Gene SLK (Mouse)

SLK

Species: Mouse
Alias: Stk2, SLK
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: SLK

Sequence

Name Sequence Type Origin Length Description Download
SLK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
SLK.AA Protein Sugen 1233 None Fasta, JSON
SLK.NA RNA Sugen 4239 None Fasta, JSON

Protein domain

Protein domains of SLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SLK.AA SLK 34-292 76 1.7e-186 625.84 In-house 1-259 (259) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-259/259
Sequence Identity: 76% (198 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQ
|||||||||||||||||||.||..|.||||.|..|.||||||||||||||..|.|||||||..|.||.|.||..||||.|||||..|.|||.||||.|||
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

VVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEP
.|||...||||.||.||.|||||||||||.|.|||..||||||||||..|.|.||.|||||||||||||||||.||.|||||||.|||||||||||..||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
||||.|||||||||.|||||||.|||.||..|||||.|||.|....||||.||.||..|
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase SLK.AA STE20 34-292 45 2.2e-154 519.18 In-house 1-288 (288) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-288/288
Sequence Identity: 45% (130 aa)

WEIIGELGDGAFGKVYKAQNKETNVL----AAAKVIDTKSE----EELEDYMVEIDILASCDHPNIVKLLDAFYYE----NNLWILIEFCAGGAVDAVML
.|.. ..| |..|||||| .|.|. .    .| |... ...    .|.|| . ||.|.. |.|||||| .......    ..|||..|.|.|| .  .| 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ELER-----PLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTR----TIQ-RRDSFIGTPYWMAPEVVMCETSK
   ....     |..|.|| ..|...|..|.||| |.|||||.||.||| | ||..|||||||.|. |.    |.| .|..|.||||||||||..|....
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIA--KSEPPTLAQ--PSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
| .||||.|.||||||.||||| |||.....|||....|.  . .|||| .  |.|||..|.||. |||.|... |.|.||||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase SLK.AA STE 34-292 33 4.1e-131 441.88 In-house 1-359 (359) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-359/359
Sequence Identity: 33% (123 aa)

WEIIGELGDGAFGKVYKAQNK------ETNVL---------AAAKVIDTKSE-----------------EELEDYMVEIDILASCD--HPNIVKLLDAFY
||.|...| ||||.|||| |.      .|. .          | |... ...                 ||..... ||.|.  |.  |||||| .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YE-------NNLWILIEFCAGGAVDAVML---ELERPLT----------ESQIQVVCKQTLEA-LNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSA
.|       ..|||  |...|| .| ..    .  .||.          |||| ..|.|.|.. |.|||...|||||.|..|||.     .||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KNTR---------------TIQ-RRDSFIGTPYWMAPEVVMCETSK-DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS-----------
. |                |.| .|..|.||| ||||||....... | .||.|.|.||||.|.||||. .||.|...|||... |...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----EPPTLAQ-----------------PSKWSSNFKDFLRKCLEKNVDARWTTSQLLQ--HPFV
    .||.| .                 |.|||..||||..|||.|. . |.|.||||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase SLK.AA MST 34-292 47 5.70000000001e-122 389.5 In-house 1-254 (254) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-254/254
Sequence Identity: 47% (124 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVMLELERPLTESQ
 .|.. || |..|.|||| .|.|. . | |.. .  .| |..   || |.  |. ..|||. . ..  ..| .|| .|.|..| |  .|    |.|.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEI
| .....||  | ||||||.||||.||||||   .|  ||||||||.  | |   |...||||||||||| .   .|   ||.||| |||||| ||||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ--EIK---YDCKADIWSLGITAIEMAEG

EPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
.|| ... |||.. .| .. |||.  |..||..| ||..||| || . |||  |||||||.
MPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase SLK.AA YSK 34-292 41 4.5e-108 326.55 In-house 1-257 (257) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-257/257
Sequence Identity: 41% (109 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVID-TKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLE-LERPLTESQ
. .    | | || |||. .. |.   | |.||  ..|.| ||   || .|..|| |.| | . ..     |||  |.|.|| .   |      .. |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEI
| .. .  | .| ||| .. |||| || |.| . .||.||.||||... | | ..|. |.||||||||||...| |.   ||.|||.|||||| .|||  
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSY---YDFKADIWSLGITAYEMAKG

EPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
|||. .. ||||.  | |..||.|   ...| .||.|   ||.|.   | . ..|| | |.
EPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase SLK.AA S_TKc 34-292 34 1.9e-101 344.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAG--GAVDAVMLELERP-----
.||. ..| ||||||||...|.|. . | |.|.       |. . ||.|| . .|||||||.|.|.  ..|..  |.| |  | .  .. .  |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDY-KADVWSLGITL
..| ... ...|...||.|.|...|||||||  |||..    ||..|||....        ..|.|||..|||||.        .|.. |.|.||.|..|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQ-------HPFV
.||.  .|| .    | ...|. .            |. .|||.||||.|. . |.|  ..||       ||..
YEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SLK.AA PAKL 34-292 43 7.4e-96 324.76 In-house 1-256 (256) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-256/256
Sequence Identity: 43% (114 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYE-NNLWILIEFCAGGAVDAVMLELERPLTESQI
 |.   ||.|..| ||||  |.||   | |||  |   | .|   ||.||  |  ||||        . |..||| ..|. | .  .|   .  |.| ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

QVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQ-RRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEI
 |. .|||  | |||   ||||| || ||| . |...|.|||||| .   .      . ||||||||||..     .  .|..|.|.||||||.||||. 
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEII-----NKQNYNNKCDIWSLGITAIEMADG

EPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
.||| ...||| .. |    |||.. | .||  | ||| .|. |    ||  ..|| ||| 
FPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase SLK.AA KHS 34-292 45 7.4e-96 322.92 In-house 1-258 (258) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-258/258
Sequence Identity: 45% (118 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQ
.|..  .| | .| ||||...... ||| |||    .....    || ..  | |||||    ..  .. ||| .|.| ||..  .  ..  ||.| || 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIY-HVTGPLSELQIA

VVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEP
 ||..||..|.||| .. .|||.|  ||| | .||.|||||||||. | || .| |||||||||||||   |  .   |.   |.|..||| ||.||. |
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDIWAVGITAIELAELQP

PHHELNPMRVLLKIAKS--EPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
|  .| |||.|. ..||  .||.| . .|||..| .|.. .| ||   | | ..|||||||
PMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase SLK.AA PAKA 34-292 39 3.4e-95 322.55 In-house 1-260 (260) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-260/260
Sequence Identity: 39% (104 aa)

WEIIGELGDGAFGKVYKAQNKETNVL--AAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELER----PL
 . . ..| || |.||.| |..||     | |... | .   |  . || .. .| |.|||. .|.. ..  ||. .|. .||    |  . ..    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

TESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIE
.|.||  ||...| .|...|....||||.|  |||   ||..|..|||  |  |.  |.|..  ||||||||||.     . . ||.| |.||||| .||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVI-----RRKQYDEKVDIWSLGIMAIE

MAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
|.| |||. . .| | .  ||.   | . .| |||..|.||| |||...|| |.....||.||| 
MIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase SLK.AA Pkinase 34-292 30 1.1e-91 315.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMV----EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGG----AVDAVML-ELE
..|.. .| |.||.|||...| |. . | |.|. ..|.. .|.      || |.....|||||.|.|.|........  |.| ||       ...  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPL--TESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDI----KLADFGVSAKN-TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKAD
...  .| ... ...|.|..|.|.|...|||||||  |||.  .|.|    |..|||....  .   .  ..| |||..|||||..    ....|..|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVD

VWSLGITLIEMAEIEPPHHEL----NPMRVLLKIAKSEPPTLAQPSKWS---------------------SNFKDFLRKCLEKNVDARWTTSQLLQHPFV
.||.|..|.||.  .||  .     | .. . .|..  .| |  .. |.                     ...|||...||.|.   |.|  |.||||..
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SLK.AA NinaC 34-292 41 1.3e-89 304.0 In-house 1-267 (267) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-267/267
Sequence Identity: 41% (110 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDIL-ASCDHPNIVKLLDAFYYEN-----NLWILIEFCAGG-AVDAV--MLELE
|||. . | | .|||.|..||.   .|| |. .  .. . |.   |  || . |||||.|.    .|         ||. .|.|.|| ..| |  .| ..
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHD-EEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCG

RPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGIT
| . |  |  . . .. .|  || |..|||| |  ||| | .| .|| ||||||  . |  ||   .|||.||||||. |. . |  ||  .||||||||
RRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGIT

LIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
 ||..  .||  .. ||| . ||    |||| .| .|.  | ||  .||||.   | . ...|.|||.
AIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase SLK.AA MSN 34-292 44 8.9e-88 289.91 In-house 1-265 (265) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-265/265
Sequence Identity: 44% (118 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILAS-CDHPNIVKLLDAFY------YENNLWILIEFCAGGAV-DAVMLELER
.|..  .| |..|.||| . . |  ||| ||.| . .|| |.   ||..|     | ||.    ||        .. ||. .|||. |.| | |    ..
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEE-EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

PLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL
 | |  |  .|.  |  | .|| .|.||||.|  |.|.| . ..|| ||||||.  ||. || .||||||||||||. |. . |. |||..|.||.||| 
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
||||| .||  .. ||| |. | .  ||.|   .|||  |..|. ||| ||   | .| |.|.|||.
IEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase SLK.AA Pkinase_Tyr 34-177 30 5.4e-23 78.51 Pfam 1-158 (270) Show / Hide 
Range on Protein: 34-177
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

WEIIGELGDGAFGKVYKAQNK----ETNVLAAAKVI-DTKSEEE--LEDYMVEIDILASC-DHPNIVKLLDAFY-YENN--LWILIEFCAGGAVDAVMLE
 ... .|| ||||.|||.  |    .|..  | |.. .. ..|.  .|| | |. |. .  .|||||.|. . .  .    ..|  |....|  .    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

L---ERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS
    ..||| ...   | |  ....||.....||||| | |.| | .. .| .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase SLK.AA TyrKc 34-292 23 8e-19 69.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASC--DHPNIVKLLDAFYYE-------NNLWILIEFCAGGAVDAVMLELE
 . . .|| ||||.|||.. |   .  | |..   .   .|| | |. |. .   .|||||.|. .   .         |.|. |....|. .    . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRT--------IQRRDSFIGTP-----YWMAPEVVMCETSKDRP
. |. ..    | |  .  .|||....||||| | |.| . .. .| .||| | . .            |  .  |.       |||||.      ... 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGK

YDYKADVWSLGITLIEMAE-IEPPHHE-----LNPMRVLLKIAKSEPPTLAQPSK--------WSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV
.  | |||| |... |.    ..|. .     ... .|. .. . .   . ||           ..   .  ..| . . . | | |..  | . 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SLK.AA Pkinase_Tyr 196-280 22 2.4e-07 25.49 Pfam 180-260 (270) Show / Hide 
Range on Protein: 196-280
Range on HMM: 180-260/270
Sequence Identity: 22% (20 aa)

WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPP-HHELNPMRVLLKI-AKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDAR
|||||. .        .  | |||| |... |.    | |   .. . .|. .|  . .   ...| . .    | ...| ... . |
WMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDR
PKK SLK.AA PKK 849-988 36 6.3e-39 140.44 Pfam 1-144 (144) Show / Hide 
Range on Protein: 849-988
Range on HMM: 1-144/144
Sequence Identity: 36% (53 aa)

KLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNVLKNRKK--EVMNEVEKAP--RELRRELTK
|.|.|.||. ..|.|.. ....... |.|..|.||||.||..||..|...|...|||. ||||.. .|.. ||..||  |.  |||| |  || |..  |
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

RRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIE
...||. | .  |||||| ....... ...... ... .|...|
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE
PKK SLK.AA PKK 1017-1158 52 4.1e-64 224.12 Pfam 1-144 (144) Show / Hide 
Range on Protein: 1017-1158
Range on HMM: 1-144/144
Sequence Identity: 52% (75 aa)

KHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTA-TPDQDREKIKQFAAQEEKRQK
|||| |.|.|||.|.||||.||||||| |||.|.....||... |||||| ||||..|.|...||.|||.||.|.... .| |..||..||  |...|.|
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

NERMAQHQKHESQMRDLQLQCEANVRE-LHQLQNEKCHLLVEHE
.|.  ..|||. |..... ||| |..| . |.|||..|.|.|||
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE