Gene RSKL1 (Mouse)

RSKL1

Species: Mouse
Alias: C80612, RSKL1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: RSKL

Sequence

Name Sequence Type Origin Length Description Download
RSKL1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 232 Kinase domain by global Sugen HMM Fasta, JSON
RSKL1.NA RNA Sugen 3316 None Fasta, JSON
RSKL1.AA Protein Sugen 1056 None Fasta, JSON

Protein domain

Protein domains of RSKL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PX RSKL1.AA PX 9-128 25 3e-17 61.65 Pfam 1-120 (120) Show / Hide 
Range on Protein: 9-128
Range on HMM: 1-120/120
Sequence Identity: 25% (33 aa)

ADLARFYTVTEPQRH----PRGYTVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFG--RFDKTVIEERRQCA
 ....  .|..|..|    ......|...  . ...  ....|  |||||||| .||..| . .      . . |. .| .. .  .||. .||.|||  
DHFLQ-VHVVDPETHKHYGDKMHYYYVYEIHMNTNP--FQKKEWHVWRRYSDFHWLHKQLKRHFP----MCIIPPLPPKHWFGRYNNFDEEFIEKRRQML

EDLLQFSANIPALYN-SRQLQDFFKGG
|. ||  ...| | | .. ..||.   
EQYLQRVCQHPELCNHCEVFHDFLHPD
PX RSKL1.AA PX 9-128 22 5.1e-16 60.46 SMART 1-142 (142) Show / Hide 
Range on Protein: 9-128
Range on HMM: 1-142/142
Sequence Identity: 22% (33 aa)

ADLARFYTVTEPQRHPRGY--TVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGR-----------------
 ....  ||.|...|...|  . .....  ........|..  |.|||||| .||. |   . . . ..  .||.    .|.|                 
DHIFI-ITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEK-RMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFN

-FDKTVIEERRQCAEDLLQFSANIPALYN----SRQLQDFFKGG
 ||. .||.||.  |. ||  ...| . |    .  ...||   
NFDEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS
MIT RSKL1.AA MIT 235-313 37 1.1e-25 92.55 SMART 1-81 (81) Show / Hide 
Range on Protein: 235-313
Range on HMM: 1-81/81
Sequence Identity: 37% (31 aa)

RRDYLEKAGELIKLALKKEE--EDDYEAASDFYRKGVDLLLEGVQGE-SSPTRREAVKRRTAEYLMRAESICSLRAAPQLHT
 |||..|| |.|..|.| .|  . |||.| . |.||.|.|..|...| ....||.|.... .|||.|.|.| .   . .|. 
QRDYYQKAIEYITQAVKADEDEWGDYEQAIEHYQKGIDYLMQGIKYEKPDEKRRHAIWAKCREYLDRMEEIKNCHDW-RLCP
MIT RSKL1.AA MIT 238-306 33 9.9e-25 89.05 Pfam 1-71 (71) Show / Hide 
Range on Protein: 238-306
Range on HMM: 1-71/71
Sequence Identity: 33% (24 aa)

YLEKAGELIKLALKKEE-EDDYEAASDFYRKGVDLLLEGVQGESSPTRREA-VKRRTAEYLMRAESICSLR
||.|| ||.| |....| . .||.| . |.............|..|..||| ......||. ||| | .. 
YLQKAIELVKKAVEADEDAGNYEEAIQCYQEAIEYFMQAIKYEPNPKWREARLRQKMQEYMDRAEQIKEHL
Kinase RSKL1.AA RSKL 340-415 39 7.7e-29 66.05 In-house 2-77 (436) Show / Hide 
Range on Protein: 340-415
Range on HMM: 2-77/436
Sequence Identity: 39% (30 aa)

RVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQRAEGGKLWSYI
|| |.|.||..| |  |  ||. . | .    ||.. ..||  || |. |  |  ||...|| |   ..| |||..
RVVGIIKKVQVVQDPATGNTFYVMKLPRCHMVSRDCSIFIPHNVPYMTQLVRYFVSEDHIFLHLEHVQPGQLWSFL
Kinase RSKL1.AA RSKL 814-1046 38 2e-200 496.39 In-house 112-436 (436) Show / Hide 
Range on Protein: 814-1046
Range on HMM: 112-436/436
Sequence Identity: 38% (124 aa)

ISSPCSGANKEHSAYADTATSEEVLLFTEPT----KEEANS--------------------------------LFQRDSEAQERGVGAGEAD--------
|....|.....|.........|.|.....|.    |....|                                ..|.|.|...|.|.....|        
ICHNLSQYHDRHMQFQCGVKQERVQAMMDPHFSLMKPSDTSSGCTVGQDRIGMEPPRTSDFTIAGNSRPAAQIHYQQDEEYMPRAVAYFQSDSKSQPCRH

-----------------KEIHQIFEDLDKRLAASSR--------------------FFIPEGCIQRWAAEMVVALDALHREG-IVCRDLNPNNILLNDGG
                 ..||..||..||......|                    ..|||.||..||.||||||.|||.|| ..||||||.||||...|
NHIQSRRQNHSPNSSPVQKIHWVFEQADKEMFYCYRWRIRQCVQKQRALRRCGWNYWDIPEQCIRQWACEMVVALHALHAEGHVICRDLNPDNILLDQKG

HIQLTYFSRWS-------EVEDSCDSDAVARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP---GCVSEEARSLIQQL
|||||||..||       .|...|...||..||||||||...|.||||||||.||||.|||.|..|..|||.||..||.|.||   ..||..|..|..||
HIQLTYFGQWSGLTSDDNWVCQQCNREAVTNMYCAPEVGQIWELTEACDWWSYGAVLYELLCGMSLYQCHPHGIQRHTQLQMPSEKEWVSHHAKDLLTQL

LQFNPMERLGAGVAGVEDIKSHPFF
||||||||||.|..||..||.||||
LQFNPMERLGMGQGGVDEIKAHPFF
Kinase RSKL1.AA AGC 892-1046 24 8.2e-68 173.46 In-house 144-395 (395) Show / Hide 
Range on Protein: 892-1046
Range on HMM: 144-395/395
Sequence Identity: 24% (63 aa)

PEGCIQRWAAE-------MVVALDALHR-EGIVCRD-LNPNNILLNDGGHIQLTYFSRWSEVEDSC----------------------------------
.| ... .|||       .| ||. ||.  ||..|| | | ||||.. ||| || |  . |. ...                                  
DEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNW

------------------DSDAV---ARMYCAPEVGAVTEETEACDWWS--LGAVLFELLTGKTLVECH-----------PAGINTHTT---------LN
                   .  .      | |||.      . ||||||  ||....|.|||..    .           |. .              . 
QRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVK

MP----------GCVSEEARSLIQQLLQFNPMERLGAGVA-----GVEDIKSHPFF
.|            .|.||..||..||. .| .|||.|       |.|.||.||.|
FPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSKL1.AA MAST 1009-1046 57 8.4e-19 53.46 In-house 302-337 (337) Show / Hide 
Range on Protein: 1009-1046
Range on HMM: 302-337/337
Sequence Identity: 57% (22 aa)

CVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF
|.|.||. ||..||| || .||||.  |...||.||||
CMSPEAQDLIKKLLQPNPKKRLGAN--GADEIKQHPFF
Kinase RSKL1.AA Pkinase 957-1046 20 1.5e-16 59.59 Pfam 177-293 (293) Show / Hide 
Range on Protein: 957-1046
Range on HMM: 177-293/293
Sequence Identity: 20% (25 aa)

YCAPEVGA-VTEETEACDWWSLGAVLFELLTGKTLVECHP----AGINTHTTLNMPGC-----------------------------VSEEARSLIQQLL
|.||||    .. . ..|.||.| .|.|.|.|...   .       ..    ... ..                             .|||....|  .|
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

QFNPMERLGAGVAGVEDIKSHPFF
...| .|..      |.|. ||.|
CKDPKKRPT-----AEQILQHPWF
Kinase RSKL1.AA SGK 1001-1046 43 1e-15 44.59 In-house 239-283 (283) Show / Hide 
Range on Protein: 1001-1046
Range on HMM: 239-283/283
Sequence Identity: 43% (20 aa)

HTTLNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF
.  |..|  .| .|..|||.||| .| .|||.  .. ..||.||||
NQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase RSKL1.AA NDR 1010-1046 51 2e-15 43.41 In-house 314-350 (350) Show / Hide 
Range on Protein: 1010-1046
Range on HMM: 314-350/350
Sequence Identity: 51% (19 aa)

VSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF
.|.||  ||..|.  .|..|||..  ||..|||||||
LSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase RSKL1.AA RSK 1003-1046 43 2.8e-15 52.58 In-house 233-278 (278) Show / Hide 
Range on Protein: 1003-1046
Range on HMM: 233-278/278
Sequence Identity: 43% (20 aa)

TLNMP--GCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF
.|.||    .|.||..||...|. .|  |||.|  ..|.||.||.|
SLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSKL1.AA AktR 998-1046 40 6e-15 54.2 In-house 217-268 (268) Show / Hide 
Range on Protein: 998-1046
Range on HMM: 217-268/268
Sequence Identity: 40% (21 aa)

INTHT--TLNMPGCVSEEARSLIQ-QLLQFNPMERLGAGVAGVEDIKSHPFF
|....    . | ..|.....||| .||. || .||| . .| |.|||||.|
IKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
S_TKc RSKL1.AA S_TKc 792-1046 22 9.5e-15 39.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 792-1046
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

SDRLGQVE-----VVVTAQALQESLFHISSPCSGANKEHSAYADTATSEEVLLFTEPTKEEANSLFQRDSEAQERGVGAGEADKEIHQIFE-------DL
 . | ..      .|  ..          .    | |. .      .  |. .  .      |     |.             .... ..|       ||
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDL

DKRLAASSR----FFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYF--SRWSEVEDSCDSDAVARMYCAPEVGAVTEETE-AC
 ...    |    | .||  ......... ||. .|. ||. ||| | ||||..  || .. |  .|        ..  . . |.||||      .  .|
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKC

DWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGV--EDIKSHPFF
||||.| .|.|.|.|... .      . ...... |  |.||...|...||..| .|..|  |    .|||.||.|
DWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSKL1.AA RSK-Unclassified 1004-1046 44 1.6e-14 41.51 In-house 239-283 (283) Show / Hide 
Range on Protein: 1004-1046
Range on HMM: 239-283/283
Sequence Identity: 44% (20 aa)

LNMP--GCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF
. .|    .| ..|.||  ||| ||  |||..    .||| ||||
VKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase RSKL1.AA RSK 1010-1046 51 2.9e-14 47.48 In-house 235-271 (271) Show / Hide 
Range on Protein: 1010-1046
Range on HMM: 235-271/271
Sequence Identity: 51% (19 aa)

VSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF
.|.|| .|. ..|  .|  |||||  |||.||.||.|
ISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSKL1.AA RSK-Unclassified 891-938 39 3.1e-13 37.43 In-house 98-145 (283) Show / Hide 
Range on Protein: 891-938
Range on HMM: 98-145/283
Sequence Identity: 39% (19 aa)

IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYF
. |  .. .|.| ..||  ||. ... ||| |.||.|   ||. || |
FCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDF
Kinase RSKL1.AA SGK 900-936 56 1.2e-12 34.94 In-house 131-167 (283) Show / Hide 
Range on Protein: 900-936
Range on HMM: 131-167/283
Sequence Identity: 56% (21 aa)

AAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLT
||| | ||. ||   |. ||| | |||| . ||. ||
AAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLT
Kinase RSKL1.AA p70 900-938 48 1.3e-12 42.14 In-house 134-172 (299) Show / Hide 
Range on Protein: 900-938
Range on HMM: 134-172/299
Sequence Identity: 48% (19 aa)

AAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYF
..| ..||  ||  ||. ||| | |..||  ||. || |
LSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDF
Kinase RSKL1.AA NDR 957-987 50 5.6e-12 32.58 In-house 247-278 (350) Show / Hide 
Range on Protein: 957-987
Range on HMM: 247-278/350
Sequence Identity: 50% (16 aa)

YCAPEVGAV-TEETEACDWWSLGAVLFELLTG
| |||| .  |. ...|||||||....|.|.|
YMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVG
Kinase RSKL1.AA NDR 901-936 47 8e-11 28.94 In-house 111-146 (350) Show / Hide 
Range on Protein: 901-936
Range on HMM: 111-146/350
Sequence Identity: 47% (17 aa)

AEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLT
||||.|....|. |.. ||. | |.|..  ||| ||
AEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLT
Kinase RSKL1.AA p70 1004-1046 44 2.9e-10 33.52 In-house 257-299 (299) Show / Hide 
Range on Protein: 1004-1046
Range on HMM: 257-299/299
Sequence Identity: 44% (19 aa)

LNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF
|..|   ..|.| ||..||  .| .|.|||   ..||..||||
LKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSKL1.AA RSK 957-989 43 9.5e-10 32.17 In-house 174-210 (278) Show / Hide 
Range on Protein: 957-989
Range on HMM: 174-210/278
Sequence Identity: 43% (16 aa)

YCAPEVGAV--TEE--TEACDWWSLGAVLFELLTGKT
|.|||. ..   ..  ..||||||||....|.|||..
YMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCP
Kinase RSKL1.AA MAST 901-936 55 1e-09 25.21 In-house 109-144 (337) Show / Hide 
Range on Protein: 901-936
Range on HMM: 109-144/337
Sequence Identity: 55% (20 aa)

AEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLT
|| | .|. ||  ||| ||| |.|.|.   ||| ||
AETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLT
Kinase RSKL1.AA RSK 900-936 52 1.5e-09 31.45 In-house 110-149 (278) Show / Hide 
Range on Protein: 900-936
Range on HMM: 110-149/278
Sequence Identity: 52% (21 aa)

AAEMVVALDALHREGIVCRDLNPNNILLND---GGHIQLT
.|| |.|.. ||  ||. ||| | |||..|    ||| ||
MAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLT
Kinase RSKL1.AA RSK 900-936 46 6.1e-09 28.28 In-house 107-147 (271) Show / Hide 
Range on Protein: 900-936
Range on HMM: 107-147/271
Sequence Identity: 46% (19 aa)

AAEMVVALDALHREGIVCRDLNPNNILLNDG----GHIQLT
.||   |.. ||  ||| ||| | |||. |     ||| ..
MAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKIC
Kinase RSKL1.AA SGK 957-988 43 4.3e-08 20.6 In-house 191-222 (283) Show / Hide 
Range on Protein: 957-988
Range on HMM: 191-222/283
Sequence Identity: 43% (14 aa)

YCAPEVGAVTEETEACDWWSLGAVLFELLTGK
| |||| .  .   . |||.||.||.|...|.
YLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGL
Kinase RSKL1.AA RSK 969-989 57 1.6e-07 23.17 In-house 183-203 (271) Show / Hide 
Range on Protein: 969-989
Range on HMM: 183-203/271
Sequence Identity: 57% (12 aa)

TEACDWWSLGAVLFELLTGKT
..||||||.|....| ||| |
DQACDWWSFGVLMYEMLTGCT
Kinase RSKL1.AA p70 957-988 43 3.8e-07 22.11 In-house 204-235 (299) Show / Hide 
Range on Protein: 957-988
Range on HMM: 204-235/299
Sequence Identity: 43% (14 aa)

YCAPEVGAVTEETEACDWWSLGAVLFELLTGK
|.|||.   .    |.||||||. ..  |||.
YMAPEILMRCGHNHAVDWWSLGCLMYDMLTGG
Kinase RSKL1.AA MAST 973-987 53 3e-06 14.23 In-house 251-265 (337) Show / Hide 
Range on Protein: 973-987
Range on HMM: 251-265/337
Sequence Identity: 53% (8 aa)

DWWSLGAVLFELLTG
||||.| ...|.|.|
DWWSMGIIMYEFLVG
Kinase RSKL1.AA AktR 900-936 44 5e-06 19.53 In-house 107-144 (268) Show / Hide 
Range on Protein: 900-936
Range on HMM: 107-144/268
Sequence Identity: 44% (17 aa)

AAEMVVALDALHRE-GIVCRDLNPNNILLNDGGHIQLT
.|... ||. || .  |. ||| | ||||   ||. .|
FAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKIT
Kinase RSKL1.AA AktR 971-989 36 5e-06 19.66 In-house 185-203 (268) Show / Hide 
Range on Protein: 971-989
Range on HMM: 185-203/268
Sequence Identity: 36% (7 aa)

ACDWWSLGAVLFELLTGKT
..|||..|....|..|| .
SVDWWAFGIFIYEMVTGCP
Kinase RSKL1.AA RSK-Unclassified 957-989 45 7e-06 13.85 In-house 188-220 (283) Show / Hide 
Range on Protein: 957-989
Range on HMM: 188-220/283
Sequence Identity: 45% (15 aa)

YCAPEVGAVTEETEACDWWSLGAVLFELLTGKT
| |||.      | | ||| || |..|.| | .
YLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCP
Kinase RSKL1.AA Pkinase 878-933 29 1e-05 21.31 Pfam 90-147 (293) Show / Hide 
Range on Protein: 878-933
Range on HMM: 90-147/293
Sequence Identity: 29% (17 aa)

DLDKRLAASSRFFI--PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHI
||  .. ....  .  .|  ..... ... .|. .|..||. ||| | |||... |||
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHI