Gene smMLCK (Mouse)
smMLCK
Sequence
Protein domains of smMLCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| I-set | smMLCK.AA | I-set | 42-132 | 42 | 2.3e-32 | 112.32 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 42-132 Range on HMM: 1-92/92 Sequence Identity: 42% (39 aa) PAFILPPRNLCVKEGATAKFEGRVRGYPEPQVTWHRKGQAITN-GGRFLLDCGVRGTFSLVIHTVREEDKGKYTCEASNGSGARQVTVELTV | |. .|... |.|| ||.|| .|.|.|.|||.|...|| ... . |. .. .|| .| | | .| ||||| |.| .| ..|.|||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | smMLCK.AA | IGc2 | 54-122 | 28 | 4.7e-13 | 50.61 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 54-122 Range on HMM: 1-56/56 Sequence Identity: 28% (20 aa) KEGATAKFEGRVRGYPEPQVTWHRKGQAITNGGRFLLDCGVRGTFSLVIHTVREEDKGKYTCEASNGSG .|| .. .. ...|.|.|...| . || . . .| | |..|| |.|||.|.| | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | smMLCK.AA | IG | 48-133 | 24 | 5.8e-13 | 50.32 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 48-133 Range on HMM: 1-58/58 Sequence Identity: 24% (22 aa) PRNLCVKEGATAKFEGRVRGYPEPQVTWHRKGQAITNGGRFLLDCGVRGTFSLVIHTVREEDK---GKYTCEASNGSGARQV--TVELTVE |. . |||| |.... | |..|. |.| |..|| | |.|.|. .| . ...|||. PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| V-set | smMLCK.AA | V-set | 42-128 | 16 | 0.00272 | 13.18 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 42-128 Range on HMM: 1-128/128 Sequence Identity: 16% (21 aa) PAFILP--PR----NLCVKEGATAKFEGRVR-GY----PEPQVTWHR-KGQ-------------AITN-----------GGRFLLDCGVRGTFSLVIHTV . .. . || . |.||...... .. .| .. ...| | . .| | ... .. ...||| |. . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL REEDKGKYTCEASN-----GSGARQVTV ...| | |.| ..| . ..|| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 67-80 | 64 | 0.962758 | 5.11 | Pfam | 32-45 (101) | Show / Hide |
Range on Protein: 67-80 Range on HMM: 32-45/101 Sequence Identity: 64% (9 aa) GYPEPQVTWHRKGQ |||.||.||.. || GYPPPQITWYLNGQ |
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| I-set | smMLCK.AA | I-set | 165-254 | 44 | 9.3e-34 | 117.06 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 165-254 Range on HMM: 1-92/92 Sequence Identity: 44% (41 aa) PKFATKLGRAVVKEGQMGRFSCKITGRPPPQVTWLKGNVPLQP-SARVSMSEKN-GMQILEIRGVTRDDLGVYTCMVVNGSGKASMSAELSI ||| .|. ...|.||. ||.|..|| |||||.|.|.. ||.| | |..|.... | . |.|..|..|| |.||| ..| .|.|. .||| . PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 171-255 | 17 | 3.9e-14 | 54.2 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 171-255 Range on HMM: 1-58/58 Sequence Identity: 17% (16 aa) LGRAVVKEGQMGRFSCKITGRPPPQVTWLKGNVPLQPSARVSMSEKNGMQILEIRGVTRDDL---GVYTCMVVNGSGKASM--SAELSIP . .||||. ...| .. |..|. |.| .|...| |.|.|.. .|.... ...|.. PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 177-244 | 33 | 2e-13 | 51.84 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 177-244 Range on HMM: 1-56/56 Sequence Identity: 33% (23 aa) KEGQMGRFSCKITGRPPPQVTWLKGNVPLQPSARVSMSEKNGMQILEIRGVTRDDLGVYTCMVVNGSG .||| .. |. ||.| |...|.| . ||. . . |.|. ||..| |.||| . | | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 165-265 | 13 | 2.8e-05 | 20.04 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 165-265 Range on HMM: 1-128/128 Sequence Identity: 13% (19 aa) PKFATK--LG----RAVVKEGQMGRFSCKITGRP----PP-QVTWLK-GNV-------------------------PLQPSARVSMSEKNGMQILEIRGV . . | . .|.|||. ...|. . . .. ...| . .. . . . ..|.. .. | |. . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL TRDDLGVYTCMVVNGSGKASMSAELSIPGLDNAARLAV ...| |.|.| | |. .. . . || | QPSDSGTYYCAVWNC----------NEDYFGHGTRLTV |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 190-218 | 25 | 0.034242 | 10.28 | Pfam | 32-67 (101) | Show / Hide |
Range on Protein: 190-218 Range on HMM: 32-67/101 Sequence Identity: 25% (9 aa) GRPPPQVTWLKGNVPL-------QPSARVSMSEKNG |.||||.||.....|. . . ... . .| GYPPPQITWYLNGQPMVPNEKTEAITTTSEQDPETG |
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| I-set | smMLCK.AA | I-set | 411-501 | 36 | 1.5e-29 | 102.8 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 411-501 Range on HMM: 1-92/92 Sequence Identity: 36% (34 aa) PRFESQPQSQEVTEGQTVKFICEVSGIPKPDVGWFLEGIPVRRREGITEVYEDG-VSHHLCLLRARTRDSGRYSCTASNSLGQVSCSWSLLV |.|. .|...||.||.|..| |.|.| |.|.| || | |.| .. . .|| . | ... .|.| |.|.|.||.|...|. .| | PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 417-502 | 23 | 1.2e-13 | 52.53 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 417-502 Range on HMM: 1-58/58 Sequence Identity: 23% (21 aa) PQSQEVTEGQTVKFICEVSGIPKPDVGWFLEGIPVRRREGITEVYEDGVSHHLCLLRARTRDS---GRYSCTASNSLGQVSC--SWSLLVD |. ..| ||.||.. | || . |. | . ... || | | |.|. ||... . | | PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 423-491 | 28 | 8.2e-12 | 46.49 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 423-491 Range on HMM: 1-56/56 Sequence Identity: 28% (20 aa) TEGQTVKFICEVSGIPKPDVGWFLEGIPVRRREGITEVYEDGVSHHLCLLRARTRDSGRYSCTASNSLG |||.| . |...| | |.. |. | |. . .| . ... |||.|.|.|.|. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 415-501 | 16 | 0.56417 | 5.19 | Pfam | 5-128 (128) | Show / Hide |
Range on Protein: 415-501 Range on HMM: 5-128/128 Sequence Identity: 16% (20 aa) SQ--PQ----SQEVTEGQTVKFICEVS-GI----PKPDVGWFL-EGI---------------PVRRREGITEVYEDGV---------SHHLCLLRARTRD .| | . .| |||.|.. | .| . . .. |. .. .. . .... . | . .| . .. | TQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSD SGRYSCTASNS-LGQVSCSWSLLV || | | ..|. .. . | | SGTYYCAVWNCNEDYFGHGTRLTV |
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| I-set | smMLCK.AA | I-set | 511-597 | 36 | 3.3e-28 | 98.25 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 511-597 Range on HMM: 1-92/92 Sequence Identity: 36% (34 aa) PSFSSVLKDSVVIEGQDFVLRCSVQGTPAPRVTWLLNGQPIQF---AHSICEAG--VAELHIQDALPEDRGTYTCLAENAMGQVSCSATVTV |.|. ..|| .| ||.. . | |.|.| | |.|. .|||.. |.. . | . | |... |.| |.||| |.| |...|.|..|| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | smMLCK.AA | IGc2 | 523-587 | 36 | 1.7e-20 | 75.36 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 523-587 Range on HMM: 1-56/56 Sequence Identity: 36% (24 aa) IEGQDFVLRCSVQGTPAPRVTWLLNGQPIQFAHSICEAGVAELHIQDALPEDRGTYTCLAENAMG .|||...|.| . | |.| ..|. |||.. . .|.|... |||.|.|||.|.|..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | smMLCK.AA | IG | 517-598 | 26 | 3.3e-16 | 61.08 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 517-598 Range on HMM: 1-58/58 Sequence Identity: 26% (23 aa) LKDSVVIEGQDFVLRCSVQGTPAPRVTWLLNGQPIQFAHSICEAGVAELHIQDALPEDR---GTYTCLAENAMGQVSC--SATVTVQ . .| ||.. .|.| |. ...|. |.| .. ||| |||.| |. ||... ..|.||| PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 515-550 | 32 | 0.00135 | 15.29 | Pfam | 1-46 (101) | Show / Hide |
Range on Protein: 515-550 Range on HMM: 1-46/101 Sequence Identity: 32% (15 aa) SVLKDS-VVIEGQ-----DFVLRC----SVQGTPAPRVTWLLNGQP .. . . .|.| |..| | | |.|..||.||||| PEIEPPPTQLEWQYQENMEVVATCVFPWSCGGYPPPQITWYLNGQP |
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| V-set | smMLCK.AA | V-set | 513-597 | 17 | 0.008751 | 11.43 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 513-597 Range on HMM: 1-128/128 Sequence Identity: 17% (22 aa) FSSVLK--------DSVVIEGQDFVLRCSVQGTP----AP-RVTWLL----NGQPIQFA---------------HSICEAGVA-----E-----LHIQDA |.| .| |||. |.|... .. .. ...| ...| . . .. . | |.|... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL LPEDRGTYTCLAENA-MGQVSCSATVTV |.| |||.| . | ... . ..|| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| I-set | smMLCK.AA | I-set | 620-709 | 40 | 2.2e-33 | 115.78 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 620-709 Range on HMM: 1-92/92 Sequence Identity: 40% (37 aa) PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHDGNEIQE-SEDFHFEQKG-GWHSLCIQEVFPEDTGTYTCEAWNSAGEVRTRAVLTV | |.| ..|..|. |. .. ..||.|.|||.| |..|| .... |. ... ..| | ..| |..|.|.|.|.||| | ||.||. ..| ||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 626-710 | 26 | 1.1e-13 | 52.67 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 626-710 Range on HMM: 1-58/58 Sequence Identity: 26% (24 aa) LSDLKVMDGSQVTMTVQVSGNPPPEVIWLHDGNEIQESEDFHFEQKGGWHSLCIQEVFPEDT---GTYTCEAWNSAGEVRT--RAVLTVQ . . |. |. ||.| || .. |. | | .| |||. |||.|.|. .|.. . |||| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 632-699 | 33 | 3.2e-09 | 37.9 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 632-699 Range on HMM: 1-56/56 Sequence Identity: 33% (23 aa) MDGSQVTMTVQVSGNPPPEVIWLHDGNEIQESEDFHFEQKGGWHSLCIQEVFPEDTGTYTCEAWNSAG | .||.| ..||| |.. |.. | ... . .| |..| ||| |.|||.| |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 620-709 | 16 | 0.000176 | 17.28 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 620-709 Range on HMM: 1-128/128 Sequence Identity: 16% (21 aa) PIFLQG--LS----DLKVMDGSQVTMTVQVSGNP----PP-EVIWLH-DGN-----------------------EIQESEDFHFEQKGG--WHSLCIQEV ...... . . | | ||.. ..| .. .. . | . . .. ..| . .. || |. . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL FPEDTGTYTCEAWNS-AGEVRTRAVLTV |.|.|||.| .||. . . ||| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| C2-set_2 | smMLCK.AA | C2-set_2 | 644-659 | 37 | 6.417991 | 2.17 | Pfam | 31-46 (101) | Show / Hide |
Range on Protein: 644-659 Range on HMM: 31-46/101 Sequence Identity: 37% (6 aa) SGNPPPEVIWLHDGNE .|.||| ..|. .|.. GGYPPPQITWYLNGQP |
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| I-set | smMLCK.AA | I-set | 1129-1218 | 39 | 4.7e-27 | 94.31 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1129-1218 Range on HMM: 1-92/92 Sequence Identity: 39% (36 aa) PVFKEKLQDVHVAEGEKLLLQCQVISDPPATVTWSLNGKTLKT-TKFIVLAQEG-SRFSVSIEKALPEDRGLYKCVAKNSAGQAECSCQVTV |.| |..|| | ||| . ..|||. ||| .|.| .|. |.. .. .. ..| . . |... |.| | |.|||.||.|.|||....|| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| I-set | smMLCK.AA | I-set | 718-808 | 33 | 3.1e-22 | 77.98 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 718-808 Range on HMM: 1-92/92 Sequence Identity: 33% (31 aa) PWFISKPRSVTATLGQSVLISCAIAGDPFPTVHWLRDGRALSKDSGHFELLQNE-DVFTLVLKNVQPWHAGQYEILLKNRVGECSCQVSLML | |. ||..|... |... .| . ||| |.| |..||. |. || .. ... . || .|||| .|.|.. .|..||..| ..| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | smMLCK.AA | IGc2 | 1141-1208 | 26 | 1.2e-13 | 52.54 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1141-1208 Range on HMM: 1-56/56 Sequence Identity: 26% (18 aa) AEGEKLLLQCQVISDPPATVTWSLNGKTLKTTKFIVLAQEGSRFSVSIEKALPEDRGLYKCVAKNSAG ||. . |.| . .| ....| |. | .. ...|. . |||.|.| |.| |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | smMLCK.AA | IG | 1135-1219 | 23 | 1.4e-13 | 52.35 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1135-1219 Range on HMM: 1-58/58 Sequence Identity: 23% (21 aa) LQDVHVAEGEKLLLQCQVISDPPATVTWSLNGKTLKTTKFIVLAQEGSRFSVSIEKALPEDR---GLYKCVAKNSAGQAEC--SCQVTVD . | | ||| . |.| | ...|. | .. ||| | | |.|. .||... . ..|| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IG | smMLCK.AA | IG | 724-809 | 17 | 9.2e-10 | 39.68 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 724-809 Range on HMM: 1-58/58 Sequence Identity: 17% (16 aa) PRSVTATLGQSVLISCAIAGDPFPTVHWLRDGRALSKDSGHFELLQNEDVFTLVLKNVQPWHA---GQYEILLKNRVGECSC--QVSLMLH |. ||. .|..| ..| .. ...|. |.. |||| .. | | . |. .. . | . PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 730-798 | 31 | 7.2e-08 | 33.39 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 730-798 Range on HMM: 1-56/56 Sequence Identity: 31% (22 aa) TLGQSVLISCAIAGDPFPTVHWLRDGRALSKDSGHFELLQNEDVFTLVLKNVQPWHAGQYEILLKNRVG |||| . | .|.| |..||.. | |. . || .|||.| ..| |. . |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 718-783 | 18 | 7.5e-05 | 18.56 | Pfam | 1-102 (128) | Show / Hide |
Range on Protein: 718-783 Range on HMM: 1-102/128 Sequence Identity: 18% (19 aa) PWFISK--PR----SVTATLGQSVLISCAIAGDP----FP-TVHWLR-DGR------------ALSKD----------SGHFELLQNED--VFTLVLKNV . ... || .||. .||||...| |. . ...| | .. . .| ... .| . |.| ..|. QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL QP || QP |
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| V-set | smMLCK.AA | V-set | 810-1218 | 6 | 0.000285 | 16.56 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 810-1218
Range on HMM: 1-128/128
Sequence Identity: 6% (27 aa)
NSPSRA-PPRGREPASCEGLCGGGGVGAHGDGDRHGTLRPCWPARGQGWPEEEDGEDVRGLLKRRVETRLHTEEAIRQQEVGQLDFRDLLGKKVSTKTVS
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QSQVTQHPPRGC-PW-------------------------------------------------------------------------------------
EDDLKDIPAEQMDFRANLQRQVKPKTISEEERKVHSPQQVDFRSVLAKKGTPKTPVPEKAPPKAATPDFRSVLGGKKKSPSENGGNSAEVLNVKAGESPT
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PAGDAQAIGALKPVGNAKPAETPKPIGNAKPTETLKPVGNTKPAETLKPIANAQPSGSLKPVTNAQPAEPQKPVGNAKSAETSKPAGKEEVKEVKNDVNC
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KKGQVGATGNEKRPESQGSAPVFKEKLQDVHVAEGEKLLLQCQVISDP----PA-TVTWSLNGKTL-KTTKFIV------------------------LA
|.|.||....|.|.. .|. . ...|. .. .. ..|. ..
----------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFS
QEGS--RFSVSIEKALPEDRGLYKCVAKNS-AGQAECSCQVTV
. .| .||..| .. |.| | | |...|. .. . . ..||
GNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
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| I-set | smMLCK.AA | I-set | 1269-1358 | 27 | 7.8e-19 | 66.42 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1269-1358 Range on HMM: 1-92/92 Sequence Identity: 27% (25 aa) PQIIQFPEDQKVRAGEPVELFGKVAGTQPITCKWMKFRKQIQE-SEHIKVENGE-SGSKLTILAARQEHCGCYTLVVENKLGSRQAQVNLTV |...| | |..|. || ... .| |. | . | | ..... |..... . . ..|||. . .. | || |..|..|. .. ..||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | smMLCK.AA | IG | 1275-1359 | 20 | 1.2e-09 | 39.27 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1275-1359 Range on HMM: 1-58/58 Sequence Identity: 20% (18 aa) PEDQKVRAGEPVELFGKVAGTQPITCKWMKFRKQIQESEHIKVENGESGSKLTILAARQEHC---GCYTLVVENKLGSRQA--QVNLTVV |. . |..||.|.| |. . .|. ||| .. |. | |. ... |. .. ..||| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | smMLCK.AA | IGc2 | 1281-1348 | 22 | 0.002153 | 7.43 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1281-1348 Range on HMM: 1-56/56 Sequence Identity: 22% (15 aa) RAGEPVELFGKVAGTQPITCKWMKFRKQIQESEHIKVENGESGSKLTILAARQEHCGCYTLVVENKLG . |..|.| ...| . .| | .... ... ||| .. |. | || ...|. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | smMLCK.AA | V-set | 1326-1358 | 29 | 0.012138 | 10.94 | Pfam | 95-128 (128) | Show / Hide |
Range on Protein: 1326-1358 Range on HMM: 95-128/128 Sequence Identity: 29% (10 aa) LTILAARQEHCGCYTLVVENK-LGSRQAQVNLTV ||| .. .. |.|. .| | .. .. ..||| LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| FN3 | smMLCK.AA | FN3 | 1362-1444 | 24 | 1.3e-13 | 52.48 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 1362-1444 Range on HMM: 1-69/69 Sequence Identity: 24% (24 aa) PDPPAGT--PCASDIRSS------SLTLSWYGSSYDGGSAVQSYNVEIWDTEDKVWKELATCRSTSFNVQDLLPD----REYKFRVRAVNV--YGTS |.|| . . ..|. |. |.|||| . .| . | .| |. ||.||||||| .| . PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| Kinase | smMLCK.AA | MLCK | 1495-1750 | 66 | 8.3e-245 | 653.55 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-257/257 Sequence Identity: 66% (170 aa) YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECI |.|.| || ||||.|.| .||.|||.|| ||.|....|.|.|...||.|||.||||.|.|| ||||.| ..||..|..|||||||||.||||.|||||.| YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI KYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGS-LKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFM .||||| |||...|.|.|||||||||||||...|...||.|||||||....... .||.|||||||||||.||.|.|..|||||.|||||.| ||||||| HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM GDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL ||||.||..||||. ||||||.||.|||.||||||.||.||...|.....||||||| GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL |
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| Kinase | smMLCK.AA | DAPK | 1497-1750 | 43 | 4e-133 | 369.1 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1497-1750 Range on HMM: 1-264/264 Sequence Identity: 43% (115 aa) IEERLGSGKFGQVFRLVEKKTGKIWAGKFFK--AYSAK----EKDNIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIID--EDFE . |.||.|.| | . .|.||| |.|| | . . .| ||.| . ||... ...| . ....|| ||||||| . |. MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREEC- LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR--IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYIL |.| . .. |.|| ||| | | . |.||||||.||| .. ||.|||||.|...|. .. .||||.||||..||||.. |||||||||| ||. LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM VSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL || ||| ||. ||..|.. ||..| |. | ||||| || || . |. ..||||||. LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI |
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| Kinase | smMLCK.AA | DAPK | 1495-1750 | 47 | 2.8e-124 | 360.39 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-264/264 Sequence Identity: 47% (127 aa) YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAK------EKDNIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFE ||. |..||| | | . ||.||| |.|| | . ..| |.|| . || . |..| | .|..|| ||||||| . ... YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKE-C LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR--IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYIL |.| | .. || .|| ..| |.|.|||||||| .. ||.||||||.| | | .||||||||||..|||| | .||||||||| ||| LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL VSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL || |||.||. |||||.| .||.| | . | ||||| || || | |. .|||||| LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
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| Kinase | smMLCK.AA | CAMK | 1500-1750 | 24 | 2.5e-119 | 386.34 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 1500-1750
Range on HMM: 1-425/425
Sequence Identity: 24% (105 aa)
RLGSGKFGQVFRLVEKKTG------------KIWAGKFFKAY----------------------------SAKEKDNIRQEISIMNC-------LHHPKL
||.| ||.|.. ..|.|. . .| |. . ..| ..|.|.||.||. |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VQCVDAFEE-------------------KANIVMVL---EIVSGGEL----FERIIDE--------------DFELTERECIKYMRQISEGVEYIHKQGI
... ...| . ...||. | .||||| |..|.. .. .||||. .|.||| ..|.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
VHLDLKPENIMCVNKTG---------------TRIKLIDFGLARRLENAG------------------------SLKVLFGTPEFVA-PEVINY------
||.|||||||..... . ||.||||.|.... .| .||||..| |||.|.
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
--------EPIGYATDMWSIGVICYILVSGLSPFMGD-------------NDNETLANVTSATWDFDDEAFDE------------ISDD--------AKD
...|...||||.|||.||...| .|| || ||.|.. ..... .||... |.. |||. .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD
FISNLLKKDMKNRLDCTQCLQHPWL
.|...|..| ..|. ..|||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | smMLCK.AA | CAMK1 | 1495-1750 | 38 | 1.1e-108 | 317.13 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-276/276 Sequence Identity: 38% (106 aa) YDIEERLGSGKFGQVFRLVEKKT---GKIWAGKFF--KAYSAKEK----DNIRQEISIMN-C--LHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERII | . ...|.| |..|.. ..|.| || .| | . | .|.. .....||.|| . ..|| ... . .|.. . .|.| |.|||||.||. YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV DEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIK--LIDFGLARRLENAG-SLKVLFGTPEFVAPEVINY---EPIGYATDM . . ||.. . |.|| . |||.|..|||| ||||||. ...| . || ..||||...... .| .|||..|||||... .| ..| || EKG-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM WSIGVICYILVSGLSPFMGDN-DNETLANVTSATWDFDDEAFDEISDD-AKDFISNLLKKDMKNRLDCTQCLQHPWL |||||| ||| | .|| ..| ||| .. .... ..|. .|.||| |||||...|..| |.|..|.|||.|||. WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | smMLCK.AA | Trio | 1495-1750 | 36 | 1e-107 | 277.13 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-258/258 Sequence Identity: 36% (94 aa) YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECI |.. | .| | |. | | ..| ||. | || | .. |. ..| ... |.|| ... |..| . .|| ..||| ... . ....|.| . YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFI-PYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRW-GSYCESEVK KYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTG--TRIKLIDFGLARRLENA--GSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLS ||.|. |.| | | ..| |||.||||.| . . .||..||| | | . . . |.|||.|||.|. .|..|.|| |||||. |.. || | TYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGIS PFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL || ...| ||..|. .| .. | .| .||.|| .| | | .||||||. PFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF |
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| Kinase | smMLCK.AA | Pkinase | 1495-1750 | 35 | 9.79999999999e-103 | 352.41 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-293/293 Sequence Identity: 35% (106 aa) YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQ----EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGG----ELFERII-DED | |....||| ||.|.. ..|.||||.| | .| ..|.. ... ||.||. |.|| |.. |.||.| .| ||.| . || .||..| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH FEL--TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR---IKLIDFGLARR--LENAGSLKVLFGTPEFVAPEVIN-YEPIGYATDMWS . .|.||..||.|| .|.||.|..||.| |||||||... ..|. .|..|||||. . | . .... |||...|||||. ....|.. |||| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS IGVICYILVSGLSPFMGD------NDNETLANVTSATWDFDDEAFDEIS-----------------DDAKDFISNLLKKDMKNRLDCTQCLQHPWL .|.|.|....| || |. .... .... .. ..|| . ..|| ...||||...|.||.| |. ..|.|||||. CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | smMLCK.AA | S_TKc | 1495-1750 | 34 | 2.5e-97 | 330.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-231/231 Sequence Identity: 34% (93 aa) YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSG--GELFERIIDEDFE----- |.| . .|.| ||.|.. ..||||.| | | | ..||.||.|. ||| .|.. |.|.. .. ||.| ..| |.||..| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY-ATDMWSIGVICYILV ..| .. .||.|| ...||.|..||.| |||||||.. . .||..||||||.| . . |||...||||. . |. . |.||.|.| |... FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML SGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQ-------HPWL .| || ...... .. |..|||||...|.|| ..|. . ..|| |||. CGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | smMLCK.AA | Ciliate-E2a | 1495-1750 | 34 | 1.1e-93 | 276.12 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-275/275 Sequence Identity: 34% (96 aa) YDIEERLGSGKFGQVFRLVEKKTGKI-WAGKFFKAYSAKE--KDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED-FELTE |... .|.|.||.|. |.||| . || |... .. | .. .||.|| .| || . . . .| . |. .|.| ..||||...|. . | . YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI RECIKYMRQIS-EGVEYIHKQGIVHLDLKPENIMCV--NKTG---TRIKLIDFGLARRL--ENAGSLKVLFGTPEFVAPEVINYEPI------GYATDMW | ..|.|. .|..|.|...|.| |||||||. .|.. . ||.||||||.. ... ||| .|||||.|.. . .. ||| QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW SIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEA-FDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL |.||| |||..| .|| | . ||.| .. ||.. . ..|...||... .|.|| |.|....|.|.||| SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | smMLCK.AA | DRAK | 1498-1750 | 38 | 2e-91 | 284.33 | In-house | 2-259 (259) | Show / Hide |
Range on Protein: 1498-1750 Range on HMM: 2-259/259 Sequence Identity: 38% (99 aa) EERLGSGKFGQVFRLVEKKTGKIWAGKFFKA--YSAKEKDNIRQEISI-MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFE-RIIDEDFELTEREC .| ||| | . ..| ||. .| || | . .| .|| . |.| |... . .| . ....||| .|||.|. . |.. ..|.. AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV IKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPF .. |||| ||| | |.. |||||||| ||. . ||..|||..| ..|. . . |||..||||. ||.|| |||||||||. |.. ...||| QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISPF MGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL .|| || |. |. .| |. .|. | ||| |. .. |. ..||.|||| VGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL |
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| Kinase | smMLCK.AA | Ciliate-E2 | 1495-1750 | 22 | 1.6e-82 | 280.44 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-365/365 Sequence Identity: 22% (85 aa) YDIEERLGSGKFGQVFRLVEKKTGKIW------------------AGKF--FKAYSAKEKDNIRQEISIMNCLH----------------HPKLVQCVDA |.. . .|.| ||.|.. .|..| ..|. | .. ... .| |||.||.... || ....... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--EKANIVMVLEIVSGGELFERIIDEDFE----------LTERECIKYMRQISE---------------GVEYIHKQG-IVHLDLKPENIMCVNKTGT |. . || .|.| ..||.||..|.. . .||.|....|.|| . ..||.|... |.| |.|||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ RIKLIDFGLARRLEN----------AGSLKVLF-----------------------GTPEFVAPEVINYEP---------IGYATDMWSIGVICYILVSG ||.|||||.... . .. .. . |||...|||..|... .|. |.||.||| |....| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG LSPFMGDNDNETLANVTSATWDFDDE--------------AFDEISDDAKDFISN----LLKKDMKNRLD-CTQCLQHPWL || . . .||. . ....|...||.|.. .|.|| ..|.. |.|.|||. KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | smMLCK.AA | CDPK | 1495-1750 | 36 | 6.1e-82 | 251.13 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-271/271 Sequence Identity: 36% (101 aa) YDIEERLGSGKFGQVFRLVEK-KTGKIW-AGKFFKAY--SAKEK-DNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLE--IVSGGELFERIIDEDFE |.|.. ||.| ||||.. ..| ||. . | | . . ||. .. .|| |. | || .. .. . |. |.| ...|||||..||.. YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH- LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIM-CVNKTGT----RIKLIDFGLARRLENA-----GSLKVLFGTPEFVAPEVINYEPIGYATDMWS .||.| ..|||| | |.|...||| |||||||. . .|... ||.||.|.... . . .. .||| .||||.. . | || FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWS IGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL .||| ||| .| || |.||.|....| .|... .|.|||.||| |...| .| |.|. . |.||||| CGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | smMLCK.AA | TyrKc | 1495-1750 | 20 | 5.3e-14 | 3.71 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1495-1750 Range on HMM: 1-280/280 Sequence Identity: 20% (61 aa) YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCL--HHPKLVQCVDAFEEK-------ANIVMVLEIVSGGELFERIIDED .. ||.| ||.|.. . | | | |... . ...|..|| | ||| .|... . .. . .|.| ...| | ... . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR FELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENA-------GSLKVLF--GTPEFV-----APEVINYEPIGY .|. .. .... ||..| ||.|.....| || |.. .. ..| ||||.| ... .. |. . |||.||| PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT ATDMWSIGVICY-ILVSGLSPFMG-----DNDNETLANVTSA-TWDFDDEAFDE-----ISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL ..| || || .. |. | .| | .. | ...| . . ... . .|. . .. . | ..| ... | . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | smMLCK.AA | Pkinase_Tyr | 1495-1617 | 25 | 4.2e-09 | 31.47 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 1495-1617
Range on HMM: 1-137/270
Sequence Identity: 25% (35 aa)
YDIEERLGSGKFGQVFRLVEK----KTGKIWAGKFFKAYSAKE---KDNIRQEISIMNCL-HHPKLVQCVDAFE-EKAN--IVMVLEIVSGGELFERIID
. . ||.| ||.|.. . | .|. | | | .. .| .. .|..|| | |||..|... . .. | .|.| . .| | . .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
E---DFELTERECIKYMRQISEGVEYIHKQGIVHLDL
. || . ... .||..| || . ....| ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
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| I-set | smMLCK.AA | I-set | 1840-1930 | 53 | 1e-48 | 167.81 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1840-1930 Range on HMM: 1-92/92 Sequence Identity: 53% (49 aa) PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRE-SRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV |.|.....|.|| ||..|||.|...|.|.|.|.||||.| .|. |...|..||.||...|.||.|. || ||||.|.||.|||.|||||.| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | smMLCK.AA | IGc2 | 1852-1920 | 30 | 3e-17 | 64.56 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1852-1920 Range on HMM: 1-56/56 Sequence Identity: 30% (21 aa) VEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLG || .... |. .|.|||.. |.| .|.. .| .| |..| .|. .|||.| |. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | smMLCK.AA | IG | 1846-1931 | 16 | 8e-13 | 49.85 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1846-1931 Range on HMM: 1-58/58 Sequence Identity: 16% (15 aa) IRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDD---AKYTCKAVNSLGEATC--TAELIVE . ..|.||. ... | .. .. |. |.| .| .| . |.| | |.... ...|.|. PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| V-set | smMLCK.AA | V-set | 1847-1930 | 15 | 0.079769 | 8.12 | Pfam | 10-128 (128) | Show / Hide |
Range on Protein: 1847-1930 Range on HMM: 10-128/128 Sequence Identity: 15% (19 aa) R----DLEVVEGSAARFDCKIE-GY----PDPEVVWFKDDQSI---------------------------RESRHFQIDYDEDGNCSLIISDVCGDDDAK | ..|.|| ... |. .| .. . |... |. .....|. . . ....|| ||.. .| . RGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPS-KNDFSLTISNLQPSDSGT YTCKAVNS-LGEATCTAELIV |.| . |. . .|.| YYCAVWNCNEDYFGHGTRLTV |
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