....  |.|  .|..|.|||. ||..|. |||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLYEVFTYGQCPYEG-----MTNHETLQQISRGYRLPRPAV--------CPAEVYVLMVECWKGSPEERPTFAILREKL
|||||....|.||||| ||.|     |.| | .... .|||.|.|.         ||.|.| .| .||.  ||.||||. ..|..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SRM.AA Frk 245-499 53 1.8e-119 403.24 In-house 1-260 (260) Show / Hide 
Range on Protein: 245-499
Range on HMM: 1-260/260
Sequence Identity: 53% (138 aa)

FVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLG--SSEGKALSLPHL
  | |.|| | |||||||||  ..||||| .|.  |   |. .|   .|.||| .||.|.|.| . ||.||.|||| .| || ||   . .|. . .. |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLAR-LLKDDV--YSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQ
.  | ||| || |||..  .||||||||||||... ||.||||||| |.||.   |    | ..|.||||||||||  |. |||||||||||.|. |||.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

CPYEGMTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKLNAIN
 || |||| | ||....|||.|.|. || ..| .| |||.  |..||||  |. ||.   
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase SRM.AA TK 245-495 25 1.8e-117 395.58 In-house 1-486 (486) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

FVLRRKLGEGFFG---EVWEGLWLGS--------------------------IPVAVKVIKS-ADMKLADLTK-----------------EIEALKS--L
 .| .||||| ||   ||..|.| |                           .|||||..|. ..|  ..                    |.. ...  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHERLIRLHAICSLG------------EPVYIVTELMGKGN----LQVYLGSSEGK--------------------------------------------
.|. ..||...|. |            ||..||.|.| .|.    |. || .. .|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------ALSLPHLLGFACQVAEGMSYLEER------RVVHRDLAARNVLVGDDLT-----------CKVADFG---
                               |....|| ...|.|.||.||...      ..|||||||||.|||....           ||.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLL-KDDVYSPSS------------------------GSKIPVKWTAPEAANYRV---------FSQKSDVWSFGILLYEVFTYG-QCPYEGM
     ||| . .|| |  .|                        | |.|..|.|||. |.||         |. ||||||||.|..|.|||| . .|.||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------HETLQQISRG--------------YRLPRPAVCP--------------AEVYVLMVECWKGSPEERPTFAILREKL
.|         .| .... ||              .|.|.|. ||              .|.| || .||.  ||.||||. |.|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SRM.AA SrcA 245-495 52 3.9e-115 365.39 In-house 1-250 (250) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-250/250
Sequence Identity: 52% (132 aa)

FVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLG
  | |.||.| ||||| | | |.  ||.| .|   |      .|   .| |||..|..| |. |  ||.||||| | || |  .|   |||.| ||.|  
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

FACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEG
 | |||||| |.|    .|||| | |.|||. | ||.||||||||..|. | .  |.| |.|||||||| |  |  ||||||||||| |. | |  || |
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG

MTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKL
| | | |.|. |||..| |  ||. .. || .||.  |||||||  |   |
MNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase SRM.AA Src-Unclassified 247-495 42 4.2e-113 382.06 In-house 3-284 (284) Show / Hide 
Range on Protein: 247-495
Range on HMM: 3-284/284
Sequence Identity: 42% (121 aa)

LRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSA---DMKLADLT--------KEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGK
| |||| | ||||| | | |.. ||||  .      |  .           .|   .| .|| .|. | |.||  || ||.||.| .| |  .|    |.
LLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGGGQ

ALSLPHL------------LGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDL-----TCKVADFGLA--RLLKDDVYSPSSGSKIPVKWTAPEAANYR
 | .. .               | ||| || |||... |||||||||||.|.         ||.|||||  .|  || | .  |.. |.||.|||.. | 
YLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFIYG

VFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRP--AVCPAEVYV-LMVECWKGSPEERPTFAILREKL
 || ||||||.||||.|..|.|| || || | |.| ...||||.|.|    ||  .|  .|  ||   |. ||||  |   .
NFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase SRM.AA SrcB 245-496 51 4.4e-110 372.03 In-house 1-251 (251) Show / Hide 
Range on Protein: 245-496
Range on HMM: 1-251/251
Sequence Identity: 51% (129 aa)

FVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLG
  | .||| | ||||| | . ... |||| .|   |      .|   .|.| |.||.||.|. .  ||.||.|| | || |  .| . ||  ||||.|. 
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTK-EPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

FACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEG
.. |.|||| |.|..  .|||| | |.|| . | ||.|||||||.. |. |    | | |.||||||| |. .|  |||||||||||.|. |||. || |
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

MTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKLN
||| | .....||||.|||  || |.| .| .|||  |||||||  |.  |.
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase SRM.AA Src-Echino1 247-495 50 2e-106 359.88 In-house 3-252 (252) Show / Hide 
Range on Protein: 247-495
Range on HMM: 3-252/252
Sequence Identity: 50% (126 aa)

LRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFA
. .|.|.| .||||.|.| |  ||||| .|   |  ||.  | . .| .||| .....|.||  ||.||||||| .|||| || . ..| . .. |.   
MDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLIDMG

CQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMT
 ..| || ||... ||||||||||||||.   ||.|||||||....|||    | |.|.|||||||| |  |  ||||||||||. |. |.|. ||.||.
AHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMM

NHETLQQISRGYRLPRPAVCPAEVYVL-MVECWKGSPEERPTFAILREKL
|.| |.|. ||||.|..  ||  .| . |. ||   |  ||||  | . .
NREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase SRM.AA UTK 245-495 34 2.6e-103 349.53 In-house 1-296 (296) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-296/296
Sequence Identity: 34% (102 aa)

FVLRRKLGEGFFGEVWEGLW------LGSIPVAVKVIKSADMKLADLT------KEIE---ALKSLR-HERLIRLHAICSLGEPVYIVTELMGKGNLQVY
  |.|.||.| |||| .. .       .   ||||| .. ...  . .      .|      .| .. |. ..|| ..|. .|| .||||.| .|.|. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LGSSEGKA------LSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDD-------LTCKVADFG---LARLLK----------DDVYSPSSGSK
| ..  ..      |.| ..|..| ..|.||.||.....|||||||||.||...       ..||.||||   ..|...          .. | ...  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPVKWTAPEAANYR-VFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRG--YRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKL
.|..|.|||| ...  |..||||||||....|..|.|. ||.||.|.....|...|  ||.|.|. ||..|| ||..||. .|.|||.|  |....
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase SRM.AA S_TKc 245-502 23 1.5e-44 155.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 245-502
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

FVLRRKLGEGFFGEVWEGLWLG-SIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGK--GNLQVYLGSSEG----KAL
. . ||.|.| ||.|. . . .    ||.|.||       .. .||. ||. .|. ...|. ..   . .|.|.|...   |.|  |. .  .    . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQ-KSDVWSFGILLYEVFT
.  |   ...|..... |. .....||||   |.|. .  . |..||||||.|        .       . |||      ..  |.|.||.|..||| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILR-EKLNAINRRL
 |. |..  . ......|            . |.  ..  |..  ||.|||  .|. | . ..   .
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase SRM.AA Pkinase 245-495 22 3.7e-42 150.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

FVLRRKLGEGFFGEVWEGLWLGS-IPVAVKVIKSADMKLADLTK-----EIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKG----NLQ----VYLG
... ||.|.| ||.|... . |. . ||||.||  . |   .       ||. .|.|.|.  .||. ..  .  .|.|.|....|     |     .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

SSEGKAL--SLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTC----KVADFGLARLLKDDVYSPSSGSKIPV---KWTAPEAAN-YRVFSQ
 ......  |  ..  .. |...|. |. .....||||   |.|. .. ..    |..|||||....   | ..|  . ..    . |||  . ..  ..
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVWSFGILLYEVFTYGQCPYEGM------TNHETLQQISR-GYRLPRPAVCP-------------------AEVYVLMVECWKGSPEERPTFAILREK
|.|.||.|..|||... |. |. |       .  . ...| .  .. ..|  |.                    |   ..  |..  |..|||.. . . 
KVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
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PWF