Gene SgK071 (Mouse)
SgK071
Sequence
Protein domains of SgK071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SgK071.AA | SgK071 | 6-273 | 60 | 1.6e-207 | 695.71 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 6-273 Range on HMM: 1-283/283 Sequence Identity: 60% (172 aa) LLQMLNPGALGVNLVVEELETETKFLIKQVECIDEHHANKALEELMPLLKLQHPNLSLYHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMENKRKLKAV ||.||||||.|||.|||..||..||.||||||.|.|||||||||.|||.|||||....||.||..|..|.....||.|||||..|.|...|..|||.|.. LLYMLNPGAQGVNFVVEHMETGKKFVIKQVECMDDHHANKALEEVMPLQKLQHPHICVYHDMFVHWDKEEAAMYLCIVMDYYKMGDFDRFMKEKRKKKKI VDTEWMHTMLSQVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKLQDMSSQALMTHEAKWNVRAEE---------------DPCQKSWMAPEALKFSFST ...|||.....|.|.||||||..||.||.||||||.|.....|||||...|..||...|||.||.. |.....|||||.|.|.||. MCEEWMQRWCGQMLHAIEYLHHRNIIHRDLKPSNIYLTDQMHCKLQDFGIQTIMTDKHKWNCRARTENTALSGPSTLILSADVWSMYWMAPEVLEFPFSQ KSDIWSLGCIILDMATCSFLNDTEAMQLRKAIRHHPGSLKPILKTMEEKQIPGTDVYYLLLPFMLHINPSDRLAIKDVMQVTF ||||||||||||||.||||..|||.|.||..||.||||||.|||||||||||..|.||.||||||||||.||..|||||..|| KSDIWSLGCIILDMTTCSFMDDTEMMHLRMGIRQHPGSLKEILKTMEEKQIPDVDDYYQLLPFMLHINPQDRISIKDVMHITF |
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| S_TKc | SgK071.AA | S_TKc | 4-274 | 20 | 2.3e-27 | 98.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 4-274 Range on HMM: 1-231/231 Sequence Identity: 20% (57 aa) YQLLQMLNPGALGVNLVVEELETETKFLIKQVECIDEHHANKALEELMPLLKLQHPNLSLYHEMFIMWNNEISSLFLCLVMDYYSQ--GTFQNIMENKRK |..|. . || |. . . .| .. ||.. .... |. | | .|||. ....| .|..||.| .. |. ....... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR --LKAVVDTEWMHTMLSQVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKLQDMSSQALMTHEAKWNVRAEEDPCQ-KSWMAPEALKFSFST-KSDIWSL |. . . . .. |...|.||.|...|.|| |||.|| | . |. | . ... | .|||| | .... |.|.||. HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL--GYGKCKCDWWSC GCIILDMATCSFLNDTEAMQLRKAIRHHPGSLKPILKTMEEKQIPGTDVYYLLLPFMLHINPSDRLAIKDVMQ-------VTFM |||. |.. . . . ... | |. .. .. .|. .|..|. . ...| .. GCILYEMLCGYPPFP-QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | SgK071.AA | Ciliate-E2 | 53-201 | 21 | 6e-21 | 68.62 | In-house | 86-286 (365) | Show / Hide |
Range on Protein: 53-201 Range on HMM: 86-286/365 Sequence Identity: 21% (45 aa) LLKLQHPNLSLYHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMENKRKLKAVV-------DTEWMHTMLSQVLD---------------AIEYLHKLN- | .|.|||. ..| |.. .. . |||.|...|. . ...|..| . . . . .. |.|. |.||||. | LEQLNHPNIIKMYECFQE----KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN IVHRNLKPSNIVLVNSGYCKLQDMSS----QALMTHEAKWNVRAEEDPCQK--------------------------SWMAPEALKFS----------FS |.||..||.||.. .|. |. . . . . ...... . | |||| |. . IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD TKSDIWSLGCII .|.||||||.|. YKCDIWSLGVIL |
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| Kinase | SgK071.AA | Ciliate-E2-Unclassified | 45-201 | 19 | 2.1e-20 | 67.47 | In-house | 54-260 (352) | Show / Hide |
Range on Protein: 45-201 Range on HMM: 54-260/352 Sequence Identity: 19% (41 aa) KALEELM--------PLLK---LQHPNLSLYHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMEN------------KRKLKAV-VDTEWMH-----TML |...... ... |.||.. ....... . . ...||.| .|. ...... ..... .. . . ... KEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC----FQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYF SQVLDAIEYLHKLN-IVHRNLKPSNIVLVNSG---YCKLQD--MSSQALMTHEAKWNVR-----------AEEDPCQKSWM----APEALKF-SFS---- |.|...||||. | |.||..||.||.. |.| |.|. | |.. . . . . . . | ||| |. . AQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA TKSDIWSLGCII |.||||||.|. YKCDIWSLGVIL |
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| Kinase | SgK071.AA | TKL | 80-207 | 20 | 1.1e-19 | 67.55 | In-house | 113-285 (364) | Show / Hide |
Range on Protein: 80-207
Range on HMM: 113-285/364
Sequence Identity: 20% (38 aa)
LCLVMDYYSQGT-FQNIMENKRKLKAVVDTEWMHTMLSQVLDAIEYLHKLN--------IVHRNLKPSNIVLVNSGY--------------CKLQDM---
||.||.|.. |. . .. . .. . .. ...||| | |.||.||..|| . . . ||. |.
LCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS
-------SSQALMTHEA-----KWNVR-AEEDPC-QKSWMAPEALK-----------------FSFSTKSDIWSLGCIILDMATC
.... ||.. . | | . .| . |||||.|. |..|.|.|..| | .. ..|.
RFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR
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| Kinase | SgK071.AA | NEK-Unclassified | 117-216 | 36 | 1.2e-16 | 51.3 | In-house | 105-202 (258) | Show / Hide |
Range on Protein: 117-216 Range on HMM: 105-202/258 Sequence Identity: 36% (37 aa) QVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKLQDMSSQALMTHEAKWNVRAEEDPCQKSWMAPEALKF-SFSTKSDIWSLGCIILDMATCS-FLNDTE | |. | | |.|| |||.|| | . . | | | .| ||.|| .. . .||.|||||||. |.|| |. || QMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMC---WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFF-DTH AM | NM |
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| Kinase | SgK071.AA | Ciliate-E2b | 117-153 | 45 | 1.6e-14 | 40.72 | In-house | 110-146 (272) | Show / Hide |
Range on Protein: 117-153 Range on HMM: 110-146/272 Sequence Identity: 45% (17 aa) QVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKLQDM ... ..||||..||..| .||.|| . . ||.|| || SICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDM |
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| Kinase | SgK071.AA | STE | 4-150 | 18 | 8.5e-12 | 38.05 | In-house | 1-188 (359) | Show / Hide |
Range on Protein: 4-150
Range on HMM: 1-188/359
Sequence Identity: 18% (37 aa)
YQLLQMLNPGALG-VNLVVEEL-----ETETK---------FLIKQVECIDE-----------------HHANKALEELMPLLKLQ--HPNLSLYHEMFI
....... || | | . . .| . . |||.. .. .. |.|. . |.. ||| |. ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
------MWNNEISSLFLCLVMDYYSQGTFQNIMENKRKLKA----------VVDTEWMHTMLSQVLDA-IEYLHKLNIVHRNLKPSNIVLVNSGYCKL
...| |...| | . |.. |...| . . ... .. ... |.| . .|||...|.|| .||.|| | .||
KEGHNHKNDDE-----LWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKL
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| Kinase | SgK071.AA | STE11-Unclassified | 178-206 | 54 | 2.2e-11 | 36.69 | In-house | 201-233 (308) | Show / Hide |
Range on Protein: 178-206 Range on HMM: 201-233/308 Sequence Identity: 54% (18 aa) WMAPEALK---F-SFSTKSDIWSLGCIILDMAT ||||| .| . ..|||||||||... ||| WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMAT |
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| Kinase | SgK071.AA | NZAK | 53-155 | 25 | 2.8e-10 | 30.2 | In-house | 52-151 (329) | Show / Hide |
Range on Protein: 53-155 Range on HMM: 52-151/329 Sequence Identity: 25% (26 aa) LLKLQHPNLSLYHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMENKRKLKAVVDTEWMHTMLSQVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKLQD | |. |.| | | . .. . | .| . . | ... |..| . . . |. . . |||| |.|| .|..|..| . || | LEKIRHFNIPRYYSACIKHAED--DNYHCIYMEWMEGGNLTQFLMNDKKQLRFKEHRIIK-MIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLID MSS .| FGS |
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| Kinase | SgK071.AA | Pkinase | 37-150 | 21 | 7e-10 | 36.02 | Pfam | 31-153 (293) | Show / Hide |
Range on Protein: 37-150 Range on HMM: 31-153/293 Sequence Identity: 21% (28 aa) CIDEHHANKALE-------ELMPLLKLQHPNLSLYHEMFIMWNNEISSLFLCLVMDYYSQG----TFQNIME--NKRKLKAVVDTEWMHTMLSQVLDAIE .|. .|... . |. ...|.||| ....| . ...||.| | ... ..... . . .. |.| ..| IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLE YLHKLNIVHRNLKPSNIVLVNSGYC----KL |.|. .|.|| |||.|| ..| |.. |. YCHSMGIIHRDLKPENILIDNNGHIDACVKI |
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| Kinase | SgK071.AA | TyrKc | 4-274 | 18 | 8.6e-10 | -64.34 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 4-274 Range on HMM: 1-280/280 Sequence Identity: 18% (57 aa) YQLLQMLNPGALGVNLVVE-ELETETKFLIKQVECIDEHHANKALEELMPLLKL--QHPN-LSLYHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMENK .|...| || |. |.. .. .. .| . ..|. . || .||| . || | ... |..|| | . | .. .. ITLGKKLGEGAFGE--VYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH RKLKAVVDTEWMHTMLSQVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKL------QDMSSQ-------ALMTH----EAK--WNVRAEEDPCQKSWMA |. . .. .. . |. . ||||. |..|| | |. . . . .| | . .. .| . .| ||| RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR---------WMA PEALKFS-FSTKSDIWSLGCI---ILDMATCSFLND----TEAMQLRKAIRHHPGSLKPILKTMEEKQI----PGTDVYYLLLPFMLHINPSDRLAIKDV ||..... |.||||.|| | |. .. .. .... ... | |. . . . ...| . . | .|.|| ... PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ--GYRMPQPPNDY-P-MSFVCCPDEMYQIMKQC-WHEDPEDRPTFSEI MQVTFM . .. --HECF |
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| Kinase | SgK071.AA | STE11 | 178-206 | 51 | 1.2e-09 | 31.3 | In-house | 201-233 (303) | Show / Hide |
Range on Protein: 178-206 Range on HMM: 201-233/303 Sequence Identity: 51% (17 aa) WMAPEALKFSF----STKSDIWSLGCIILDMAT ||||| .| . ..|.|||||||... ||| WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMAT |
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| Kinase | SgK071.AA | NZAK | 179-205 | 42 | 4.3e-08 | 22.74 | In-house | 239-266 (329) | Show / Hide |
Range on Protein: 179-205 Range on HMM: 239-266/329 Sequence Identity: 42% (12 aa) MAPEALKFSFST-KSDIWSLGCIILDMA |||| .. . .. |||.||.||....|. MAPENKNNHRINEKSDVWSFGCTVWQMF |
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| Kinase | SgK071.AA | STE | 174-206 | 45 | 2e-07 | 22.41 | In-house | 226-263 (359) | Show / Hide |
Range on Protein: 174-206 Range on HMM: 226-263/359 Sequence Identity: 45% (18 aa) CQKSWMAPEALK---FS----FSTKSDIWSLGCIILDMAT .. ||||| .. . .||.||||||| |. ||| TP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT |
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| Kinase | SgK071.AA | Pkinase | 178-206 | 38 | 2e-06 | 23.59 | Pfam | 177-207 (293) | Show / Hide |
Range on Protein: 178-206 Range on HMM: 177-207/293 Sequence Identity: 38% (12 aa) WMAPEALK--FSFSTKSDIWSLGCIILDMAT .|||| .. ..|.|.||.|||. |.. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | SgK071.AA | STE11 | 117-152 | 45 | 4e-06 | 18.55 | In-house | 124-160 (303) | Show / Hide |
Range on Protein: 117-152 Range on HMM: 124-160/303 Sequence Identity: 45% (17 aa) QVLDAIEYLHKLNIVHRNLKPSNIVLVNSGY-CKLQD |.| .. |||. .|.|| .|. || | | ||| | QILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLAD |
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| Kinase | SgK071.AA | Pkinase_Tyr | 178-198 | 59 | 5.6e-05 | 17.49 | Pfam | 180-201 (270) | Show / Hide |
Range on Protein: 178-198 Range on HMM: 180-201/270 Sequence Identity: 59% (13 aa) WMAPEALKFS-FSTKSDIWSLG |||||..... |.||||.|| | WMAPECINYGKFTTKSDVWSFG |
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| Kinase | SgK071.AA | STE11-Unclassified | 117-152 | 44 | 6.4e-05 | 13.43 | In-house | 115-150 (308) | Show / Hide |
Range on Protein: 117-152 Range on HMM: 115-150/308 Sequence Identity: 44% (16 aa) QVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKLQD |.| ..|||. .|.|| .|. || . | ||| | QILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTD |
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| Kinase | SgK071.AA | Ciliate-E2b | 178-198 | 37 | 0.008365 | 4.54 | In-house | 171-197 (272) | Show / Hide |
Range on Protein: 178-198 Range on HMM: 171-197/272 Sequence Identity: 37% (10 aa) WMAPEALK------FSFSTKSDIWSLG .|||| .. ..|.||||.| YMAPEIIQSLQPGGKGYTYKVDIWSVG |
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| Kinase | SgK071.AA | Ciliate-E2 | 254-274 | 18 | 0.165462 | 0.92 | In-house | 344-365 (365) | Show / Hide |
Range on Protein: 254-274 Range on HMM: 344-365/365 Sequence Identity: 18% (4 aa) MLHINPSDRLA-IKDVMQVTFM || .|. |. ...... .. MLQKDPEKRITGWEQILNHPWF |
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| Kinase | SgK071.AA | Pkinase_Tyr | 80-135 | 26 | 0.250485 | 5.12 | Pfam | 82-137 (270) | Show / Hide |
Range on Protein: 80-135 Range on HMM: 82-137/270 Sequence Identity: 26% (15 aa) LCLVMDYYSQGTFQNIMENKRKLKAVVDTEWMHTMLSQVLDAIEYLHKLNIVHRNL ...|| | | . ..| | ...... | |. .. |||. |..|| | IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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| Kinase | SgK071.AA | Pkinase | 254-274 | 19 | 1.421601 | 3.11 | Pfam | 273-293 (293) | Show / Hide |
Range on Protein: 254-274 Range on HMM: 273-293/293 Sequence Identity: 19% (4 aa) MLHINPSDRLAIKDVMQVTFM .|. .|..|. .....| .. CLCKDPKKRPTAEQILQHPWF |
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