Gene SgK085 (Mouse)
SgK085
Species: Mouse
Alias: SgK085
External Links:
Annotation:
Sequence
Protein domains of SgK085.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | SgK085.AA | MLCK | 107-362 | 63 | 8.70000000001e-242 | 645.42 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 107-362 Range on HMM: 1-257/257 Sequence Identity: 63% (164 aa) VSKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDKEDVKNEISVMNQLDHVNLIQLYDAFESKHDIILVMEYVEGGELFDRIIDENCNLTELDTI .. | ||.|.||.||.|.||.||...|||.||.| .||||.|||||..||||.| ||||..||||.|......|||..|||||.||.||...|||...| YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI LFMKQICEGIRYMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREK-LKVNFGTPEFLAPEVVNYDFVSFSTDMWSVGVITYMLLSGLSPFL ..|.|||||...||...|.|||||||||.|..| .|||||||||||.|.|.|| .||.||||||.||||||||.|.|.|||||||||.||||||||||. HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM GDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL ||||.||..|...|.|| .||.|.|||.||| |||.||.|.|..| .|.|.|.|||| GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL |
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Kinase | SgK085.AA | DAPK | 109-362 | 47 | 4.7e-134 | 371.69 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 109-362 Range on HMM: 1-264/264 Sequence Identity: 47% (125 aa) KSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDK------EDVKNEISVMNQLD-HVNLIQLYDAFESKHDIILVMEYVEGGELFDRIID--ENCN .| || |.| | || .| ||.. ||| || | . |. . ||.. .. | |.| | ...| . |.||. ||| |||||| . | | MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREEC- LTELDTILFMKQICEGIRYMHQMYILHLDLKPENILCVNRDAKQ--IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFSTDMWSVGVITYML |.| | . ||||| ||..|.|. | ||||||.||. .| | ||||||||.|. .. | .. .||||..|||.|||. | .|||||.|||||.. LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM LSGLSPFLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL ||| ||||||. ||..|| ... | ..|.|. ||.|| || .|| |. | .| |.|.|||. LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI |
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Kinase | SgK085.AA | CAMK | 112-362 | 25 | 7.89999999999e-123 | 397.84 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 112-362 Range on HMM: 1-425/425 Sequence Identity: 25% (110 aa) ILGGGRFGQVHKCEEKATG------------LKLAAKIIKTRGAK----------------------------DKEDVKNEISVMNQ-------LDHVNL .|| |.||.|..|..| |. | |.|||... .| |.. |..||..|.. ||| |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IQLYDAFESKH-------------------DIILVM---EYVEGGEL----FDRIIDENCN--------------LTELDTILFMKQICEGIRYMHQMYI |.||...|..| ....|| ||..|||| ||.|.. |. .|| .. ...|||....|.|.. | IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LHLDLKPENILCVNRDA---------------KQIKIIDFGLARRYKP------------------------REKLKVNFGTPEFLA-PEVVNY------ |.||||||||..... .|||||||.|....| .|.| .||||. | |||.|. VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM --------DFVSFSTDMWSVGVITYMLLSGLSPFLGD-------------NDAETLTNILACRWDLEDEEFQD------------ISEE--------AKE . .....||||.|||.|..|.| .|| || || |.. .|.....| ....| . ||.| .| QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD FISKLLIKEKSWRISASEALKHPWL .|.|.| .. . |......|.|||. LIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | SgK085.AA | DAPK | 108-362 | 47 | 8.60000000001e-120 | 347.21 | In-house | 2-264 (264) | Show / Hide |
Range on Protein: 108-362 Range on HMM: 2-264/264 Sequence Identity: 47% (125 aa) SKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAK------DKEDVKNEISVMNQLD-HVNLIQLYDAFESKHDIILVMEYVEGGELFDRIIDENCNL | .| | | | || || ||.. ||| || | . ||. |.|. .. | | | | |..| | |..|. | | |||||| . .. | | DMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKEC-L TELDTILFMKQICEGIRYMHQMYILHLDLKPENILCVNRDAKQ--IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFSTDMWSVGVITYMLL .| | ||| .|...|| | |.||||||| .| . . |||||||||.| .| . | |||||| |||.||| . |||||.||||| || NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL SGLSPFLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL || ||||||. |||.|| | . . ..| |.. || || || .||.|. |. |.|.||| SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
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Kinase | SgK085.AA | Trio | 105-362 | 40 | 2.3e-114 | 294.58 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 105-362 Range on HMM: 1-258/258 Sequence Identity: 40% (105 aa) YTVSKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDKEDVKNEISVMNQLDHVNLIQLYDAFESKHDIILVMEYVEGGELFDRIIDENCNLTELD ||. . || | |||. |..| .||||. .|||.| | ..||| | | ... | | ...| |..|. ||. | .||| ... . ..| . YTF-QEEI-GRGRFSVVRRCWHKATGRTCAAKFIPYR-MMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWG-SYCESE TILFMKQICEGIRYMHQMYILHLDLKPENILCVNRDA--KQIKIIDFGLARRYKPR--EKLKVNFGTPEFLAPEVVNYDFVSFSTDMWSVGVITYMLLSG .. .| |. |...| |. |||||.||||.. . . | ||||.||| | . | | . |.||| |||... . || || ||.||.|| .||| VKTYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSG LSPFLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL |||....| ||. ||. . ..... |. .|..||.|| |.| . | .|||.| |||. ISPFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF |
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Kinase | SgK085.AA | CAMK1 | 105-362 | 38 | 3e-101 | 295.1 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 105-362 Range on HMM: 1-276/276 Sequence Identity: 38% (107 aa) YTVSKSEILGGGRFGQVHKCEEKAT---GLKLAAKII--KTRGAKDK----EDVKNEISVMN---QLDHVNLIQLYDAFESKHDIILVMEYVEGGELFDR | . | ..| | |..|..|..| | | . | |.| |. .|.. | ..|||..| ..|| | |..|. .||. .. ||||.| ||||||| YEFGK--EIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR IIDENCNLTELDTILFMKQICEGIRYMHQMYILHLDLKPENILCVNR-DAKQIK--IIDFGLARRYKPRE-KLKVNFGTPEFLAPEVVNY---DFVSFST |.. | || | . ||||.. . |||.. | | ||||||.|... . .|| |.||||...... | ..| .|||.. ||||... .. . . IVEKG-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKAC DMWSVGVITYMLLSGLSPFLGDN-DAETLTNILACRWDLEDEEFQDISEE-AKEFISKLLIKEKSWRISASEALKHPWL ||||.||||| || | .|| ..| |.| . |. | .. .. .||.. ||.||...| .. . |......|.|||. DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | SgK085.AA | Ciliate-E2a | 105-362 | 39 | 1.7e-92 | 272.61 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 105-362 Range on HMM: 1-275/275 Sequence Identity: 39% (110 aa) YTVSKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDK---EDVKNEISVMNQLDHVNLIQLYDAFESKHDIILVMEYVEGGELFDRIIDENCNLT | . | ..| | ||.| . . | || . |.|... . . .| | ..|||. | |||| |.|.||. .|... . |||||.|||||.|.|. .. . YKFIK--KIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFE E-LDTILFMKQIC-EGIRYMHQMYILHLDLKPENILCV--NRDA---KQIKIIDFGLARRYKPREK--LKVNFGTPEFLAPEVVNYDFV------SFSTD | . .|.|. .|. |||| |.| |||||||| . . ..|||||||||..... || ... ||| ..|||| |. | . . | EIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCD MWSVGVITYMLLSGLSPFLGDNDAETLTNILACRWDLEDEE-FQDISEEAKEFISKLLIKEKSWRISASEALKHPWL |||.||| | ||.| .|| | . .|.| .. .| |... | ....| |.| ...|.| | . ||.| .||.||| MWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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Kinase | SgK085.AA | S_TKc | 107-362 | 35 | 2.6e-92 | 313.9 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 107-362 Range on HMM: 1-231/231 Sequence Identity: 35% (95 aa) VSKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDKEDVKNEISVMNQLDHVNLIQLYDAFESKHDIILVMEYVEG--GELFDRIIDENCN----- . ...| | ||.|.|| .| || . | |||| |....||... . .| |...|||.|.. ... .||||..| |.|||.| . ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LTELDTILFMKQICEGIRYMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSF-STDMWSVGVITYMLL ..| .. .|.|||... |.|.. |.| ||||||||. . .|||.||||||.. . |||...||||. .. . |.||.|.| | .| FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML SGLSPFLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALK-------HPWL .| || ...... .|. |.|||.||.|.| |. . |..| |||. |||. CGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | SgK085.AA | DRAK | 109-362 | 40 | 1.8e-91 | 284.51 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 109-362 Range on HMM: 1-259/259 Sequence Identity: 40% (106 aa) KSEILGGGRFGQVHKCEEKATGLKLAAKIIKTR--GAKDKEDVKNEISV-MNQLDHVNLIQLYDAFESKHDIILVMEYVEGGELFD-RIIDENCNLTELD . .| |.| | || .| || ||| .| | | ..... || | |. | ..| | . .| . ..|||.|| |||.|. . |. ..| | TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKD TILFMKQICEGIRYMHQMYILHLDLKPENI-LCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFSTDMWSVGVITYMLLSGLSP . |.|| ||..|.|| | |||||| || | . |||.|||..| . | . |||...|||. ||| .. .|||||.||.||..|...|| VQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP FLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL |.|| || || | | .|.| .|..| || .|. .. |..| | |.|||| FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL |
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Kinase | SgK085.AA | CDPK | 107-362 | 38 | 1.1e-88 | 272.19 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 107-362 Range on HMM: 1-271/271 Sequence Identity: 38% (105 aa) VSKSEILGGGRFGQVHKCEEK-ATGLKL-AAKIIKTRGAKDKED---VKNEISVMNQLDHVNLIQLYDAFESKHDIILVME--YVEGGELFDRIIDENCN ....|| | |||| |. .| .|. . | |||. . ||||. ..||| .. |||| | |..| .. . . .||| |..||||||.||.... YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH- LTELDTILFMKQICEGIRYMHQMYILHLDLKPENIL-CVNRDAK----QIKIIDFGLARRYKPR-----EKLKVNFGTPEFLAPEVVNYDFVSFSTDMWS .|| .. . |.|| . |.|. | | |||||||| . . | .||.||.|....... .|.. .||| .|||| . . | || FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWS VGVITYMLLSGLSPFLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL ||| | ||.| || |.|| |.. .. .. ..|..|...||.||| |.|.| .. |.||..||.||| CGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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Kinase | SgK085.AA | Pkinase | 107-362 | 35 | 2.5e-88 | 304.52 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 107-362 Range on HMM: 1-293/293 Sequence Identity: 35% (104 aa) VSKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDKEDVKN----EISVMNQLDHVNLIQLYDAFESKHDIILVMEYVEGG----ELFDRII-DEN . ...| | ||.| || .| || . | |||| |..|...|. . ||..|. |.| | ..|||.||.| .| .||||.||| .|||.| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH CNL--TELDTILFMKQICEGIRYMHQMYILHLDLKPENILCVNRDAK--QIKIIDFGLARR--YKPREKLKVNFGTPEFLAPEVVN-YDFVSFSTDMWSV ... .| . . .|.||..|. |.|.| |.| ||||||||..|.. .||.|||||. | . . ... |||...||||.. . . . ||||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVITYMLLSGLSPFLGD------NDAETLTNILACRWDLEDEEFQDIS-----------------EEAKEFISKLLIKEKSWRISASEALKHPWL |.| | .|.| || |. .. . . .|. .... . .. .|| ||.|.||...| | . |..| ..|.|||. GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | SgK085.AA | Ciliate-E2 | 107-362 | 24 | 1.3e-81 | 277.48 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 107-362 Range on HMM: 1-365/365 Sequence Identity: 24% (93 aa) VSKSEILGGGRFGQVHKCEE-----------------------KATGLKLAAKIIKTRGAKDKEDVKNEISVMN-------------QLDHVNLIQLYDA . ...| | ||.| ||. |... . | ||.| .. . .. ..... .| ||.| |.|..|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--SKHDIILVMEYVEGGELFDRII--DENC--------NLTELDTILFMKQICE---------------GIRYMHQMY-ILHLDLKPENILCVNRDAK |. ... | |||||..||.|||.|. . .. ..|| . .||||.. ...|.|. |.| |.|||||| FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ QIKIIDFGLARRYKPR----------EKLKVNF-----------------------GTPEFLAPEVVNYDF---------VSFSTDMWSVGVITYMLLSG ||||||||...|.. .... . |||...|||..|. ... |.||.||| |..|.| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG LSPFLGDNDAETLTNILACRWDLEDEE--------------FQDISEEAKEFISK----LLIKEKSWRIS-ASEALKHPWL || . .|. | .|. .| ....|.|.| .|.| .| |. . ||. ....|.|||. KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | SgK085.AA | Pkinase_Tyr | 107-253 | 32 | 1.5e-19 | 66.84 | Pfam | 1-159 (270) | Show / Hide |
Range on Protein: 107-253 Range on HMM: 1-159/270 Sequence Identity: 32% (52 aa) VSKSEILGGGRFGQVHKCEEK----ATGLKLAAKIIKTRGAKDK----EDVKNEISVMNQL-DHVNLIQLYDAFE-SKHD--IILVMEYVEGGELFDRII ... . || | ||.|.|.. | |... | |.. || .. || .|...| || .| |...|| . . |..||||...| | | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR DE---NCNLTELDTILFMKQICEGIRYMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLAR . . .|| | . . ||..| | ... . | || |.| |... ..|| |||||| KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCL-VTENN-VVKICDFGLAR |
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Kinase | SgK085.AA | TyrKc | 107-335 | 22 | 6.7e-16 | 34.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 107-335 Range on HMM: 1-280/280 Sequence Identity: 22% (66 aa) VSKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDKEDVKNEISVMNQL--DHVNLIQLYDAFESK-------HDIILVMEYVEGGELFDRIIDEN ... ..|| | ||.|.|.. | .. | | .| .|| .|...| .| .| |...|| . .. . . .||||...| | |.. . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR CNLTELDTILFMKQICEGIRYMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPR-------EKLKVNF--GTPE-----FLAPEVVNYDFVSF .|. | . |. ||..| .| |.. . | || |.| .. ..|| ||||.| . . .. |. .|||. || .. PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT STDMWSVGVITY-MLLSGLSPFLG-----DNDAETLTNILAC-RWDLEDE-----------------------------EFQDISEEA .| || || . .. | .| | ...| . .. . | . .. |..| |. KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |