Gene SRC (Mouse)

SRC

Species: Mouse
Alias: SRC, Src
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
SRC.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
SRC.AA Protein Sugen 541 None Fasta, JSON
SRC.NA RNA Sugen 3887 None Fasta, JSON

Protein domain

Protein domains of SRC.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 SRC.AA SH3 86-149 35 4.7e-22 80.5 SMART 1-58 (58) Show / Hide 
Range on Protein: 86-149
Range on HMM: 1-58/58
Sequence Identity: 35% (23 aa)

TTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSD
 ...|||||..... .||||||. ..... .      ...|| .   .|||.|..|||||.. |
PYVRALYDYQAQNPDELSFKKGDIITVLEKD------DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 SRC.AA SH3_1 89-142 42 3.8e-18 64.15 Pfam 1-49 (49) Show / Hide 
Range on Protein: 89-142
Range on HMM: 1-49/49
Sequence Identity: 42% (23 aa)

VALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPS
||||||. ... .||||||. .....   |.|   .||| . ...|||.|..||
VALYDYQAQQPDELSFKKGDIIHVIE---KSDD--WDWWKGRCNNTGQEGWFPS
SH3_2 SRC.AA SH3_2 87-148 22 5.8e-11 41.29 Pfam 1-68 (68) Show / Hide 
Range on Protein: 87-148
Range on HMM: 1-68/68
Sequence Identity: 22% (16 aa)

TFVALYDYES-RTETD-----LSFKKGERLQIV-NNTRKVDVREGDWWLAHSL-STGQT--GYIPSNYVAPS
 .... ||.. . ...     |.||||. . .  | ... |    .||...   ..|..  |..||..|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD----NWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 SRC.AA SH2 156-238 60 2.8e-50 149.44 Pfam 1-81 (81) Show / Hide 
Range on Protein: 156-238
Range on HMM: 1-81/81
Sequence Identity: 60% (50 aa)

WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY
||.|||.| | ||||.| .||.|||||||||.|.| | ||| |...  | .||||.|...| ||.||| |..|.|||.|| .|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SRC.AA SH2 154-244 44 2.6e-39 137.82 SMART 1-87 (87) Show / Hide 
Range on Protein: 154-244
Range on HMM: 1-87/87
Sequence Identity: 44% (41 aa)

EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITS--RTQFNSLQQLVAYYSKHADG
..||.|.|.| | |.||.| ..| |.||||.||...|.|.||| .        ||||.||..|.|..||.   |..|.|| .||..|.....|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase SRC.AA SrcA 275-524 89 8e-225 718.08 In-house 1-250 (250) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-250/250
Sequence Identity: 89% (223 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDM
.|||..||||||||||||||||||.|||||||||||||||||.|||.||||||.|||||||||||||||||||||.|||||||||.|.||||.|||||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

SAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM
.||.|.||||.|||||.|||||||||||||||.||.|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL
.|||||.||||||.||||..||||||.||||||||.|||||||||||.||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase SRC.AA Src 275-524 76 5.4e-204 683.98 In-house 1-255 (255) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-255/255
Sequence Identity: 76% (194 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLK-GETGKYLRLPQLV
..|. |||||.|||||||.|||.| ||.||||||||||||||||||.|||||||||||||||.|.| |||||||||..|||||.||  ..|..|.||||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP
||.||.|.|||| |.|||.||||.|.|.|||||.|||||||||||||.  |.||.||.|||||||||||||..|||||||||||||||||||. |.||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMVNREVLDQVERGYRMPCPPECPESLHD-LMCQCWRKEPEERPTFEYLQAFL
|||| |.|||.|||||||||||..||..|.. .|.|||.|.||.|||||||| ||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase SRC.AA SFK-Src 275-528 64 1.8e-190 570.36 In-house 1-259 (259) Show / Hide 
Range on Protein: 275-528
Range on HMM: 1-259/259
Sequence Identity: 64% (168 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVD
 ||| |||.| ||.|| |.||.|| ||.||||||.|| | |||||||||||||..|.|||||    |||||.|| |  |||||.|.   |. ||.|||||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY
| ||.|.|||| |  |.||||| | |.|||.| ||||.|||..| .. |.| |||..|||||||||||||... || |||||||||||..|. | ||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMVNREVLDQVER--GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF
||| | ||| ||.|  |||||||| ||. .. .| .||..||..||||| |.  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase SRC.AA SrcB 275-525 70 2.2e-166 559.06 In-house 1-251 (251) Show / Hide 
Range on Protein: 275-525
Range on HMM: 1-251/251
Sequence Identity: 70% (177 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDM
|.|. ||| | |||||||..|. ..||.||.|.|||||||||.|| |||.| |..||.|||||. |||||.||||.||.|||||| . |  | ||.|.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

SAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM
||||| ||||.|||||.||||||||||| | |.||.|||||||.||||||||| |||||||||||||  .| ||||||||||||||.|. | ||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE
 | ||. ..|||||||.| .||| | ..| .||.. |||||||.|||. |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase SRC.AA Src-Unclassified 275-524 53 3.5e-157 528.48 In-house 1-284 (284) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-284/284
Sequence Identity: 53% (151 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG---TMSPEAFL--------QEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKGET
..|  |||.| ||||| | | |   ||.||..||   ||||||||        ||||.|||.|| .||.|||| | |||.||.|||| .||||..|.  .
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GKYLRLPQL------------VDMSAQIASGMAYVERMNYVHRDLRAANILVGENL-----VCKVADFGLA--RLIEDNEYTARQGAKFPIKWTAPEAAL
|.|| .. .            ||..||.|||| | |   |||||| | |.|.|.|      | ||.|||||  .|..| .| .|.||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHD-LMCQCWRKEPEERPTFEYLQAFL
|| |.|||||||.|||| |. |||..||||| ||||| .|||||||| |    ||... . .| .|| | |. ||||. |  ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase SRC.AA Pkinase_Tyr 275-524 49 2.5e-150 509.73 Pfam 1-270 (270) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-270/270
Sequence Identity: 49% (133 aa)

LRLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLKPGTMSP----EAFLQEAQVMKKL-RHEKLVQLYAVVS--EEP--IYIVTEYMNKGSLLDFLKG
...  |||.|.||||..|||.     ... ||.|.||.|.|..    |.|..||..||.| .|...|.||.|..  .||  ||||.||| .|.|||.|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E--TGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSF
    .. | ...|..|..|||.||.| |..|..||||.| |.||.||.|.|..||||||.| .| .| ..|.|.|.||||.|||.  ||.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTELTTKGRVP-YPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL
|.|. |. | |. | |||| | ||.... |.|||||||. ||. ..|||.|||...||.||||.... .|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SRC.AA Frk 275-528 63 6.4e-146 491.07 In-house 1-260 (260) Show / Hide 
Range on Protein: 275-528
Range on HMM: 1-260/260
Sequence Identity: 63% (166 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLK--GETGKYLRLPQL
..|  .|| | ||||| | || || ||.|||||||| |. ||.|||.|||||| ||.|||||   ||||||.|| | .|||...|.   ..|. ....||
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR
|||.||.|.||||.| .||.|||| | |.||||...||.||||||| |. |||  | .|.||.||||||||||| | .||||||||||||||||. | ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF
.||||| |.|||..|..|||||.||.||. | ..| .||...|..||||| ||  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase SRC.AA Src-Echino1 275-524 62 3.6e-140 471.95 In-house 1-252 (252) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-252/252
Sequence Identity: 62% (158 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVD
||.. |.|.| .|||| | ||| | ||.||||..|||| .|| || ||||.||| .||.||| |.. ||||||| |..|.|.|.|| . .| .....|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG
| |.||||| |... |.||||| | |.|||.  |||.|||||||......| ..||||.|||||||||||||||||||||||||||.||. | ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MVNREVLDQVERGYRMPCPPECPESLHDL-MCQCWRKEPEERPTFEYLQAFL
| ||||||||.|||||| . .||.||... | .|| |.|  |||||.|  |.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase SRC.AA TyrKc 275-524 42 9.20000000001e-134 451.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-280/280
Sequence Identity: 42% (121 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL--RHEKLVQLYAVVSE--------EPIYIVTEYMNKGSLLDFLKGETGK
..|. ||| |.||||. |||.  . ||.|.||...   |.|..||..|.||  .|. .|.||.|...        ||..||.||| .|.|.|.|.   .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

YLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN--------EYTARQ--GAK--FPIKWTAPEAALYGRFTIKSD
 | ...|.... |||.||.| ...|..|||| | |.|||||...|..||||.| |.|          |....  |.|  .||.|.|||.  ||.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTELTTKGRVPYPG-----MVNREVLDQVERGYRMPCPPE--------CPESLHDLMCQCWRKEPEERPTFEYLQAFL
|||||... |. | |  ||||     | |.||. .|..|||||.||.        ||. ....| |||. .||.||||. .  ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SRC.AA SRM 275-525 52 8.3e-126 422.89 In-house 1-253 (253) Show / Hide 
Range on Protein: 275-525
Range on HMM: 1-253/253
Sequence Identity: 52% (132 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLV
  |  |||.| ||||| | | |  .||||  |    |  . . .| | ||||||.... |.||.|  .|.||.|| | ||.|. .|.   .| |..|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP
|.  |.| ||.| |  ||.|||| | |.|||.|..|||.|||||||| |  |    . . |.|||||||| |. . .||||||||||| |. |.| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE
|| | | . |..|||||||| ||| . | || .||...||.||.|  |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase SRC.AA TK 275-524 27 1.6e-124 419.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-486/486
Sequence Identity: 27% (134 aa)

LRLEVKLGQGCFG---EVWMGTWNGT--------------------------TRVAIKTLKPG-TMSPEA--------------FLQEAQVMKKLR----
..|. |||.| ||   ||..|.|.|                           |.||.|.||.| .||.|.              ||.||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HEKLVQLYAVVSEE-------------PIYIVTEYMNKGS----LLDFLK--GETGKY-----------------------------------------
 |. .|.||.|....             |..||.|||..|.    |.|.|.   ....                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRLPQLVDMSAQIASGMAYVERM------NYVHRDLRAANILVGENLV-----------CKVADFG---
                               | ..||. |..|||.||.| ...      |.||||| | |.|||||.|           ||.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-EDNEYTARQ------------------------GAKFPIKWTAPEAAL---------YGRFTIKSDVWSFGILLTELTTKGRVPYPG-M
     ||| | .| .|....                        |.|.||.|.|||. .         ||.||.||||||||.|. |. | |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

VN---------REVLDQVERG--------------YRMPCPPECP--------------ESLHDLMCQCWRKEPEERPTFEYLQAFL
 |         .||.....||              .|||.|| ||              | ..|||.|||...||.||||. |. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SRC.AA Tec 275-526 45 1.2e-109 370.55 In-house 1-254 (254) Show / Hide 
Range on Protein: 275-526
Range on HMM: 1-254/254
Sequence Identity: 45% (117 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQ--L
| .   ||.| || | .| | .   ||||..| |.|| | |..||.||.|| |.|||||| | |.. ||||||||| .|.||..|. | .. ..  .  |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLR-EHKHHFQKNMAIL

VDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY
 .|  ..  |||| || ...|||| | | |||.. | ||.|||..| . | .||   |.|||.|| .||   | |.  |||||.||.|  |  . |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED
. | | || ..| .|.|.  |  |.... . | .||. .|||||||. |   ...
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase SRC.AA S_TKc 275-528 25 1.8e-56 194.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 275-528
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNK--GSLLDFLKGETG----KYLR
 ..  |.|.| ||.|. .....   .|||| .|      | ...| |..|| .|. .|.|| |  .. .|.|.||..   |.|.|..|   .    ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI-KSDVWSFGILLTELTTK
  .   . .||.....|  ... .||||  .|||. |  . |..||||||..                . |||      ..  |.|.||.|..| |. . 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQA-----FLEDYF
|. |.|     ......            .... |....|..|.||.|||   . .      .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRC.AA Pkinase 275-524 26 1.5e-48 172.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 275-524
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ-----EAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKG----SLLDFLKGETG
.... |.|.| ||.|. ... || . ||.|..|  . ...   .     |.|.||.|.|.  |.|| .. ..  ||.|.||...|    .| |..... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KYL--RLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVC----KVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVW
. .     .. ..  ||..|..|  .|. .||||  .|||. .| ..    |..|||||..  .  |..| . |  .   . |||  . .   . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDMW

SFGILLTELTTKGRVPYPGM-----VNREVLDQVERG--YRMPCPPECP-------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
|.|..| |. . || |.||      ..  .. .  .|  .. ..| .|.                   |.. |... |..| |..|||.| .     .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF