Gene SgK223 (Mouse)

SgK223

Species: Mouse
Alias: D8Ertd82e, SgK223
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NKF3

Sequence

Name Sequence Type Origin Length Description Download
SgK223.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 321 Kinase domain by global Sugen HMM Fasta, JSON
SgK223.NA RNA Sugen 4506 None Fasta, JSON
SgK223.AA Protein Sugen 1373 None Fasta, JSON

Protein domain

Protein domains of SgK223.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK223.AA NKF3 973-1295 62 1.6e-302 833.22 In-house 1-360 (360) Show / Hide 
Range on Protein: 973-1295
Range on HMM: 1-360/360
Sequence Identity: 62% (225 aa)

TCNKPCCDSGDAIYYCATCSEDPGSIYAVKICKTP--EPKSASYCS-----PSVPVHFNIQQDCGHFVASVPSSMLAS--PDTSS---------------
||.||||.||||.|||||...||||.||||||..|  ...|..||.     .|.|||||||||||||.|.|||.||..  ||...               
TCDKPCCRSGDAVYYCATHPKDPGSNYAVKICCDPNKAKQSQQYCHMTKVMQSHPVHFNIQQDCGHFIAEVPSRMLQWEDPDAPEKDEDDMEDTEEDAKA

----KDTAPAVSPQPPAQE---------QDCVVVITREVPHQTASDFVRDSMASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAHC
    |...|.....||.||         |||||||||||||||..||||||||.|..|||||||.|||.|||||.||.|||||...|.|||||||||.||
ETDGKNPSPCLETHPPQQENQRVMNRKQQDCVVVITREVPHQTVADFVRDSMAHHEHEPEVYERQVCFMLLQLCQGLCHLKEHHMCHCDLCLENLLLVHC

NPQSSPGPSATPTVPTTTSRCPSAAPAATTACQGGPGEKQLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELLHQP
.||..|....||..||||.|||||||..||||..||.||||||||||||..||||.|.|.|.|||..|||||||||.|.||.|..||||||||||.||||
QPQGGPHQGPTPADPTTTARCPSAAPCPTTACPEGPREKQLPRLIISNFMQAKQKSGHTVNPQQKRDQARLAPEIVTAKQYQKCHEFQTGILIYEMLHQP

NPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCL
|||..|.|||||||.|.|||..|..|.||.|||||||.||...|..|||...|||.||||
NPFDTRPQLRERDYTRDDLPRIPVRSPYSWGLQQLAHCLLNKNPQDRIRCNQAKRILQCL
Kinase SgK223.AA Aur 1098-1132 42 4.7e-09 19.51 In-house 100-134 (257) Show / Hide 
Range on Protein: 1098-1132
Range on HMM: 100-134/257
Sequence Identity: 42% (15 aa)

ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL
| | ..   |.||.|... . .|||||.  ||.||
EQRAAKYMYQICNALDYCHSKNIIHRDIKPENILL
Kinase SgK223.AA RSK 1098-1134 43 8.4e-08 24.98 In-house 103-139 (278) Show / Hide 
Range on Protein: 1098-1134
Range on HMM: 103-139/278
Sequence Identity: 43% (16 aa)

ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAH
|...|| . ..   .||| ..||||||| .|| |...
EDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDD
Kinase SgK223.AA S_TKc 987-1295 14 2e-07 -67.9 SMART 16-231 (231) Show / Hide 
Range on Protein: 987-1295
Range on HMM: 16-231/231
Sequence Identity: 14% (50 aa)

YCATCSEDPGSIYAVKICKTPEPKSASYCSPSVPVHFNIQQDCGHFVASVPSSMLASPDTSSKDTAPAVSPQPPAQEQDCVVVITREVPHQT--------
|...  .  | |.|.|| |                                                                | ||.            
YKCRHKK-TGRIVAIKIIK--------------------------------------------------------------EHIRREIQILKKHHPNIVK

------------ASDFVRD---SMASHRAEPE-------VYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAHCNPQSSPGPSATPTVPTTTSRC
              ...     .. ..  .           | ...|.. |.|..||.. .||||||||  ||.|| .                      
LYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------------------

PSAAPAATTACQGGPGEKQLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQYRKFDEFQT--------GILIYELLHQPNPFEVRAQLRERD
                     .. |. |  |.|         .  .   .|||..          . .        |...||.|    ||.   . .  .
---------------------HIKICDFGLARQL------TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFK

YRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR------VLQCL
  .            || . ..   .|. || ||. . || .        . .
KIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SgK223.AA CAMK 1098-1134 37 2.9e-07 18.69 In-house 178-214 (425) Show / Hide 
Range on Protein: 1098-1134
Range on HMM: 178-214/425
Sequence Identity: 37% (14 aa)

ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAH
|| ....  |.| ..... .|.|.|||| .||.|| .
EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDD
Kinase SgK223.AA RSK 1098-1133 41 3.1e-07 22.1 In-house 100-135 (271) Show / Hide 
Range on Protein: 1098-1133
Range on HMM: 100-135/271
Sequence Identity: 41% (15 aa)

ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLA
|| |.| .. . . .|.| ..||.||||  || |..
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYD
Kinase SgK223.AA AMPK 1098-1134 48 5.2e-07 16.91 In-house 114-150 (254) Show / Hide 
Range on Protein: 1098-1134
Range on HMM: 114-150/254
Sequence Identity: 48% (18 aa)

ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAH
||  | .. |  .|.| . .|.| |||| .||||| |
EREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDH
Kinase SgK223.AA DCAMKL 1098-1132 42 5.3e-07 17.23 In-house 114-148 (279) Show / Hide 
Range on Protein: 1098-1132
Range on HMM: 114-148/279
Sequence Identity: 42% (15 aa)

ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL
||    ....||. |..| | .|.|||. .||||.
ERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLV
Kinase SgK223.AA Ciliate-C1 1107-1132 46 8.1e-07 13.14 In-house 137-162 (328) Show / Hide 
Range on Protein: 1107-1132
Range on HMM: 137-162/328
Sequence Identity: 46% (12 aa)

QLCNGLEHLKEHGIIHRDLCLENLLL
|| |... . . .| |||| .||.||
QLINVIQYIHQNNICHRDLKPENILL
Kinase SgK223.AA CAMKL 1107-1134 39 1e-06 16.92 In-house 135-162 (297) Show / Hide 
Range on Protein: 1107-1134
Range on HMM: 135-162/297
Sequence Identity: 39% (11 aa)

QLCNGLEHLKEHGIIHRDLCLENLLLAH
|.. ..... .|||.|||. .||.|| .
QIVSAVNYCHSHGIVHRDIKPENILLDE
Kinase SgK223.AA NKF2 1225-1282 31 4.8e-05 13.84 In-house 288-355 (365) Show / Hide 
Range on Protein: 1225-1282
Range on HMM: 288-355/365
Sequence Identity: 31% (22 aa)

GILIYELLHQPNPFEV----------RAQLRERD--YRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKR
| ..|| . | |||             . |  .   |.  .||..|  .   |.|.||  .||  || ||
GAIAYEIFGQKNPFYSSSGGMAREQGEMHLDSCNSDYQEDQLPQMP--QSCPPVLRQLVYNLLQRDPSKR
Kinase SgK223.AA Pkinase 1098-1132 45 5.4e-05 18.73 Pfam 107-141 (293) Show / Hide 
Range on Protein: 1098-1132
Range on HMM: 107-141/293
Sequence Identity: 45% (16 aa)

ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL
|. ..| ..|.. |||.. ..||||||| .||.|.
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase SgK223.AA TyrKc 1021-1292 12 0.000485 -157.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 1021-1292
Range on HMM: 1-280/280
Sequence Identity: 12% (42 aa)

VHFNIQQDCGHF------VASVPSSMLASPDTSSKDTAPAV-SPQPPAQEQD--------CVV------------VITRE-------VPHQTASDFV---
.... .  .|.|      ...               .  || . .. | ..|        | .            |.| .        |.     ..   
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

--RDSMASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAHCNPQSSPGPSATPTVPTTTSRCPSAAPAATTACQGGPGEKQLPRLII
  .|   .|| .  .  .  .   .| ..| |.| ....|||||   | |... .                                         .  |
DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------------------------------TVKI

SNFLKAKQKPGG-------TTNLQQKKSQAR-------LAPEIVSASQYRKFDEFQT-----GILIYELLHQ------------PNPFEVRAQLRERDYR
| |  ..    .        .  ........       .|||     .|.||  ...     |....|..               ...||..........
SDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM

REDLPPLPTLSL----YSPGLQQLAHLLLEADPIKRIRIGEAKRVL
.    ..    .     .. . |.     ..|| .| .  | .. .
PQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SgK223.AA NKF2 1099-1132 29 0.000829 9.32 In-house 182-215 (365) Show / Hide 
Range on Protein: 1099-1132
Range on HMM: 182-215/365
Sequence Identity: 29% (10 aa)

RRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL
. .  ...|.  .  ||  ||. |||.   | |.
WTRMMMIAQMLEACDHLHQHGVAHRDMKSDNILV
Kinase SgK223.AA AMPK 1264-1294 32 0.061864 1.6 In-house 224-254 (254) Show / Hide 
Range on Protein: 1264-1294
Range on HMM: 224-254/254
Sequence Identity: 32% (10 aa)

SPGLQQLAHLLLEADPIKRIRIGEAKRVLQC
||  ..| . .|. ||.||| | . .    .
SPEAKDLIKHMLQVDPMKRITIHDIRNHPWF