Gene SMG1 (Mouse)

SMG1

Species: Mouse
Alias: SMG1, C130002K18Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: SMG1

Sequence

Name Sequence Type Origin Length Description Download
SMG1.NA RNA Sugen 11227 None Fasta, JSON
SMG1.AA Protein Sugen 3658 None Fasta, JSON
SMG1.kin_dom Protein Kinase Domain None 299 None Fasta, JSON

Protein domain

Protein domains of SMG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FATC SMG1.AA FATC 1465-1475 45 5.137683 3.05 Pfam 1-11 (33) Show / Hide 
Range on Protein: 1465-1475
Range on HMM: 1-11/33
Sequence Identity: 45% (5 aa)

KKLSTQGQVDE
..||...|||.
EPLSVEQQVDR
HEAT SMG1.AA HEAT 1820-1850 32 2.6e-05 22.26 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1820-1850
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

IIPQLFSRLNHPEVYVRQSICNLLCRVAQDS
|.| |.. ||.|.  ||.. |. |..... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase SMG1.AA SMG1 2126-2367 97 1.2e-228 764.99 In-house 1-242 (242) Show / Hide 
Range on Protein: 2126-2367
Range on HMM: 1-242/242
Sequence Identity: 97% (237 aa)

ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAA

LQAQKAQDSYQTPQNPSIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMV
|||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMV

GYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPE
||||||||||||||||||||||||||||..||||||.|.|||
GYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase SMG1.AA PIKK 2118-2415 43 4.3e-165 554.75 In-house 1-290 (290) Show / Hide 
Range on Protein: 2118-2415
Range on HMM: 1-290/290
Sequence Identity: 43% (130 aa)

TIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK
 | .    .|....|.||||....|.|||.||||.||.|||..|.|.||.....||.............|.|.|||.|...|.|||.|||....|...||
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

RWQQREAALQAQKAQDSYQTPQNPSIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYAR
.|.|.......|.||..|||.... .....|         ..|..... ......||||....|..|.|..|||....|..|.....|..||.....|.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS---------YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTR

STAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE-KGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAF
|.|||.|||||.||||||..|..|||.|||.||||...||| ... |.||||||||.|.|...|.|..||||||| .||.|...||..||||.|..|.|
SYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase SMG1.AA PI3_PI4_kinase 2147-2425 23 2.4e-68 238.19 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2147-2425
Range on HMM: 1-300/300
Sequence Identity: 23% (76 aa)

SYPYLFKGLEDLH--LDERIMQFLSIVN-------------------TMFATINRQETPRFH----ARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQ
 ||..||| .||.   |.|.||.....                    ... .. ...   .     ...|.. |.|...|.|.||. .|.. .. . .  
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

REA--ALQAQKAQDSYQTPQNPSIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTP-DEWWRVTQSYARS
...  ... .. .   ..| ... .                              .  .. | |. .  ||.. | ...|.. ... .|||.. . ..||
KCKHKHFNKEHKMWMKMWPDWWHLM------------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRS

TAVMSMVGYIIGLGDRHLDNVLI--DMTTGEVVHIDYNVCFE--KGKSLRVPEKVPFRMTQ------NIETAL------GVTGVEGVFRLSCEQVLHIMR
 |.|..|.||.|.||||.|| ..  |.|||...|||.. ||.  |.| . .||.|||| |.      ..  |.      ...| .| || .|.... ..|
CAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALR

RGRETLLTLL-------EAFVYDPLVDWTA
|  . ...||       |..|.|.|..|. 
RHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase SMG1.AA PI3Kc 2149-2493 21 5.3e-52 180.0 SMART 1-336 (336) Show / Hide 
Range on Protein: 2149-2493
Range on HMM: 1-336/336
Sequence Identity: 21% (77 aa)

PYLFKGLEDLHLDERIMQFLSIVNTMFATI----NRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK---RWQQREAALQAQKAQDSYQTPQNP
. .||. .||. |.|.||.....|.. ..     .|     .|.| |.. |.| ..|.|.||  ...|  . |    |.  . ...  .  |   .|.  
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRR----DLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ

SIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPD-EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVL
    ..  .  .. .  ...    .. ..       .... |.   ...|. |.. .|. ...|. .|| .   ..||.|...||.|| |.||||.|| .
-K-NMY-MMIWHQQACHWMMMYQHMTHME-------WLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIM

IDMTTGEVVHIDYNVCFEKGKSLRVP-----EKVPFRMTQNIETALG----VTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPL-VDWTAGGEAG
.||.||...|||.. .|..|... ..     |.|||| |... .. |    ..|..| ||  |.... .||. ......|.|..||||.  .|...    
LDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----

FAGAVYGGGGQQAESKQSKREMERE-ITRSLFSSRVAE-IKVNWFKNR-DEMLVVLPKLDSSLDEY
           .   |. .  .. .  .  . . ...   ..   ..  ..... .  ..  . .|
-----------EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase SMG1.AA ATM 2305-2424 54 1.5e-50 159.52 In-house 130-249 (304) Show / Hide 
Range on Protein: 2305-2424
Range on HMM: 130-249/304
Sequence Identity: 54% (65 aa)

PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRG
|  |.     | || |  |.||||.||||||  |.||     |.||||  | ||.|| |  || ||||.|  |   .|.||||||||  ||. . .||  
PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNS

RETLLTLLEAFVYDPLVDWT
 |||||. |  .|||| |||
QETLLTIVEVLLYDPLFDWT
Kinase SMG1.AA ATR 2305-2415 46 3.7e-48 161.98 In-house 157-267 (267) Show / Hide 
Range on Protein: 2305-2415
Range on HMM: 157-267/267
Sequence Identity: 46% (52 aa)

PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRG
| .|.   . | ||.||..|||||||||||| ||.|||  .||.||.|||. | .|. . ||| ||||.|.|.. ..|  . .|.||  || .. .||  
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDH

RETLLTLLEAF
|. .. ....|
RDDIMSVWDCF
Kinase SMG1.AA FRAP 2281-2425 41 4.9e-42 145.97 In-house 106-251 (251) Show / Hide 
Range on Protein: 2281-2425
Range on HMM: 106-251/251
Sequence Identity: 41% (60 aa)

VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKG-KSLRVPEKVPFRMTQNIET
. .  |. |  . |.| ||      . |      | || |.|||.|||.||||||. |....  || .||||.  |||   .  . |||.|||.|  .  
IFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVN

ALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTA
|. ..|.|| .|  || |. ..|  .| ..  |||||||||  |  
AMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase SMG1.AA DNAPK 2315-2425 29 1.4e-21 75.14 In-house 190-301 (301) Show / Hide 
Range on Protein: 2315-2425
Range on HMM: 190-301/301
Sequence Identity: 29% (33 aa)

YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE-KGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLE
..|. ||    ..| | |||||.| .. | .|... ||.   |   .  | |||  |||.|      .   .. |... .    .  .|. |  |.   .
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

AFVYDPLVDWTA
 |. ||..||  
VFINDPSFDWKN
Kinase SMG1.AA ATR 2117-2207 32 1e-13 42.66 In-house 1-91 (267) Show / Hide 
Range on Protein: 2117-2207
Range on HMM: 1-91/267
Sequence Identity: 32% (30 aa)

VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
  |      . || .  ||||. . ||||| |  . |  .||  | | |.| ...| .     ..    .| | |.| ||  ....| ||.
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVN
Kinase SMG1.AA FRAP 2148-2206 35 6e-13 44.02 In-house 2-60 (251) Show / Hide 
Range on Protein: 2148-2206
Range on HMM: 2-60/251
Sequence Identity: 35% (21 aa)

YPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV
| .| || ||.  |||.||   ..|.. .     .      . ||. || ...||| ||
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWV
Kinase SMG1.AA DNAPK 2117-2207 31 1.4e-11 38.18 In-house 2-92 (301) Show / Hide 
Range on Protein: 2117-2207
Range on HMM: 2-92/301
Sequence Identity: 31% (29 aa)

VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
| |      .|..    .||...  | | .  |...|| ||| .| || |   . |  |.            | |.. |.  | ||| |||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVD
Kinase SMG1.AA ATM 2150-2211 30 0.000463 8.42 In-house 2-63 (304) Show / Hide 
Range on Protein: 2150-2211
Range on HMM: 2-63/304
Sequence Identity: 30% (19 aa)

YLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATP
 | || .||  |  . |   . ||.          .     | | ||  ||| . |  |  |
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIP
FATC SMG1.AA FATC 3626-3658 48 1.4e-15 52.92 Pfam 1-33 (33) Show / Hide 
Range on Protein: 3626-3658
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

RRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV
  .|| .|||  |.|||. .||.|.| || .|.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW