Gene SgK069 (Mouse)

SgK069

Species: Mouse
Alias: SgK069
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: Other
Family: NKF1

Sequence

Name Sequence Type Origin Length Description Download
SgK069.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
SgK069.AA Protein Sugen 362 None Fasta, JSON
SgK069.NA RNA Sugen 1145 None Fasta, JSON

Protein domain

Protein domains of SgK069.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK069.AA NKF1 62-325 49 1.4e-179 602.9 In-house 1-269 (269) Show / Hide 
Range on Protein: 62-325
Range on HMM: 1-269/269
Sequence Identity: 49% (133 aa)

YEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQSTSLRGFLYEFCVGLSLGTHSAIVTAYGIGIESAN--SYSFLTEPVLHGDLITFIQP--KVGLPQ
||..|.||.|..|..||..|||.||..|||..||..|.|..|..|||.|..|..|..|||.|........  .|.|..|....|||...|||  ..|||.
YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE

PAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDP-ACQRVKLTDFGHTRPRGTLLRLTGPPIPYTAPELCAPPPLPEGLPIQPSLDAWALGVLIFCL
....||.|||||||...||..||.||.|||||||.|| .||||||.|||||||||...|......||.|||.|...|..||.|..||.|.|..||||||.
NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC

LTGYFPWDQPLVEVDPFFEDFLIWQASGQPQDRPQPWYSLSPAADTLLWGLLDPHPRKRNPVGSIKSYL
|||.|||.......||..|.|..||...||...||||....|.|......||.|||..|.|| ....|.
LTGCFPWQKADWMCDPCYEWFMWWQRRKQPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM
Kinase SgK069.AA S_TKc 62-330 24 2.7e-41 144.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 62-330
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

YEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQSTSLRGFLYEFCVGLSLGTHSAIVTAYGIGIESANSYSFLTEPVLH--GDLITFIQPKVG-----
|| .|..|.| ||.| ...|.  |   |.|...      . .. |  .  .   |  ||. |..  .  ... . .| . .  ||| ..|. . .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPACQRVKLTDFGHTRPRGTLLRLTGPPIPYTAPELCAPPPLPEGLPIQP-SLDAWALGVL
 .|   |.. ..|...|||..|||| ..|||||||.|...    ..|..|||  |       . | |  | |||..         .  . . | |..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL---TTFCGTP-WYMAPEVL---------GYGKCKCDWWSCGCI

IFCLLTGYFPWDQPLVEVDPFFEDFLIWQASGQPQDRPQPWYSLSPAADTLLWGLLDPHPRKRNPVGSIKS-YLG---QPWK
.. .|.|| |..          .......  |            || |  .. ..|.  |.||  .  .    .     || 
LYEMLCGYPPFP----------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SgK069.AA Pkinase 62-264 25 1.7e-37 133.7 Pfam 1-213 (293) Show / Hide 
Range on Protein: 62-264
Range on HMM: 1-213/293
Sequence Identity: 25% (57 aa)

YEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQSTSLRGFLY-----EFCVGLSLGTHSAIVTAYGIGIESANSYSFLTEPVLHG----DLITFIQ--
|. .|..|.| ||.| . .|.  |   |.|...|....     .     | .. ..|  |  ||. |..  .. . | . .| . .|    || ..|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTW

PKVGL--PQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPACQR---VKLTDFGH-----TRPRGTLLRLTGPPIPYTAPELCAPPPLPEGLPI
 . ..  .   ..... |....||..||.| ..|||||||.|.    ..    ||..|||      . . . .  ..| | .| |||..      .| ..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP-WYMAPEVIR-----GGQYY

QPSLDAWALGVLIFCLLTGYFPWD
 |. | |..|......|.|..|..
GPKVDMWSCGCILYEMLCGRPPFP
Kinase SgK069.AA CAMK 160-315 20 1.8e-21 65.31 In-house 181-413 (425) Show / Hide 
Range on Protein: 160-315
Range on HMM: 181-413/425
Sequence Identity: 20% (48 aa)

AQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDP--------------ACQR-VKLTDFGHTRPRGT---------------------------LLRLT
|.|.  |..||....|||. | |||||||.|..|                 .  .|..|||  .                               .    
ARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFC

GPPIPYTA-PELCAPPP--------LPEGLPIQPSLDAWALGVLIFCLLTGYFPWDQPLVEVDP-----FFEDFLIWQA--SGQPQDRPQP---------
| | .| | ||.    .        . |  .. |. | |..||. . .|.||.|.. .  . ..      ..|  ...   .|. .  | .         
GTP-EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYG

---WYSLSPA--------ADTLLWGLLDPHPRKR
   | . |          .  |. ..| . | ||
PEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKR
Kinase SgK069.AA Ciliate-E2-Unclassified 142-315 21 7.2e-20 65.62 In-house 105-340 (352) Show / Hide 
Range on Protein: 142-315
Range on HMM: 105-340/352
Sequence Identity: 21% (53 aa)

HGDLITFIQ--PK---------------VGLPQPAAQ-----RCAAQLASALEHIHSHG-LVYRDLKPENVLVCDPACQ--RVKLTDFGHTR--------
.|||. .|.  .|                 ..  .|.     . .||. ..||..|. .  ..||.||||.|. |  ..  ..|..|||  .        
GGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF-DNNGKNYYIKIIDFGISKKYQQNNNC

-----------PRGTLLRLTGPPI--P-YTAPELCAPPPLPEGLPIQPS----LDAWALGVLIFCLLTGYFPWDQPLVEVDPF----------FEDFLIW
           ..  .   .| |.  | |||||      . .|     |     | |.|||.....|.||.| ...  | . .          .. .. .
DTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE------VLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

QASGQPQDRPQPW----YSLSPAADTLLW----GLLDPHPRKR
.  ...| ...||    . .|| |  ..      .|.  | ||
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKR
Kinase SgK069.AA AGC 143-205 34 7.7e-19 43.91 In-house 127-200 (395) Show / Hide 
Range on Protein: 143-205
Range on HMM: 127-200/395
Sequence Identity: 34% (26 aa)

G-DLITFIQ---PKVGLPQPAAQRCAAQ-------LASALEHIHS-HGLVYRD-LKPENVLVCDPACQRVKLTDFG
| .| . .|    .  .. ..|.  ||.       ...|||..|| .| ..|| |||||.|  .     .||||||
GCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED--GHIKLTDFG
Kinase SgK069.AA MSK 159-265 33 1.8e-17 55.65 In-house 102-212 (277) Show / Hide 
Range on Protein: 159-265
Range on HMM: 102-212/277
Sequence Identity: 33% (38 aa)

AAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPAC-QRVKLTDFGHTR--PRGTLLRLTGP--PIPYTAPELCAPPPLPEGLP-IQPSLDAWALGVL
...   ..| .|..|.|. | ..|||||||.|  |     .|||.|||  |  |..   |.  |   . | |||. .     .. .   .. | | |||.
ECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRR--GYAQDGGYDEACDWWSLGVI

IFCLLTGYFPWDQ
 . .|||  |  |
LYTMLTGQVPFQQ
Kinase SgK069.AA CDK4 144-205 39 1.4e-16 53.16 In-house 94-155 (290) Show / Hide 
Range on Protein: 144-205
Range on HMM: 94-155/290
Sequence Identity: 39% (25 aa)

DLITFIQ--PKVGLPQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPACQRVKLTDFG
|| |..   |. |.|.. ...  .|| ....  |||  . |||||.|.||     ..|||.|||
DLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVT--SDGHVKLADFG
Kinase SgK069.AA RSK 164-205 47 4.1e-14 48.29 In-house 110-152 (278) Show / Hide 
Range on Protein: 164-205
Range on HMM: 110-152/278
Sequence Identity: 47% (21 aa)

AAQLASALEHIHSHGLVYRDLKPENVLVCDPACQ--RVKLTDFG
.|....|.||.|..| ..|||||||.|  |   .  ..||||||
MAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFG
Kinase SgK069.AA CAMKL 143-205 35 6.1e-14 40.73 In-house 106-174 (297) Show / Hide 
Range on Protein: 143-205
Range on HMM: 106-174/297
Sequence Identity: 35% (25 aa)

GD--LITFI--QPKVG--LPQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPA-CQRVKLTDFG
|.  |  .|  .....  .| . |.|   |. ||....|||| | ||.||||.|. .   .  .|..|||
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFG
Kinase SgK069.AA Ciliate-E2 164-205 39 1.4e-13 42.97 In-house 166-201 (365) Show / Hide 
Range on Protein: 164-205
Range on HMM: 166-201/365
Sequence Identity: 39% (17 aa)

AAQLASALEHIHSHG-LVYRDLKPENVLVCDPACQRVKLTDFG
.|.. .|||..|| .  ..||.||||.|.       .|..|||
IACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFG
Kinase SgK069.AA CAMKL 242-315 26 8e-10 27.37 In-house 215-285 (297) Show / Hide 
Range on Protein: 242-315
Range on HMM: 215-285/297
Sequence Identity: 26% (20 aa)

PSLDAWALGVLIFCLLTGYFPWDQPLVE-VDPFFEDFLIWQASGQPQDRPQPWYSLSPAADTLLWGLLDPHPRKR
|  | |..||. . ...||.|.|.. ..    .    | |.  ..   .| .||..|  .  |. ..| . | ||
PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG--YYPPIWYHVS-DCRDLIRKMLQVNPEKR
Kinase SgK069.AA TyrKc 62-325 20 8.6e-10 -64.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 62-325
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

YEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQSTSLRGFLYEFCVGLSLG-THSAIVTAYGIGIESA------NSYSFLTEPVLHGDLITFIQPKVG
 .  . || | ||.| . | .   .. | | | . .  .. |. |  .  .||  |  ||  ||. ...         .  ..| . ||||  ... . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LPQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPACQRVKLTDFGHTRPRG---------TLLRL----TGP---PIPYTAPELCAPPPLPEG
 |. .     . | |.  |..||.... |||   |.|| ..   .|| .||| .|  .            |      |    ||  .|||          
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE----------

LPIQPSL---------DAWALGVLIFCLLT-GYFPWDQPLVEVDPFFEDFLIWQASGQPQDRPQPWY--------SLSPAADTLLWGLLDPHPRKRNPVG
     ..         | |. ||... ..| |  |.  .  .   . ... . .   |   .||| .          .   . .     .  | .|    
-----CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS

SIKSYL
 |....
EIHECF
Kinase SgK069.AA AGC 62-96 31 1.6e-09 19.27 In-house 1-41 (395) Show / Hide 
Range on Protein: 62-96
Range on HMM: 1-41/395
Sequence Identity: 31% (13 aa)

YEEVRPLGQGRFGRVLLVTHR------QKGTPLALKQLPKQ
.| ....|.| ||.| || ..      . |   |.| | |.
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKK
Kinase SgK069.AA PKA 164-190 60 2.8e-09 37.17 In-house 106-133 (263) Show / Hide 
Range on Protein: 164-190
Range on HMM: 106-133/263
Sequence Identity: 60% (17 aa)

AA-QLASALEHIHSHGLVYRDLKPENVL
|| |  .||| .||. ..|||||||| |
AASQIVLALEYLHSQNIIYRDLKPENIL
Kinase SgK069.AA CAMKL 62-103 34 2e-07 19.57 In-house 1-43 (297) Show / Hide 
Range on Protein: 62-103
Range on HMM: 1-43/297
Sequence Identity: 34% (15 aa)

YEEVRPLGQGRFGRVLLVTH-RQKGTPLALKQLPKQSTSLRGF
|. .. ||.| || | | || |  |.  | | . |. .... .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPW
Kinase SgK069.AA CAMK 67-96 26 6.6e-07 17.52 In-house 1-42 (425) Show / Hide 
Range on Protein: 67-96
Range on HMM: 1-42/425
Sequence Identity: 26% (11 aa)

PLGQGRFGRVLLVTHRQKG------------TPLALKQLPKQ
 ||.|.|| | |..|.. .            .  | | ..|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKK
Kinase SgK069.AA PKA 62-96 45 1.6e-05 21.72 In-house 1-35 (263) Show / Hide 
Range on Protein: 62-96
Range on HMM: 1-35/263
Sequence Identity: 45% (16 aa)

YEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQ
.| .. ||.|.|||| |. |.. |   |.|.| ||
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQ
Kinase SgK069.AA Ciliate-E2-Unclassified 62-96 31 2e-05 14.83 In-house 1-35 (352) Show / Hide 
Range on Protein: 62-96
Range on HMM: 1-35/352
Sequence Identity: 31% (11 aa)

YEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQ
|. .. .||| || | .. |....   |.|.. |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKI
Kinase SgK069.AA Ciliate-E2 245-263 42 0.000157 11.45 In-house 278-296 (365) Show / Hide 
Range on Protein: 245-263
Range on HMM: 278-296/365
Sequence Identity: 42% (8 aa)

DAWALGVLIFCLLTGYFPW
| |.|||.....|.|..|.
DIWSLGVILYEMLFGKPPF
Kinase SgK069.AA Ciliate-E2 62-85 29 0.000226 10.9 In-house 1-24 (365) Show / Hide 
Range on Protein: 62-85
Range on HMM: 1-24/365
Sequence Identity: 29% (7 aa)

YEEVRPLGQGRFGRVLLVTHRQKG
|. .. .||| || | ........
YKFIKKIGQGNFGSVYKCKVWKVQ
Kinase SgK069.AA Pkinase_Tyr 62-205 27 0.000996 13.25 Pfam 1-156 (270) Show / Hide 
Range on Protein: 62-205
Range on HMM: 1-156/270
Sequence Identity: 27% (43 aa)

YEEVRPLGQGRFGRVLLVTHR----QKGTPLALKQLPKQSTSLRG-----FLYEFCVGLSLGTHSAIVTAYGIGIESANS--YSFLTEPVLHGDLITFIQ
 .  . ||.| ||.| . | .    ....| | | | |.... .      |. |  .  .|| |  ||  ||. ..   .  .   .| . |||| .. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

P----KVGLPQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDPACQRVKLTDFG
     |  |. .     ..| |...|. .|.... |||   |.|| ..    || .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN--VVKICDFG
Kinase SgK069.AA AGC 247-262 50 0.003222 2.58 In-house 287-304 (395) Show / Hide 
Range on Protein: 247-262
Range on HMM: 287-304/395
Sequence Identity: 50% (9 aa)

WA--LGVLIFCLLTGYFP
|.  ||.|.. .|||| |
WSFGLGCLMYEMLTGYPP
Kinase SgK069.AA RSK 245-262 55 0.00936 6.34 In-house 194-211 (278) Show / Hide 
Range on Protein: 245-262
Range on HMM: 194-211/278
Sequence Identity: 55% (10 aa)

DAWALGVLIFCLLTGYFP
| | ||||.. .|||. |
DWWSLGVLMYEMLTGCPP
Kinase SgK069.AA CDK4 62-92 35 0.021889 3.75 In-house 1-31 (290) Show / Hide 
Range on Protein: 62-92
Range on HMM: 1-31/290
Sequence Identity: 35% (11 aa)

YEEVRPLGQGRFGRVLLVTHRQKGTPLALKQ
|..|  .|.| .| |  .   . |   ||||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQ
Kinase SgK069.AA PKA 247-262 62 0.038957 6.67 In-house 183-198 (263) Show / Hide 
Range on Protein: 247-262
Range on HMM: 183-198/263
Sequence Identity: 62% (10 aa)

WALGVLIFCLLTGYFP
||||.||. .|.|| |
WALGILIYEMLAGYPP
Kinase SgK069.AA RSK 65-95 41 0.176261 1.63 In-house 1-34 (278) Show / Hide 
Range on Protein: 65-95
Range on HMM: 1-34/278
Sequence Identity: 41% (14 aa)

VRPLGQGRFGRVLLV---THRQKGTPLALKQLPK
.. |||| .| | |.   ||...|.  | |.| |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKK